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Computed tomography myocardial perfusion vs 15O-water positron emission tomography and fractional flow reserve.

Authors :
Williams, Michelle
Mirsadraee, Saeed
Dweck, Marc
Weir, Nicholas
Fletcher, Alison
Lucatelli, Christophe
MacGillivray, Tom
Golay, Saroj
Cruden, Nicholas
Henriksen, Peter
Uren, Neal
McKillop, Graham
Lima, João
Reid, John
Beek, Edwin
Patel, Dilip
Newby, David
Williams, Michelle C
Dweck, Marc R
Weir, Nicholas W
Source :
European Radiology; Mar2017, Vol. 27 Issue 3, p1114-1124, 11p, 1 Color Photograph, 5 Charts, 2 Graphs
Publication Year :
2017

Abstract

<bold>Objectives: </bold>Computed tomography (CT) can perform comprehensive cardiac imaging. We compared CT coronary angiography (CTCA) and CT myocardial perfusion (CTP) with 15O-water positron emission tomography (PET) and invasive coronary angiography (ICA) with fractional flow reserve (FFR).<bold>Methods: </bold>51 patients (63 (61-65) years, 80 % male) with known/suspected coronary artery disease (CAD) underwent 320-multidetector CTCA followed by "snapshot" adenosine stress CTP. Of these 22 underwent PET and 47 ICA/FFR. Obstructive CAD was defined as CTCA stenosis >50 % and CTP hypoperfusion, ICA stenosis >70 % or FFR <0.80.<bold>Results: </bold>PET hyperaemic myocardial blood flow (MBF) was lower in obstructive than non-obstructive territories defined by ICA/FFR (1.76 (1.32-2.20) vs 3.11 (2.44-3.79) mL/(g/min), P < 0.001) and CTCA/CTP (1.76 (1.32-2.20) vs 3.12 (2.44-3.79) mL/(g/min), P < 0.001). Baseline and hyperaemic CT attenuation density was lower in obstructive than non-obstructive territories (73 (71-76) vs 86 (84-88) HU, P < 0.001 and 101 (96-106) vs 111 (107-114) HU, P 0.001). PET hyperaemic MBF corrected for rate pressure product correlated with CT attenuation density (r = 0.579, P < 0.001). There was excellent per-patient sensitivity (96 %), specificity (85 %), negative predictive value (90 %) and positive predictive value (94 %) for CTCA/CTP vs ICA/FFR.<bold>Conclusion: </bold>CT myocardial attenuation density correlates with 15O-water PET MBF. CTCA and CTP can accurately identify obstructive CAD.<bold>Key Points: </bold>•CT myocardial perfusion can aid the assessment of suspected coronary artery disease. • CT attenuation density from "snapshot" imaging is a marker of myocardial perfusion. • CT myocardial attenuation density correlates with 15 O-water PET myocardial blood flow. • CT attenuation density is lower in obstructive territories defined by invasive angiography. • Diagnostic accuracy of CTCA+CTP is comparable to invasive angiography + fractional flow reserve. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09387994
Volume :
27
Issue :
3
Database :
Complementary Index
Journal :
European Radiology
Publication Type :
Academic Journal
Accession number :
121148714
Full Text :
https://doi.org/10.1007/s00330-016-4404-5