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Mystroxylon aethiopicum (Thumb.) Loes subsp. schlechteri (loes.) R. H. Archeris, a member of the Celastracea family, is widely used in traditional medicine to treat several diseases, such as hemorrhagic diarrhoea and respiratory tract infections. The study aimed to isolate the biologically active compounds from the leaves of M. aethiopicum. The leaves were ground to a fine powder and sequentially extracted with n-hexane, dichloromethane, acetone and methanol using serial exhaustive extraction (SEE) method. The bioautography and broth micro-dilution methods were used to analyse the antibacterial activities. The bioautography assay revealed that the compounds in the n-hexane, dichloromethane and acetone extracts have activity against all tested microorganisms. In contrast, the methanol extracts exhibited no antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli. The n-hexane extract had the lowest average MIC of 0.08 mg/mL, followed by the acetone (0.71 mg/mL) and dichloromethane (0.82 mg/mL) extracts. The bioassay-guided fractionation of dichloromethane and acetone extracts led to the isolation of 3-Oacetyloleanolic acid. The structure of the isolated compound was elucidated using NMR data and comparison with literature data. This is the first report on the isolation of 3-O-acetyloleanolic acid from the leaves of M. aethiopicum. [ABSTRACT FROM AUTHOR]

The structure of pyridin-4-ylmethyl 4-aminobenzoate was determined using single crystal X-ray diffraction. The compound was also characterized by elemental analysis, which showed the product was pure, and Fourier-transform infrared spectroscopy, which showed all important functional groups associated with the molecule. The compound crystallized in the orthorhombic space group Pna21, and the unit cell parameters were: a = 11.1735(16) Å, b = 8.3548(13) Å, c = 12.3831(17) Å, V = 1156.0(3) Å3, Z = 4. The crystal structure was solved by intrinsic phasing and refined to the final values R1 = 0.0429 and wR2 = 0.1312. [ABSTRACT FROM AUTHOR]

The reaction of ethyl acetoacetate and 2'-hydroxychalcones under atmospheric air to furnish a series of functionalized 6H-benzo[c]chromen-6-ones in moderate yields is reported. The reaction proceeds through trans-esterification, intra-molecular Michael addition, Robinson annulation and oxidative aromatization. [ABSTRACT FROM AUTHOR]

In this study, 12 compounds, which include a new flavanone 5-methoxy mundulin (1), were isolated from the leaves, stem bark and twigs of Mundulea sericea (Willd.) A. Chev. (Fabaceae; Papilionoideae). The structures of the compounds were identified based on spectral data analyses. The constituents of M. sericea also showed antimicrobial activities (MIQ = 0.01–100 µg) against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. [ABSTRACT FROM PUBLISHER]

The structure of pyridin-4-ylmethyl 4-aminobenzoate was determined using single crystal X-ray diffraction. The compound was also characterized by elemental analysis, which showed the product was pure, and Fourier-transform infrared spectroscopy, which showed all important functional groups associated with the molecule. The compound crystallized in the orthorhombic space group Pna21, and the unit cell parameters were: a = 11.1735(16) Å, b = 8.3548(13) Å, c = 12.3831(17) Å, V = 1156.0(3) Å3, Z = 4. The crystal structure was solved by intrinsic phasing and refined to the final values R1 = 0.0429 and wR2 = 0.1312. [ABSTRACT FROM AUTHOR]