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5. National scientific medical meeting 1997 abstracts

Author

Willison, H. J., Lastovica, A. J., Prendergast, M. M., Moran, A. P., Walsh, C., Flitcroft, I., Eustace, P., McMahon, C., Smith, J., Smith, O. P., Lakshmandass, G., Taylor, M. R. H., Holland, C. V., Cox, D., Good, B., Kearns, G. M., Gaffney, P., Shark, K., Frauenshuh, M., Ortmann, W., Messner, R., King, R., Rich, S., Behrens, T., Mahmud, N., Molloy, A., McPartlin, J., Scott, J. M., Weir, D. G., Walsh, K. M., Thorburn, D., Mills, P., Morris, A. J., Good, T., Cameron, S., McCruden, E. A. B., Bennett, M. W., O’Connell, J., Brady, C., Roche, D., Collins, J. K., Shanahan, F., O’Sullivant, G. C., Henry, M., Koston, S., McMahon, K., MacNee, W., FitzGerald, M. X., O’Connor, C. M., McGonagle, D., Gibbon, W., O’Connor, P., Emery, P., Murphy, M., Watson, R., Casey, E., Naidu, E., Murphy, M., Watson, R., Barnes, L., McCann, S., Murphy, M., Watson, R., Barnes, L., Sweeney, E., Barrett, E. J., Graham, H., Cunningham, R. T., Johnston, C. F., Curry, W. J., Buchanan, K. D., Courtney, C. H., McAllister, A. S., McCance, D. R., Hadden, D. R., Bell, P. M., Leslie, H., Sheridan, B., Atkinson, A. B., Kilbane, M. T., Smith, D. F., Murray, M. J., Shering, S. G., McDermott, E. W. M., O’Higgins, N. J., Smyth, P. P. A., McEneny, J., Trimble, E. R., Young, I. S., Sharpe, P., Mercer, C., McMaster, D., Young, I. S., Evans, A. E., Young, I. S., Cundick, J., Hasselwander, O., McMaster, D., McGeough, J., Savage, D., Maxwell, A. P., Evans, A. E., Kee, F., Larkin, C. J., Watson, R. G. P., Johnston, C., Ardill, J. E. S., Buchanan, K. D., McNamara, D. A., Walsh, T. N., Bouchier-Hayes, D. J., Madden, C., Timon, C., Gardiner, N., Lawler, M., O’Riordan, J., Duggan, C., McCann, S. R., Gowing, H., Braakman, E., Lawler, M., Byrne, C., Martens, A. C. M., Hagenbeek, A., McCann, S. R., Kinsella, N., Cusack, S., Lawler, M., Baker, H., White, B., Smith, O. P., Lawler, M., Gardiner, N., Molloy, K., Gowing, H., Wogan, A., McCann, S. R., McElwaine, S., Lawler, M., Hollywood, D., McCann, S. R., Mcmahon, C., Merry, C., Ryan, M., Smith, O., Mulcahy, F. M., Murphy, C., Briones, J., Gardiner, N., McCann, S. R., Lawler, M., White, B., Lawler, M., Cusack, S., Kinsella, N., Smith, O. P., Lavin, P., McCaffrey, M., Gillen, P., White, B., Smith, O. P., Thompson, L., Lalloz, M., Layton, M., Barnes, L., Corish, C., Kennedy, N. P., Flood, P., Mulligan, S., McNamara, E., Kennedy, N. P., Flood, P., Mathias, P. M., Ball, E., Duiculescu, D., Calistru, P., O’Gorman, N., Kennedy, N. P., Abuzakouk, M., Feighery, C., Brannigan, M., Pender, S., Keeling, F., Varghese, J., Lee, M., Colreavy, M., Gaffney, R., Hone, S., Herzig, M., Walsh, M., Dolan, C., Wogan, A., Lawler, M., McCann, S. R., Hollywood, D., Donovan, D., Harmey, J., Bouchier-Hayes, D. J., Haverty, A., Wang, J. H., Harmey, J. H., Redmond, H. P., Bouchier-Hayes, D. J., McGreal, G., Shering, S. G., Moriarty, M. J., Shortt, A., Kilbane, M. T., Smith, D. F., McDermott, E. W. M., O’Higgins, N. J., Smyth, P. P. A., McNamara, D. A., Harmey, J., Wang, J. H., Donovan, D., Walsh, T. N., Bouchier-Hayes, D. J., Kay, E., Pidgeon, G., Harmey, J., McNamara, D. A., Bouchier-Hayes, D. J., Dunne, P., Lambkin, H., Russell, J. M., O’Neill, A. J., Dunne, B. M., O’Donovan, M., Lawler, M., Gaffney, E. F., Gillan, J. E., Cotter, T. G., Horan, J., Jones, D., Biswas, S. K., Mulkerrin, E. C., Brady, H., O’Donnell, J., Neary, J., Healy, E., Watson, A., Keogh, B., Ryan, M., Cassidy, C., Ward, S., Stokes, E., Keoghan, F., Barrett, A., O’Connell, P., Ryall, N., O’Connell, P. A., Jenkinson, A., O’Brien, T., O’Connell, P. G., Harrison, R., Barrett, T., Bailey, D. M. D., Butler, A., Barton, D. E., Byrne, C., McElwaine, S., McCann, S. R., Lawler, M., Cusack, S., Lawler, M., White, B., Smith, O. P., Daly, G., Gill, M., Heron, S., Hawi, Z., Fitzgerald, M., Hawi, Z., Mynett-Johnson, L., Shiels, D., Kendler, K., McKeon, P., Gill, M., Straub, R., Walsh, D., Ryan, F., Barton, D. E., McCabe, D., Murphy, R., Segurado, R., Mulcahy, T., Larson, B., Comerford, C., O’Connell, R., O’Mahony, E., Gill, M., Donnelly, J., Minahan, F., O’Neill, D., Farrell, Z., O’Neill, D., Jones, D., Horan, J., Glynn, C., Biswas, S. K., Mulkerrin, E., Brady, H., Lennox, S. E., Murphy, A., Rea, I. M., McNulty, H., McMeel, C., O’Neill, D., McEvoy, H., Freaney, R., McKenna, M. J., Crowe, M., Keating, D., Colreavy, M., Hone, S., Norman, G., Widda, S., Viani, L., Galvin, Nolan, C. M., Hardiman, O., Hardiman, O., Brett, F., Droogan, O., Gallagher, P., Harmey, M., King, M., Murphy, J., Perryrnan, R., Sukumaran, S., Walsh, J., Farrell, M. A., Hughes, G., Cunningham, C., Walsh, J. B., Coakley, D., O’Neill, D., Hurson, M., Flood, P., McMonagle, P., Hardiman, O., Ryan, F., O’Sullivan, S., Merry, C., Dodd, P., Redmond, J., Mulcahy, F. M., Browne, R., Keating, S., O’Connor, J., Cassidy, B. P., Smyth, R., Sheppard, N. P., Cullivan, R., Crown, J., Walsh, N., Denihan, A., Bruce, I., Radic, A., Coakley, D., Lawlor, B. A., Bridges, P. K., O’Doherty, M., Farrington, A., O’Doherty, M., Farragher, B., Fahy, S., Kelly, R., Carey, T., Owens, J., Gallagher, O., Sloan, D., McDonough, C., Casey, P., Horgan, A., Elneihum, A., O’Neill, C., McMonagle, T., Quinn, J., Meagher, D., Murphy, P., Kinsella, A., Mullaney, J., Waddington, J. L., Rooney, S., Rooney, S., Bamford, L., Sloan, D., O’Connor, J. J., Franklin, R., O’Brien, K., Fitzpatrick, G., Laffey, J. G., Boylan, J. F., Laffey, J., Coleman, M., Boylan, J., Laffey, J. G., McShane, A. J., Boylan, J. F., Loughrey, J. P. R., Gardiner, J., McGinley, J., Leonard, I., Carey, M., Neligan, P., O’Rourke, J., Cunningham, A., Fennessy, F., Kelly, C., Bouchier-Hayes, D., Fennessy, F., Wang, J. H., Kelly, C., Bouchier-Hayes, D., Fennessy, F., Wang, J. H., Kelly, C., Bouchier-Hayes, D. J., Kellett, J., Laffey, J., Murphy, D., Regan, J., O’Keeffe, D., Mahmud, A., Hemeryck, L., Feely, J., Mahmud, A., Hemeryck, L., Hall, M., Feely, J., Menown, I. B. A., Mathew, T. P., Nesbitt, G. S., Syme, M., Young, I. S., Adgey, A. A. J., Menown, I. B. A., Turtle, F., Allen, J., Anderson, J., Adgey, A. A. J., O’Hanlon, R., Codd, M. B., Walkin, S., McCann, H. A., Sugrue, D. D., Rasheed, A. M., Chen, G., Kelly, C., Bouchier-Hayes, D. J., Leahy, A., Rasheed, A. M., Kay, E., Jina, S., Bouchier-Hayes, D. J., Leahy, A., McDowell, I., Rasheed, A. M., Wang, J. H., Wo, Q., Kelly, C., Bouchier-Hayes, D. J., Leahy, A., Shuhaibar, M. N., McGovern, E., Turtle, F., Menown, I. B. A., Manoharan, G., Kirkpatrick, R., Campbell, N. P. S., Walkin, S., Codd, M. B., O’Hanlon, R., McCarthy, C., McCann, H. A., Sugrue, D. D., Wen, Y., Killalea, S., Hall, M., Hemeryck, L., Feely, J., Fahy, C. J., Griffith, A., McGinley, J., McCabe, D., Fraser, A., Casey, E., Ryan, T., Murphy, R., Browne, M., Fenton, J., Hughes, J., Timon, C. I., Fenton, J., Curran, A., Smyth, D., Viani, L., Walsh, M., Hughes, J. P., Fenton, J., Lee, P., Kelly, A., Timon, C. I., Hughes, J. P., Fenton, J., Shine, N., Blayney, A., McShane, D. P., Timon, C. I., Hussey, J., Howlett, M., Langton, A., McEvoy, A., Slevin, J., Fitzpatrick, C., Turner, M. J., Enright, F., Goggin, N., Costigan, C., Duff, D., Osizlok, P., Wood, F., Watson, R., Fitzsimons, R. B., Flanagan, N., Enright, F., Barnes, L., Watson, R., Molloy, E., Griffin, E., Deasy, P. F., Sheridan, M., White, M. J., Moore, R., Gray, A., Hill, J., Glasgow, J. F. T., Middleton, B., Slattery, D., Donoghue, V., McMahon, A., Murphy, J., Slattery, D., McCarthy, A., Oslislok, P., Duff, D., Colreavy, M., Keogh, I., Hone, S., Walsh, M., Henry, M., Koston, S., McMahon, K., MacNee, W., FitzGerald, M. X., O’Connor, C. M., Russell, K. J., Henry, M., Fitzgerald, M. X., O’Connor, C. M., Kavanagh, P. V., McNamara, S. M., Feely, J., Barry, M., O’Brien, J. E., McCormick, P., Molony, C., Doyle, R. M., Walsh, J. B., Coakley, D., Codd, M. B., O’Connell, P. R., Dowey, L. C., McGlynn, H., Thurnham, D. I., Elborn, S. J., Flynn, L., Carton, J., Byrne, B., O’Farrelly, C., Kelehan, P., O’Herlihy, C., O’Hara, A. M., Moran, A. P., Orren, A., Fernie, B. A., Merry, C., Clarke, S., Courtney, G., de Gascun, C., Mulcahy, F. M., Merry, C., Ryan, M., Barry, M., Mulcahy, F. M., Merry, C., Ryan, M., Barry, M., Mulcahy, F. M., Byrne, M., Moylett, E., Murphy, H., Butler, K., Nourse, C., Thaker, H., Barry, C., Russell, J., Sheehan, G., Boyle, B., Hone, R., Conboy, B., Butler, C., Moris, D., Cormican, M., Flynn, J., McCormack, O., Corbally, N., Murray, A., Kirrane, S., O’Keane, C., Hone, R., Lynch, S. M., Cryan, B., Whyte, D., Morris, D., Butler, C., Cormican, M., Flynn, J., Corbett-Feeney, G., Murray, A., Corbally, N., Hone, R., Mackle, T., Colreavy, M., Perkins, J., Saidlear, C., Young, A., Eustace, P., Wrigley, M., Clifford, J., Waddington, J. L., Tighe, O., Croke, D. T., Drago, J., Sibley, D. R., Feely, J., Kelly, A., Carvalho, M., Hennessy, M., Kelly, M., Feely, J., Hughes, C., Hanlon, M., Feely, J., Sabra, K., Keane, T., Egan, D., Ryan, M., Maerry, C., Ryan, M., Barry, M., Mulcahy, F. M., Maerry, C., Ryan, M., Barry, M., Mulcahy, F. M., Sharma, S. C., Williams, D., Kelly, A., Carvalho, M., Feely, J., Williams, D., Kelly, A., Carvalho, M., Feely, J., Codd, M. B., Mahon, N. G., McCann, H. A., Sugrue, D. D., Sayers, G. M., Johnson, Z., McNamara, S. M., Kavanagh, P. V., and Feely, J.

Published
1998
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6. Royal Academy of Medicine in Ireland Section of Biomedical Sciences

Author

Ruddock, W., Burns, D. M., Brown, J. C. W., Allen, J. M., Hirst, D. G., Love, G. P., Keenan, A. K., Lally, C., Bird, A., Ryan, M. P., O’Connor, N., O’Boyle, K. M., McGeown, J. G., McCarron, J. G., Drummond, R. M., Fay, F. S., Connor, T. J., Kelly, J. P., Leonard, B. E., Gilmartin, L., O’Cuinn, G., MacDonncha, C., Watson, A. W. S., McGrath, S., Brady, K. J., McKillen, H-C., Taylor, C. W., Smith, S. K., Thornton, S., Martin, A. D., Bailie, J. R., McKeown, S. R., Higgins, C. A., Hatton, W. J., McKerr, G., Harvey, D., Carson, J., Hannigan, B. M., Morrow, D. M. P., McGlynn, H., Thompson, C. M. G., Higgins, C., Galligan, E. S., Murray, M. M., Leckey, J. L., Nevin, G. B., Soppitt, D. S., Esfandiary, M. H., Gilmore, W. S., Robson, T., Dineen, T., Greer, A., Houghton, J. A., O’Halloran, K. D., Bradford, A., McGuire, M., MacDermott, M., Coogan, A., O’Connor, J. J., Regan, C. S., Redmond, A. M., Harkin, A., Lowe, A. S., Baxter, G. D., Kennovin, G. D., Leek, M., Friery, O. P., Hejmadi, M. V., Patterson, L. H., Robinson, J., Hill, I., Kilbride, J., Cotton, K. D., Hollywood, M. A., McHale, N. G., Thornbury, K. D., Halligan, C. P., O’Connell, D. P., Harvey, B. J., Fanning, P., O’Farrell, A., Cantillon, D., Cryan, J. F., O’Leary, D., O’Malley, D. T., Nolan, A., Moran, A. P., Fitzgerald, K. A., O’Neill, L. A. J., McElligott, A., Baker, A. H., Joyce, K. M., Ruane, T., Hall, W. J., Markos, F., Carey, M. F., Galvin, C., Perl, E. R., Curran, A. K., Connolly, C., Abdullah, K., Docherty, J. R., Gavin, K. T., Browne, M., Frazer, C-A., Walsh, D. M., Atkinson, S., Brown, D., O’Connor, J. M., Wasson, G. R., Bonham, M. P., McKelvey-Martin, V. J., Strain, J. J., Downes, C. S., Dineen, T. M., Powell, R., Van Hemelrijk, B., Abujaffom, T. Mubarak, Caulfield, B., Garrett, M., Brennan, L., Griffin, M. J., McShane, A. J., Convery, P. N., Milligan, K. R., Quinn, P., Scott, K., Fee, J. P. H., Cashman, M., Dunne, A., Healy, E., Walsh, J., Watson, A. J., Walsh, D. M., Noble, G., Baxter, G. D., Allen, J. M., Campion, D. P., Leek, B. F., Ryan, J. P., Quinn, T., Dumbleton, M., Smith, K. M., McGrath, J. C., Macmillan, J. B., Doherty, L., Lynch, F., Sweeney, M., O’Regan, R. G., McLoughlin, P., Padua, R. A., Dudeney, S., O’Byrne, J., Moran, R., O’Kelly, K. U., McCormack, B. A. O., Lyons, C. G., Brady, C. L., Simms, C., Maher, S., Schreiber, B., Taylor, D., Carr, A. J., Higgins, B., Dempsey, G. J., Imam, S. Z., Harbinson, M., Adgey, A. A. J., Anderson, J., Aodha, S. Ní, Wilcox, D., Rice, J., Jenkinson, A., O’Rourke, K., O’Brien, T., Devitt, A., McCormack, D., Ikadi, Y., Quinlan, W., Noelke, L., McMahon, G. T., Mulville, J. P., Lee, T. C., Rizvi, A., Fitzpatrick, D., McCarthy, M. A., McGloughlin, T., Monaghan, J., Shine, J., Arendt, E., Lew, B., Lewis, J., Kelly, P. A., Lennon, A. B., Hill, R. G., Dunne, N. J., Thompson, C., Orr, J. F., Beverland, D. E., Prenderville, T., Prendergast, P. J., Huiskes, R., Søballe, K., Mukunda, M. C., Kelly, C. J., Cregg, N., Leahy, A., Dwyer, R., Watson, R. G. K., Bouchier-Hayes, D. J., O’Boyle, C. J., Murchan, P., Mitchell, C. J., Macfie, J., Delicata, R. J., Davies, E. V., Lloyds, D., Petitt, E. J., Carey, P. D., Buckley, D. J., Riordain, M. G. O., Barry, T., Gorey, T. F., Fitzpatrick, J. M., Rothwell, J., Flaherty, J., Wilson, G., Walsh, T. N., Hennessy, T. P. J., O’Donoghue, J., Panchal, J., Mehdi, S., O’Sullivan, S. T., O’Shaughnessy, M., O’Connor, T. P. F., Cox, M. A., Dingle, J. T., Flavin, B. M., Regan, M. C., and O’Connell, P. R.

Published
1997
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7. Inaugural national scientific medical meeting

Author

Cooke, T. T., Sheahan, R., Foley, D., D’Arcy, G., Gibney, M., Jauch, W., Gearty, G., Crean, P., Walsh, M., Murchan, P. M., O’Donoghue, M. K., Marks, P., Leen, E. J., Shanik, G. D., Feely, T. M., O’Riordan, J., Kellett, J. G., Sheahan, N. F., MacMahon, M., Colgan, M., Walsh, J. B., .Shanik, G, Moore, R., Malone, J. F., Coakley, D., Subareddy, K., Hurley, J., McGovern, E., Sullivan, P. A., O’Mahony, S., Carroll, K., Chua, A., Keeling, R. W. N., O’Kane, A., Dinan, T., Collins, J. K., O’Sullivan, G., Hahnvajanawong, C., McCarthy, M., O’Brien, F., Collins, R. A., Beattie, S., Hamilton, H., O’Morain, C. A., Lynch, S., Murphy, A., Weir, D. G., Feighery, C., O’Farrelly, C., Kelleher, D., Murphy, D., O’Brien, M., Harte, P., Shahi, C. N., Fan, X. J., Huang, J., Smyth, C. J., McDevitt, J., Keeling, P. W. N., Cleary, M., Morrow, G., O’Loughlin, S., Murphy, G. M., Elder, G., Abouzakouk, M., Casey, E., Veale, D., Fitzgerald, O., Bradford, A., O’Regan, R. G., Nolan, P., McKeogh, D., Howell, F., O’Connor, C. M., Rook, G., FitzGerald, M. X., Power, C., Sreenan, S., Poulter, L. W., Burke, C. M., Shanahan, P., O’Donnell, N., Birthistle, K., O’Mahony, M., Shattock, A. G., Hillery, I. B., Bolger, C., Sheehan, N., Hutchinson, M., Phillips, J. P., Malone, J., Esmonde, T. F. G., Will, R. G., Faller, D., Ryan, M. P., Manning, B., Martin, F., McCormack, P. M. E., McGrath, A., Lawlor, R., Donegan, C., Boyce, C., O’Neill, D., Smith, S., Moloney, C., Feely, J., Stanton, A., Atkins, N., O’Brien, E., O’Malley, K., Gough, D. B., Jordan, A., Mannick, J. A., Rodrick, M. L., McCarthy, E., Cooney, C. M., Bourke, J., Phelan, D. M., Robertson, A. M., McShane, A. J., Buggy, D., Breathnach, A., Keogh, B., Coole†, T., Behan, P. O., Cavanagh, H. M. A., Gow, J. W., Simpson, K., Behan, W. M. H., Foley, M., Firth, R., Stronge, J., Bonnar, J., Sheppard, B. L., McClelland, R. J., Watson, D. R., Lawless, V., Houston, H. G., Adams, D., Fitzpatrick, C., Keary, K., Jennings, S., Matthews, T. G., Gormally, S., O’Regan, M., Ward, O. C., Kehoe, S., Luesley, D., Chan, K., Ward, K., Cox, M., Caird, J., Owens, D., Gilligan, S., McBrinn, S., Collins, P., Johnson, A., Tomkin, G., Fiad, T. M., Culliton, M., McKenna, T. J., Collins, P. B., Tomkin, G. H., Stinson, J. C., Clancy, L., Shannon, A., Lucey, M., Cooney, M., Stinson, J., Corcoran, P., Kelly, P., Hayes, C., Laffoy, M., McKnight, J. A., McCance, D. R., O’Hare, F., Wisdom, B., Hayes, J. R., Thornton, L., Fogarty, J., O’Flanagan, D., Corcoran, R., O’Mahony, D., Rowan, M., Clyne, M. G., Duffy, M. J., Davis, M., Kelly, D. G., Quinlan, D. M., Corbally, N., Keane, M. M., Grogan, L., Dervan, P. A., Carney, D. N., Duffy, K., Nugent, A., McDermott, E. W. M., O’Higgins, N. J., Fennelly, J. J., Atkinson, A. B., Ferrett, C. G., Leslie, H., Mcllrath, E. M., Ritchie, C. M., Russell, C. F. J., Sheridan, B., Bashyam, M., O’Sullivan, N., Baker, H., Duggan, P. F., Mitchell, T. H., Beatty, O., Browne, J., Clarke, K., Bell, P. M., Devlin, J. G., Laski, J., O’Neill, S., Redington, F., Dominique, A. V., Scanlan, P., Firth, R. G. R., Fiad, T., Freaney, R., Murray, B., McKenna, M. J., Murphy, J., Love, Wm. C., Cunningham, S. K., Crothers, J. G., McIlrath, E., Chiardha, F. Ni, Gebruers, E. M., Hall, W. J., Hegarty, D. A., O’Hare, J., Geoghegan, M., Abuaisha, F., Passmore, A. P., Whitehead, E. M., Crawford, V., Johnson, G. D., Gallagher, H. G., Stokes, M., Plank, L., Knight, G., Mitra, S., Hill, G., Buckley, P., O’Callaghan, E., Redmond, O., Stack, J. T., Ennis, J. T., Waddington, J. L., Larkin, C., Cannon, M., Byrne, M., Cotter, D., Sham, P., Colgan, K., Walsh, D., Gillian, A. M., Byrne, N., Breen, K. C., Lane, A., Mulvaney, F., Wadding-ton, J. L., Walsh, D., Lawlor, B. A., Colohan, H. A., Walshe, D., Gibson, T., Ronayne, E., Maguire, T. M., Staunton, H., Coughlin, A., Ming, P. Shu, Phillips, J., Youssef, H. A., Adebayo, G., Feely, G., Daly, S. A., Fennell, J. S., Coakley, F., Johnson, Z., Hall, M., McCormack, P. M., Martin, M., O’Connor, M., Curley, P., O’Connell, Y., Mulryan, G., Meenan, E., Kelly, J., Kilfeather, S., Cotter, T., McGlynn, H., Gharbháin, F. Ó, Chambers, P. L., Campbell, H., Stout, R. W., Hegarty, V., Scott, T., Keane, C. T., Healy, M., O’Moore, R. R., Coakley, D., Mulkerin, E., Brain, A., Hampton, D., Penney, M., Woodhouse, K., and Treacy, F.

Published
1993
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8. Royal academy of medicine in ireland section of biological sciences: Proceedings of the section of biological sciences section, summer meeting, ucg, 23rd & 24th june, 1989.

Author

McCabe, J. P., Waldron, R. P., Kerin, M. J., Courtney, D. F., Given, H. F., McAnena, O. J., Grimes, H., Tymkewycz, P. M., Gascoine, P. S., Gaffney, P. J., Felle, P., Gaine, S., Cox, J., England, R., Walsh, J., Coakley, D., Feely, J., O’Brien, E., O’Malley, K., Daly, L., Sheppard, B. L., Carroll, E., Hennelly, B., Bonnar, J., Fahy, M. M., Carragher, V., Kane, M. T., McGuinness, S., Pratt, I., Ryan, M. P., Cahill, P. A., Daly, S., Keenan, A. K., Barrett, R. P., Rowan, M. J., Smyth, Maria, O’Cuinn, G., Sharma, S. C., Sheppard, B. L., Bonnar, J., Feely, S., Kennedy, M., O’Regan, R. G., Hughes, Gwen, Allen, J. M., McHale, N. G., Thombury, K. D., Croal, S., Anderson, J. McC, Allen, J. D., Jamison, J. P., Mercer, C. G., Gracey, A. E., Flynn, N., Otoole, D. P., O’Malley, K., Clery, A. P., Cunningham, A. J., Dundee, J. W., Ghaly, R. G., Yang, Jing, Sharma, S. C., Etwebi, A. B., Alazreg, A. A., Lavelle, S. M., Etwebi, A., Comerford, F. R., Donohoe, N., Kagashe, Godeliver A. B., Leonard, B. E., Kelly, J. P., Bannon, C., Nolan, P., Bradford, A., McGlynn, H., Kavanagh, B., Bullock, Caroline G., O’Connor, Brigid A., Pippard, Corinna J., Wallace, W. F. M., Holland, P. C., Pratt, I., Ryan, M. P., Blake, M., Redmond, E., Keenan, A. K., Redmond, E. M., Brennan, M., Anwyl, R., Gaynor, A., Luckwill, R. G., Caldwell, M., Lyons, O., McNamara, D., Lynott, A., Fleming, F., Walsh, R., Farrell, L., Homer, C. H., Glacken, P., O’Brien, M., Caird, J., Grogan, A., Ng, C. Y., Glacken, P., O’Brien, M., Arora, A., Carroll, M., McKone, E., O’Gradaigh, D., O’Reilly, P. M. R., FitzGerald, M. J. T., Tierney, S., Russell, J., and Folan, J. C.

Published
1990
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9. Selected abstracts

Author

Corkery, P. P., Leek, B. F., Caulfield, B., Garrett, M., Gormley, J. P., OʼDonnell, P. M., Kennedy, N., Sayers, K., Stokes, E., Bresnihan, B., Fitzgerald, O., McGarvey, M. A., Tonra, M., Hooper, A. C. B., Barry, J., Maurer, B., Hussey, J., Gormley, J., Noble, J. G., Alves-Guerreiro, J., Lowe, A. S., Walsh, D. M., NicNiocaill, B., Harte, M., OʼConnor, W. T., OʼHara, A. M., Orren, A., Moran, A. P., Hardiman, D. A., Lee, T. C., Croke, D. T., Tolan, R., McBennett, S., Warmington, S., McGuire, M., Bradford, A., OʼHare, T., MacDermott, M., Lynch, F., OʼRegan, R. G., McLoughlin, P., Quinn, T., Ryan, J. P., Pickering, M., Campion, D. P., Jones, J. F. X., Ryan, S., McNicholas, W. T., Nolan, P., Doyle, F. J., Rackard, S. M., Beddy, P., Campbell, V. A., Bakhle, Y. S., Bell, C., Usher, C., Chan, L., Keenan, A. K., McQuaid, K. E., Cullen, V. C., Smith, E. M., Kelly, A., Lynch, M. A., Freir, D. B., Holscher, C., Herron, C. E., Pearson, H. A., Curran, B. P., OʼConnor, J. J., Quinn, A., McHale, J., Moriarty, D., OʼConnor, J., Glennon, J. C., Van Vliet, B. J., Long, S. K., Kruse, C., Gallagher, H. C., Bacon, C. L., Boland, B., Griffin, A. M., Preisler, J., OʼBrien, L., Regan, C. M., Hurley, S., Kearney, P. J., Slevin, J., Barry-Kinsella, C., Ryan, C. A., Kllleen, O., Glllan, J., Clarke, T., Matthews, T., Corcoran, D., Dunn, E., Geary, M., OʼHerlihy, C., Keane, D., OʼLeary, M. J., Morrison, J. J., Ryan, E., Gorman, W. A., Bourke, A., Larkin, J., Mayes, C., Jenkins, J., Ryan, M., Lalchandani, S., Sheil, O., Lynch, N., Costigan, C., Murphy, J. F., Bhatia, R., Foran, A., Donohue, V., McParland, P., LaSjaunais, P., Rodesch, G., McGinn, M., McAloon, J., OʼLeary, M., Astbury, K., Harmon, D., Sharkey, A., Gaffney, G., OʼRegan, G., McMahon, C., Murray, D., McDermott, C., Woolhead, E., Gillan, J., Cartmill, J. L., Harper, M. A., Al-Shabibi, N., Hanahoe, M., Wingfield, M., Larkin, J. A. M., Bell, A. H., McClure, B. G., Sweeney, L., Martin, D. H., OʼDonoghue, P., Davoren, A., Lucas, G. F., McKiernan, J., Gallagher, D. M. T., Dunne, K. P., Fulena, O., Sheridan, M., Griffin, E., White, M., Deasy, P., OʼRiordan, M., OʼGorman, C., Mongan, C., McCafferkey, M., Henry, G., McKenna, P., OʼMalley, A., Devaney, D., Kelleghan, P., Mooney, E. E., Gillan, J. E., Fitzpatrick, M., McQuillan, K., Heffron, C., Hodnett, P., Curtain, A., OʼConnor, T. C. F., Connell, T. G., Waldron, D., Gorman, W., Bolger, T., OʼKeefe, M., Murphy, J., Dolan, L. M., Traub, A. I., Slattery, M. M., Curley, A. E., Halliday, H. L., Tubman, T. R. J., Kileen, O., Riadha, H., Russell, J., Philips, R., Regan, C., Ali, I., Coughlan, A. C. J., Turner, M. J., Smith, A., OʼFlanagan, D., Igoe, D., Ryan, F., Forde, D., McArdle, E., Ko, D., Bedford, D., Hegarty, M., Dunlevy, B., Corcoran, R., Holohan, T., Feeney, A., McGee, H., Shannon, W., Condon, M., Hyland, C., Sayers, G., Feely, E., Crowley, D., OʼReilly, D., OʼConnell, T., Cronin, M., Johnson, H., Fitzgeraldi, M., Cafferkey, M., Breslin, A., Bonner, C. J., Foley, B., Fitzgerald, M., Wall, P. G., McNamara, E., Costigan, P., Prendergast, T., Foye, K., Cosgrove, C., Keane, A., Murphy, E., OʼDonnell, J., Quinlan, A., Thornton, L., Roch, E. A., Lyons, R. A., Maddocks, A., Barnes, P., Price, L., McCabe, M., Nash, P., Midha, A., Doyle, Y., Kilgallen, A., Wright, P., Ryan, T., De La Harpe, D., Harkins, V., Brennan, C., OʼConnell, V., Evans, D. S., Mhuircheartaigh, Ni J., OʼDonnell, J. M., Rhatigan, A., Shelley, E., Collins, C., Byrne, M., Murphy, A. W., Plunkett, P. K., Murray, A., Bury, G., Lynam, F., McMahon, G., Greally, T., Kane, D., Veale, D., Reece, R., Busteed, S., Bennett, M. W., Stone, M., Molloy, C., OʼConnell, J., Molloy, M. G., Shanahan, F., Guerin, J., Casey, E., Feighery, C., Lin, F., Jackson, J., Pendleton, A., Wright, G. D., Hughes, A. E., OʼGradaigh, D., Debham, I., Compston, J., McEvoy, A., Murphy, E. P., Salonen, D., Payne, P., Lax, M., Lapp, V., Inman, R., OʼRourke, K., Brennan, D., Harty, J., McCarthy, C., OʼByrne, J., Eustace, S., Chirayath, H., Liggett, N. W., Morgan, M. P., Fitzgerald, D. J., McCarthy, C. J., McCarthy, G. M., Lee, R. Z., Wai, K., Nevin, D., Leary, A. O., Lee, R., Casey, E. B., OʼLeary, A., Breen, D., Tuite, D., McInerney, D., Sim, R., Frederic, A. L., Smith, O., White, B., Murphy, M., Silke, C., OʼKeeffe, E., Fanning, N., Spence, L., Parfrey, N. A., McConnell, J. R., Crockard, A. D., Cairns, A. P., Bell, A. L., Kavanagh, O., Moyes, D. A., Finch, M., Rooney, M., Bell, A., Founas, I., El-Magbri, A., Mooney, S., Kennedy, M., Coughlan, R. J., Ramakrishnan, S. A., Gsel, A., Finnerty, O., Burns, M., Yateman, M., Camaco-Hubner, C., Matthews, C. F., Taggart, A., Fuller, K., Murphy, M. S., Phelan, M., Murphy, T. B., Wynne, F., Quane, K., Daly, M., OʼLeary, J., da Silva, I., Bermingham, N., Gogarty, M., Gallagher, L. P., OʼHara, R., Godson, C., Brady, H., Osman, H., El-Rafie, A., Foley-Nolan, D., Kirwan, P., Corcoran, O., Duffy, T., Drummond, F., Madigan, A., Williams, D., Gallagher, P., Hatton, C., Cunningham, S., FitzGerald, O., Minnock, P., Wylie, E., Egan, D., Mc Cormack, J., Shea, M. O., Evans, D., OʼLorcain, P., Comber, H., Evans, A., Jones, J., Garavan, C., Kelleher, K., Boland, M. C., Healy, R., OʼSullivan, M. B., Burke, M., Mc Donald, P., Smithson, R., Glass, J., Mason, C. A., Mullins, N., Nolan, D., McCormick, P., Coughlan, S., Dooley, S., Kelleher, C. C., Hope, A., Murphy, F., Barry, M., Sixsmith, J., MacFarlane, A., MacLeod, C., McElroy, G., OʼLoan, D., Kennedy, F., Kerr, R. M., Lim, J., Allwright, S. P. A., Bradley, F. L., Barry, J. M. G., Long, J., Parry, J. V., Creagh, D., Perry, I. J., Collins, A., Neilson, S., Colwell, N., OʼHalloran, D., OʼNeill, S., McErlain, S., Okasha, M., Gaffney, B., McCarron, P., Hinchion, R., Drew, C., Gavin, A., Fitzpatrick, D., Campbell, R., Wannamethee, S. G., Shaper, A., Friel, S., Kelleher, C., Kee, F., Atterson, C. C., Wilson, E. A., McConnell, J. M., Wheeler, S. M., Watson, J. D., Rahman, Norashikin N., Sheehan, J., Wall, C., Kelleher, B., OʼBroin, S. D., Mullan, R. N., McKeveney, P. J., Hodges, V. M., Winter, P. C., Maxwell, P., Simpson, D. A., Lappin, T. R. J., Maxwell, A. P., Eustace, J. A., Coresh, J., Kutchey, C., Te, P. L., Gimenez, L. F., Scheel, P. J., Walser, M., McMahon, R. A., Clarkson, M., Martin, F., Brady, H. R., Blake, C., OʼMeara, Y. M., Gupta, S., MacKenzie, H., Doyle, S., Fotheringham, T., Haslam, P., Logan, M. P., Conlon, P., Lee, M., Maderna, P., Cottell, D. C., Mitchell, S., Gulmann, C., Østerby, R., Bangstad, H. J., Rljdberg, S., Dempsey, M., Nathwani, S., Ryan, M. P., McMahon, B., Stenson, C., Murtagh, H., Brown, J. H., Doran, P., McGinty, A., Little, M. A., OʼBrien, E., Owens, P., Holian, J., Mee, F., Walshe, J. J., Omer, S. A., Power, D., Diamond, P., Watson, R. W., Shahsafei, A., Jiang, T., Brenner, B. M., Mackenzie, H. S., Neary, J., Dorman, A., Keoghan, M., Campbell, E., Walshe, J., Little, M., Nee, L., OʼCeallaigh, C., McGlynn, H., Bergin, E., Keane, T., Gormley, G., Watson, A., Atta, M. G., Perl, T. M., Song, X., Healy, E., Leonard, M., Lynch, J., Watson, A. J., Lappin, D., Lappin, D. W. P., Hannan, K., Burne, M., Daniels, F., Rabb, H., McBride, B., Kieran, N., Shortt, C., Codd, M., Murray, F., McCormack, A., Brown, C., Wong, C., Dorman, A. M., Keogan, M., Donohue, J., Farrell, J., Donohoe, J., OʼBroin, S., Balfe, A., Mellotte, G. J., Abraham, K. A., McGorrian, C., Wood, A. E., Neligan, M., Kelly, B. D., Finnegan, P., Cormican, M., Callaghan, J., Crean, J. K. G., Moffitt, T. A., Devlin, H. L., Garrett, P. J., Soosay, A., OʼNeill, D., Counihan, A., Hickey, D., Keogan, M. T., Harvey, K., OʼRiordan, E., Waldek, S., Kalra, P. A., OʼDonoghue, D. J., Foley, R. N., Kelliher, D., Mellotte, G., Giblin, L., Keogh, J. A. B., OʼConnell, M., OʼMeara, A., Breatnach, F., Gillick, J., Tazawa, H., Puri, P., Molloy, E., OʼNeill, A. J., Sheridan-Pereira, M., Fitzpatrick, J. M., Webb, D. W., Watson, R. W. G., Linnane, B., OʼDonnell, C., Clarke, T. A., Martin, C., McKay, M., McBrien, J., Glynn, F., OʼDonovan, C., Hall, W. W., Smith, J., Khair, K., Liesner, R., Hann, I. M., Smith, O. P., Gallagher, S., Mahony, M. J., Hilal, A., Cosgrove, J. F., Monaghan, C., Craig, B., Walsh, K., Duff, D., Slizlok, P. O., Halahakoon, C., McMillan, S., Dalzell, E. E., McCaughan, J., Redmond, A. O. B., DeCaluwe, D., Yoneda, A., Akl, U., Dempsey, E., Farrell, M., Webb, D., Elabbas, A., Fox, G., Gormally, S., Grant, B., Corkey, C. W. B., Nicholson, A., Murphy, A., OʼGrady, P., Barry, O., Stewart, M. C., Alderdice, F., Matthews, T. G., McDonnell, M., McGarvey, C., OʼRegan, M., Chróinín, Ní M., Tormey, P., Ennis, S., Green, A. J., Abbas, S., OʼMarcaigh, A., Conran, M., Crushell, E., Saidi, A., Curran, P., Donoghue, V., King, M. D., Elnazir, B., Leonard, J., Kavanagh, C., Brown, D., Corrigan, N., McCord, B., Quinn, M., OʼConnell, L., Mcdonagh, B., Awan, A., Gill, D., Kakkar, R., Warner, J. A., OʼConnor, C., Herzig, M., Twomey, A., White, M. J., Sweeney, B., Surana, R., Hodgson, A., Rafferty, M., Livingstone, W., Peake, D., Wassemer, E., Whitehouse, W., Abdullah, N., Al-Hassan, A., Oslizlok, P., OʼConnell, N., Balding, J., Livingstone, W. J., Healy, M., Mynett-Johnson, L., McAllister, I., Dick, A. C., Herron, B., Boston, V. E., Callaghan, C. O., Brien, D. O., Walsh, A., Philip, M., McShane, D., Hoey, M. C. V., Sharif, F., McDermott, M., Dillon, M., Drumm, B., Rowland, M., Imrie, C., Kelleher, S., Bourke, B., Iqbal, M., Ziedan, Y., OʼNeill, M., OʼRiordan, S., Basheer, S. M. B., OʼCallaghan, S., Chong, A., Kelly, M., Nicholson, A. J., Cooke, R., Sreenan, C., Fallon, M., Denham, B., Dowding, V., Cussen, G., McManus, V., Hensey, O., Monaghan, H., Basheer, S. N., Quinn, E., Hoey, H. M. C. V., Mohamed, S., Ramesh, R. R., Mayne, P., Tracy, E., Gormally, S. M., Curtis, E., McCallion, N., Watson, R., OʼMahony, O., Keegan, M., Ward, K., Barton, D., Poulton, J., Treacy, E., Honour, J., deCaluwe, D., Chróinín, Ni M., Cosgrove, J., Chaudhry, T. S., Long, N. M., Lynch, B., Lasjaunais, P., McDonald, D. G. M., McMenamin, J. B., Farrell, M. J., Roche, E. F., Menon, A., Buckley, C., Mackey, A., Ohlandieck, K., Das, A., Reilly, D., Killeen, O., Harper, J., Roche, E., Hoey, H., Caird, J., OʼBrien, D., Allcutt, D., Farrington, N., Murphy, J. F. A., Savage, J. M., Sands, A. J., Casey, F. A., Craig, B. G., Dornan, J. C., Johnston, J., Patterson, C., Lynch, C., Mulholland, H. C., Watkins, D. C., Young, I., Cran, G., Boreham, C. A. G., McCallion, W. A., Clements, N. F., Stevenson, M. R., Macpherson, C., Jenkins, L., Thompson, A. J., Shields, M. D., Taylor, R. T., Kerr, R., Hughes, J. L., Stewart, M., Jackson, P., Fitzpatrick, C., Rasheed, M., Colhoun, E., Bailie, A. G., Gray, S., Brown, S., Curley, A., Sweet, D. G., MacMahon, K. J., OʼConnor, C. M., Nichelson, A., Lynch, N. E., Finch, D., Foley, M., Scallan, E., Dillon, B., Lyons, S., OʼLoughlin, R., Ward, M., Nally, R., Harkin, A., Kelly, J. P., Leonard, B. E., Magee, P., Connor, T. J., Shen, Y., McCullough, G. R., McDonough, S. M., Niocaill, Nic B., Cramp, A. F. L., Hynes, M., Corkery, P., Carey, M., McGarrigle, D., Higgins, S., Murray, H., Moran, C. J., Dennedy, M. C., Brosnan, J., Morris, L., Sheppard, B. L., Black, A., Wilkins, B., Folan-Curran, J., Skelton, K., Owens, M., Nemeroff, C., Houlihan, D., OʼKeeffe, C., Nolan, N., McCormick, P. A., Baird, A. W., Raducan, I., Corcoran, P., Brennan, R., Molloy, P., Friel, A., Maher, M., Glennon, M., Smith, T., Nolan, A., Houghton, J. A., Carroll, O., Colleran, S., OʼCuinn, G., Snow, H. M., OʼRegan, D., Markos, H. F., Pollock, K., Cannon, D. M., McBean, G., OʼRiordan, A., Quinlan, L. R., Kane, M. T., Higglns, B. D., Moriarty, D. M., Fitzgerald, D., Katkada, A., Canny, G., MacMathuna, P., OʼDonoghue, D., OʼDonovan, M. M., Schuur, A. G., Murphy, K. J., Foley, A. G., ten Bruggencate, S. J. M., and Ireland, L.

Published
2000
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12. Royal Academy of Medicine in Ireland — Section of biological sciences Proceedings of Summer Meeting held on Thursday and Friday, 23rd and 24th June, 1988 Donegan Medal and Prize communications (* indicates competitor). The 1988 Donegan Medalist was E. Stuart, Department of Pharmacology, U.C.D.

Author

Murphy, M., Teeling, M., Clancy, D. N., Pratt, I., Conlon, D. B., Kilfeather, S. A., O’Malley, K., Stuart, E., McGlynn, H., Ryan, M. P., Young, T., Blunnie, W. P., Lamont, B., Scanlon, P., Phelan, D. M., Grealy, Maura, O’Donnell, J. M., Beausang, P., Norris, L. A., Carroll, M. E., Bonnar, J., Murphy, C. M., Arbuthnott, E. R., Andrews, J. F., McCoy, C., Donne, B., Andrews, J. F., Carr, B., Scott, T., Walsh, J. B., Coakley, D., Mulvihill, E., Keane, C., Carr, B., Scott, T., Walsh, J. B., Coakley, D., Mulvihill, E., Keane, C., Morrissey, M., O’Connor, C. M., Pratt, I., FitzGerald, M. X., Cahill, P. A., Keenan, A. K., Larkin, Sarah, Treacy, M., Martin, F., Schuster, W. A., Larkin, Sarah, Martin, F., Casey, P., Counihan, T. B., Ryan, M. P., Nolan, S. B., Wilson, A. M., O’Mahony, D. P., Smith, A. I., Scholfield, C. N., Connaughton, Sonia, Docherty, J. R., Moore, D., Sugrue, M., Borton, Meriel, Walsh, Theresa, Docherty, J. R., Luke, D., Neligan, M., Wood, F., O’Connor, J. J., Rowan, M. J., Anwyl, R., Murray, Angela M., Waddington, J. L., O’Neill, D., Rowan, M. J., Abraham, D., Feely, J., Walsh, J. B., Coakley, D., Felle, P., Folan, J. C., Felle, P., Harding, B., O’Donohoe, M. K., Blake, A., Waldron, R. P., Dervan, P., Fitzpatrick, J. M., Stanley, S. T., Davies, M. G., McCollum, P. T., Grouden, M. C., Fitzpatrick, P. M., Moore, D. J., Shanik, G. D., Harty, H. R., McGeown, J. G., McHale, N. G., Thornbury, K. D., Crotty, T. P., Lee, T. C., FitzGerald, D. E., O’Brien, M., O’Regan, M., Sheppard, B. L., Gleeson, Noreen, Daly, Leisha, Jordan, Marie, Bonnar, J., O’Carroll, D., Hetherton, A. M., Murray, M., Smith, D. F., McDermott, E., O’Higgins, N. J., Smyth, P. P. A., Surgrue, P. C., Delanty, F. J. N., O’Sullivan, V. R., O’Byrne, S., O’Connor, P., Collins, W. J., Barry, M., Feely, J., Davies, M. G., McCollum, P. T., Kent, P., Stanley, S. T., Moore, D. J., Shanik, G. D., Davies, M. G., Rowan, M. J., MacMathuna, P., Feely, J., Keeling, P. W. N., and Weir, D. G.

Published
1988
Full Text
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15. Selected abstracts

Author

Corkery, P. P., Leek, B. F., Caulfield, B., Garrett, M., Gormley, J. P., O’Donnell, P. M., Kennedy, N., Sayers, K., Stokes, E., Bresnihan, B., Fitzgerald, O., McGarvey, M. A., Tonra, M., Hooper, A. C. B., Barry, J., Maurer, B., Hussey, J., Gormley, J., Noble, J. G., Alves-Guerreiro, J., Lowe, A. S., Walsh, D. M., NicNiocaill, B., Harte, M., O’Connor, W. T., O’Hara, A. M., Orren, A., Moran, A. P., Hardiman, D. A., Lee, T. C., Croke, D. T., Tolan, R., McBennett, S., Warmington, S., McGuire, M., Bradford, A., O’Hare, T., MacDermott, M., Lynch, F., O’Regan, R. G., McLoughlin, P., Quinn, T., Ryan, J. P., Pickering, M., Campion, D. P., Jones, J. F. X., Ryan, S., McNicholas, W. T., Nolan, P., Doyle, F. J., Rackard, S. M., Beddy, P., Campbell, V. A., Bakhle, Y. S., Bell, C., Usher, C., Chan, L., Keenan, A. K., McQuaid, K. E., Cullen, V. C., Smith, E. M., Kelly, A., Lynch, M. A., Freir, D. B., Holscher, C., Herron, C. E., Pearson, H. A., Curran, B. P., O’Connor, J. J., Quinn, A., McHale, J., Moriarty, D., O’Connor, J., Glennon, J. C., Van Vliet, B. J., Long, S. K., Kruse, C., Gallagher, H. C., Bacon, C. L., Boland, B., Griffin, A. M., Preisler, J., O’Brien, L., Regan, C. M., Hurley, S., Kearney, P. J., Slevin, J., Barry-Kinsella, C., Ryan, C. A., Kllleen, O., Glllan, J., Clarke, T., Matthews, T., Corcoran, D., Dunn, E., Geary, M., O’Herlihy, C., Keane, D., Slattery, M. M., O’Leary, M. J., Morrison, J. J., Ryan, E., Gorman, W. A., Bourke, A., Larkin, J., Mayes, C., Jenkins, J., Ryan, M., Lalchandani, S., Sheil, O., Lynch, N., Costigan, C., Murphy, J. F., Bhatia, R., Foran, A., Donohue, V., McParland, P., LaSjaunais, P., Rodesch, G., McGinn, M., McAloon, J., O’Leary, M., Astbury, K., Harmon, D., Sharkey, A., Gaffney, G., O’Regan, G., McMahon, C., Murray, D., McDermott, C., Woolhead, E., Gillan, J., Cartmill, J. L., Harper, M. A., Al-Shabibi, N., Hanahoe, M., Wingfield, M., Larkin, J. A. M., Bell, A. H., McClure, B. G., Sweeney, L., Martin, D. H., O’Donoghue, P., Davoren, A., Lucas, G. F., McKiernan, J., Gallagher, D. M. T., Dunne, K. P., Fulena, O., Sheridan, M., Griffin, E., White, M., Deasy, P., O’Riordan, M., O’Gorman, C., Mongan, C., McCafferkey, M., Henry, G., McKenna, P., O’Malley, A., Devaney, D., Kelleghan, P., Mooney, E. E., Gillan, J. E., Fitzpatrick, M., McQuillan, K., Heffron, C., Hodnett, P., Curtain, A., O’Connor, T. C. F., Connell, T. G., Waldron, D., Gorman, W., Bolger, T., O’Keefe, M., Murphy, J., Dolan, L. M., Traub, A. I., Slattery, M. M., O’Leary, M. J., Curley, A. E., Halliday, H. L., Tubman, T. R. J., Kileen, O., Riadha, H., Russell, J., Philips, R., Regan, C., Ali, I., Coughlan, A. C. J., Turner, M. J., Smith, A., O’Flanagan, D., Igoe, D., Ryan, F., Forde, D., McArdle, E., Ko, D., Bedford, D., Hegarty, M., Dunlevy, B., Corcoran, R., Holohan, T., Feeney, A., McGee, H., Shannon, W., Condon, M., Hyland, C., Sayers, G., Feely, E., Crowley, D., O’Reilly, D., O’Connell, T., Cronin, M., Johnson, H., Fitzgeraldi, M., Cafferkey, M., Breslin, A., Bonner, C. J., Foley, B., Fitzgerald, M., Wall, P. G., McNamara, E., Costigan, P., Prendergast, T., Foye, K., Cosgrove, C., Keane, A., Murphy, E., O’Donnell, J., Quinlan, A., Thornton, L., Roch, E. A., Lyons, R. A., Maddocks, A., Barnes, P., Price, L., McCabe, M., Nash, P., Midha, A., Doyle, Y., Kilgallen, A., Wright, P., Ryan, T., De La Harpe, D., Harkins, V., Brennan, C., O’Connell, V., Evans, D. S., Ni Mhuircheartaigh, J., O’Donnell, J. M., Rhatigan, A., Shelley, E., Collins, C., Byrne, M., Murphy, A. W., Plunkett, P. K., Murray, A., Bury, G., Lynam, F., McMahon, G., Greally, T., Kane, D., Veale, D., Reece, R., Busteed, S., Bennett, M. W., Stone, M., Molloy, C., O’Connell, J., Molloy, M. G., Shanahan, F., Guerin, J., Casey, E., Feighery, C., Lin, F., Jackson, J., Pendleton, A., Wright, G. D., Hughes, A. E., O’Gradaigh, D., Debham, I., Compston, J., McEvoy, A., Murphy, E. P., Salonen, D., Payne, P., Lax, M., Lapp, V., Inman, R., O’Rourke, K., Brennan, D., Harty, J., McCarthy, C., O’Byrne, J., Eustace, S., Chirayath, H., Liggett, N. W., Morgan, M. P., Fitzgerald, D. J., McCarthy, C. J., McCarthy, G. M., Lee, R. Z., Wai, K., Nevin, D., Leary, A. O., Lee, R., Leary, A. O., Casey, E. B., Leary, A. O., O’Leary, A., Breen, D., Tuite, D., McInerney, D., Sim, R., Frederic, A. L., Smith, O., White, B., Murphy, M., Silke, C., O’Keeffe, E., Fanning, N., Spence, L., Parfrey, N. A., McConnell, J. R., Crockard, A. D., Cairns, A. P., Bell, A. L., Kavanagh, O., Moyes, D. A., Finch, M., Rooney, M., Bell, A., Founas, I., El-Magbri, A., Mooney, S., Kennedy, M., Coughlan, R. J., Ramakrishnan, S. A., Gsel, A., Finnerty, O., Burns, M., Yateman, M., Camaco-Hubner, C., Matthews, C. F., Taggart, A., Fuller, K., Murphy, M. S., Phelan, M., Murphy, T. B., Wynne, F., Quane, K., Daly, M., O’Leary, J., da Silva, I., Bermingham, N., Gogarty, M., Gallagher, L. P., O’Hara, R., Godson, C., Brady, H., Osman, H., El-Rafie, A., Foley-Nolan, D., Kirwan, P., Corcoran, O., Duffy, T., Drummond, F., Madigan, A., Williams, D., Gallagher, P., Hatton, C., Cunningham, S., FitzGerald, O., Minnock, P., Wylie, E., Egan, D., Mc Cormack, J., Shea, M. O., Evans, D., O’Lorcain, P., Comber, H., Evans, A., Jones, J., Garavan, C., Kelleher, K., Boland, M. C., Healy, R., O’Sullivan, M. B., Burke, M., Mc Donald, P., Smithson, R., Glass, J., Mason, C. A., Mullins, N., Nolan, D., McCormick, P., Coughlan, S., Dooley, S., Kelleher, C. C., Hope, A., Murphy, F., Barry, M., Sixsmith, J., MacFarlane, A., MacLeod, C., McElroy, G., O’Loan, D., Kennedy, F., Kerr, R. M., Lim, J., Allwright, S. P. A., Bradley, F. L., Barry, J. M. G., Long, J., Parry, J. V., Creagh, D., Perry, I. J., Collins, A., Neilson, S., Colwell, N., O’Halloran, D., O’Neill, S., McErlain, S., Okasha, M., Gaffney, B., McCarron, P., Hinchion, R., Drew, C., Gavin, A., Fitzpatrick, D., Campbell, R., Wannamethee, S. G., Shaper, A., Friel, S., Kelleher, C., Kee, F., Atterson, C. C., Wilson, E. A., McConnell, J. M., Wheeler, S. M., Watson, J. D., Norashikin Rahman, N., Sheehan, J., Wall, C., Kelleher, B., O’Broin, S. D., Mullan, R. N., McKeveney, P. J., Hodges, V. M., Winter, P. C., Maxwell, P., Simpson, D. A., Lappin, T. R. J., Maxwell, A. P., Eustace, J. A., Coresh, J., Kutchey, C., Te, P. L., Gimenez, L. F., Scheel, P. J., Walser, M., McMahon, R. A., Clarkson, M., Martin, F., Brady, H. R., Blake, C., O’Meara, Y. M., Gupta, S., MacKenzie, H., Doyle, S., Fotheringham, T., Haslam, P., Logan, M. P., Conlon, P., Lee, M., Maderna, P., Cottell, D. C., Mitchell, S., Gulmann, C., Østerby, R., Bangstad, H. J., Rljdberg, S., Dempsey, M., Nathwani, S., Ryan, M. P., McMahon, B., Stenson, C., Murtagh, H., Brown, J. H., Doran, P., McGinty, A., Little, M. A., O’Brien, E., Owens, P., Holian, J., Mee, F., Walshe, J. J., Omer, S. A., Power, D., Diamond, P., Watson, R. W., Shahsafei, A., Jiang, T., Brenner, B. M., Mackenzie, H. S., Neary, J., Dorman, A., Keoghan, M., Campbell, E., Walshe, J., Little, M., Nee, L., O’Ceallaigh, C., McGlynn, H., Bergin, E., Garrett, P. J., Keane, T., Gormley, G., Watson, A., Atta, M. G., Perl, T. M., Song, X., Healy, E., Leonard, M., Lynch, J., Watson, A. J., Lappin, D., Lappin, D. W. P., Hannan, K., Burne, M., Daniels, F., Rabb, H., McBride, B., Kieran, N., Shortt, C., Codd, M., Murray, F., McCormack, A., Brown, C., Wong, C., Dorman, A. M., Keogan, M., Donohue, J., Farrell, J., Donohoe, J., O’Broin, S., Balfe, A., Mellotte, G. J., Abraham, K. A., McGorrian, C., Wood, A. E., Neligan, M., Kelly, B. D., Finnegan, P., Cormican, M., Callaghan, J., Crean, J. K. G., Moffitt, T. A., Devlin, H. L., Garrett, P. J., Soosay, A., O’Neill, D., Counihan, A., Hickey, D., Keogan, M. T., Harvey, K., O’Riordan, E., Waldek, S., Kalra, P. A., O’Donoghue, D. J., Foley, R. N., O’Riordan, A., Kelliher, D., Mellotte, G., Giblin, L., Keogh, J. A. B., O’Connell, M., O’Meara, A., Breatnach, F., Gillick, J., Tazawa, H., Puri, P., Molloy, E., O’Neill, A. J., Sheridan-Pereira, M., Fitzpatrick, J. M., Webb, D. W., Watson, R. W. G., Linnane, B., O’Donnell, C., Clarke, T. A., Martin, C., McKay, M., McBrien, J., Glynn, F., O’Donovan, C., Hall, W. W., Smith, J., Khair, K., Liesner, R., Hann, I. M., Smith, O. P., Gallagher, S., Mahony, M. J., Hilal, A., Cosgrove, J. F., Monaghan, C., Craig, B., Al-Hassan, A., Walsh, K., Duff, D., Slizlok, P. O., Halahakoon, C., MacPherson, C., McMillan, S., Dalzell, E. E., McCaughan, J., Redmond, A. O. B., DeCaluwe, D., Yoneda, A., Akl, U., Dempsey, E., Farrell, M., Webb, D., Elabbas, A., Fox, G., Gormally, S., Grant, B., Corkey, C. W. B., Nicholson, A., Murphy, A., O’Grady, P., Barry, O., Macpherson, C., Stewart, M. C., Alderdice, F., Matthews, T. G., McDonnell, M., McGarvey, C., O’Regan, M., Ní Chróinín, M., Tormey, P., Ennis, S., Green, A. J., Abbas, S., O’Marcaigh, A., Conran, M., Crushell, E., Saidi, A., Curran, P., Donoghue, V., King, M. D., Elnazir, B., Leonard, J., Kavanagh, C., Brown, D., Corrigan, N., McCord, B., Quinn, M., O’Connell, L., Mcdonagh, B., Awan, A., Gill, D., Kakkar, R., Sweet, D. G., Warner, J. A., O’Connor, C., Herzig, M., Twomey, A., White, M. J., Sweeney, B., Surana, R., Hodgson, A., Rafferty, M., Livingstone, W., Peake, D., Wassemer, E., Whitehouse, W., Abdullah, N., Al-Hassan, A., Oslizlok, P., O’Connell, N., Balding, J., Livingstone, W. J., Healy, M., Mynett-Johnson, L., McAllister, I., Dick, A. C., Herron, B., Boston, V. E., Callaghan, C. O., Brien, D. O., Walsh, A., Philip, M., McShane, D., Hoey, M. C. V., Sharif, F., McDermott, M., Dillon, M., Drumm, B., Rowland, M., Imrie, C., Kelleher, S., Bourke, B., Iqbal, M., Ziedan, Y., O’Neill, M., O’Riordan, S., Basheer, S. M. B., O’Callaghan, S., Chong, A., Kelly, M., Nicholson, A. J., Cooke, R., Sreenan, C., Fallon, M., Denham, B., Dowding, V., Cussen, G., McManus, V., Hensey, O., Monaghan, H., Basheer, S. N., Quinn, E., Hoey, H. M. C. V., Mohamed, S., Ramesh, R. R., Mayne, P., Tracy, E., Gormally, S. M., Curtis, E., McCallion, N., Watson, R., O’Mahony, O., Keegan, M., Ward, K., Barton, D., Poulton, J., Treacy, E., Honour, J., deCaluwe, D., Ni Chróinín, M., Cosgrove, J., Chaudhry, T. S., Long, N. M., Lynch, B., Lasjaunais, P., McDonald, D. G. M., McMenamin, J. B., Farrell, M. J., Roche, E. F., Menon, A., Buckley, C., Mackey, A., Ohlandieck, K., Das, A., Reilly, D., Killeen, O., Harper, J., Roche, E., Hoey, H., Caird, J., O’Brien, D., Allcutt, D., Farrington, N., Murphy, J. F. A., Savage, J. M., Sands, A. J., Casey, F. A., Craig, B. G., Dornan, J. C., Johnston, J., Patterson, C., Lynch, C., Mulholland, H. C., Watkins, D. C., Young, I., Cran, G., Boreham, C. A. G., McCallion, W. A., Clements, N. F., Stevenson, M. R., Macpherson, C., O’Donoghue, D., Jenkins, L., Thompson, A. J., Shields, M. D., Taylor, R. T., Kerr, R., Hughes, J. L., Stewart, M., Jackson, P., Fitzpatrick, C., Rasheed, M., Colhoun, E., Bailie, A. G., Gray, S., Brown, S., Curley, A., Sweet, D. G., MacMahon, K. J., O’Connor, C. M., Nichelson, A., Lynch, N. E., Finch, D., Foley, M., Scallan, E., Dillon, B., Lyons, S., O’Loughlin, R., Ward, M., Nally, R., Harkin, A., Kelly, J. P., Leonard, B. E., Nic Niocaill, B., Magee, P., Connor, T. J., Shen, Y., McCullough, G. R., McDonough, S. M., Nic Niocaill, B., Cramp, A. F. L., Hynes, M., Corkery, P., Carey, M., McGarrigle, D., Higgins, S., Murray, H., Moran, C. J., Dennedy, M. C., Brosnan, J., Morris, L., Sheppard, B. L., Black, A., Wilkins, B., Folan-Curran, J., Skelton, K., Owens, M., Nemeroff, C., Houlihan, D., O’Keeffe, C., Nolan, N., McCormick, P. A., Baird, A. W., Raducan, I., Corcoran, P., Brennan, R., Molloy, P., Friel, A., Maher, M., Glennon, M., Smith, T., Nolan, A., Houghton, J. A., Carroll, O., Colleran, S., O’Cuinn, G., Snow, H. M., O’Regan, D., Markos, H. F., Pollock, K., Cannon, D. M., McBean, G., O’Riordan, A., Quinlan, L. R., Kane, M. T., Higglns, B. D., Moriarty, D. M., Fitzgerald, D., Katkada, A., Canny, G., MacMathuna, P., O’Donoghue, D., O’Donovan, M. M., Schuur, A. G., Murphy, K. J., Foley, A. G., ten Bruggencate, S. J. M., and Ireland, L.

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17. Phytoestrogens inhibit invasiveness of MDA-MB-231 breast cancer cells in vitro

Author

Magee, P.J., McGlynn, H., and Rowland, I.

Subjects
Isoflavones -- Health aspects, Isoflavones -- Research, Breast cancer -- Prevention, Breast cancer -- Research, Food/cooking/nutrition
Abstract

Metastasis is a major cause of morbidity and mortality in breast cancer. Tumor cell invasion is a crucial step in the metastatic process. It has been proposed that dietary phytoestrogens (including those found in soy) are responsible for the low incidence of breast cancer in Eastern populations such as China and Japan. The aim of this study was to investigate the effects of a panel of phytoestrogens, including isoflavones, lignans, and coumestans, on the invasion of breast cancer cells (MDAMB-231 and MCF-7) and the noncancerous breast cell line MCF-10A through Matrigel. MCF-7 and MCF-10A cells were not invasive through Matrigel and therefore the effect of phytoestrogens on these cells was not investigated. In comparison MDA-MB-231 cells were highly invasive. The isoflavones genistein, glycitein, daidzein, equol, and O-desmethylangolensin (O-DMA) and the coumestan coumestrol induced a significant, dose-dependent, inhibition of MDA-MB-231 cell invasion through Matrigel. Most of the isoflavones and coumestrol inhibited invasion by ~30% when present at a concentration of 10 [micro]mol/L (e.g., O-DMA inhibited invasion by 29.3 [+ or -] 10.3%, P = 0.04). Inhibition of invasion was apparent with all compounds, even at 2.5 [micro]mol/L, with ODMA inhibiting invasion by 31% (P = 0.032). At 50 [micro]mol/L, genistein and coumestrol exerted the most potent inhibitory effects on invasion [decreases of 60.2 [+ or -] 28.5% (P = 0.00) and 55.5 [+ or -] 21.1% (P = 0.001), respectively]. The effects of the phytoestrogen metabolites equol and O-DMA on invasion were not significantly different from that of daidzein, their parent compound (P = 0.379, 0.241 vs. daidzein, respectively). Of the 4 lignans tested only secoisolariciresinol and its metabolite enterodiol induced a significant decrease in cell invasion (23.7 [+ or -] 12.8%, P = 0.04; 27.4 [+ or -] 23.5%, P = 0.05, respectively), but this only occurred at the highest concentration tested (50 [micro]mol/L). The potent inhibitory effect on MDA-MB-231 cell invasion induced by the isoflavones and coumestrol was not due to cell killing or growth inhibition because cell viability was unaffected (MTT assay). These findings highlight the possible chemopreventive effects of these compounds.

Published
2004

21. 138 Mutant RAS or FMS confer abnormal growth in haematopoietic cells: Poor clinical outcome in myelodysplasia with RAS , FMS and p53 mutations

Author

Padua, R.A., primary, Darley, R., additional, McGlynn, H., additional, Al-Sabah, A., additional, Oscier, D., additional, West, R., additional, Guinn, B., additional, Smith, M., additional, Taylor, C., additional, Pettersson, T., additional, Ridge, S., additional, Carter, G., additional, White, D., additional, and Burnett, A., additional

Published
1997
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25. Alternative Terrain Following System Concepts

Author

AERONAUTICAL SYSTEMS DIV WRIGHT-PATTERSON AFB OHIO, McGlynn,H J, AERONAUTICAL SYSTEMS DIV WRIGHT-PATTERSON AFB OHIO, and McGlynn,H J

Abstract

Three terrain following system concepts were evaluated, each based on a radar altimeter for sensing terrain clearance. The first concept develops an inertial altitude rate command in response to errors in terrain clearance altitude. This command is limited and summed with the actual rate of change of inertial altitude. The normal acceleration command is generated in response to errors in the inertial altitude rate. This command must be limited in order to maintain the vehicle within aerodynamic, structural, and engine-inlet distortion constraints. The second concept develops a clearance altitude rate command in response to errors in the clearance altitude. This command is limited and summed with the rate of change of clearance altitude. The normal acceleration command is generated in response to errors in the rate of change of terrain clearance. System Concept B describes a frequently used control law. The third concept incorporates the damping feedbacks of System A and System B. Both control laws are executed simultaneously and the most positive normal acceleration command is selected for control purposes. The most positive logic scheme assures smooth switching from one control law to the other.

Published
1977

32. Associations between animal and herd management factors, serological response to three respiratory pathogens and pluck lesions in finisher pigs on a farrow-to-finish farm.

Author

Fitzgerald RM, O'Shea H, Manzanilla EG, Moriarty J, McGlynn H, and Calderón Díaz JA

Abstract

Background: Serological screening is a common method to monitor antibody response to pathogen exposure, but results could vary due to several factors. This study aimed to quantify animal and management related factors associated with variation in antibody levels in finisher pigs at slaughter, in an Irish farrow-to-finish farm endemically infected with Actinobacillus pleuropneumonia (App), Mycoplasma hyopneumoniae (Mhyo) and swine influenza virus (SIV). A second objective was to estimate differences in antibody levels in pigs presenting pluck lesions. This was an observational study whereby pigs were managed as per routine farm practice. Data on sow parity, number of born alive (NBA) pigs per litter, cross-fostering status, birth and weaning body weight were recorded from 1016 pigs born from one farrowing batch. At slaughter, blood samples were collected for serological analysis and pigs were inspected for presence of enzootic pneumonia (EP)-like lesions, pleurisy, pericarditis and heart condemnations. Pigs were retrospectively classified into three production flows, depending on time spent in each production stage: flow 1 (F1; pigs followed the normal production flow); flow 2 (F2; pigs which were delayed by 1 week from advancing forward); and flow 3 (F3; pigs delayed by > 1 week from advancing forward). A nested case-control design was applied by matching pigs from each flow by sow parity, birth weight and NBA., Results: Pigs born from primiparous sows had higher antibody levels for App than those born to parity ≥5 sows (P < 0.05) and there was no association between any of the pathogens investigated and other early life indicators (P > 0.05). Pigs in F1 had lower antibody levels for App but higher antibody levels for SIV than F2 and F3 pigs (P < 0.05). There was no association between pluck lesions and respiratory pathogens (P > 0.05), except for increased antibody levels for Mhyo when EP-like lesions were present (P = 0.006)., Conclusion: Results indicate that offspring from primiparous sows develop higher antibody levels for App IV toxin when exposed to this disease and that enforcement of a strict all-in/all-out production system would reduce on-farm disease circulation. A high percentage of pigs were affected with EP-like lesions which were associated with higher antibody levels for Mhyo.

Published
2020
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33. Distinction between perimortem and postmortem fractures in human cranial bone.

Author

Ribeiro P, Jordana X, Scheirs S, Ortega-Sánchez M, Rodriguez-Baeza A, McGlynn H, and Galtés I

Subjects
Adult, Aged, Algorithms, Decision Trees, Female, Humans, Male, Middle Aged, Postmortem Changes, Forensic Medicine methods, Skull injuries, Skull Fractures pathology
Abstract

Timing of cranial trauma is challenging in forensic cases and literature on the subject is scarce. This study analysed the macroscopic fracture patterns of perimortem cranial fractures and compared them to experimentally reproduced cranial fractures on dry human craniums. The results showed nine traits associated with fresh cranial fractures: undulated margin, flake defects, peels with peel defects, fissures, crushed margins, bridge, bone scales and beveling. All the traits appear on the outer table or on the inner table of the cranium. Although not all characteristics must be present at the same time in all cranial fractures, they do define a new perimortem fracture pattern. Statistical analyses showed that six of these traits (undulated margins, flake defects, crushed margins, bone scales, fissures and peels) are distinctly related with perimortem (fresh) bone conditions. Considering the most discriminant perimortem traits, a decision-making algorithm is developed as a probabilistic approach to distinguish peri- from postmortem cranial fractures with an accuracy of 87%. This algorithm allows the forensic practitioner to incorporate more confidence during cranial trauma evaluation.

Published
2020
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34. Porcine reproductive and respiratory syndrome virus: phylogenetic analysis of circulating strains in the Republic of Ireland from 2016 to 2017.

Author

Fitzgerald RM, Collins PJ, McMenamey MJ, Leonard FC, McGlynn H, and O'Shea H

Subjects
Amino Acid Sequence, Animals, Genetic Variation, Genotype, Ireland epidemiology, Open Reading Frames, Porcine Reproductive and Respiratory Syndrome epidemiology, Porcine respiratory and reproductive syndrome virus genetics, Swine, Viral Envelope Proteins genetics, Phylogeny, Porcine Reproductive and Respiratory Syndrome virology, Porcine respiratory and reproductive syndrome virus classification, Porcine respiratory and reproductive syndrome virus isolation & purification
Abstract

In order to investigate the genetic diversity of porcine reproductive and respiratory syndrome virus (PRRSV) strains currently circulating in the Republic of Ireland (ROI), the ORF5 gene from 17 field strains originating from four vaccinating commercial herds was sequenced and phylogenetically analysed. High genetic variability was observed between farms at the nucleotide (86.3-95.2%) and amino acid (85.5-96%) levels. Phylogenetic analysis confirmed that all field strains belonged to the European species (type 1) and clustered into three separate groups within the subtype 1 subgroup. This variation may pose challenges for diagnosis and prophylactic control of PRRSV through vaccination in the ROI.

Published
2020
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35. Visualization and documentation of perimortem traits in long bone fractures using computed tomography.

Author

Scheirs S, Cos M, McGlynn H, Ortega-Sánchez M, Malgosa A, and Galtés I

Subjects
Documentation, Forensic Anthropology, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Fractures, Bone diagnostic imaging, Tomography, X-Ray Computed
Abstract

Perimortem fracture patterns in long bones, defined in previous publications, include layered breakage, bone scales, crushed margins, flakes with flake defect, wave lines, and plastic deformation. The traits help professionals during trauma analysis to differentiate peri- from post-mortem fractures. This study will therefore investigate whether these traits can be recorded with Computed Tomography (CT) as the non-invasive 3D imaging technique is becoming more popular in forensic science. CT scans of macerated bone samples (n = 15; humerus: n = 1; ulna: n = 1; radius: n = 1; femur: n = 12) were investigated using multi-planar reconstructions (MPRs) and volume renderings. Tension lines and severe plastic deformation were visible on the individual multi-planar reconstructions (MPRs) and the 3D models. Additionally, layered breakage and flake defects were also clearly distinguishable on the volume renderings. Based on the results, CT imaging may be a useful and fast tool to document, visualize, and analyze findings of blunt force trauma.

Published
2020
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36. Intra vitam trauma pattern: changing the paradigm of forensic anthropology?

Author

Scheirs S, Hevink B, Ortega-Sánchez M, Jordana X, McGlynn H, Rodriguez-Baeza A, Malgosa A, and Galtés I

Subjects
Aged, Aged, 80 and over, Forensic Anthropology, Humans, Logistic Models, Middle Aged, Models, Biological, Death, Fractures, Bone pathology
Abstract

This study aims to improve a previous study that reported new traits to characterize a perimortem fracture pattern in human long bones. This second study aims to acquire further knowledge about these perimortem traits, specifically by improving the experimental setting-by using a Blunt Force Trauma Simulator-and increasing the sample size with a total of 43 autopsy specimens and 57 reproduced fractures. Additionally, we investigated whether these traits could be related to muscular contractions by adding axial compression in the experimentally fractured specimens. If intra vitam traits can be found, it would consequentially be more valuable for forensic anthropologists to shorten the perimortem period. We demonstrate that all traits are perimortem traits. Furthermore, based on our results, we see the tendency that the combination of traits-instead of the presence of each trait individually-may make it possible to distinguish intra vitam from perimortem fractures. This study confirms these distinct characteristics that can be valuable to utilize in the distinction between peri- and postmortem fractures.

Published
2019
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37. Perimortem fracture pattern in ribs by blunt force trauma.

Author

Scheirs S, Langenhorst W, Malgosa A, Ortega-Sánchez M, McGlynn H, Santos C, Jordana X, Rodriguez-Baeza A, and Galtés I

Subjects
Accidents, Adult, Aged, Aged, 80 and over, Cardiopulmonary Resuscitation adverse effects, Female, Forensic Pathology, Humans, Male, Middle Aged, Models, Biological, Rib Fractures etiology, Time Factors, Young Adult, Rib Fractures pathology, Wounds, Nonpenetrating complications
Abstract

Literature on timing of rib trauma is scarce but remains challenging during forensic cases. This study analysed the macroscopic fracture patterns of perimortem rib fractures and compared them to experimentally reproduced rib fractures on fresh and dry ribs. Six distinctive macroscopic traits were found in ribs that might provide information about the timing of trauma, fracture mechanism and/or trauma circumstances. These traits are peels, folds, differential fracture edges, incomplete fractures, plastic deformation and longitudinal lines. Peels, folds and plastic deformation might provide information about trauma timing. Folds and different fracture edges might provide information about the fracture mechanism. Statistical analyses showed that longitudinal lines, folds and incomplete fractures might provide information about the trauma circumstances and that age might have an influence on the occurrence of complete fractures, longitudinal lines and peels (p ≤ 0.05). The new insights presented in this study might be valuable for forensic anthropologists in rib trauma analysis.

Published
2018
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38. Enterolactone restricts the proliferation of the LNCaP human prostate cancer cell line in vitro.

Author

McCann MJ, Gill CI, Linton T, Berrar D, McGlynn H, and Rowland IR

Subjects
4-Butyrolactone pharmacology, Cell Line, Tumor, Cell Survival drug effects, Humans, Male, Mitochondria drug effects, Mitochondria pathology, Polymerase Chain Reaction, Prostate-Specific Antigen drug effects, Prostate-Specific Antigen genetics, Prostatic Neoplasms pathology, 4-Butyrolactone analogs & derivatives, Cell Division drug effects, Lignans pharmacology, Phytoestrogens pharmacology
Abstract

Ecological data suggest a long-term diet high in plant material rich in biologically active compounds, such as the lignans, can significantly influence the development of prostate cancer over the lifetime of an individual. The capacity of a pure mammalian lignan, enterolactone (ENL), to influence the proliferation of the LNCaP human prostate cancer cell line was investigated as a function of cell density, metabolic activity, expression and secretion of prostate specific antigen (PSA), cell cycle profile, and the expression of genes involved in development and progression of prostate cancer. Treatment with a subcytotoxic concentration of ENL (60 muM for 72 h) was found to reduce: cell density (57.5%, SD 7.23, p < 0.001), metabolic activity (55%, SD 0.03, p < 0.001), secretion of PSA (48.50% SD 4.74, p = 0.05) and induce apoptosis (8.33-fold SD 0.04, p = 0.001) compared to untreated cells. Cotreatment with 10 muM etoposide was found to increase apoptosis by 50.17% (SD 0.02, p < 0.001). Additionally, several key genes (e. g. MCMs, survivin and CDKs) were beneficially regulated by ENL treatment (p < 0.05). The data suggest that the antiproliferative activity of ENL is a consequence of altered expression of cell cycle associated genes and provides novel molecular evidence for the antiproliferative properties of a pure lignan in prostate cancer.

Published
2008
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39. Inhibitory effects of olive oil phenolics on invasion in human colon adenocarcinoma cells in vitro.

Author

Hashim YZ, Rowland IR, McGlynn H, Servili M, Selvaggini R, Taticchi A, Esposto S, Montedoro G, Kaisalo L, Wähälä K, and Gill CI

Subjects
Adenocarcinoma prevention & control, Caffeic Acids therapeutic use, Collagen, Colonic Neoplasms prevention & control, Drug Combinations, Humans, Laminin metabolism, Neoplasm Invasiveness, Olive Oil, Phenylethyl Alcohol analogs & derivatives, Phenylethyl Alcohol therapeutic use, Proteoglycans, Tumor Cells, Cultured, Adenocarcinoma drug therapy, Anticarcinogenic Agents therapeutic use, Cell Survival drug effects, Colonic Neoplasms drug therapy, Phenols therapeutic use, Plant Oils therapeutic use
Abstract

Studies in human, animal and cellular systems suggest that phenols from virgin olive oil are capable of inhibiting several stages in carcinogenesis, including metastasis. The invasion cascade comprises cell attachment to extracellular matrix components or basement membrane, degradation of basement membrane by proteolytic enzymes and migration of cells through the modified matrix. In the present study, we investigated the effect of phenolics extracted from virgin olive oil (OVP) and its main constituents: hydroxytyrosol (3,4-dihydroxyphenylethanol), tyrosol (p-hydroxyphenylethanol), pinoresinol and caffeic acid. The effects of these phenolics were tested on the invasion of HT115 human colon carcinoma cells in a Matrigel invasion assay. OVP and its compounds showed different dose-related anti-invasive effects. At 25 microg/ml OVP and equivalent doses of individual compounds, significant anti-invasive effects were seen in the range of 45-55% of control. Importantly, OVP, but not the isolated phenolics, significantly reduced total cell number in the Matrigel invasion assay. There were no significant effects shown on cell viability, indicating the reduction of cell number in the Matrigel invasion assay was not due to cytotoxicity. There were also no significant effects on cell attachment to plastic substrate, indicating the importance of extracellular matrix in modulating the anti-invasive effects of OVP. In conclusion, the results from this study indicate that phenols from virgin olive oil have the ability to inhibit invasion of colon cancer cells and the effects may be mediated at different levels of the invasion cascade., ((c) 2007 Wiley-Liss, Inc.)

Published
2008
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40. Effect of colonic bacterial metabolites on Caco-2 cell paracellular permeability in vitro.

Author

Hughes R, Kurth MJ, McGilligan V, McGlynn H, and Rowland I

Subjects
Ammonia metabolism, Ammonia pharmacology, Bile Acids and Salts metabolism, Bile Acids and Salts pharmacology, Caco-2 Cells, Carbon Radioisotopes, Chenodeoxycholic Acid metabolism, Chenodeoxycholic Acid pharmacology, Cholic Acid metabolism, Cholic Acid pharmacology, Colon microbiology, Deoxycholic Acid metabolism, Deoxycholic Acid pharmacology, Dose-Response Relationship, Drug, Electric Impedance, Humans, Mannitol pharmacology, Membrane Proteins drug effects, Occludin, Phenol metabolism, Phenol pharmacology, Tight Junctions metabolism, Mannitol metabolism, Membrane Proteins metabolism, Permeability drug effects, Tight Junctions drug effects
Abstract

One common effect of tumor promoters is increased tight junction (TJ) permeability. TJs are responsible for paracellular permeability and integrity of the barrier function. Occludin is one of the main proteins responsible for TJ structure. This study tested the effects of physiological levels of phenol, ammonia, primary bile acids (cholic acid, CA, and chenodeoxycholic acid, CDCA), and secondary bile acids (lithocholic acid, LCA, and deoxycholic acid, DCA) on paracellular permeability using a Caco-2 cell model. Paracellular permeability of Caco-2 monolayers was assessed by transepithelial electrical resistance (TER) and the apical to basolateral flux of [14C]-mannitol. Secondary, but not primary, bile acids increased permeability as reflected by significantly decreased TER and increased mannitol flux. Both phenol and ammonia also increased permeability. The primary bile acid CA significantly increased occludin expression (P < 0.05), whereas CDCA had no significant effect on occludin expression as compared to the negative control. The secondary bile acids DCA and LCA significantly increased occludin expression (P < 0.05), whereas phenol had no significant effect on the protein expression as compared to the negative control. This suggests that the increased permeability observed with LCA, DCA, phenol, and ammonia was not related to an effect on occludin expression. In conclusion, phenol, ammonia, and secondary bile acids were shown to increase paracellular permeability and reduce epithelial barrier function at doses typical of levels found in fecal samples. The results contribute to the evidence these gut microflora-generated products have tumor-promoting activity.

Published
2008
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41. Potential anti-cancer effects of virgin olive oil phenols on colorectal carcinogenesis models in vitro.

Author

Gill CI, Boyd A, McDermott E, McCann M, Servili M, Selvaggini R, Taticchi A, Esposto S, Montedoro G, McGlynn H, and Rowland I

Subjects
Cell Adhesion drug effects, Cell Cycle drug effects, Cell Survival drug effects, Collagen metabolism, Drug Combinations, Humans, Hydrogen Peroxide toxicity, In Vitro Techniques, Laminin metabolism, Neoplasm Invasiveness, Olive Oil, Phenols isolation & purification, Plant Oils chemistry, Proteoglycans metabolism, Tumor Cells, Cultured, Anticarcinogenic Agents therapeutic use, Colorectal Neoplasms prevention & control, DNA Damage drug effects, Phenols therapeutic use, Plant Oils therapeutic use
Abstract

The traditional Mediterranean diet is thought to represent a healthy lifestyle; especially given the incidence of several cancers including colorectal cancer is lower in Mediterranean countries compared to Northern Europe. Olive oil, a central component of the Mediterranean diet, is believed to beneficially affect numerous biological processes. We used phenols extracted from virgin olive oil on a series of in vitro systems that model important stages of colon carcinogenesis. The effect the extract on DNA damage induced by hydrogen peroxide was measured in HT29 cells using single cell microgel-electrophoresis. A significant anti-genotoxic linear trend (p=0.011) was observed when HT29 cells were pre-incubated with olive oil phenols (0, 5, 10, 25, 50, 75, 100 microg/ml) for 24 hr, then challenged with hydrogen peroxide. The olive oil phenols (50, 100 microg/ml) significantly (p=0.004, p=0.002) improved barrier function of CACO2 cells after 48 hr as measured by trans-epithelial resistance. Significant inhibition of HT115 invasion (p<0.01) was observed at olive oil phenols concentrations of 25, 50, 75, 100 microg/ml using the matrigel invasion assay. No effect was observed on HT115 viability over the concentration range 0, 25, 50 75, 100 microg/ml after 24 hr, although 75 and 100 microg/ml olive oil phenols significantly inhibited HT115 cell attachment (p=0.011, p=0.006). Olive oil phenols had no significant effect on metastasis-related gene expression in HT115 cells. We have demonstrated that phenols extracted from virgin olive oil are capable of inhibiting several stages in colon carcinogenesis in vitro., (Copyright (c) 2005 Wiley-Liss, Inc.)

Published
2005
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42. All-trans retinoic acid-induced downregulation of annexin II expression in myeloid leukaemia cell lines is not confined to acute promyelocytic leukaemia.

Author

Olwill SA, McGlynn H, Gilmore WS, and Alexander HD

Subjects
Analysis of Variance, Annexin A2 analysis, Annexin A2 genetics, Cell Differentiation, Cell Line, Tumor, Down-Regulation, Fibrinolysis drug effects, Flow Cytometry, Hemostasis, Humans, Leukemia, Myeloid metabolism, Leukemia, Promyelocytic, Acute drug therapy, RNA, Messenger analysis, Reverse Transcriptase Polymerase Chain Reaction, Annexin A2 metabolism, Leukemia, Myeloid drug therapy, Tretinoin therapeutic use
Abstract

Most acute promyelocytic leukaemia (APL) patients suffer from disordered haemostasis. APL can be treated successfully in most instances by all-trans retinoic acid (ATRA) therapy, which induces endpoint maturation of the leukaemic promyelocytes with the characteristic t(15;17). Annexin II (AnII), a profibrinolytic protein, has been implicated in the bleeding manifestation seen in APL. Our group has shown previously that high levels of AnII are expressed on other acute myeloid leukaemia subtypes that are sometimes associated with disordered haemostasis, albeit less frequently than APL. This study examined the effects of ATRA on AnII expression and cell differentiation, on myeloid leukaemia cell lines to determine whether a regulatory influence on AnII may contribute to the return of haemostatic stability in APL following treatment. The results confirmed that AnII expression in the APL cell line (NB4) was significantly downregulated in response to ATRA (P < 0.01), with associated morphological and immunophenotypical evidence of myeloid differentiation. ATRA also downregulated AnII expression on other myeloid cell lines, albeit to a lesser extent than observed on NB4 cells. The results provide evidence that ATRA may resolve the hyperfibrinolysis in APL by downregulation of AnII expression.

Published
2005
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43. Role of mammalian lignans in the prevention and treatment of prostate cancer.

Author

McCann MJ, Gill CI, McGlynn H, and Rowland IR

Subjects
Animals, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacokinetics, Biological Availability, Humans, Life Style, Lignans chemistry, Lignans pharmacokinetics, Male, Phytoestrogens administration & dosage, Phytoestrogens therapeutic use, Prevalence, Risk Factors, Antineoplastic Agents, Phytogenic therapeutic use, Diet, Lignans therapeutic use, Prostatic Neoplasms epidemiology, Prostatic Neoplasms prevention & control
Abstract

Prostate cancer is poised to become the most prevalent male cancer in the Western world. In Japan and China, incidence rates are almost 10-fold less those reported in the United States and the European Union. Epidemiological data suggest that environmental factors such as diet can significantly influence the incidence and mortality of prostate cancer. The differences in lifestyle between East and West are one of the major risk factors for developing prostate cancer. Traditional Japanese and Chinese diets are rich in foods containing phytoestrogenic compounds, whereas the Western diet is a poor source of these phytochemicals. The lignan phytoestrogens are the most widely occurring of these compounds. In vitro and in vivo reports in the literature indicate that lignans have the capacity to affect the pathogenesis of prostate cancer. However, their precise mechanism of action in prostate carcinogenesis remains unclear. This article outlines the possible role of lignans in prostate cancer by reviewing the current in vitro and in vivo evidence for their anticancer activities. The intriguing concept that lignans may play a role in the prevention and treatment of prostate cancer over the lifetime of an individual is discussed.

Published
2005
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44. Annexin II cell surface and mRNA expression in human acute myeloid leukaemia cell lines.

Author

Olwill SA, McGlynn H, Gilmore WS, and Alexander HD

Subjects
Annexin A2 analysis, Cell Line, Tumor, Fibrinolysis, Hemorrhage etiology, Humans, Leukemia, Myeloid pathology, Leukemia, Promyelocytic, Acute metabolism, Membrane Proteins, Annexin A2 genetics, Gene Expression Regulation, Neoplastic, Leukemia, Myeloid metabolism, Leukemia, Promyelocytic, Acute complications, RNA, Messenger analysis
Abstract

Introduction: Acute promyelocytic leukaemia (APL) (M3) is associated with both a characteristic t(15;17) and severe bleeding diathesis caused by disseminated intravascular coagulation (DIC) and/or hyperfibrinolysis. It has been suggested that annexin II, a coreceptor for tissue plasminogen activator (t-PA) and plasminogen (PLG), is overexpressed on the surface of promyelocytes, leading to an increased fibrinolytic potential., Materials and Methods: This study examined the level of annexin II cell surface and mRNA expression in a range of acute myeloid leukaemia (AML) cell lines. The evidence that annexin II levels are higher in APL would lend support to the hypothesis that the bleeding disorder seen in APL is caused by hyperfibrinolysis., Results: Cell surface annexin II was found to be expressed at higher levels on NB4 (promyelocytic) cells than on either KG1a (early myeloid) or HL60 (myelocytic) cells. However, even higher levels were found on U937 and MM6 (histo-monocytic) and HEL (erythroid) cells (p<0.01). MM6 cells showed a threefold increase in annexin II mRNA compared to any of the other cell lines., Conclusions: These findings do not fully support the concept of the coagulopathy associated with APL being caused by hyperfibrinolysis alone. Further investigations are required to identify the significance of annexin II expression and regulation in leukaemia.

Published
2005
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45. Docosahexaenoic acid reduces in vitro invasion of renal cell carcinoma by elevated levels of tissue inhibitor of metalloproteinase-1.

Author

McCabe AJ, Wallace JM, Gilmore WS, McGlynn H, and Strain SJ

Subjects
Carcinoma, Renal Cell drug therapy, Carcinoma, Renal Cell pathology, Cell Line, Tumor, Humans, Prostaglandins biosynthesis, Carcinoma, Renal Cell metabolism, Docosahexaenoic Acids pharmacology, Fatty Acids, Unsaturated pharmacology, Neoplasm Invasiveness prevention & control, Tissue Inhibitor of Metalloproteinase-1 biosynthesis
Abstract

We demonstrate in this study that the n-3 polyunsaturated fatty acids derived from fish oil, namely, eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA), can increase levels of tissue inhibitors of metalloproteinase-1 (TIMP-1) in the renal cell carcinoma cell line caki-1 by 26% and 17.42% respectively. The result of this elevation in TIMP-1 levels is a reduction of 48.48% in caki-1 invasion through the basement membrane component matrigel when cells are treated with DHA. By inhibition of 2-series prostaglandin production, a similar increase in TIMP-1 was observed in caki-1 cells. We conclude that the polyunstaurated fatty acid DHA, a component of fish oil, is capable of significantly reducing the invasive profile of renal cell carcinoma, and that this reduction is regulated by levels of 2-series prostaglandin production.

Published
2005
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46. The effect of cruciferous and leguminous sprouts on genotoxicity, in vitro and in vivo.

Author

Gill CI, Haldar S, Porter S, Matthews S, Sullivan S, Coulter J, McGlynn H, and Rowland I

Subjects
Adult, Antioxidants analysis, Brassica enzymology, Comet Assay, DNA Damage, Fabaceae enzymology, Female, Glutathione Peroxidase blood, Glutathione Transferase blood, HT29 Cells metabolism, Humans, Hydrogen Peroxide toxicity, In Vitro Techniques, Lymphocytes drug effects, Male, Middle Aged, Mutagenicity Tests, Risk Reduction Behavior, Superoxides blood, Antioxidants pharmacology, Brassica metabolism, Colorectal Neoplasms prevention & control, Diet, Fabaceae metabolism, HT29 Cells drug effects, Lymphocytes metabolism
Abstract

Vegetable consumption is associated with a reduced risk of colorectal cancer, which is the second most common cancer after lung/breast cancer within Europe. Some putative protective phytochemicals are found in higher amounts in young sprouts than in mature plants. The effect of an extract of mixed cruciferous and legume sprouts on DNA damage induced by H(2)O(2) was measured in HT29 cells using single cell microgelelectrophoresis (comet). Significant antigenotoxic effect (P < or = 0.05) was observed when HT29 cells were pre-incubated with the extract (100 and 200 microL/mL) for 24 hours and then challenged with H(2)O(2). A parallel design intervention study was carried out on 10 male and 10 female healthy adult volunteers (mean age = 25.5 years) fed 113 g of cruciferous and legume sprouts daily for 14 days. The effect of the supplementation was measured on a range of parameters, including DNA damage in lymphocytes (comet), the activity of various detoxifying enzymes (glutathione S-transferase, glutathione peroxidase, and superoxide dismutase), antioxidant status using the ferric reducing ability of plasma assay, plasma antioxidants (uric acid, ascorbic acid, and alpha-tocopherol), blood lipids, plasma levels of lutein, and lycopene. A significant antigenotoxic effect against H(2)O(2)-induced DNA damage was shown in peripheral blood lymphocytes of volunteers who consumed the supplemented diet when compared with the control diet (P = 0.04). No significant induction of detoxifying enzymes was observed during the study, neither were plasma antioxidant levels or activity altered. The results support the theory that consumption of cruciferous vegetables is linked to a reduced risk of cancer via decreased damage to DNA.

Published
2004

47. Molecular, cytogenetic and genetic abnormalities in MDS and secondary AML.

Author

Padua RA, McGlynn A, and McGlynn H

Subjects
Acute Disease, Apoptosis genetics, Biomarkers, Tumor, Chromosome Deletion, Chromosome Painting, Chromosomes, Human genetics, Chromosomes, Human ultrastructure, Clone Cells pathology, Disease Progression, Genes, Tumor Suppressor, Genetic Predisposition to Disease, Genetic Therapy, Growth Substances genetics, Hematopoietic Stem Cells pathology, Humans, Karyotyping, Leukemia, Myeloid etiology, Leukemia, Myeloid pathology, Multigene Family, Myelodysplastic Syndromes pathology, Myelodysplastic Syndromes therapy, Neoplasm Proteins genetics, Neoplastic Stem Cells pathology, Oncogenes, Preleukemia genetics, Preleukemia pathology, Receptors, Growth Factor genetics, Signal Transduction genetics, Transcription, Genetic genetics, Translocation, Genetic, Trisomy, Aneuploidy, Chromosome Aberrations, Leukemia, Myeloid genetics, Myelodysplastic Syndromes genetics
Abstract

Myelodysplasia (MDS) is a clonal disease, which increases with age, suggesting that multiple steps are required for the evolution of the condition. Approximately 30% of MDS evolve into acute myelogenous leukemia (AML). In this review, we intend to delineate the genetic events, which may drive this sequence and therefore we will focus primarily on cytogenetic abnormalities where the genes have been identified and oncogenes and suppressor genes that have been implicated. In terms of the biological mechanisms, which characterise this process, it is generally thought that the MDS cell has impaired differentiation, and has increased apoptosis. As the disease progresses in addition, the cells have increased proliferation. As the disease evolves, the population of cells, which predominate remain immature, have decreased apoptosis and in many cases, upregulate anti-apoptotic genes and have deregulated proliferation as the number of blast cells increase. Etiological factors, which contribute to the development of leukemia, include therapeutic agents administered for a primary malignancy. The cytogenetic abnormalities, predisposition factors and genes involved in secondary leukemia will also be reviewed.

Published
2001
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48. Tissue inhibitor of metalloproteinase expression. A target for gene therapy in renal cell carcinoma.

Author

McElligott AM, Baker AH, and McGlynn H

Subjects
Adenoviridae, Carcinoma, Renal Cell pathology, Humans, Kidney Neoplasms pathology, Neoplasm Invasiveness, Recombinant Proteins biosynthesis, Tissue Inhibitor of Metalloproteinase-1 biosynthesis, Tissue Inhibitor of Metalloproteinase-2 biosynthesis, Transfection, Tumor Cells, Cultured, Carcinoma, Renal Cell therapy, Genetic Therapy methods, Kidney Neoplasms therapy, Tissue Inhibitor of Metalloproteinase-1 genetics, Tissue Inhibitor of Metalloproteinase-2 genetics
Published
1998

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