667 results on '"Mattos M"'
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2. PRODUÇÃO DE LIPOSSOMAS ALIMENTÍCIOS UTILIZANDO A TÉCNICA DE INJEÇÃO DE ETANOL
- Author
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Mourão, M. S., primary, Mattos, M. V. C. V., additional, Michelon, M., additional, and Burkert, J. F. M., additional
- Published
- 2022
- Full Text
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3. Circadian rest-activity rhythm is associated to mnemonic processing speed of individuals with chronic migraine.
- Author
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David, M. C. M. M., Mattos, M. S. B., Souto, J. J. S., dos Santos, N. F., Brito, S. A. C. F., Galdino, G. S., Sampaio, P. G. G., Franco, C. I. F., and Matos, R. J. B.
- Abstract
Cognitive impairment by changes in the sleep-wake cycle may be present in individuals with migraine. Adjuvant evaluation methods in this area may favor the search for new treatments. We investigated the relationship between possible changes in the rest-activity rhythm (RAR) and visuospatial memory in individuals with chronic migraine (CM) using actigraphy and the Rey-Osterrieth Complex Figure Test (ROCFT), respectively. Actigraphy was analyzed in healthy individuals (CG) and patients with CM (CMG) for 15 days. The CMG had a longer latency time to start copying, copying time and visuospatial memory recall in comparison to the CG. However, there were no differences regarding short-term memory between groups. The lower relative amplitude and rhythmic percentage of the RAR contributed to the higher latency to initiate copying in CMG. In conclusion, misalignment of the RAR could be associated with a slower mnemonic processing speed in individuals with CM than in healthy individuals. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
4. TEORIAS, EXPERIÊNCIAS E INTERVENÇÕES: a profissionalização do psicopedagogo
- Author
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GHIRALDELLO, L., primary, O'REILLY, M. C. R. B., additional, and MATTOS, M. J. V. M., additional
- Published
- 2021
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5. INTERDISCIPLINARIDADE E INTERPROFISSIONALIDADE: um diálogo com diferentes campos do conhecimento
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MATTOS, M. J. V. M., primary, QUINTEIRO, R. S., additional, and PEREIRA, Sibélius Cefas, additional
- Published
- 2021
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6. PREFÁCIO: REFLEXÕES SOBRE TEMPOS SOMBRIOS
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MATTOS, M. B., primary
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- 2020
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7. Updates in Supply Chain Management and Logistics in Latin America and the Caribbean
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Mejía Argueta, C., primary, Yoshizaki, H., additional, and Mattos, M. G., additional
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- 2020
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8. Novel nanohybrid biocatalyst: application in the kinetic resolution of secondary alcohols
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Galvão, W. S., Pinheiro, B. B., Golçalves, L. R. B., de Mattos, M. C., Fonseca, T. S., Regis, T., Zampieri, D., dos Santos, J. C. S., Costa, L. S., Correa, M. A., Bohn, F., and Fechine, P. B. A.
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- 2018
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9. A Qualidade na Gestão de Projetos de Construção e Montagem
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Mattos, M. H. M., primary
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- 2023
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10. Correlation between pre- and post-dialysis blood pressure levels in hemodialysis patients with intradialytic hypertension
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Mattos, M. S. Rita de Cássia, Lemes, Helton P., and Ferreira-Filho, Sebastião R.
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- 2016
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- View/download PDF
11. Nightly Variation in Sleep Influences Self-efficacy for Adhering to a Healthy Lifestyle: A Prospective Study
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Kariuki, J.K., Kline, C.E., Mattos, M., Kriska, A., Ewing, L., Shiffman, S., Imes, C.C., Cajita, M.I., Mendez, D.D., Burke, L.E., Goode, R., Zheng, Y., Rathbun, S.L., and Chasens, E.R.
- Abstract
Background: Self-efficacy, or the perceived capability to engage in a behavior, has been shown to play an important role in adhering to weight loss treatment. Given that adherence is extremely important for successful weight loss outcomes and that sleep and self-efficacy are modifiable factors in this relationship, we examined the association between sleep and self-efficacy for adhering to the daily plan. Investigators examined whether various dimensions of sleep were associated with self-efficacy for adhering to the daily recommended lifestyle plan among participants (N = 150) in a 12-month weight loss study. Method: This study was a secondary analysis of data from a 12-month prospective observational study that included a standard behavioral weight loss intervention. Daily assessments at the beginning of day (BOD) of self-efficacy and the previous night’s sleep were collected in real-time using ecological momentary assessment. Results: The analysis included 44,613 BOD assessments. On average, participants reported sleeping for 6.93 ± 1.28 h, reported 1.56 ± 3.54 awakenings, and gave low ratings for trouble sleeping (3.11 ± 2.58; 0: no trouble; 10: a lot of trouble) and mid-high ratings for sleep quality (6.45 ± 2.09; 0: poor; 10: excellent). Participants woke up feeling tired 41.7% of the time. Using linear mixed effects modeling, a better rating in each sleep dimension was associated with higher self-efficacy the following day (all p values
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- 2022
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12. A comparison of virulence patterns and in vivo fitness between hospital- and community-acquired methicillin-resistant Staphylococcus aureus related to the USA400 clone
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Guimarães, M. A., Ramundo, M. S., Américo, M. A., de Mattos, M. C., Souza, R. R., Ramos-Júnior, E. S., Coelho, L. R., Morrot, A., Melo, P. A., Fracalanzza, S. E. L., Ferreira, F. A., and Figueiredo, A. M. S.
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- 2015
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13. Expert design knowledge: a case study in dental education
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Davenport, J. C., Fitzpatrick, F. J., Randell, D. A., Hammond, P., de Mattos, M. G., Tinsley, J. David, editor, and van Weert, Tom J., editor
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- 1995
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14. A FORMAÇÃO EM ENFERMAGEM E O CUIDADO ÀS PESSOAS EM SITUAÇÃO DE RUA
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Mattos, M., primary, Henrique, B. L. S., additional, Borges, M. E. B., additional, and Bittencourt, B. F., additional
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- 2021
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15. The role of Two-component regulation systems in the physiology of the bacterial cell
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BEKKER, MARTIJN, DE MATTOS, M. JOOST TEIXEIRA, and HELLINGWERF, KLAAS J.
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- 2006
16. Concepções de evolução entre alunos do sétimo ano do ensino fundamental em uma escola brasileira
- Author
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Salgado de Mattos, M. and Silva, Maria Augusta
- Abstract
A teoria da Origem das Espécies é um conceito chave para a compreensão da diversidade biológica e suas adaptações. Os alunos têm contato aprofundado com estes temas em torno do sétimo ano, dos doze, no ensino escolar brasileiro. No Brasil tem se observado um antagonismo entre posições religiosas e pessoais com as informações científicas divulgadas em sala de aula. O professor lida com estas concepções prévias que estão presentes em sua sala de aula ao abordar o tema da evolução. O objetivo deste estudo é levantar as concepções dos alunos sobre a evolução para permitir que o professor conheça melhor o ambiente em que suas aulas são ministradas. Foram utilizados questionários com os alunos e uma análise dos materiais didáticos utilizados pelo professor. Conclusões apontam para um desconhecimento do tema pelos alunos, com mais ausência de informação do que distorções no conceito.
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- 2021
17. Antigen-triggered interferon-γ and interleukin-10 pattern in cured mucosal leishmaniasis patients is shaped during the active phase of disease
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Nogueira, R. S., Gomes-Silva, A., Bittar, R. C., Mendonça, Silva D., Amato, V. S., da Silva Mattos, M., Oliveira-Neto, M. P., Coutinho, S. G., and Da-Cruz, A. M.
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- 2014
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18. Protein production by Escherichiacoli wild-type and ΔptsG mutant strains with IPTG induction at the onset
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Picon, A., de Mattos, M. J. Teixeira, and Postma, P. W.
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- 2008
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19. Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions
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Sosinska, Grazyna J., de Groot, Pier W.J., de Mattos, M. Joost Teixeira, Dekker, Henk L., de Koster, Chris G., Hellingwerf, Klaas J., and Klis, Frans M.
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Bacterial cell walls -- Research ,Candida albicans -- Physiological aspects ,Hypoxia -- Research ,Biological sciences - Abstract
Proteins that are covalently linked to the skeletal polysaccharides of the cell wall of Candida albicans play a major role in the colonization of the vaginal mucosal surface, which may result in vaginitis. Here we report on the variability of the cell-wall proteome of C. albicans as a function of the ambient [O.sub.2] concentration and iron availability. For these studies, cells were cultured at 37 [degrees]C in vagina-simulative medium and aerated with a gas mixture consisting of 6 % (v/v) C[O.sub.2], 0.01-7 % (v/v) [O.sub.2] and N2, reflecting the gas composition in the vaginal environment. Under these conditions, the cells grew exclusively in the non-hyphal form, with the relative growth rate being halved at ~0.02 % (v/v) [O.sub.2]. Using tandem MS and immunoblot analysis, we identified 15 covalently linked glycosylphosphatidylinositol (GPI) proteins in isolated walls (Als1, Als3, Cht2, Crh11, Ecm33, Hwp1, Pga4, Pga10, Phr2, Rbt5, Rhd3, Sod4, Ssr1, Ywp1, Utr2) and 4 covalently linked non-GPI proteins (MP65, Pir1, Sim1/Sun42, Tos1). Five of them (AIs3, Hwp1, Sim1, Tos1, Utr2) were absent in cells grown in rich medium. Immunoblot analysis revealed that restricted [O.sub.2] availability resulted in higher levels of the non-GPI protein Pir1, a putative [beta]-1,3-glucan cross-linking protein, and of the GPI-proteins Hwp1, an adhesion protein, and Pga10 and Rbt5, which are involved in iron acquisition. Addition of the iron chelator ferrozine at saturating levels of [O.sub.2] resulted in higher cell wall levels of Hwp1 and Rbt5, suggesting that the responses to hypoxic conditions and iron restriction are related.
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- 2008
20. The Metabolic Response of Saccharomyces Cerevisiae to Continuous Heat Stress
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Mensonides, Femke I.C., Schuurmans, J. Merijn, de Mattos, M. Joost Teixeira, Hellingwerf, Klaas J., and Brul, Stanley
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- 2002
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21. Quantitative assessment of oxygen availability: perceived aerobiosis and its effect on flux distribution in the respiratory chain of Escherichia coli
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Alexeeva, Svetlana, Hellingwerf, Klaas J., and Mattos, M. Joost Teixeira de
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Bacteriology -- Research ,Oxygen -- Physiological aspects ,Escherichia coli -- Physiological aspects ,Cytochrome oxidase -- Analysis ,Cells -- Growth ,Biological sciences - Abstract
Research has been conducted on the role of oxygen in the cellular process. The quantitative description of the cellular physiology of Escherichia coli growth in the microaerobic range and the description of the cellular activity variations of the cytochrome oxidases are presented.
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- 2002
22. Overproduction of Metabolites
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Neijssel, Oense M., primary, de Mattos, M. Joost Teixeira, additional, and Tempest, David W., additional
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- 2008
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23. Influence of the Notch system in the therapeutic response of American tegumentary leishmaniasis
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Rodrigues, K. M.P., Oliveira, M. P., Maretti-Mira, A. C., Oliveira-Neto, M. P., Mattos, M. S., Silva, L., Soares, D. A., Dolci, E. L.L., Perico, R. A.P.N., and Pirmez, C.
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- 2011
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24. Natural Language Processing Characterization of Recurring Calls in Public Security Services
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de Oliveira, Nicollas R., primary, Lucio Reis, H. A., additional, Fernandes, Natalia C., additional, Carlos Bastos, A. M., additional, Dianne Medeiros, S. V., additional, and Diogo Mattos, M. F., additional
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- 2020
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25. Current topics in signal transduction in bacteria
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Hellingwerf, Klaas J., Crielaard, Wim C., Teixeira de Mattos, M. Joost, Hoff, Wouter D., Kort, Remco, Verhamme, Daniel T., and Avignone-Rossa, Claudio
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- 1998
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26. Effects of limited aeration and of the ArcAB system on intermediary pyruvate catabolism in Escherichia coli
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Alexeeva, Svetlana, Kort, Bart de, Sawers, Gary, Hellingwerf, Klaas J., and Mattos, M. Joost Teixeira de
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Escherichia coli -- Physiological aspects ,Metabolism -- Analysis ,Metabolic regulation -- Analysis ,Cell physiology -- Research ,Biological sciences - Abstract
Results show that in the process of catabolic adaptation to redox conditions Escherichia coli uses the pyruvate formate-lyase and the pyruvate dehydrogenase complex under microaerobic conditions. Data indicate that the global regulatory system ArcAB controls the above two operons during microaerobiosis.
- Published
- 2000
27. Modified section method for laser-welding of ill-fitting cp Ti and Ni–Cr alloy one-piece cast implant-supported frameworks
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TIOSSI, R., FALCÃO-FILHO, H., AGUIAR JÚNIOR, F. A., RODRIGUES, R. C., MATTOS, M. da G., and RIBEIRO, R. F.
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- 2010
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28. The steady-state internal redox state (NADH/NAD) reflects the external redox state and is correlated with catabolic adaptation in Escherichia coli
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Graef, Mark R. de, Alexeeva, Svetlana, Snoep, Jacky L., and Mattos, M. Joost Teixeira de
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Escherichia coli -- Research ,Oxidation-reduction reaction -- Research ,Pyridine -- Research ,Nucleotides -- Research ,Coenzymes -- Research ,Biological sciences - Abstract
The steady-state internal redox state in prokaryotes was investigated by growing Escherichia coli MC4100 in anaerobic glucose-limited cultures in the presence of an electron acceptor or fully fermentatively. The steady-state NADH/NAD ratio was found to be dependent on the nature of external electron acceptors. Results also showed that the synthesis and activity of the pyruvate dehydrogenase complex occur under anaerobic respiratory conditions and correlate with the cellular steady-state redox state.
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- 1999
29. A low-cost system for temperature controlling and monitoring in aquariums
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Lima, M. E. C. D., Pereira, D. S., Oliveira, F. M., Mattos, M. S., Xavier, Fabio Contrera, and Biofouling, Benthic Ecology and Marine Biotechnology Meeting, 013., 2019, Arraial do Cabo (RJ)
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Ciência, tecnologia e inovação ,Ecologia Marinha - Abstract
First life form on Earth developed at moderate temperatures, before it evolves into a much warmer environment and later in a climate similar to the current one. In this sense, it is well known that temperature has an important role in the life and of all organisms growth around the planet. For example, marine organisms suffer from small changes in temperature, which can affect their behavior and metabolism. Also, a area that requires great attention when the subject is temperature, is aquarium industry, that is the creation of fish and other aquatic organisms in aquariums. However, keeping aquariums in certain conditions, as the summer, requires special attention to preserve life, because temperature increasing creates some risks for this environment. Then, it is necessary an equipment that suppress this failure, making stable the temperature in the aquariums. However, in most cases the high cost these devices is a major constraint for this area. Therefore, this work aims to develop a low cost system for temperature controlling and monitoring in aquariums. This system is based on physical programmable circuit board (Arduino) connected to 1 temperature sensor and 4 peltier modules (2 to heat and 2 to cold). User can be adjust temperature thresholds (minimum and maximum) according to desired. From this, temperature sensor measures and sends information to Arduino. When this temperature exceeds configured thresholds, Arduino turn on the peltier module. For equipment test, was performed an experiment using an aquarium with 1.5l of water. This test showed that for increasing and decreasing of 1 degree the system took 30 seconds and 27 seconds, respectively. Thus, this system prevents abrupt changes in temperature that can be harmful to organisms. The main conclusions that can be drawn are that this system is low cost, quick deployment and customizable.
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- 2019
30. Can interferon-γ and interleukin-10 balance be associated with severity of human Leishmania (Viannia) braziliensis infection?
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Gomes-Silva, A., de Cássia Bittar, R., dos Santos Nogueira, R., Amato, V. S., da Silva Mattos, M., Oliveira-Neto, M. P., Coutinho, S. G., and Da-Cruz, A. M.
- Published
- 2007
31. Genetic relatedness between group B streptococci originating from bovine mastitis and a human group B streptococcus type V cluster displaying an identical pulsed-field gel electrophoresis pattern
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Oliveira, I. C. M., de Mattos, M. C., Pinto, T. A., Ferreira-Carvalho, B. T., Benchetrit, L. C., Whiting, A. A., Bohnsack, J. F., and Figueiredo, A. M. S.
- Published
- 2006
32. Increased stability of recombinant plasmids by Tn1000 insertion in chemostat cultures of recombinantEscherichia coli GT123
- Author
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Nudel, B. Clara, Vosman, Ben, de Mattos, M. Joost Teixeira, Hellingwerf, Klaas J., and Neijssel, Oense M.
- Published
- 1993
- Full Text
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33. Gluconate metabolism of Klebsiella pneumoniae NCTC 418 grown in chemostat culture
- Author
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Simons, Joost A., Teixeira de Mattos, M. Joost, and Neijssel, Oense M.
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- 1993
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34. Sputum cytology in the diagnosis of pulmonary paracoccidioidomycosis
- Author
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Iwama de Mattos, M. C. F., Mendes, R. P., Marcondes-Machado, J., Meira, D. A., Morceli, J., Pereira, P. C. M., and Barraviera, B.
- Published
- 1991
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35. Futile cycling of ammonium ions via the high affinity potassium uptake system (Kdp) of Escherichia coli
- Author
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Buurman, Ed T., Joost Teixeira de Mattos, M., and Neijssel, Oense M.
- Published
- 1991
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36. Involvement of pyruvate dehydrogenase in product formation in pyruvate-limited anaerobic chemostat cultures of Enterococcus faecalis NCTC 775
- Author
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Snoep, Jacky L., Teixeira de Mattos, M. Joost, Postma, Pieter W., and Neijssel, Oense M.
- Published
- 1990
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37. The role of magnesium and calcium ions in the glucose dehydrogenase activity of Klebsiella pneumoniae NCTC 418
- Author
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Buurman, Ed T., Boiardi, José L., Teixeira de Mattos, M. Joost, and Neijssel, Oense M.
- Published
- 1990
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38. pH and glucose profiles in aggregates of Bacillus laevolacticus
- Author
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Boer, Jan P., de, Cronenberg, Carel C.H., Beer, Dirk de, Heuvel, Johannes C. van den, Mattos, M. Joost Teixeira de, and Neijssel, Oense M.
- Subjects
Bacillus (Bacteria) -- Research ,Glucose -- Measurement ,Biological sciences - Abstract
A study of the size distributions and glucose and pH profiles of aggregates of the D-(-)-lactic acid-producing organism Bacillus laevolacticus showed that the organisms were grown in continuous culture with a medium glucose concentration of 280 or 110 mM. A maximal aggregate diameter of 2.2 mm and a Sauter mean of 1.46 mm were determined for the earlier culture conditions, while aggregates from a culture with 110 mM glucose input had a maximal diameter of 1.9 mm with Sauter mean 1.07 mm. In cultures with high glucose input, lactic acid accumulated within the aggregates, and the metabolism in the central region of the larger aggregates stopped.
- Published
- 1993
39. The role of lipoic acid in product formation by Enterococcus faecalis NCTC 775 and reconstitution in vivo and in vitro of the pyruvate dehydrogenase complex
- Author
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Snoep, Jacky L., Bommel, Mark van, Lubbers, Frank, Mattos, M. Joost Teixeira de, and Neijssel, Oense M.
- Subjects
Enzymes -- Research ,Dehydrogenases -- Usage ,Bacteria -- Research ,Biological sciences - Abstract
The function of the pyruvate dehydrogenase complex (PDC) in the development of several fermentation products is analyzed by Enterococcus faecalis. Very little activity in vivo and vitro was identified in PDC when the organism was grown on a medium devoid of lipoic acid. Acetoin was a common product in the absence of lopoic acid, but in its presence acetoin was generated only when the intracellular pyruvate concentration was comparatively large.
- Published
- 1993
40. Energetic efficiency of Escherichia coli: effects of mutations in components of the aerobic respiratory chain
- Author
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Calhoun, Melissa W., Oden, Kristine L., Gennis, Robert B., Mattos, M. Joost Teixeira de, and Neijssel, Oense M.
- Subjects
Escherichia coli -- Physiological aspects ,Microbial mutation -- Analysis ,Microbial respiration -- Research ,Biological sciences - Abstract
The effects of specific respiratory defects on the growth of Escherichia coli were reported. The growth yields for a set of isogenic strains were determined for cells grown in glucose-limited conditions. An enhanced bioenergetic efficiency of the bo-type oxidase is observed in strains that lack the membrane-bound NADH dehydrogenase 2. Although the bd-type oxidase is less efficient than the bo-type oxidase, it is still coupled in the respiratory chain.
- Published
- 1993
41. Pyruvate catabolism during transient state conditions in chemostat cultures of Enterococcus faecalis NCTC 775: importance of internal pyruvate concentrations and NADH/NAD+ ratios
- Author
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Snoep, Jacky L., Graef, MarkR. de, Teixeira de Mattos, M. Joost, and Neijssel, Oense M.
- Subjects
Glucose metabolism -- Research ,Microbial metabolism -- Research ,NAD (Coenzyme) -- Physiological aspects ,Biological sciences - Abstract
Enterococcus faecalis was grown in glucose-limited chemostat cultures under aerobic and anaerobic conditions to study the regulation of pyruvate catabolism. Switching from aeorbic to anaerobic growth resulted in a rapid increase of the NADH/NAD+ ratio with a concomitant inhibition of the pyruvate dehydrogenase complex (PDC). In contrast, switching from anaerobic to aerobic growth increased both PDC activity and NADH/NAD+ ratio. A pyruvate pulse also resulted in catabolic fluxes. Therefore, both NADH/NAD+ ratio and pyruvate concentration are important in regulating PDC.
- Published
- 1992
42. Anaerobic 2-ketogluconate metabolism of Klebsiella pnuemoniae NCTC 418 grownin chemostat culture: involvement of the pentose phosphate pathway
- Author
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Simons, Joost A., Snoep, Jacky L., Feitz, Sjoerd, Mattos, M. Joost Teixeira de, and Neijssel, Oense M.
- Subjects
Klebsiella -- Research ,Microbial metabolism -- Research ,Biological sciences - Abstract
Klebsiella pneumoniae NCTC 418 can convert 2-ketogluconate to biomass, acetate, formate, carbon dioxide, ethanol and succinate under anaerobic conditions. The results indicatedthat K. pneumoniae utilizes both the Entner-Doudoroff and pentose phosphate pathway in the anaerobic catabolism of 2-ketogluconate. It was also observed that sudden relief of 2-ketogluconate-limited conditions led to an increase in catabolism rate and a decrease in the anabolism rate of 2-ketogluconate. This was accompanied by increased lactate production, probably, as a form of energy dissipation.
- Published
- 1992
43. DIFFERENCES IN ILLNESS PERCEPTIONS BETWEEN PARTICIPANTS WITH MILD COGNITIVE IMPAIRMENT AND THEIR CARE PARTNERS
- Author
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Mattos, M, primary, Sereika, S, additional, Kim, H, additional, Tamres, L, additional, Knox, M, additional, and Lingler, J, additional
- Published
- 2018
- Full Text
- View/download PDF
44. Ezetimibe added to statin therapy after acute coronary syndromes
- Author
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Cannon, Christopher P., Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Kyungah, Im, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, Califf, Musliner T, Robert M., Tershakovec, A, Gurfinkel, E, Aylward, P, Tonkin, A, Maurer, G, Van de Werf, F, Nicolau, Jc, Theroux, P, Genest, J, Armstrong, P, Corbalan, R, Isaza, D, Spinar, J, Grande, P, Voitk, J, Kesaniemi, A, Bassand, Jp, Farnier, M, Darius, H, Keltai, M, Mathur, A, Mittal, S, Reddy, K, Lewis, B, De Ferrari GM, Ophuis, To, Jukema, J, White, H, Pedersen, T, Britto, F, Ruzyllo, W, Carrageta, M, Duris, T, Dalby, A, Seung, Kb, Lopez-Sendon, J, Dellborg, M, Mach, F, Guneri, S, Parkhomenko, A, Brady, A, Cannon, C, Blazing, M, Ballantyne, C, de Lemos, J, Kleiman, N, Mcguire, Dk, Centeno, E, Casalins, M, Cartasegna, L, Beltrano, Mc, Guerrero, R, Fanuele, M, Berra, F, Egido, J, Colombo, H, Dellatorre, M, Terns, P, Blumberg, E, Reges, P, Azize, G, Ramos, H, Fernandez, R, Carlessi, C, Milesi, R, Schmuck, R, Duronto, E, Procopio, G, Carlevaro, O, Maffeo, H, Beloscar, J, Viso, M, Hominal, M, Castoldi, M, Bluguermann, J, Mauro, D, Macin, S, Cocco, N, Ruiz, N, Ricart, J, Lozada, A, Nani, S, Turri, D, Fernandez, H, Caruso, O, Zarandon, R, Bono, J, Arias, V, Allall, O, Marino, J, Cusimano, S, Schygiel, P, Buzetti, C, Penaloza, N, Berli, M, Worthley, S, Roach, A, Chew, D, Wright, T, Leitch, J, Hicks, E, Rankin, J, Venn-Edmonds, C, Lehman, R, Morrison, H, Shaw, J, Mak, V, Hii, C, Smith, K, Cross, D, Lilwall, L, Nelson, G, Loxton, A, Horowitz, J, Rose, J, Steinwender, C, Leisch, F, Kammler, J, Brussee, H, Zweiker, R, Niederl, E, Weihs, W, Giorgio, G, Lang, I, Drexel, H, Zanolin, D, Hoppe, U, Atzenhofer-Baumgartner, K, Pichler, M, Hainzer, D, Eber, B, Pichler, F, Foeger, B, Wechselberger, T, Mayr, H, Hofer, J, Stockenhuber, F, Warlits, B, Huber, K, Egger, F, Weidinger, F, Ziegler, B, Jirak, P, Metzler, B, Pachinger, O, Wanitschek, M, Auer, J, Grabscheit, G, 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G., Herman, O., Zemberova, A., Pella, D., Fedacko, J., Banikova, A., Micko, K., Macek, V., Moscovic, M., Vahala, P., Vykoukalova, T., Dzupina, A., Marusakova, M., Stevlik, J., Akubzanova, E., Hatalova, K., Burgess, L., Coetzee, C., Mabin, T., Roos, J., Mohamed, Z., Pillay, T., Corbett, C., Bodenstein, W., Tayob, F., Ebrahim, I., Bolsman, C., Horak, A., Lloyd, E., Pretorius, M., Commerford, P., De Andrade, M., Roux, J., Murray, A., Soma, P., Delport, E., Cassel, G., Van Zyl, L., Cronje, T., Sarvan, M., Moodley, R., Guerra, M., Swanepoel, N., Bayat, J., Klug, E., Hellig, S., Yoon, J., Kim, J., Chung, W., Choi, Y., Cho, M., Lee, S., Kwon, H., Hong, B., Seung, K., Chang, K., Rha, S., Jeong, M.H., Hong, Y., Lee, C., Seong, I., Jeong, J., Tahk, S., Yoon, M., Chae, S.C., Kim, H., Lopez, V., Roldan, J.M., Mancisidor, P., Froufe, J., López, A., Franco, S., Molina, A., Soriano, F., Cobos, M., Mejía, H.D., Sanz, R., Vazquez, A., Garri, F., Esteban, I., Marco, P., Artaecheverria, J., Cequier, A., 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Lycksell, M., Lundgren, C., Herlitz, J., Sjölin, M., Erlinge, D., Matson, E., Cizinsky, S., Carlsson, F., Ryttberg, B., Johansson, K., Tygesen, H., Bergsten, J., Naslund, U., Sundholm, C., Timberg, I., Wikström, P., Hårdhammar, P., Lisbeth, A., Lund, L., Hage, C., Rosenqvist, U., Grändås, M., Larsson, L., Hammerman, A., Andersson, G., Johansson, S., Bennermo, M., Tjerneld, H., Forsgren, M., Eriksson, K., Eriksson, M., Bengtsson, P.O., Yu, W., Ceder-Brolin, K., Stafberg, C., Andersson, E., Roussine, V., Ångman, K., Melin, B., Thorsen, S., Lundell, L., Buijs, F., Östberg, S., Sigaud, P., Moccetti, T., Bondio, M., Kuehlkamp, V., Pieper, M., Gallino, A., Zender, H., Genné, D., Gauthey, J., Wilhelm, M., Saner, H., Trachsel, L., Roethlisberger, C., Schlaepfer, H., Kujawski, T., Pagnamenta, A., Meyer-Monard, S., Krapf, R., Biedermann, B., Schneider, H., Rickli, H., Ramsay, D., Linka, A., Ballmer, P., Oswald, M., Girod, G., Charng, M., Shu-Ling, H., Ping-Han, L., Wu, C., Liu, S., Lin, M., Chian-Yi, W., Yeh, H., Mei-Juan, C., Hsieh, I., Wang, Y., Ural, E., Sahin, T., Yildiz, Z., Kayikcioglu, M., Kultursay, H., Yigit, Z., Calpar, I., Ata, N., Goktekin, O., Senol, U., Yalcin, R., Timurkaynak, T., Kaya, U., Yildirir, A., Karacaglar, E., Faynyk, A., Sorokivskyy, M., Koval, O., Kaplan, P., Kraiz, I., Popova, K., Kyyak, Y., Barnett, O., Karpenko, O., Todoriuk, L., Tseluyko, V., Kopytsya, M., Petyunina, O., Kovalskyy, I., Zhukova, Y., Katerenchuk, I., M'yakinkova, L., Lutay, Y., Syvolap, V., Kyselov, S., Vakaliuk, I., Nesterak, R., Nikonov, V., Feskov, O., Goloborodko, B., Golovtsev, Y., Berezniakov, I., Lebedynska, M., Rudenko, L., Tutov, I., Ahsan, A., Burton, J., Levy, T., Lakeman, N., Spratt, J., Langford, E., Sutcliffe, S., Khwanda, A., Davis, G., Rodrigues, E., Dickinson, D., Been, M., Trouton, T., Riddell, J., Moriarty, A., McEneaney, D., Squire, I., Narayan, H., Goode, G., Helliwell, L., Boos, C., Greaves, K., Knops, K., Pegge, N., Signy, M., Wong, Y., Moore, S., Fluck, D., Atkinson, C., Adgey, A., McKeag, N., Bishop, A., Glover, J., Barbir, M., Breen, J., Robson, H., Townend, J., Dwenger, E., Ekpo, E., Shakespeare, C., Barr, C., McClements, B., McAllister, A., De Belder, M., Cooke, J., Williams, S., Daniel, D., Pye, M., Griffith, K., Wright, L., Trevelyan, J., Doughty, A., Hughes, E., Phillips, C., Penny, W., Groves, P., Kardos, A., Purvis, J., McNeill, A., Jones, A., Brown, J., Saeed, B., Sprigings, D., Herity, N., Brown, C., Unks, M., Cauthren, T., Bertolet, B., Jones, M., Decker, S., Chambers, J., Stahlberg, J., Varma, S., Gencheff, N., Price, A., McElroy, D., Chu, A., Crutchfield, B., Eaton, G., Looney, A., Qureshi, M., Wilks, J., Drenning, D., Overman, A., Andreou, C., Russo, P., Stuckey, T., Pruitt, H., D'Urso, M., DeRaad, R., Rogers, W., Thorington, S., Pasquini, J., Iwaoka, R., Tannenbaum, M., Prouty, D., Wiseman, A., Sharow, A., Graham, B., Ali, M.I., Dale, H., Tarsi, D., Picone, M., Juarez, S., Hamroff, G., Hollenweger, L., Scirica, B., Sabatine, M., Marti, J., Perlman, R., Pavlides, A., Joffe, I., Albirini, A., Campbell, T., Puri, S., Lopez, C., Pearce, D., Shah, D., McPherson, J., Donegan, R., Murdock, D., Block, D., Malik, A., Musina, R., Dauber, I., Varner, C., Bach, R., Palazzolo, M., Bhalla, H., Thompson, M., Pollock, S., Johnson, S., Lipson, L., Brunk, S., Karas, S., Vicari, R., Kuvin, J., Mooney, P., Aycock, G., Lane, B., Sharma, M., Gibson, T., Chang, G., DiVito, P., Mehta, R., Watkins, K., Chiu, A., Gunderson, J., Tedder, B., Williams, P., Hage-Korban, E., Childs, A., Banerjee, S., Kazi, F., Bennett, J., Barnes, D., Wohns, D., Noorman, C., Aggarwal, K., Lau-Sickman, A., Paulowski, J., Amos, M., Rider, J., Fenton, S., Schantz, M., Hakas, J., Mcsorley, J., Felten, W., Bitzer, V., Russell, J., Loyo, J., Adjei, A., Mehta, K., Uretsky, B., Hale, M., Shaikh, S., Miller, M., Hollenbaugh, D., Crawford, K., Fortuin, D., Galindo, A., Del Core, M., Butkus, E., Collins, J., Prior, J., Hahn, R., Greene-Nashold, J., Alexander, J., Genova, E., MacDonell, A., Broadwater, S., Kereiakes, D., White, D., Lopez, M., Schenks, R., Lui, H., Gibbons, P., Davis, B., Thornton, K., Daley, P., Budzon, S., McCullum, K., Delio-Cox, B., Nadar, V., Keim, S., McLaurin, B., Davis, C., Betzu, R., Al-Jumaily, J., Bolli, R., Alshaher, M., Leesar, M., Collins, T., Akkad, H., Bilazarian, S., Marsters, M., Kennett, J., Melegrito, K., Mostel, E., Harris, R., Chang, M., Hatfield, G., Makam, S., Garvey, M., Levite, H., White, J., Abdel-Latief, A., Pelletier, L., Carr, K., Mckenna, K., De Lemos, J., Soto, G., Kozina, J., Harris, D., Vlastaris, A., Bittel, B., Riba, A., Gugudis, J., Singh, N., Qureshi, I., Doty, W., Lehmann, J., Lieber, I., Martin, S., Nicu, M., Bhalodkar, N., Ravi, P., Canto, J., Bass, M., Campbell, C., Steinhubl, S., Moles, K., Harjai, K., Stapleton, D.D., Hoey, K., Erwin, J., Fikes, W., Stein, B., Sabatino, K., Teklinski, A., Colfer, H., Ward, P., Langevin, E., Faucett, S., Mamdani, S., DeSimone, L., Tuohy, E., Cullen, T., Eisenberg, S., Chronos, N., Allen, R.P., Erickson, B., Mahon, K., Kirby, A., Siegel, C., Stroud, L., Johnson, J., Panchal, V., Pearson, A., Abell, T., De Gregorio, M., Boomer, L., Vahdat, O., VanNatta, B., Long, P., Chalavarya, G., Skatrud, L., Carey, C., Wright, W., Mechem, C., Matthews, B., Adams, A., Vora, K., Wead, J., Koren, M., Gregory, D., El Khadra, M., Peacock, G., Kieval, J., Barron, M., Lewis, D., Grice, R., Bobek, M., Moore, C., Nygaard, T., Fischell, T., Salman, W., Schneider, C., Muhlestein, B., Peeler, D., Chang, D., Todd, A., Chilakamarri, V., Hanley, P., Gelormini, J., Iacona, M.A., Effron, B., Mazzurco, S., Mazzella, M., Wyman, P., Orchard, R., Battin, D., Rezkalla, S., Bishop, C., Sharp, S., Gredler, F., Knap, P., Fadel, M., Saucedo, J., Keng, A., Imburgia, M., Blank, E., Effat, M., Khoury, S., Mardis, R., Baldari, D., Tafuri, L., Mascolo, R., Taylor, D., Mandviwala, M., Khan, W., Mumford, T., Mayer, N., Mitchell, B., Oliver, T., Lombardi, W., Zimmerman, T., Rohrbeck, S., Cooke, L., Craig, M., Mego, D., Griffin, B., Perez, J., LeClerc, K., Addington, J., Aboufakher, R., Ahmed, A., Westecott, B., Steel, K., Hawkins, K., Shah, A., Ward, U., McGreevy, M., Goldberg, R., Prashad, R., McDonough, C., Silver, K., Josephson, R., Witsaman, S., Labib, S., Woodhead, G., Schrank, J., Bell, K., Chandna, H., Holly, D., Bethea, C., Fife, B., Gruberg, L., Singer, A., Ramgadoo, M., Lalonde, T., Morin, R., French, W., Barillas, O., Gradner, G., Kahn, Z., Gress, J., Rocco, D., Thew, S., Stifter, W., Fisher, M., McNamara, J., Kupfer, J., Agocha, A., Cush, S., Jones, S., Whitaker, T., Stover, T., Kumkumian, G., Kent, K., Greenberg, A., Pandey, P., Pytlewski, G., Matsumura, M., Kai, W., Sameshima, S., Thomas, J., MacNicholas, D., Pillai, K., Jones, D., Navas, J.P., Laskoe, B., Patel, P., Fini, G., Minor, S., Shipwash, T., Cabrera-Santamaria, A., Rivera, E., Mincher, L., Jafar, M., Yen, M., Finkle, C., Rahimtoola, A., Severson, L., Labroo, A., Jinich, D., Tam, K., Vogel, C., Aggarwal, R., Zakhary, B., Curtis, S., Lyster, M., Humphrey, K., Lavine, P., Fujise, K., Birnbaum, Y., Allen, J., Kesselbrenner, M., Michel, K., Staniloae, C., Liu, M., Sonel, A., Macioce-Caffas, A., Amidon, T., Leggett, J., Yedinak, S., Gudmundsson, G., Sabharwal, J., Dagefoerde, N., Wu, W., Meyerrose, G., Roongsritong, C., Jenkins, L., Lieberman, S., Sokol, S., Gutierrez, C., Nelson, C., Barrett, J., Hotchkiss, D., Farley, A., Atassi, K., Christy, L., Baig, M., Di Fazio, J., Meengs, M., Thomas, K., Surmitis, J., DeVault, S., Farhat, N., Hulyalkar, A., Riddell, L., Rivera, W., Sheynberg, B., Kobayashi, J., Katsaropoulos, J., Jan, M., Krucoff, M., Paterno, C., Chandrasekaran, S., Curry, R., Cassavar, D., Wheeler, M., McGarvey, J., Schwarz, L., Miller, E., Andrea, B., Carswell, B.S., Lurie, M., Patti, J., Bowden, W., Vasiliauskas, T., Latham, R., Schwartz, B., Bradford, L., Mattleman, S., Wertheimer, J., Goulden, D., Khan, M., Hawkins, B., Ostfeld, R., Mueller, H., Ash, Y., Wilson, V., Bayer, M., Marshall, J., Dobies, D., Dawson, G., Osman, A., Saba, F., Costello, T., Fuentes, F., Underwood, C., Vijay, N., Washam, M., Dietz, W., Glasgow, B., Mukherjee, S., Hinchion, N., Speirs, S., Thornley, A., Lee, K., Movahed, M., Strootman, D., Chernick, R., Parrott, C., Flock, C., Marques, V., Syzmanski, E., Rama, P., Domingo, D., Wu, L., Bauer, B., Dionisopoulos, P., Aggarwal, A., Holcomb, R., Foster, R., Hancock, T., Hargrove, J., Fletcher, A., Stine, R., Bullivant, M., Adams, K., Lohman, J., Klepper, V., Kabour, A., Neidhardt, J., Phillips, W., Tardiff, S., Aji, J., Corut, S., Foster, G., Firek, C., St Goar, F., Sumner, R., Davis, T., Schneider, R., Schneider, W., Villa, A., Desai, V., Chhabra, A., Banks, K., Herzog, W., Burley, T., Quyyumi, A., Smiley, W., Manocha, P., Fishbein, G., Weller, C., Coffman, A., Kim, C., Kedia, A., Firth, B., Rizvi, M., Dahiya, R., Foster, B., Balcells, E., Metzger, D.C., Lester, J., Bissett, J., Fahdi, I., Sides, E.A., Azrin, M., Martin, C., Quick, A., Conaway, D., Garg, M., Schallert, G., Lancaster, L., Mckissick, S., Atieh, M., Garbarino, J., Eisenberg, D., Uusinarkaus, K., Wirtemburg, P., Ellis, J., Cristaldi, J., Berglund, R., Negus, B., Pappas, J., Rocha, R., Nguyen, T., Stone, J., Janosik, D., Labovitz, A., Elmore, N., Dave, R., Loffredo, K., Gabriel, G., Snyder, C., Ahmed, O., Stone, H., Kelley, M., Diffenback, M., Friedman, B., Zirkle, J., Severa, L., Sample, S., Dignen, K., Raisinghani, A., Ben-Yehuda, O., Ghannadian, B., Moscoso, R., Mankowski, J., Boliek, W., Rukavina, M., Davis, W., Ledbetter, S., Handel, F., Mastouri, R., Mahenthiran, J., Foltz, J., Malhotra, V., Jonas, J., Berk, M., Singh, V., Nelson, M., Elsner, G., Gall, J., Kondo, N., Frank, S., Chandraratna, P., Ranasinghe, S., Ebrahimi, R., Treadwell, M., Walters, B., Hughes, L., Kramer, J., Kumar, K., Mente, T., Lachterman, B., Schifferdecker, B., Munshi, K., Sease, D., Waldo, D., Chandler, G., Manns, D., Nahhas, A., Kamalesh, M., Williams, V., Reich, D., Desalca, M., Sharma, S., Liston, M., Gupta, K., Costa, M., Altschuller, A., Lemmertz, K., Shanes, J., Hansen, C., Therrien, M., Mendelson, R., Ramnarine, R., Myers, G., Donovan, C., Klein, M., Fine, D., Owens, S., Murray, C., Ketroser, R., Heifetz, S., Darnell, Z., Touchon, R., Taghizadeh, B., Bohle, D., Norwood, D., Forrest, T., Jackson, S., Shumate, K., Bayles, A., Masroor, M., North, W.K., Fishberg, R., Merveil-Ceneus, B., Butcher, R., Menapace, F., Kilbride, S., Ramabadran, R.S., Loukinen, K., Khalil, J., Ramabadran, R., Walsh, S., Gill, S., Cyncar, R., McLachlan, J., Surakanti, V., Rusterholtz, L., Shoukfeh, F., Stephenson, L., Tsang, M., Nolan, V., Gilchrist, I., Jefferson, D., Feldman, T., Reyes, L., Santos, R., Little, W., Wesley, D., Gharib, W., Mendell, A., Esham, G., Kakavas, P., Whitcomb, C., Book, K., Bazzi, A., Alvarez, J., Cohen, Y., Ayres, T., Rhule, V., Labib, A., Schuler, P., Zughaib, M., Telck, K., Bikkina, M., Turnbull, K., Sharma, T., Orosz, S., Shah, R., Petrino, M., Hughes, M., Hershey, J., Hudock, D., Hui, P., Von Bakonyi, A., Arnold, A., Kappel, D., Pennock, G., Cloud, B., Tucker, K., Harp, L., Hoover, C., Eisenhauer, M., Roth, J., Young, C., Thai, H., Escalante, A., Bautista, J., Gazmuri, R., Nyland, J., Cubeddu, L., DeFranco, A., Dias, D., Fielding, M., Reeves, R., Hermany, P., Meissner-Dengler, S., Evans, M., Flores, E., Tannenbaum, A., McGarr, K., Moran, J., Stout, E., Allred, S., Henderson, D., Crandall, L., Strote, J., Voyles, W., Robeson, D., Bedoya, R., Omar, B., Pettyjohn, F., Revere, C., Coy, K., Margolis, J., Sotolongo, C., Scheffel, M., Munir, A., Shirwany, A., Douglas, L., Girala, R., Humphreys, R., Agarwal, J., Bankowski, D., Watson, R., Bishop, B., Klementowicz, P., Blais, D., Cohen, B., Lobur, E., Dimenna, J., Dempsey, K., Izzo, M., Bondi, L., Carell, E., Eaton, C., Saltiel, F., Grewal, G., Connolly, T., Little, T., Wiegman, P., Gips, S., Held, J., Paraschos, A., Quesada, R., Goudreau, E., Sears, M., Istfan, P., Holt, S., McClung, J., Nguyen, N., Quintana, O., Gottlieb, D., Knutson, T., Barringhaus, K., Lester, F., Sullivan, P., Rodriguez-Ospina, L., Cannon, Cp, Blazing, Ma, Giugliano, Rp, Mccagg, A, White, Ja, Theroux, P, Darius, H, Lewis, B, Ophuis, To, Jukema, Jw, De Ferrari, Gm, Ruzyllo, W, De Lucca, P, Im, K, Bohula, Ea, Reist, C, Wiviott, Sd, Tershakovec, Am, Musliner, Ta, Braunwald, E, Califf, Rm, for the IMPROVE-IT, Investigator, Cianflone, D, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], College of Information Science and Engineering, Ritsumeikan University, Montreal Heart Institute (MONTREAL HEART INSTITUTE), Laboratoire des Micro-algues toxiques, Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD), Interuniversity Cardiology Institute Netherlands, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Merck Sharp & Dohme Corp., Merck & Co. Inc, DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 06 - Scienze mediche, Cannon, C.P., Blazing, M.A., Giugliano, R.P., Mccagg, A., White, J.A., Lewis, B.S., Jukema, J.W., De Lucca, P., Im, K., Bohula, E.A., Reist, C., Wiviott, S.D., Tershakovec, A.M., Musliner, T.A., Braunwald, E., Califf, R.M., for the IMPROVE-IT Investigators [.., C. Rapezzi, ], Other departments, Cannon, Christopher P, Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Kyungah, Im, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, and Califf, Robert M.
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Male ,Simvastatin ,acute coronary syndrome ,aged ,anticholesteremic agents ,azetidines ,cardiovascular diseases ,cholesterol, ldl ,double-blind method ,drug therapy, combination ,ezetimibe ,female ,humans ,hydroxymethylglutaryl-coa reductase inhibitors ,kaplan-meier estimate ,male ,middle aged ,simvastatin ,triglycerides ,medicine (all ,[SDV]Life Sciences [q-bio] ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Bococizumab ,Triglyceride ,chemistry.chemical_compound ,0302 clinical medicine ,Azetidine ,Cardiovascular Disease ,Anticholesteremic Agent ,Acute Coronary Syndrome ,Aged ,Anticholesteremic Agents ,Azetidines ,Cardiovascular Diseases ,Cholesterol, LDL ,Double-Blind Method ,Drug Therapy, Combination ,Female ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Middle Aged ,Triglycerides ,030212 general & internal medicine ,Medicine (all) ,Research Support, Non-U.S. Gov't ,Hazard ratio ,General Medicine ,Acute Coronary Syndrome, Aged ,Anticholesteremic Agents, Azetidines, Cardiovascular Diseases ,Ezetimibe, Female, Humans ,Male, Middle Aged ,3. Good health ,Multicenter Study ,Editorial ,Cholesterol ,Randomized Controlled Trial ,Combination ,Ezetimibe ,lipids (amino acids, peptides, and proteins) ,Human ,medicine.drug ,medicine.medical_specialty ,Acute Coronary Syndroms ,Urology ,Acute Coronary Syndrome/drug therapy ,Anticholesteremic Agents/adverse effects ,Anticholesteremic Agents/therapeutic use ,Azetidines/adverse effects ,Azetidines/therapeutic use ,Cardiovascular Diseases/epidemiology ,Cardiovascular Diseases/mortality ,Cardiovascular Diseases/prevention & control ,Cholesterol, LDL/blood ,Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ,Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ,Simvastatin/therapeutic use ,Triglycerides/blood ,NO ,LDL ,03 medical and health sciences ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Drug Therapy ,Internal medicine ,Journal Article ,medicine ,Comparative Study ,Alirocumab ,business.industry ,PCSK9 ,ta3121 ,Lomitapide ,DOENÇAS CARDIOVASCULARES ,Endocrinology ,chemistry ,Statin Therapy ,Hydroxymethylglutaryl-CoA Reductase Inhibitor ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known.METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal stroke. The median follow-up was 6 years.RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (PCONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit. (Funded by Merck; IMPROVE-IT ClinicalTrials.gov number, NCT00202878.).
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- 2015
45. EFEITO DO PRÉ-TRATAMENTO ALCALINO DA CASCA DE AVEIA PARA PRODUÇÃO DE ENDO-β-1,4-XILANASE POR Aureobasidium pullulans CCT 1261
- Author
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GAUTÉRIO, G. V., additional, CORRÊA Jr, L. C. S., additional, MACHADO, T. B., additional, MATTOS, M. V. C. V., additional, SANZO, A. V. L., additional, and KALIL, S. J., additional
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- 2018
- Full Text
- View/download PDF
46. Pyrroloquinolone quinone, a chemotactic attractant for Escherichia coli
- Author
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De Jonge, Rob, De Mattos, M. Joost Teixeira, Stock, Jeffrey B., and Neijssel, Oense M.
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Escherichia coli -- Physiological aspects ,Chemotaxis -- Research ,Bacteria -- Motility ,Biological sciences - Abstract
Escherichia coli is unable to synthesize pyrroquinoline quinone (PQQ) but compensates by chemotaxis toward PQQ via the phosphoenolpyruvate-sugar-phosphotransferase system. Utilization of swarm plates and capillary assay revealed that the sensory mechanisms in E. coli show chemotaxis toward a mixture of glucose and PQQ. E. coli strains lacking the methylated chemotaxis receptor protein Tar showed no chemotaxis toward PQQ.
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- 1996
47. Sociodemographic, Anthropometric, and Psychosocial Predictors of Attrition across Behavioral Weight-Loss Trials
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Hu, L., Mattos, M., Sereika, S.M., Chasens, E., Ewing, L.J., Burke, L.E., Goode, R.W., Acharya, S.D., Osier, N., Imes, C.C., Danford, C., Mancino, J., Zheng, Y., and Ye, L.
- Abstract
Preventing attrition is a major concern in behavioral weight loss intervention studies. The purpose of this analysis was to identify baseline and six-month predictors associated with participant attrition across three independent clinical trials of behavioral weight loss interventions (PREFER, SELF, and SMART) that were conducted over 10 years. Baseline measures included body mass index, Barriers to Healthy Eating, Beck Depression Inventory-II (BDI), Hunger Satiety Scale (HSS), Binge Eating Scale (BES), Medical Outcome Study Short Form (MOS SF-36 v2) and Weight Efficacy Lifestyle Questionnaire (WEL). We also examined early weight loss and attendance at group sessions during the first 6 months. Attrition was recorded at the end of the trials. Participants included 504 overweight and obese adults seeking weight loss treatment. The sample was 84.92% female and 73.61% white, with a mean (± SD) age of 47.35 ± 9.75 years. After controlling for the specific trial, for every one unit increase in BMI, the odds of attrition increased by 11%. For every year increase in education, the odds of attrition decreased by 10%. Additional predictors of attrition included previous attempts to lose 50–79 lbs, age, not possessing health insurance, and BES, BDI, and HSS scores. At 6 months, the odds of attrition increased by 10% with reduced group session attendance. There was also an interaction between percent weight change and trial (p < .001). Multivariate analysis of the three trials showed education, age, BMI, and BES scores were independently associated with attrition (ps ≤ .01). These findings may inform the development of more robust strategies for reducing attrition.
- Published
- 2016
- Full Text
- View/download PDF
48. Educação, cidadania e exclusão: o aluno como agente de mudança na avaliação escolar
- Author
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De Mattos, M. L., Grion, Valentina, and Almeida De Castro, P.
- Published
- 2016
49. Effect of commercial dental investments at low temperature on the marginal adaptation of cast cp Ti inlays
- Author
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Rodrigo Galo, Ribeiro, R. F., Da Glória Chiarello Mattos, M., and Pires-De-Souza, F. C. P.
- Subjects
Titanium ,Inlay ,Dentistry ,RK1-715 ,Investment ,Porosity ,Marginal adaptation - Abstract
Aim: The purpose of this study was to evaluate the adaptation of inlay restorations cast in commercially pure titanium (cp Ti) after inclusion of the wax patterns in either a phosphate-bonded investment (Rematitan Plus® ) or a silicon oxide-based investment (Termocast® ). Methods: The wax patterns were prepared over an inlay-type mold. After waxing, 5 measurements of the marginal adaptation were made on the mesial and distal faces. Five wax patterns were included in each type of investment under vacuum. The cast specimens were repositioned in the mold and other 5 measurements of the adaptation were made based on the same initial testing conditions. Data were analyzed statistically by two-way ANOVA and Duncan’s post-hoc (P
- Published
- 2015
50. Activation of the protein kinase C1 pathway upon continuous heat stress in Saccharomyces cerevisiae is triggered by an intracellular increase in osmolarity due to trehalose accumulation
- Author
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Mensonides, Femke I.C., Brul, Stanley, Klis, Frans M., Hellingwerf, Klaas J., and Teixeira de Mattos, M. Joost
- Subjects
Heat exhaustion -- Research ,Protein kinases -- Structure ,Protein kinases -- Research ,Brewer's yeast -- Genetic aspects ,Brewer's yeast -- Physiological aspects ,Biological sciences - Abstract
The accumulation of trehalose and the activation of the protein kinase C1 (PKC1) (cell integrity) pathway in both glucose- and ethanol-grown cells were analyzed upon temperature upshifts within the narrow range of growth temperatures. The results showed that under heat stress conditions the activation of the PKC1 pathway is triggered by an increase in intracellular osmolarity, due to the accumulation of trehalose, rather than by the increase in temperature.
- Published
- 2005
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