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449 results on '"Matsukawa N"'

1. Failure to improve after ovarian resection could be a marker of recurrent ovarian teratoma in anti-NMDAR encephalitis: a case report

Author

Uchida Y, Kato D, Yamashita Y, Ozaki Y, and Matsukawa N

Subjects
N-methyl-D-aspartate receptor, antibody, autoimmune encephalitis, refractory, recurrence, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Yuto Uchida,1 Daisuke Kato,1 Yoriko Yamashita,2 Yasuhiko Ozaki,3 Noriyuki Matsukawa1 1Department of Neurology, 2Department of Experimental Pathology, 3Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Abstract: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a type of autoimmune encephalitis that can be paraneoplastic and usually responds to tumor resection and immunotherapy. More than 75% of patients with anti-NMDAR encephalitis fully recover or have only mild sequelae, whereas the remainder experience severe disability. It remains unknown why certain cases have refractory clinical disease courses. We report a case of anti-NMDAR encephalitis with bilateral ovarian teratomas who was refractory to tumor resection and early initiation of immunotherapy. During intensive care, immunohistochemical analyses of her cerebrospinal fluid showed persistently high reactivity of NMDAR antibody over time. Six months after the operation, pelvic computed tomography detected a recurrent ovarian teratoma. After total enucleation of the bilateral ovaries, with significant pathological findings of bilateral mature cystic teratomas, her clinical condition improved rapidly, paralleled by a decrease in anti-NMDAR reactivity. This case illustrates the need to keep considering why extensive treatment fails to influence the disease when we encounter patients with refractory anti-NMDAR encephalitis. Failure to improve after ovarian resection could be a marker of recurrent ovarian teratoma in anti-NMDAR encephalitis. Keywords: N-methyl-D-aspartate receptor, antibody, autoimmune encephalitis, refractory, recurrence

Published
2018

9. beta 1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain

Author

Fujioka, T, Kaneko, N, Ajioka, I, Nakaguchi, K, Omata, T, Ohba, H, Fassler, R, Garcia-Verdugo, JM, Sekiguchi, K, Matsukawa, N, and Sawamoto, K

Subjects
Vasculature-guided migration, Stroke, nervous system, Chain migration, beta 1 integrin, Blood vessel, Laminin
Abstract

Cerebral ischemic stroke is a main cause of chronic disability. However, there is currently no effective treatment to promote recovery from stroke-induced neurological symptoms. Recent studies suggest that after stroke, immature neurons, referred to as neuroblasts, generated in a neurogenic niche, the ventricular-subventricular zone, migrate toward the injured area, where they differentiate into mature neurons. Interventions that increase the number of neuroblasts distributed at and around the lesion facilitate neuronal repair in rodent models for ischemic stroke, suggesting that promoting neuroblast migration in the post-stroke brain could improve efficient neuronal regeneration. To move toward the lesion, neuroblasts form chain-like aggregates and migrate along blood vessels, which are thought to increase their migration efficiency. However, the molecular mechanisms regulating these migration processes are largely unknown. Here we studied the role of beta 1-class integrins, transmembrane receptors for extracellular matrix proteins, in these migrating neuroblasts. We found that the neuroblast chain formation and blood vessel-guided migration critically depend on beta 1 integrin signaling. beta 1 integrin facilitated the adhesion of neuroblasts to laminin and the efficient translocation of their soma duringmigration. Moreover, artificial laminin-containing scaffolds promoted neuroblast chain formation and migration toward the injured area. These data suggest that laminin signaling via beta 1 integrin supports vasculature-guided neuronal migration to efficiently supply neuroblasts to injured areas. This study also highlights the importance of vascular scaffolds for cell migration in development and regeneration. (C) 2017 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Published
2017

10. Microstructure and soft magnetic properties of FeSiAI(Ti/Ta)(O)N

Author

Hiramoto, M., Matsukawa, N., Sakakima, H., Ichikawa, Y., and Lijima, K.

Subjects
Thin films -- Magnetic properties, Microstructure -- Observations, Physics
Abstract

The magnetic, structural and corrosive properties of sputtered FeSiA1(Ti/Ta)(O)N films were investigated. The films are believed to be sensitive on the grain structure due to the small magnetocrystalline anisotropy (K(sub1)) of the FeSiA1 system. Soft magnetic properties were observed following thermal treatment, and the composition of the granular grains and needle shaped grains were mostly Fe and FeSi.

Published
1998

11. Cover Image

Author

Uchida, Y., primary, Terada, K., additional, Madokoro, Y., additional, Fujioka, T., additional, Mizuno, M., additional, Toyoda, T., additional, Kato, D., additional, and Matsukawa, N., additional

Published
2018
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14. Paranodal axo-glial detachment in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 antibodies

Author

Koike, H., primary, Kadoya, M., additional, Kaida, K.I., additional, Nishi, R., additional, Ikeda, S., additional, Kawagashira, Y., additional, Iijima, M., additional, Kato, D., additional, Ogata, H., additional, Yamasaki, R., additional, Matsukawa, N., additional, Kira, J.I., additional, Katsuno, M., additional, and Sobue, G., additional

Published
2017
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17. Stiripentol for the treatment of super-refractory status epilepticus with cross-sensitivity

Author

Uchida, Y., primary, Terada, K., additional, Adachi, K., additional, Madokoro, Y., additional, Yamada, G., additional, Kondo, Y., additional, Fujioka, T., additional, Mizuno, M., additional, Kawashima, S., additional, Toyoda, T., additional, Oomura, M., additional, Ueki, Y., additional, Okita, K., additional, Kato, D., additional, and Matsukawa, N., additional

Published
2017
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18. Dopaminergic performances in patients with parkinsonism — A combination study of dopamine transporter SPECT, dopamine synthesis and receptor pet

Author

Horimoto, Y., primary, Hayashi, E., additional, Ito, Y., additional, Iida, A., additional, Hibino, H., additional, Inagaki, A., additional, Tajima, T., additional, Fukagawa, K., additional, Okita, K., additional, Yasui, K., additional, Nanbu, I., additional, Anan, C., additional, Uematsu, N., additional, Katada, E., additional, Matsukawa, N., additional, and Kabasawa, H., additional

Published
2017
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21. Follow-up of child growth regarding new technologies: testicular sperm extraction (TESE), in vitro maturation (IVM), and assisted oocyte activation (AOA)

Author

Matsukawa, N., primary, Shibasaki, S., additional, Takahashi, M., additional, Sasaki, C., additional, Nakamura, Y., additional, Sato, Y., additional, Hattori, H., additional, Nakajo, Y., additional, Aono, N., additional, Okuyama, N., additional, Takeuchi, T., additional, and Kyono, K., additional

Published
2015
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30. Microvascular Architecture of the Filiform Papillae in Primates and Insectivores

Author

Okada, S., Ohta, Y., Matsukawa, N., and Sugioka, S.

Subjects
integumentary system, stomatognathic system, Microvasculature, vascular corrosion casting, urogenital system, primates, insectivores, filiform papilla, scanning electron microscope, Biology
Abstract

The microvascular architecture of filiform papillae was investigated under a scanning electron microscope in man, Japanese monkeys, common squirrel monkeys, common marmosets, common tree shrews, large Japanese moles and dwarf shrews utilizing microvascular corrosion casts. Filiform papillae were circularly arranged in primates, and each of them was supplied by a hairpin capillary loop. These papillae sometimes were aggregated. The filiform papillae of Japanese monkeys exhibited markedly locational differences on the lingual dorsum and were supplied by circularly arranged capillary loops or by an intrapapillary capillary network. Small filiform papillae were located on an epithelial eminence in the lingual radix, each of them supplied by a low and simple hairpin capillary loop. The aggregated filiform papillae of common squirrel monkeys were less frequent without any locational differences. Low filiform papillae of common marmosets and tree shrews were simpler in form, being arranged in a circle and supplied by a simple hairpin capillary loop. The filiform papillae of insectivores were not arranged in a circle. The filiform papillae of dwarf shrews were supplied by an incomplete capillary ring without a loop. With respect to species differences, the circularly arranged capillary loops in man were most complicated and highly developed. Microvascular architecture of the filiform papillae of insectivores was much simpler, different from those observed in primates.

Published
1992

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