1. In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic
- Author
-
Eiko Inoue, Masashi Minamimura, Susumu Mitsuhashi, and Yumi Taniyama
- Subjects
Lactams ,Gram-positive bacteria ,medicine.medical_treatment ,Microbial Sensitivity Tests ,Gram-Positive Bacteria ,beta-Lactams ,medicine.disease_cause ,beta-Lactamases ,Microbiology ,Minimum inhibitory concentration ,Drug Stability ,Enterobacteriaceae ,Gram-Negative Bacteria ,medicine ,Pharmacology (medical) ,Antibacterial agent ,Pharmacology ,biology ,Pseudomonas aeruginosa ,biology.organism_classification ,Anti-Bacterial Agents ,Citrobacter freundii ,Infectious Diseases ,Beta-lactamase ,bacteria ,Antibacterial activity ,Enterobacter cloacae ,Research Article - Abstract
In in vitro susceptibility tests, the new penem CP-70,429 showed potent antibacterial activity against gram-positive and gram-negative bacteria except Pseudomonas aeruginosa and Xanthomonas maltophilia. CP-70,429 was stable to various types of beta-lactamases except for the enzyme from X. maltophilia and was 16- to 128-fold more active than the other compounds against beta-lactamase-producing strains of Enterobacter cloacae and Citrobacter freundii.
- Published
- 1993