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Induction of a Four‐Way Junction Structure in the DNA Palindromic Hexanucleotide 5′‐d(CGTACG)‐3′ by a Mononuclear Platinum Complex
- Source :
- Angewandte Chemie (International Ed. in English), Angewandte Chemie International Edition, 'Angewandte Chemie International Edition ', vol: 58, pages: 9378-9382 (2019), Angewandte Chemie, 131(28), 9478-9482, Angewandte Chemie International Edition, 58(28), 9378-9382. WILEY-V C H VERLAG GMBH
- Publication Year :
- 2019
- Publisher :
- John Wiley and Sons Inc., 2019.
-
Abstract
- Four‐way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA‐damage repair. In this study, a new mononuclear platinum(II) complex 1 was prepared that is capable of driving the crystallization of the DNA oligomer 5′‐d(CGTACG)‐3′ specifically into a 4WJ‐like motif. In the crystal structure of the 1–CGTACG adduct, the distorted‐square‐planar platinum complex binds to the core of the 4WJ‐like motif through π–π stacking and hydrogen bonding, without forming any platinum–nitrogen coordination bonds. Our observations suggest that the specific molecular properties of the metal complex are crucially responsible for triggering the selective assembly of this peculiar DNA superstructure.
- Subjects :
- Models, Molecular
Stereochemistry
Stacking
Supramolecular chemistry
chemistry.chemical_element
Crystal structure
010402 general chemistry
01 natural sciences
Oligomer
Catalysis
supramolecular chemistry
Adduct
chemistry.chemical_compound
DNA Superstructures
Humans
platinum
010405 organic chemistry
Hydrogen bond
Communication
General Medicine
General Chemistry
DNA
hydrogen bonding
Communications
hydrogen bonding · metallodrugs · nucleic acids ·platinum · supramolecular chemistry
0104 chemical sciences
nucleic acids
chemistry
metallodrugs
Nucleic Acid Conformation
Platinum
Subjects
Details
- Language :
- English
- ISSN :
- 15213773 and 14337851
- Volume :
- 58
- Issue :
- 28
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie (International Ed. in English)
- Accession number :
- edsair.doi.dedup.....f28aade4f19929bec04d3d3cd01af7fc