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Docosahexaenoic acid reduces in vitro invasion of renal cell carcinoma by elevated levels of tissue inhibitor of metalloproteinase-1.
- Source :
-
The Journal of nutritional biochemistry [J Nutr Biochem] 2005 Jan; Vol. 16 (1), pp. 17-22. - Publication Year :
- 2005
-
Abstract
- We demonstrate in this study that the n-3 polyunsaturated fatty acids derived from fish oil, namely, eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA), can increase levels of tissue inhibitors of metalloproteinase-1 (TIMP-1) in the renal cell carcinoma cell line caki-1 by 26% and 17.42% respectively. The result of this elevation in TIMP-1 levels is a reduction of 48.48% in caki-1 invasion through the basement membrane component matrigel when cells are treated with DHA. By inhibition of 2-series prostaglandin production, a similar increase in TIMP-1 was observed in caki-1 cells. We conclude that the polyunstaurated fatty acid DHA, a component of fish oil, is capable of significantly reducing the invasive profile of renal cell carcinoma, and that this reduction is regulated by levels of 2-series prostaglandin production.
- Subjects :
- Carcinoma, Renal Cell drug therapy
Carcinoma, Renal Cell pathology
Cell Line, Tumor
Humans
Prostaglandins biosynthesis
Carcinoma, Renal Cell metabolism
Docosahexaenoic Acids pharmacology
Fatty Acids, Unsaturated pharmacology
Neoplasm Invasiveness prevention & control
Tissue Inhibitor of Metalloproteinase-1 biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0955-2863
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of nutritional biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 15629236
- Full Text :
- https://doi.org/10.1016/j.jnutbio.2004.07.006