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1. Reporting session

Author

Subedi, Deepak, primary, Gregoriades, Marialena, additional, Choi, En Hsun, additional, Murchison, John T, additional, and McKillop, Graham, additional

Published
2022
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2. Oral examinations

Author

Subedi, Deepak, primary, Gregoriades, Marialena, additional, Choi, En Hsun, additional, Murchison, John T, additional, and McKillop, Graham, additional

Published
2022
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3. The examination

Author

Subedi, Deepak, primary, Gregoriades, Marialena, additional, Choi, En Hsun, additional, Murchison, John T, additional, and McKillop, Graham, additional

Published
2022
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5. Rapid reporting

Author

Subedi, Deepak, primary, Gregoriades, Marialena, additional, Choi, En Hsun, additional, Murchison, John T, additional, and McKillop, Graham, additional

Published
2022
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12. Influence of Intracerebral Hemorrhage Location on Incidence, Characteristics, and Outcome: Population-Based Study

Author

Samarasekera, Neshika, Fonville, Arthur, Lerpiniere, Christine, Farrall, Andrew J., Wardlaw, Joanna M., White, Philip M., Smith, Colin, Al-Shahi Salman, Rustam, Addison, Anne, Ahmad, Kate, Alhadad, Syed, Andrews, Peter, Bisset, Elaine, Bodkin, Peter, Bouhaidar, Ralph, Brennan, Paul, Campbell, Brian, Chandran, Siddharthan, Cook, Helen, Davenport, Richard, Dennis, Martin, Derry, Chris, Dodds, Katrina, Doubal, Fergus, Duncan, Susan, Elder, Andrew, Fitzpatrick, Mike, Foley, Peter, Fouyas, Ioannis, Ghosh, Sudipto, Gibson, Rod, Gordon, Claire, Grant, Robin, Hewett, Russell, Hughes, Fiona, Hughes, Mark, Hunt, David, Hunter, Neil, Ironside, James, Liaquat, Imran, Josephson, Colin, Kamat, Anant, Kealley, Susan, Keir, Sarah, Kerr, Gillian, Kerrigan, Simon, Keston, Peter, King, Matthew, Knight, Richard, Macdonald, Elizabeth, Mackay, Graham, Macleod, Donald, Macleod, Malcolm, Maguire, Conor, Makin, Steven, Mathews, Ashok, Maxwell, Fiona, McClellan, Stuart, Millar, Tracey, Morris, Zoe, Morse, Tim, Mumford, Colin, Murray, Katherine, Myles, Lynn, Nimmo, Graham, Ng, Yi, Pal, Suvankar, Rannikmae, Kristiina, Rhodes, Jonathan, Ross, Jerard, Russell, Tim, Sandercock, Peter, Sellar, Robin, Shanmuganathan, Mano, Shekhar, Himanshu, Simms, Henry, Sittampalam, Mara, Soleiman, Hamza, Spiers, Helen, Statham, Patrick, Stavrinos, Neo, Stone, Jon, Stuart, Joyce, Sudlow, Cathie, Summers, David, Taylor, Pat, Torgersen, Antonia, van Dijke, Margarethe, Walker, Robert, Weller, Belinda, Whiteley, William, Whittle, Ian, Will, Robert, Young, Wendy, Anderson, Judith, Broadbent, Seona, Butler, Laura, Caesar, Dave, Cantley, Patricia, Carter, Jonathan, Clegg, Gareth, Coull, Andrew, Crosswaite, Alastair, Dear, James, Dummer, Simon, Duncan, Fiona, Elder-Gracie, Trish, Enright, Kate, Fitzgerald, Tom, Fothergill, Jane, Frier, Brian, Grant, David, Gray, Alasdair, Hart, Simon, Henderson, Robin, Jaap, Alan, Leigh-Smith, Simon, Jones, Michael, Masson, Moyra, McCallum, Lynn, McKechnie, Martin, McKillop, Graham, Mead, Gillian, Morley, Wendy, Morrow, Billie, Morrow, Frank, Murchison, Jon, Murphy, Ross, Ng, Jasmine, Ogundipe, Olayinka, Patel, Dilip, Pollock, Alison, Reed, Matthew, Roberts, Geraint, Selvarajah, Johann, Smith, Randy, Stirling, Claire, Turner, Neil, Wilson, Matthew, Yordanov, Stanko, Bell, Nicola, Chambers, Sarah, Dewar, Sandra, Farquhar, Donald, Harmouche, Ali, Jacob, Ashok, Jackson, Katherine, Knox, Anne, McCafferty, Jon, Moultrie, Sam, Munang, Latana, Noble, Donald, Ramsay, Scott, Spence, Linda, Threlfall, Bethany, Williams, Adrian, Wilson, James, Fitzgerald, Alastair, Jamieson, Andrew, Lange, Peter, McIntosh, Andrew, Morrison, Lewis, and Todd, Iain

Published
2015
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14. In Vivo Mononuclear Cell Tracking Using Superparamagnetic Particles of Iron Oxide: Feasibility and Safety in Humans

Author

Richards, Jennifer M.J., Shaw, Catherine A., Lang, Ninian N., Williams, Michelle C., Semple, Scott I.K., MacGillivray, Thomas J., Gray, Calum, Crawford, Julie H., Alam, Shirjel R., Atkinson, Anne P.M., Forrest, Elaine K., Bienek, Carol, Mills, Nicholas L., Burdess, Anne, Dhaliwal, Kev, Simpson, A. John, Wallace, William A., Hill, Adam T., Roddie, P. Huw, McKillop, Graham, Connolly, Thomas A., Feuerstein, Giora Z., Barclay, G. Robin, Turner, Marc L., and Newby, David E.

Published
2012
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16. Aortic Wall Inflammation Predicts Abdominal Aortic Aneurysm Expansion, Rupture, and Need for Surgical Repair

Author

Newby, David, Forsythe, Rachael, McBride, Olivia, Robson, Jennifer, Vesey, Alex, Chalmers, Roderick, Burns, Paul, Garden, O James, Semple, Scott, Dweck, Marc, Gray, Calum, MacGillivray, Tom, Wang, Chengjia, Koutraki, Yolanda Georgia, Mitchard, Neil, Cooper, Annette, van Beek, Edwin, McKillop, Graham, Ho, Weiyang, Fraser, Liz, Cuthbert, Hayley, Hoskins, Peter, Doyle, Barry, Conlisk, Noel, Stuart, Wesley, Berry, Colin, Roditi, Giles, Murdoch, Laura, Holdsworth, Richard, Scott, Emma, Milne, Lyndsey, Strachan, Fiona, Wee, Fiona, Oatey, Katerine, Graham, Catriona, Murray, Gordon, Milne, Garry, Bucukoglu, Marise, Goodman, Kirsteen, Kaczynski, Jakub, Shah, Anoop S V, Tambyraja, Andrew, Brittenden, Julie, Lambie, Robert, and Norrie, John

Subjects
Male, Contrast Media, Blood Pressure, 030204 cardiovascular system & hematology, 0302 clinical medicine, Original Research Articles, Medicine, Prospective Studies, 030212 general & internal medicine, Magnetite Nanoparticles, Aorta, medicine.diagnostic_test, Smoking, Dextrans, Middle Aged, Magnetic Resonance Imaging, Abdominal aortic aneurysm, 3. Good health, Survival Rate, cardiovascular system, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, Radiology, medicine.symptom, Cardiology and Cardiovascular Medicine, MRI, medicine.medical_specialty, Aortic Rupture, Inflammation, Disease-Free Survival, 03 medical and health sciences, Sex Factors, abdominal aortic aneurysm, Physiology (medical), medicine.artery, Journal Article, Humans, In patient, Aortic rupture, Aged, Proportional Hazards Models, Surgical repair, business.industry, Magnetic resonance imaging, medicine.disease, Aortic wall, repair, rupture, business, Aortic Aneurysm, Abdominal
Abstract

Supplemental Digital Content is available in the text., Background: Ultrasmall superparamagnetic particles of iron oxide (USPIO) detect cellular inflammation on magnetic resonance imaging (MRI). In patients with abdominal aortic aneurysm, we assessed whether USPIO-enhanced MRI can predict aneurysm growth rates and clinical outcomes. Methods In a prospective multicenter open-label cohort study, 342 patients with abdominal aortic aneurysm (diameter ≥40 mm) were classified by the presence of USPIO enhancement and were monitored with serial ultrasound and clinical follow-up for ≥2 years. The primary end point was the composite of aneurysm rupture or repair. Results Participants (85% male, 73.1±7.2 years) had a baseline aneurysm diameter of 49.6±7.7 mm, and USPIO enhancement was identified in 146 (42.7%) participants, absent in 191 (55.8%), and indeterminant in 5 (1.5%). During follow-up (1005±280 days), 17 (5.0%) abdominal aortic aneurysm ruptures, 126 (36.8%) abdominal aortic aneurysm repairs, and 48 (14.0%) deaths occurred. Compared with those without uptake, patients with USPIO enhancement have increased rates of aneurysm expansion (3.1±2.5 versus 2.5±2.4 mm/year, P=0.0424), although this was not independent of current smoking habit (P=0.1993). Patients with USPIO enhancement had higher rates of aneurysm rupture or repair (47.3% versus 35.6%; 95% confidence intervals, 1.1–22.2; P=0.0308). This finding was similar for each component of rupture (6.8% versus 3.7%, P=0.1857) or repair (41.8% versus 32.5%, P=0.0782). USPIO enhancement was associated with reduced event-free survival for aneurysm rupture or repair (P=0.0275), all-cause mortality (P=0.0635), and aneurysm-related mortality (P=0.0590). Baseline abdominal aortic aneurysm diameter (P

Published
2017

18. Non-invasive assessment of coronary artery bypass graft patency using 16-slice computed tomography angiography

Author

Uren Neal G, Sengupta Anshuman, Lawton Tristan, Houslay Emma S, McKillop Graham, and Newby David E

Subjects
Surgery, RD1-811, Anesthesiology, RD78.3-87.3
Abstract

Abstract Background Invasive coronary angiography is the gold standard means of imaging bypass vessels and carries a small but potentially serious risk of local vascular complications, including myocardial infarction, stroke and death. We evaluated computed tomography as a non-invasive means of assessing graft patency. Methods Fifty patients with previous coronary artery bypass surgery who were listed for diagnostic coronary angiography underwent contrast enhanced computed tomography angiography using a 16-slice computed tomography scanner. Images were retrospectively gated to the electrocardiogram and two dimensional axial, multiplanar and three dimensional reconstructions acquired. Sensitivity, specificity, positive and negative predictive value, accuracy and level of agreement for detection of graft patency by multidetector computed tomography. Results A total of 116 grafts were suitable for analysis. The specificity of CT for the detection of graft patency was 100%, with a sensitivity of 92.8%, positive predictive value 100%, negative predictive value 85.8% and an accuracy of 94.8%. The kappa value of agreement between the two means of measuring graft patency was 0.9. Mean radiation dose was 9.0 ± 7.2 mSv for coronary angiography and 18.5 ± 4 mSv for computed tomography. Pooled analysis of eight studies, incorporating 932 grafts, confirmed a 97% accuracy for the detection of graft patency by multidetector computed tomography. Conclusion Computed tomography is an accurate, rapid and non-invasive method of assessing coronary artery bypass graft patency. However, this was achieved at the expense of an increase in radiation dose.

Published
2007
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20. CT coronary angiography in patients with suspected angina due to coronary heart disease (SCOT-HEART): an open-label, parallel-group, multicentre trial

Author

Newby, David, Williams, Michelle, Hunter, Amanda, Pawade, Tania, Shah, Anoop, Flapan, Andrew, Forbes, John, Hargreaves, Allister, Stephen, Leslie, Lewis, Steff, McKillop, Graham, McLean, Scott, Reid, John, Spratt, James, Uren, Neal, Timmis, Adam, Berry, Colin, Boon, Nicholas, Clark, Liz, Craig, Peter, Barlow, Tom, Flather, Marcus, McCormack, Chiara, Roditi, Giles, van Beek, Edwin, Shepherd, Susan, Bucukoglu, Marise, Assi, Valentina, Parker, Richard, Krishan, Ashma, Wee, Fiona, Wackett, Anthony, Walker, Allan, Milne, Lynsey, Oatey, Kat, Neary, Paul, Donaldson, Gillian, Fairbairn, Terry, Fotheringham, Marlene, Hall, Fiona, Glen, Stephen, Perkins, Sarah, Taylor, Fiona, Cram, Louiss, Beveridge, Catherine, Cairns, Avril, Dougherty, Frances, Eteiba, Hany, Rae, Alan, Robb, Kate, Crawford, Wenda, Clarkin, Patricia, Lennon, Elisabeth, Houston, Graeme, Pringle, Stuart, Ramkumar, Prasad Guntur, Sudarshan, Thiru, Fogart, Yvonne, Barrie, Dawn, Bissett, Kim, Dawson, Adelle, Dundas, Scott, Letham, Deborah, O'Neill, Linda, Ritchie, Valerie, Weir-McCall, Jonathan, Dougall, Hamish, Ahmed, Faheem, Cormack, Alistair, Findlay, Iain, Hood, Stuart, Murphy, Clare, Peat, Eileen, McCabe, Lynne, McCubbin, Margaret, Allen, Barbara, Behan, Miles, Bertram, Danielle, Brian, David, Cowan, Amy, Cruden, Nicholas, Denvir, Martin, Dweck, Marc, Flint, Laura, Fyfe, Samantha, Grubb, Neil, Keanie, Collette, Lang, Chris, MacGillivray, Tom, MacLachlan, David, MacLeod, Margaret, Mirsadraee, Saeed, Morrison, Avril, Mills, Nicholas, Northridge, David, Phillips, Alyson, Queripel, Laura, Weir, Nicholas, Jacob, Ashok, Bett, Fiona, Divers, Frances, Fairley, Katie, Keegan, Edith, White, Tricia, Fowler, Julia, Gemmill, John, McGowan, James, Henry, Margo, Francis, Mark, Sandeman, David, Dinnel, Lorraine, Bloomfield, Peter, Henrikson, Peter, MacLeod, Donald, Mangion, Kenneth, Mordi, Ify, Tzemos, Nikolaos, Connolly, Eugene, Boylan, Heather, Brown, Ammani, Farrell, Lesley, Frood, Alison, Glover, Caroline, Johnstone, Janet, Lanaghan, Kirsten, McGlynn, Deborah, McGregor, Lorraine, McLennan, Evonne, Murdoch, Laura, Paterson, Victoria, Teyhan, Fiona, Teenan, Marion, Woodward, Rosie, and Steedman, Tracey

Abstract

Background:\ud The benefit of CT coronary angiography (CTCA) in patients presenting with stable chest pain has not been systematically studied. We aimed to assess the effect of CTCA on the diagnosis, management, and outcome of patients referred to the cardiology clinic with suspected angina due to coronary heart disease.\ud \ud Methods:\ud In this prospective open-label, parallel-group, multicentre trial, we recruited patients aged 18–75 years referred for the assessment of suspected angina due to coronary heart disease from 12 cardiology chest pain clinics across Scotland. We randomly assigned (1:1) participants to standard care plus CTCA or standard care alone. Randomisation was done with a web-based service to ensure allocation concealment. The primary endpoint was certainty of the diagnosis of angina secondary to coronary heart disease at 6 weeks. All analyses were intention to treat, and patients were analysed in the group they were allocated to, irrespective of compliance with scanning. This study is registered with ClinicalTrials.gov, number NCT01149590.\ud \ud Findings:\ud Between Nov 18, 2010, and Sept 24, 2014, we randomly assigned 4146 (42%) of 9849 patients who had been referred for assessment of suspected angina due to coronary heart disease. 47% of participants had a baseline clinic diagnosis of coronary heart disease and 36% had angina due to coronary heart disease. At 6 weeks, CTCA reclassified the diagnosis of coronary heart disease in 558 (27%) patients and the diagnosis of angina due to coronary heart disease in 481 (23%) patients (standard care 22 [1%] and 23 [1%]; p\ud \ud Interpretation:\ud In patients with suspected angina due to coronary heart disease, CTCA clarifies the diagnosis, enables targeting of interventions, and might reduce the future risk of myocardial infarction.

Published
2015

21. Computed tomography myocardial perfusion vs 15O-water positron emission tomography and fractional flow reserve

Author

Williams, Michelle C., primary, Mirsadraee, Saeed, additional, Dweck, Marc R., additional, Weir, Nicholas W., additional, Fletcher, Alison, additional, Lucatelli, Christophe, additional, MacGillivray, Tom, additional, Golay, Saroj K., additional, Cruden, Nicholas L., additional, Henriksen, Peter A., additional, Uren, Neal, additional, McKillop, Graham, additional, Lima, João A. C., additional, Reid, John H., additional, van Beek, Edwin J. R., additional, Patel, Dilip, additional, and Newby, David E., additional

Published
2016
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22. Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial:study protocol for randomized controlled trial

Author

Newby, David E, Williams, Michelle C, Flappan, Andrew D, Forbes, John F, Hargreaves, Allister D, Leslie, Stephen J, Lewis, Stephanie, McKillop, Graham, McLean, Scott, Reid, John, Spratt, James C, Uren, Neal G, van Beek, Edwin J, Boon, Nicholas A, Clark, Liz, Craig, Peter, Flather, Marcus D, McCormack, Chiara, Roditi, Giles, Timmis, Adam D, Krishan, Ashma, Donaldson, Gillian, Fotheringham, Marlene, Hall, Fiona J, Neary, Paul, Cram, Louisa, Perkins, Sarah, Taylor, Fiona, Eteiba, Hany, Rae, Alan P, Robb, Kate, Barrie, Dawn, Bissett, Kim, Dawson, Adelle, Dundas, Scot, Fogarty, Yvonne, Ramkumar, Prasad G, Houston, Graeme J, Letham, Deborah, O'Neill, Linda, Pringle, Stuart, Ritchie, Valerie, Sudarshan, Thiru, Weir-McCall, Jonathan, Cormack, Alistair, Findlay, Iain N, Hood, Stuart, Murphy, Clare, Peat, Eileen, Allen, Barbara, Bertram, Danielle, Brian, David, Cowan, Amy, Cruden, Nicholas L, Dweck, Marc R, Flint, Laura, Fyfe, Samantha, Harding, Collette, Macgillivray, Tom J, Maclachlan, David S, Macleod, Margaret, Misadraee, Saeed, Morrison, Avril, Mills, Nicholas L, Phillips, Alyson, Queripel, Laura J, Weir, Nicholas W, Bett, Fiona, Divers, Frances, Fairley, Katie, Jacob, Ashok J, Keegan, Edith, White, Tricia, Gemmil, John, Henry, Margo, McGowan, James, Dinnel, Lorraine, Francis, Marc C, Sandeman, Dennis, Yerramasu, Ajay, Berry, Colin, Boylan, Heather, Brown, Ammani, Duffy, Karen, Frood, Alison, Johnstone, Janet, Langhan, Kirsten, Macduff, Ross, Macleod, Martin, McGlynn, Deborah, McMillan, Nigel, Murdoch, Laura, Noble, Colin, Paterson, Victoria, Steedman, Tracey, Tzemos, Nikolaos, Baird, Andrew, and Minns, Fiona C

Subjects
Time Factors, Medicine (miscellaneous), Coronary Disease, Research & Experimental Medicine, Rapid access chest pain clinic, Coronary Angiography, Chest pain, ANGIOGRAPHY, DISEASE, Health Services Accessibility, law.invention, Angina, Study Protocol, Clinical Protocols, Randomized controlled trial, Risk Factors, law, Pharmacology (medical), Prospective Studies, Prospective cohort study, 1102 Cardiorespiratory Medicine and Haematology, Computed tomography, medicine.diagnostic_test, Prognosis, Coronary heart disease, Medicine, Research & Experimental, Research Design, Predictive value of tests, Cardiology Service, Hospital, Radiology, medicine.symptom, Emergency Service, Hospital, Life Sciences & Biomedicine, ACCIDENT, medicine.medical_specialty, Angina Pectoris, Decision Support Techniques, Time-to-Treatment, CORONARY-ARTERY CALCIUM, Predictive Value of Tests, General & Internal Medicine, Multidetector Computed Tomography, medicine, Humans, Science & Technology, business.industry, 1103 Clinical Sciences, Emergency department, medicine.disease, EMERGENCY-DEPARTMENT, CALCIFICATION, Cardiovascular System & Hematology, Scotland, Angiography, Imaging technology, business
Abstract

Background Rapid access chest pain clinics have facilitated the early diagnosis and treatment of patients with coronary heart disease and angina. Despite this important service provision, coronary heart disease continues to be under-diagnosed and many patients are left untreated and at risk. Recent advances in imaging technology have now led to the widespread use of noninvasive computed tomography, which can be used to measure coronary artery calcium scores and perform coronary angiography in one examination. However, this technology has not been robustly evaluated in its application to the clinic. Methods/design The SCOT-HEART study is an open parallel group prospective multicentre randomized controlled trial of 4,138 patients attending the rapid access chest pain clinic for evaluation of suspected cardiac chest pain. Following clinical consultation, participants will be approached and randomized 1:1 to receive standard care or standard care plus ≥64-multidetector computed tomography coronary angiography and coronary calcium score. Randomization will be conducted using a web-based system to ensure allocation concealment and will incorporate minimization. The primary endpoint of the study will be the proportion of patients diagnosed with angina pectoris secondary to coronary heart disease at 6 weeks. Secondary endpoints will include the assessment of subsequent symptoms, diagnosis, investigation and treatment. In addition, long-term health outcomes, safety endpoints, such as radiation dose, and health economic endpoints will be assessed. Assuming a clinic rate of 27.0% for the diagnosis of angina pectoris due to coronary heart disease, we will need to recruit 2,069 patients per group to detect an absolute increase of 4.0% in the rate of diagnosis at 80% power and a two-sided P value of 0.05. The SCOT-HEART study is currently recruiting participants and expects to report in 2014. Discussion This is the first study to look at the implementation of computed tomography in the patient care pathway that is outcome focused. This study will have major implications for the management of patients with cardiovascular disease. Trial registration ClinicalTrials.gov Identifier: NCT01149590

Published
2012

23. Valvular 18F-Fluoride and 18F-Fluorodeoxyglucose Uptake Predict Disease Progression and Clinical Outcome in Patients With Aortic Stenosis

Author

Jenkins, William S.A., primary, Vesey, Alex T., additional, Shah, Anoop S.V., additional, Pawade, Tania A., additional, Chin, Calvin W.L., additional, White, Audrey C., additional, Fletcher, Alison, additional, Cartlidge, Timothy R.G., additional, Mitchell, Andrew J., additional, Pringle, Mark A.H., additional, Brown, Oliver S., additional, Pessotto, Renzo, additional, McKillop, Graham, additional, Van Beek, Edwin J.R., additional, Boon, Nicholas A., additional, Rudd, James H.F., additional, Newby, David E., additional, and Dweck, Marc R., additional

Published
2015
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24. MRI using ultrasmall superparamagnetic particles of iron oxide in patients under surveillance for abdominal aortic aneurysms to predict rupture or surgical repair: MRI for abdominal aortic aneurysms to predict rupture or surgery—the MA3RS study

Author

McBride, Olivia M B, primary, Berry, Colin, additional, Burns, Paul, additional, Chalmers, Roderick T A, additional, Doyle, Barry, additional, Forsythe, Rachael, additional, Garden, O James, additional, Goodman, Kirsteen, additional, Graham, Catriona, additional, Hoskins, Peter, additional, Holdsworth, Richard, additional, MacGillivray, Thomas J, additional, McKillop, Graham, additional, Murray, Gordon, additional, Oatey, Katherine, additional, Robson, Jennifer M J, additional, Roditi, Giles, additional, Semple, Scott, additional, Stuart, Wesley, additional, van Beek, Edwin J R, additional, Vesey, Alex, additional, and Newby, David E, additional

Published
2015
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25. Ultrasmall superparamagnetic particles of iron oxide-enhanced magnetic resonance imaging in the assessment of cellular inflammation after myocardial infarction

Author

Stirrat, Colin G, primary, Alam, Shirjel, additional, MacGillivray, Thomas J, additional, Gray, Calum D, additional, Dweck, Marc R, additional, Mirsadraee, Saeed, additional, McKillop, Graham, additional, Henriksen, Peter A, additional, Newby, David, additional, and Semple, Scott, additional

Published
2015
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26. Computed tomography myocardial perfusion vs 15O-water positron emission tomography and fractional flow reserve.

Author

Williams, Michelle, Mirsadraee, Saeed, Dweck, Marc, Weir, Nicholas, Fletcher, Alison, Lucatelli, Christophe, MacGillivray, Tom, Golay, Saroj, Cruden, Nicholas, Henriksen, Peter, Uren, Neal, McKillop, Graham, Lima, João, Reid, John, Beek, Edwin, Patel, Dilip, Newby, David, Williams, Michelle C, Dweck, Marc R, and Weir, Nicholas W

Subjects
COMPUTED tomography, MYOCARDIAL perfusion imaging, CORONARY angiography, POSITRON emission tomography, CORONARY disease
Abstract

Objectives: Computed tomography (CT) can perform comprehensive cardiac imaging. We compared CT coronary angiography (CTCA) and CT myocardial perfusion (CTP) with 15O-water positron emission tomography (PET) and invasive coronary angiography (ICA) with fractional flow reserve (FFR).Methods: 51 patients (63 (61-65) years, 80 % male) with known/suspected coronary artery disease (CAD) underwent 320-multidetector CTCA followed by "snapshot" adenosine stress CTP. Of these 22 underwent PET and 47 ICA/FFR. Obstructive CAD was defined as CTCA stenosis >50 % and CTP hypoperfusion, ICA stenosis >70 % or FFR <0.80.Results: PET hyperaemic myocardial blood flow (MBF) was lower in obstructive than non-obstructive territories defined by ICA/FFR (1.76 (1.32-2.20) vs 3.11 (2.44-3.79) mL/(g/min), P < 0.001) and CTCA/CTP (1.76 (1.32-2.20) vs 3.12 (2.44-3.79) mL/(g/min), P < 0.001). Baseline and hyperaemic CT attenuation density was lower in obstructive than non-obstructive territories (73 (71-76) vs 86 (84-88) HU, P < 0.001 and 101 (96-106) vs 111 (107-114) HU, P 0.001). PET hyperaemic MBF corrected for rate pressure product correlated with CT attenuation density (r = 0.579, P < 0.001). There was excellent per-patient sensitivity (96 %), specificity (85 %), negative predictive value (90 %) and positive predictive value (94 %) for CTCA/CTP vs ICA/FFR.Conclusion: CT myocardial attenuation density correlates with 15O-water PET MBF. CTCA and CTP can accurately identify obstructive CAD.Key Points: •CT myocardial perfusion can aid the assessment of suspected coronary artery disease. • CT attenuation density from "snapshot" imaging is a marker of myocardial perfusion. • CT myocardial attenuation density correlates with 15 O-water PET myocardial blood flow. • CT attenuation density is lower in obstructive territories defined by invasive angiography. • Diagnostic accuracy of CTCA+CTP is comparable to invasive angiography + fractional flow reserve. [ABSTRACT FROM AUTHOR]

Published
2017
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27. Left Ventricular Hypertrophy With Strain and Aortic Stenosis

Author

Shah, Anoop S.V., primary, Chin, Calvin W.L., additional, Vassiliou, Vassilis, additional, Cowell, S. Joanna, additional, Doris, Mhairi, additional, Kwok, T’ng Choong, additional, Semple, Scott, additional, Zamvar, Vipin, additional, White, Audrey C., additional, McKillop, Graham, additional, Boon, Nicholas A., additional, Prasad, Sanjay K., additional, Mills, Nicholas L., additional, Newby, David E., additional, and Dweck, Marc R., additional

Published
2014
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28. Quantitative Serial MRI of the Treated Fibroid Uterus

Author

Munro, Kirsty I., primary, Thrippleton, Michael J., additional, Williams, Alistair R. W., additional, McKillop, Graham, additional, Walker, Jane, additional, Horne, Andrew W., additional, Newby, David E., additional, Anderson, Richard A., additional, Semple, Scott I., additional, Marshall, Ian, additional, Lewis, Steff C., additional, Millar, Robert P., additional, Bastin, Mark E., additional, and Critchley, Hilary O. D., additional

Published
2014
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30. INCIDENCE OF TYPE 5 MYOCARDIAL INFARCTION BY THE THIRD UNIVERSAL DEFINITION

Author

Alam, Shirjel, primary, Spath, Nick, additional, Dweck, Marc, additional, Shah, Anoop, additional, Semple, Scott, additional, Mckillop, Graham, additional, Mirsadraee, Saeed, additional, Pessotto, Renzo, additional, Zamvar, Vipin, additional, Mills, Nicholas, additional, Newby, David, additional, and Henriksen, Peter, additional

Published
2013
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31. NANOPARTICLE ENHANCED MRI: A NOVEL METHOD OF INVESTIGATING MYOCARDIAL INFLAMMATION

Author

Alam, Shirjel, primary, Spath, Nick, additional, Richards, Jennifer, additional, Hunter, Amanda, additional, Shah, Anoop, additional, Lang, Ninian, additional, MacGillivray, Tom, additional, Mckillop, Graham, additional, Mirsadraee, Saeed, additional, Pessotto, Renzo, additional, Zamvar, Vipin, additional, Semple, Scott, additional, Newby, David, additional, and Henriksen, Peter, additional

Published
2013
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32. Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial

Author

Newby, David E, primary, Williams, Michelle C, additional, Flapan, Andrew D, additional, Forbes, John F, additional, Hargreaves, Allister D, additional, Leslie, Stephen J, additional, Lewis, Steff C, additional, McKillop, Graham, additional, McLean, Scott, additional, Reid, John H, additional, Sprat, James C, additional, Uren, Neal G, additional, van Beek, Edwin J, additional, Boon, Nicholas A, additional, Clark, Liz, additional, Craig, Peter, additional, Flather, Marcus D, additional, McCormack, Chiara, additional, Roditi, Giles, additional, Timmis, Adam D, additional, Krishan, Ashma, additional, Donaldson, Gillian, additional, Fotheringham, Marlene, additional, Hall, Fiona J, additional, Neary, Paul, additional, Cram, Louisa, additional, Perkins, Sarah, additional, Taylor, Fiona, additional, Eteiba, Hany, additional, Rae, Alan P, additional, Robb, Kate, additional, Barrie, Dawn, additional, Bissett, Kim, additional, Dawson, Adelle, additional, Dundas, Scot, additional, Fogarty, Yvonne, additional, Ramkumar, Prasad Guntur, additional, Houston, Graeme J, additional, Letham, Deborah, additional, O’Neill, Linda, additional, Pringle, Stuart D, additional, Ritchie, Valerie, additional, Sudarshan, Thiru, additional, Weir-McCall, Jonathan, additional, Cormack, Alistair, additional, Findlay, Iain N, additional, Hood, Stuart, additional, Murphy, Clare, additional, Peat, Eileen, additional, Allen, Barbara, additional, Baird, Andrew, additional, Bertram, Danielle, additional, Brian, David, additional, Cowan, Amy, additional, Cruden, Nicholas L, additional, Dweck, Marc R, additional, Flint, Laura, additional, Fyfe, Samantha, additional, Keanie, Collette, additional, MacGillivray, Tom J, additional, Maclachlan, David S, additional, MacLeod, Margaret, additional, Mirsadraee, Saeed, additional, Morrison, Avril, additional, Mills, Nicholas L, additional, Minns, Fiona C, additional, Phillips, Alyson, additional, Queripel, Laura J, additional, Weir, Nicholas W, additional, Bett, Fiona, additional, Divers, Frances, additional, Fairley, Katie, additional, Jacob, Ashok J, additional, Keegan, Edith, additional, White, Tricia, additional, Gemmill, John, additional, Henry, Margo, additional, McGowan, James, additional, Dinnel, Lorraine, additional, Francis, C Mark, additional, Sandeman, Dennis, additional, Yerramasu, Ajay, additional, Berry, Colin, additional, Boylan, Heather, additional, Brown, Ammani, additional, Duffy, Karen, additional, Frood, Alison, additional, Johnstone, Janet, additional, Lanaghan, Kirsten, additional, MacDuff, Ross, additional, MacLeod, Martin, additional, McGlynn, Deborah, additional, McMillan, Nigel, additional, Murdoch, Laura, additional, Noble, Colin, additional, Paterson, Victoria, additional, Steedman, Tracey, additional, and Tzemos, Nikolaos, additional

Published
2012
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33. Ultrasmall Superparamagnetic Particles of Iron Oxide in Patients With Acute Myocardial Infarction

Author

Alam, Shirjel R., primary, Shah, Anoop S.V., additional, Richards, Jennifer, additional, Lang, Ninian N., additional, Barnes, Gareth, additional, Joshi, Nikhil, additional, MacGillivray, Tom, additional, McKillop, Graham, additional, Mirsadraee, Saeed, additional, Payne, John, additional, Fox, Keith A.A., additional, Henriksen, Peter, additional, Newby, David E., additional, and Semple, Scott I.K., additional

Published
2012
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34. Coronary Arterial 18F-Sodium Fluoride Uptake

Author

Dweck, Marc R., primary, Chow, Marcus W.L., additional, Joshi, Nikhil V., additional, Williams, Michelle C., additional, Jones, Charlotte, additional, Fletcher, Alison M., additional, Richardson, Hamish, additional, White, Audrey, additional, McKillop, Graham, additional, van Beek, Edwin J.R., additional, Boon, Nicholas A., additional, Rudd, James H.F., additional, and Newby, David E., additional

Published
2012
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35. CORONARY ARTERIAL 18F-NAF UPTAKE: A NOVEL MARKER OF PLAQUE BIOLOGY

Author

Dweck, Marc R., primary, Chow, Marcus WL, additional, Joshi, Nikhil V., additional, Williams, Mlchelle C., additional, Jones, Charlotte, additional, Fletcher, Alison M., additional, Richardson, Hamish, additional, White, Audrey, additional, McKillop, Graham, additional, van Beek, Edwin JR, additional, Boon, Nicholas A., additional, Rudd, James HF, additional, and Newby, David E., additional

Published
2012
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36. Assessment of Valvular Calcification and Inflammation by Positron Emission Tomography in Patients With Aortic Stenosis

Author

Dweck, Marc Richard, primary, Jones, Charlotte, additional, Joshi, Nikhil V., additional, Fletcher, Alison M., additional, Richardson, Hamish, additional, White, Audrey, additional, Marsden, Mark, additional, Pessotto, Renzo, additional, Clark, John C., additional, Wallace, William A., additional, Salter, Donald M., additional, McKillop, Graham, additional, van Beek, Edwin J.R., additional, Boon, Nicholas A., additional, Rudd, James H.F., additional, and Newby, David E., additional

Published
2012
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37. Abdominal Aortic Aneurysm Growth Predicted by Uptake of Ultrasmall Superparamagnetic Particles of Iron Oxide

Author

Richards, Jennifer M.J., primary, Semple, Scott I., additional, MacGillivray, Thomas J., additional, Gray, Calum, additional, Langrish, Jeremy P., additional, Williams, Michelle, additional, Dweck, Marc, additional, Wallace, William, additional, McKillop, Graham, additional, Chalmers, Roderick T.A., additional, Garden, O. James, additional, and Newby, David E., additional

Published
2011
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42. MRI using ultrasmall superparamagnetic particles of iron oxide in patients under surveillance for abdominal aortic aneurysms to predict rupture or surgical repair: MRI for abdominal aortic aneurysms to predict rupture or surgery-the MA3RS study

Author

McBride, Olivia M. B., Berry, Colin, Burns, Paul, Chalmers, Roderick T. A., Doyle, Barry, Forsythe, Rachael, Garden, O. James, Goodman, Kirsteen, Graham, Catriona, Hoskins, Peter, Holdsworth, Richard, MacGillivray, Thomas J., McKillop, Graham, Murray, Gordon, Oatey, Katherine, Robson, Jennifer M. J., Roditi, Giles, Semple, Scott, Stuart, Wesley, and van Beek, Edwin J. R.

Published
2015
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47. Coronary Arterial 18F-Sodium Fluoride Uptake A Novel Marker of Plaque Biology

Author

Dweck, Marc R., Chow, Marcus W.L., Joshi, Nikhil V., Williams, Michelle C., Jones, Charlotte, Fletcher, Alison M., Richardson, Hamish, White, Audrey, McKillop, Graham, van Beek, Edwin J.R., Boon, Nicholas A., Rudd, James H.F., and Newby, David E.

Subjects
calcification, risk prediction, positron emission tomography, inflammation, acute coronary syndrome
Abstract

ObjectivesWith combined positron emission tomography and computed tomography (CT), we investigated coronary arterial uptake of 18F-sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) as markers of active plaque calcification and inflammation, respectively.BackgroundThe noninvasive assessment of coronary artery plaque biology would be a major advance particularly in the identification of vulnerable plaques, which are associated with specific pathological characteristics, including micro-calcification and inflammation.MethodsWe prospectively recruited 119 volunteers (72 ± 8 years of age, 68% men) with and without aortic valve disease and measured their coronary calcium score and 18F-NaF and 18F-FDG uptake. Patients with a calcium score of 0 were used as control subjects and compared with those with calcific atherosclerosis (calcium score >0).ResultsInter-observer repeatability of coronary 18F-NaF uptake measurements (maximum tissue/background ratio) was excellent (intra-class coefficient 0.99). Activity was higher in patients with coronary atherosclerosis (n = 106) versus control subjects (1.64 ± 0.49 vs. 1.23 ± 0.24; p = 0.003) and correlated with the calcium score (r = 0.652, p < 0.001), although 40% of those with scores >1,000 displayed normal uptake. Patients with increased coronary 18F-NaF activity (n = 40) had higher rates of prior cardiovascular events (p = 0.016) and angina (p = 0.023) and higher Framingham risk scores (p = 0.011). Quantification of coronary 18F-FDG uptake was hampered by myocardial activity and was not increased in patients with atherosclerosis versus control subjects (p = 0.498).Conclusions18F-NaF is a promising new approach for the assessment of coronary artery plaque biology. Prospective studies with clinical outcomes are now needed to assess whether coronary 18F-NaF uptake represents a novel marker of plaque vulnerability, recent plaque rupture, and future cardiovascular risk. (An Observational PET/CT Study Examining the Role of Active Valvular Calcification and Inflammation in Patients With Aortic Stenosis; NCT01358513)

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50. Abnormal Anatomy Encountered During VATS Left Upper Lobe Trisegmentectomy.

Author

Woolley, Steve, Hughes, Michael, McKillop, Graham, and Walker, William S.

Subjects
HUMAN anatomy, PULMONARY artery abnormalities, PULMONARY blood vessels, BRONCHI physiology, THORACOSCOPY, SURGICAL excision, PHYSIOLOGY
Abstract

Overview Abnormalities of pulmonary vasculature and bronchial anatomy are of key importance in performing lung resections especially via a VATS approach. This series of images illustrates the need to be aware of structural abnormalities when completing thoracic procedures. [ABSTRACT FROM AUTHOR]

Published
2012

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