1. Induction of a Four‐Way Junction Structure in the DNA Palindromic Hexanucleotide 5′‐d(CGTACG)‐3′ by a Mononuclear Platinum Complex
- Author
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Bianka Siewert, Samantha L. Hopkins, Maxime A. Siegler, Marta Ferraroni, Luigi Messori, Paola Gratteri, Anja Busemann, Francesco Papi, Corjan van de Griend, Mathijs F. Wissingh, Sylvestre Bonnet, Carla Bazzicalupi, Vincent H. S. van Rixel, and Tiziano Marzo
- Subjects
Models, Molecular ,Stereochemistry ,Stacking ,Supramolecular chemistry ,chemistry.chemical_element ,Crystal structure ,010402 general chemistry ,01 natural sciences ,Oligomer ,Catalysis ,supramolecular chemistry ,Adduct ,chemistry.chemical_compound ,DNA Superstructures ,Humans ,platinum ,010405 organic chemistry ,Hydrogen bond ,Communication ,General Medicine ,General Chemistry ,DNA ,hydrogen bonding ,Communications ,hydrogen bonding · metallodrugs · nucleic acids ·platinum · supramolecular chemistry ,0104 chemical sciences ,nucleic acids ,chemistry ,metallodrugs ,Nucleic Acid Conformation ,Platinum - Abstract
Four‐way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA‐damage repair. In this study, a new mononuclear platinum(II) complex 1 was prepared that is capable of driving the crystallization of the DNA oligomer 5′‐d(CGTACG)‐3′ specifically into a 4WJ‐like motif. In the crystal structure of the 1–CGTACG adduct, the distorted‐square‐planar platinum complex binds to the core of the 4WJ‐like motif through π–π stacking and hydrogen bonding, without forming any platinum–nitrogen coordination bonds. Our observations suggest that the specific molecular properties of the metal complex are crucially responsible for triggering the selective assembly of this peculiar DNA superstructure.
- Published
- 2019