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Cabozantinib inhibits multiple receptor tyrosine kinases, including the TAM kinase family, and may enhance response to immune checkpoint inhibitors. One cohort of the ongoing phase Ib COSMIC-021 study (NCT03170960) evaluating cabozantinib plus the PD-L1 inhibitor atezolizumab in men with metastatic castration-resistant prostate cancer (mCRPC) that has progressed in soft tissue on/after enzalutamide and/or abiraterone treatment for metastatic disease has shown promising efficacy. Here, we describe the rationale and design of a phase III trial of cabozantinib plus atezolizumab versus a second novel hormone therapy (NHT) in patients who have previously received an NHT for mCRPC, metastatic castration-sensitive PC or nonmetastatic CRPC and have measurable visceral disease and/or extrapelvic adenopathy - a population with a significant unmet need for treatment options. Trial Registration Clinical Trial Registration: NCT04446117 (ClinicalTrials.gov) Registered on 24 June 2020.

Many young people who engage in self-harm do not seek help from health services. For those that do, emergency departments (EDs) are a key point of contact. Substantial gaps remain in current knowledge related to young consumers' experiences and views on optimal treatment of self-harm in the ED. In this study, semi-structured interviews were conducted with thirteen young people (Mage = 21.2 years), who were engaged with care at headspace early intervention centers and had presented to an ED with a self-inflicted physical injury. Participants were asked to describe their experience in the ED and the care they received. Data were analyzed thematically. Three inter-related themes were identified: 1. The ED was experienced through a lens of significant distress, 2. The ED environment and processes were counter-therapeutic, and 3. Staff were perceived to be disinterested, dismissive, and lacking in knowledge. The study highlights the overwhelmingly negative nature of participants' experiences, and presents recommendations for service and practice improvements, such as the provision of staff training and increased aftercare.

Objectively comparing cashmere goats with different cashmere production, mean fibre diameter (MFD) and staple length (SL) is difficult for farmers. We aimed to develop indices to enable cashmere producers to identify productive goats within their own farms once adjustments had been made for the primary determinants of cashmere production. That is we aimed to develop indices that identify goats and herds that biologically have a high fleece weight in relation to MFD and SL. We used a sample of 1244 commercial cashmere fleeces from goats originating from many Australian farms based in different environmental zones and a previously developed general linear model that related the logarithm of clean cashmere production (CCMwt) and any other potential determinant. In the present study, sub-models were investigated in order to develop new indices for comparing goats in the same farm, based on fleece characteristics and biological efficiency. New Index (MFD), equal to 6.02×CCMwt/1.1531MFD, was developed to identify animals of biologically high CCMwt in relation to their MFD. Unlike previously reported results that MFD is not a useful measurement for comparing the biological efficiency of cashmere goats across farms, the New Index (MFD) allows comparison of the biological efficiency of cashmere goats within farms. New Index (SL), equal to 2.70 × CCMwt/1.1414SL, was developed to identify animals of biologically high CCMwt in relation to their SL. New Index (SL) is very similar to the Clean Cashmere Staple Length Index (CCSLI) that had been previously reported for comparison of cashmere goats across farms, and thus the CCSLI can be usefully used for comparing the biological efficiency of cashmere goats both across and within farms. New Index MFD, SL = 8.90 × CCMwt/1.243(MFD+SL)/2 was developed to identify animals of biologically high CCMwt in relation to both their MFD and SL within farms, and provides useful information above

Two instruments have been developed by the Sheep CRC that provide the tools for a new standard in comfort and handle for the next generation of next-to-skin wool knitwear. The Wool ComfortMeter and Wool HandleMeter provide a rapid, accurate and objective measure of two important characteristics of wool knitwear that are currently determined by subjective assessment. The Wool HandleMeter allows the prediction of a set of handle attribute values that can quantify the hand feel of a lightweight jersey fabric. The instrument uses the principle of pushing a fabric sample through a ring. The force displacement curve associated with the fabric test is characterised and used to define each fabric. These values were then compared to the average handle values, as determined by a group of experts, of a large set of lightweight knitted fabrics. Algorithms were developed that enable the instrument to more accurately predict each of seven handle attributes than an individual expert. The Wool ComfortMeter provides a measure of the fibres that are protruding from the surface of the fabric that are responsible for the itchy sensation caused by some knitwear. The results from the instrument have been compared to the results from extensive wearer trials to provide an understanding of the relationship between the instrument value and the comfort perceptions of wearers. The results have shown a very clear relationship between the instrument and wearer trials.