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In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic
- Source :
- Antimicrobial Agents and Chemotherapy. 37:1547-1551
- Publication Year :
- 1993
- Publisher :
- American Society for Microbiology, 1993.
-
Abstract
- In in vitro susceptibility tests, the new penem CP-70,429 showed potent antibacterial activity against gram-positive and gram-negative bacteria except Pseudomonas aeruginosa and Xanthomonas maltophilia. CP-70,429 was stable to various types of beta-lactamases except for the enzyme from X. maltophilia and was 16- to 128-fold more active than the other compounds against beta-lactamase-producing strains of Enterobacter cloacae and Citrobacter freundii.
- Subjects :
- Lactams
Gram-positive bacteria
medicine.medical_treatment
Microbial Sensitivity Tests
Gram-Positive Bacteria
beta-Lactams
medicine.disease_cause
beta-Lactamases
Microbiology
Minimum inhibitory concentration
Drug Stability
Enterobacteriaceae
Gram-Negative Bacteria
medicine
Pharmacology (medical)
Antibacterial agent
Pharmacology
biology
Pseudomonas aeruginosa
biology.organism_classification
Anti-Bacterial Agents
Citrobacter freundii
Infectious Diseases
Beta-lactamase
bacteria
Antibacterial activity
Enterobacter cloacae
Research Article
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....48fd220210dc826c71ff3cb6a864c31f