40 results on '"Masamura K"'
Search Results
2. ENVIRONMENTAL EFFECTS ON CORROSION BEHAVIOR OF STAINLESS STEEL IN A SIMULATED REFUSE INCINERATOR CONDITION
- Author
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Masamura, K., primary, Takemura, Masahiro, additional, Shimada, Toru, additional, and Sakai, Jun-ichi, additional
- Published
- 1994
- Full Text
- View/download PDF
Catalog
3. Mechanical properties of 8Cr–2WVTa steel aged for 30 000 h
- Author
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Tamura, M, Shinozuka, K, Esaka, H, Sugimoto, S, Ishizawa, K, and Masamura, K
- Published
- 2000
- Full Text
- View/download PDF
4. General lectures (II)
- Author
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Segawa, K., Nakazawa, S., Koide, N., Imai, K., Matsuo, N., Yamamoto, Y., Shiobara, M., Shimada, H., Kawai, K., Machida, K., Okabe, N., Hoshi, Y., Koizumi, Y., Watanuki, T., Hiroshima, Y., Matsusaka, Y., Katase, K., Sakuma, Y., Matoba, N., Murata, N., Toyama, Y., Murai, S., Nukaga, A., Ishimatsu, N., Watanabe, Y., Abe, M., Ono, Y., Hirai, K., Iwabuchi, S., Suzuki, K., Aoki, T., Masamura, K., Yoshida, K., Ikeuchi, J., Nagao, F., Kobayashi, A., Toriie, S., Nakajima, M., Kohli, M., Ida, K., Kawai, K., Masuda, M., Hattori, T., Fujita, S., Tamada, T., Inoue, K., Usui, T., Yamaya, S., Ohtsuka, K., Shiraki, Y., Fujishima, S., Tochikubo, O., Miyamoto, S., Ueda, A., Asano, K., Kunisada, M., Miyake, H., Fujii, Y., Yoshimoto, S., Hiramatsu, K., Nakano, S., Takeda, T., Kitamura, K., Horiguchi, Y., Okada, K., Okada, M., Kuwabara, T., Tanaka, M., Konno, K., Hattori, T., Isobe, K., Iwasaki, A., Unoura, T., Matsumoto, M., Yoshida, T., Takahashi, I., Abe, M., Maeda, H., Hayashi, T., Koizumi, H., Iwasaki, M., Takahashi, K., Honda, T., Ariga, K., Mohri, S., Suga, Y., Ono, T., Kobayashi, K., Mizuno, T., Sameshima, Y., Shiozaki, Y., Sasakawa, M., Hiramatsu, A., Ikehara, K., Nagata, T., Tatsumi, K., Abe, M., Aoki, M., Iwasaki, S., Aizawa, T., Kajiwara, K., Sata, K., Omata, S., Imamura, K., Kondo, K., Sajima, H., Sato, Y., Kiryu, H., Mimoto, S., Masuoka, T., Kira, K., Mizumoto, R., Kuratsuka, H., Honjo, I., Hojo, Y., Nakajima, H., Tosaka, T., Arai, O., Kobayashi, N., Obata, N., Ito, S., Takaoka, T., Uragami, Y., Kitamura, Y., Kishi, S., Fujii, S., Okuda, H., Hirano, K., Kano, H., Ogino, M., Ueda, Y., Nishiwaki, K., Iwamura, N., Aoki, T., Hiramatsu, K., Kamada, T., Suematsu, T., Fusamoto, H., Okuda, H., Abe, H., Katayama, S., Yamaguchi, K., Fukuda, M., Ishii, T., Kaito, I., Sato, S., Sasaki, H., Onodera, H., Yamanaka, M., Akagi, K., Miyazaki, S., Okumura, M., Omae, T., Nakamura, Y., Wada, M., Nakai, Y., Inoue, S., Arima, T., Yamasaki, S., Takano, T., Katsuta, Y., Yano, T., Isoda, K., Aramaki, T., Fukuda, N., Ichikawa, T., Okumura, H., Adachi, Y., Inoue, R., Iwasaki, Y., Tanaka, S., Yamamoto, T., Wakisaka, G., Nakaya, H., Takase, S., Ikegami, F., Takada, A., Kobayashi, K., Takeuchi, J., Kato, Y., Funayama, A., Kakumu, S., Ito, S., Okuyama, S., Taoka, Y., Endo, T., Chizuka, R., Yanagida, T., Chizuka, S., Usui, H., Ando, T., Takai, T., Wakahara, T., Kojima, M., Fukazawa, T., Takahashi, Y., Miyamura, S., Urakawa, T., Shima, T., Miyaji, K., Okazaki, T., Kashimura, S., Koyama, K., Yamauchi, H., Matsuo, Y., Takagi, Y., Muto, I., Owada, Y., Otowa, T., Sato, T., Naito, C., Okada, K., Sugawara, K., Nokiba, T., Fujii, Y., Kido, H., Sasaki, M., Sugai, Y., Nishimura, G., Nanbu, H., Kamiyama, Y., Yamada, T., Yamaoka, Y., Takeda, H., Ohsawa, T., Kamano, T., Mizukami, T., Kitamura, O., Ozawa, K., Takasan, H., Honjo, I., Miyasaki, R., Katayama, T., Amakawa, T., Hirose, K., Furukawa, Y., Noguchi, M., Okamoto, M., Maezawa, H., Tanaka, N., Yamada, S., Hisata, T., Hata, C., Sawa, J., Kato, Y., Mituda, Y., Oohira, S., Hayasaka, A., Okuyama, T., Fukui, S., Takeda, T., Furuichi, T., Yamamitsu, S., Yamauchi, K., Konishi, Y., Maeda, S., Setoyama, S., Otsuji, S., Ibata, T., Niu, H., Ogawa, A., Tujioka, E., Maeda, T., Takewa, M., Matumoto, T., Tamada, K., Maeda, A., Sumita, H., Iseki, Y., Yukawa, S., Nitta, Y., Isida, K., Nomoto, H., Setoyama, S., Maeda, S., Otsuji, S., Sato, R., Sato, G., Toyokawa, S., Yamamoto, G., Ohtomi, S., Haga, M., Ueno, Y., Fukuda, M., Endo, R., Yokota, T., Ohsawa, J., Kohno, A., Ohtoshi, E., Yasugi, H., Ichikawa, H., Mizumoto, R., Honjo, I., Ando, K., Suzuki, H., Nishiwaki, T., Kishimoto, T., Miki, T., Takeshige, K., Sawada, M., Hidemura, R., Yamamoto, S., Itoh, S., Kashiwagi, T., Kishida, M., Imamura, O., Suematus, T., Kamada, T., Sakoda, K., Kawada, T., Arima, Y., Kamimura, T., Takesue, M., Katsuki, T., Akita, H., Yakeishi, Y., Takehisa, I., Miyasato, K., Yoshida, H., Hidemura, R., Kubota, K., Aoki, S., Suzuki, S., Kishimoto, T., Miyahara, T., Ando, K., Nishiwaki, T., Miki, T., Takeshige, K., Sawada, M., Itoh, S., Yamamoto, S., Fujiwara, K., Sakai, T., Oda, T., Igarashi, S., Fukuhara, M., Tsujii, T., Tamura, T., Matsuoka, Y., Takahashi, H., Sakamoto, T., Fukuda, S., Oku, M., Matsui, T., Morita, T., Oyazato, Y., Kimura, K., Moriya, W., Fukui, S., Suzuki, K., Morimoto, S., Tsuiki, S., Shoji, K., Nakai, Y., Hata, M., Kubo, J., Yoshizawa, K., Nagayama, K., Ozawa, Y., Yoshida, M., Horiguchi, M., Machii, A., Nitta, Y., Aiso, Y., Kitahara, N., Kitazawa, E., Fukuda, K., Saiti, N., Murakami, Y., Nao, Y., Okazaki, I., Funatsu, K., Maruyama, K., Takagi, B., Yasuraoka, S., Ishii, K., Matsuzaki, S., Takahashi, H., Ishii, H., Kamegaya, K., Sambe, K., Ishikawa, H., Tajima, Y., Kuroda, A., Ishihara, Y., Sato, N., Ishikawa, I., Noro, T., Kakumoto, Y., Mekjian, H. S., Thomford, N. R., Yokomura, T., Adachi, S., Yamamoto, A., Saito, I., Kawamura, A., Miyata, M., Kasai, S., Kawanishi, N., Tamaki, A., Mito, M., Kasai, Y., Hasumi, A., Uchiyama, T., Tachikawa, Y., Takanashi, T., Kanke, T., Matsuda, K., Takanashi, T., Kanke, T., Matsuda, K., Hamana, G., Sakuma, M., Sugita, T., Tomita, K., Yamasaki, S., Tsuzuki, T., Uekusa, M., Matsuzaki, M., Takagi, B., Tsuchiya, M., Uchimura, M., Murohisa, T., Muto, Y., Ishigaki, J., Waki, S., Tsuchiya, R., Sho, M., Furukawa, M., Suzuki, N., Nagashima, H., Matsushiro, T., Saitoh, T., Nakamura, N., Hatanaka, T., Kobayashi, N., Nakamura, Y., Sato, T., Tooi, K., Tanaka, Y., Kadokura, N., Okada, Y., Yanakgi, I., Tanaka, N., Sekiya, V. M., Adachi, K., Miyashita, M., Moriyama, Y., Onda, M., Yoshioka, M., Teraoka, T., Shimizu, Y., Fujishima, G., Ookawa, K., Miki, M., Shirota, A., Aihara, K., Shiga, T., Sano, H., Hayashi, S., Hori, M., Sato, H., Chuman, Y., Tsukase, S., Nakahara, N., Ehira, S., Setoyama, S., Nishimata, H., Irisa, T., Tokutome, K., Nakashima, Y., Koga, H., Yokoyama, H., Otsuji, T., Chujo, Y., Yamamoto, T., Gotoda, S., Uchiyama, S., Kosaki, G., Ohkura, H., Mukojima, T., Hattori, N., Sasaki, O., Soejima, K., Inokuchi, K., Utsunomiya, J., Maki, T., Iwama, T., Matsunaga, Y., Shimomura, T., Nakajima, T., Ichikawa, S., Miyanaga, T., Sengoku, K., Hamaguchi, E., Aoki, N., Nomura, T., Matsuoka, A., Suzuki, N., Nagahama, A., Kazumi, T., Miyawaki, H., Sakamoto, T., Miyasaki, K., Kato, K., Miyazaki, Y., Harada, N., Yamada, K., Tashiro, S., Sakai, K., Ho, N., Murayama, H., Yada, M., Sakabe, T., Shimizu, H., Kuroki, M., Nishida, S., Kato, K., Ishiyama, S., Yukawa, K., Hayashi, M., Soh, K., Doi, K., Fukuda, M., Nakagawa, A., Yukawa, E., Uematsu, Y., Nara, K., Hattori, H., Watanabe, M., Yoshida, H., Sato, K., Okuse, S., Sato, K., Murotani, T., Takasu, S., Konta, M., Uchiya, T., Fujimaki, N., Yoshida, K., Yoshikawa, K., Uchida, M., Nakamura, N., Nagao, F., Kawana, S., Tamura, K., Hashimoto, T., Kobayashi, K., Hara, T., Nosaka, J., Fukui, O., Inaba, E., Otsukasa, S., Sanada, K., Hiraide, H., Senyo, G., Ootani, A., Nakayama, T., Takei, S., Miki, H., Tanaka, M., Minota, S., Nakayama, K., Nakagawa, K., Shiraishi, T., Kawauchi, H., Nagaya, H., Mizushima, K., Tachimi, Y., Namiki, M., Masuda, K., Mitsutani, N., Mukuta, T., Koizumi, T., Takeuchi, T., Nemoto, T., Takabayashi, H., Takagi, M., Hongo, Y., Kojima, H., Nishimura, M., Hino, S., Hirayama, J., Nakamura, M., Irisa, T., Koga, S., Hirayama, C., Kikuch, S., Ito, M., Hidano, S., Ooya, T., Banno, H., Tomura, A., Kato, K., Koyama, T., Takei, T., Tomimura, T., Yamauchi, M., Kobayashi, K., Nakaya, Y., Takase, S., Kato, Y., Takeuchi, J., Ikegami, F., Matsuda, Y., Takada, A., Udo, K., Kojima, M., Hukuda, N., Kametani, M., Miyagawa, T., Wakahara, T., Takahashi, Y., Imaeda, T., Senda, K., Fujita, S., Okubo, H., Kanoda, K., Miyashita, B., Ishizuka, H., Goto, T., Oto, K., Kaneda, H., Hase, M., Matsuda, J., Kawai, T., Ikehara, H., Baba, S., Ishii, M., Tozawa, T., Inoue, E., Mizuno, N., Saeki, S., Nakaji, T., Narabayashi, T., Okuno, T., Yamada, H., Tanno, M., Chiba, K., Iio, M., Shibata, K., Furuhashi, F., Mizuochi, K., Ohashi, S., Kato, K., Nakano, M., Otsuka, S., Irie, M., Akima, M., Maruyama, Y., Oyamada, F., Nagata, E., Kubo, Y., Arishima, T., Otsuyama, Y., Kaneto, A., Shimogawa, Y., Tanigawa, K., Okabe, N., Nakajima, K., Onishi, S., Kasahara, A., Shimizu, T., Ikehara, Y., Tajima, H., Okamoto, A., Komibuchi, T., Negoro, T., Nihonsugi, A., Ishii, M., Tozawa, T., Ogawa, Y., Otani, H., Ishida, M., Yashima, H., Shoji, K., Tsuiki, S., Morimoto, S., Nakai, Y., Ryo, M., Ozawa, Y., Tanaka, T., Horiguchi, M., Taketa, K., Watanabe, A., Yumoto, Y., Tanaka, A., Takesue, A., Aoe, H., Ueda, M., Shimamura, J., Kosaka, K., Kashiwara, E., Orita, K., Konaga, E., Suzuki, K., Tanaka, S., Kaneda, S., Ogawa, K., Tamura, H., Okanishi, S., Ueda, T., Horie, H., Kamachi, M., Asihara, T., Daido, R., Izumi, T., Kurihara, M., Sumida, M., Haraikawa, M., Hayakawa, H., Shirakabe, H., Yasui, A., Noguchi, M., Okamoto, M., Furukawa, Y., Miyasaki, R., Hirose, K., Katayama, T., and Maezawa, H. more...
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- 1974
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5. Quantitative analysis of Cr-depleted zone morphology in low carbon martensitic stainless steel using FE-(S)TEM
- Author
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Nakamichi, H., Sato, K., Miyata, Y., Kimura, M., and Masamura, K.
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- 2008
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6. THE EFFECT LDL APHERESIS ON PERIPHERAL CIRCULATION
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Kutsumi, Y., primary, Masamura, K., additional, Katoh, M., additional, and Kabuto, H., additional
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- 2001
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7. Mechanical properties of 8Cr–2WVTa steel aged for 30000 h
- Author
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Tamura, M, primary, Shinozuka, K, additional, Esaka, H, additional, Sugimoto, S, additional, Ishizawa, K, additional, and Masamura, K, additional
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- 2000
- Full Text
- View/download PDF
8. Solubility product and precipitation of TaC in Fe–8Cr–2W steel
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Tamura, M, primary, Shinozuka, K, additional, Masamura, K, additional, Ishizawa, K, additional, and Sugimoto, S, additional
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- 1998
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9. Evidence of macrophage foam cell formation by very low-density lipoprotein receptor: interferon-gamma inhibition of very low-density lipoprotein receptor expression and foam cell formation in macrophages.
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Kosaka, S, Takahashi, S, Masamura, K, Kanehara, H, Sakai, J, Tohda, G, Okada, E, Oida, K, Iwasaki, T, Hattori, H, Kodama, T, Yamamoto, T, and Miyamori, I
- Published
- 2001
10. Fundamental consideration of piezoelectric ceramic multi-morph actuators.
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Tomikawa, Y., Masamura, K., Sugawara, S., and Konno, M.
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- 1986
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11. Diagnostic use of serum deoxyribonuclease I activity as a novel early-phase marker in acute myocardial infarction.
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Kawai Y, Yoshida M, Arakawa K, Kumamoto T, Morikawa N, Masamura K, Tada H, Ito S, Hoshizaki H, Oshima S, Taniguchi K, Terasawa H, Miyamori I, Kishi K, and Yasuda T
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- 2004
12. Oxidation-reduction equilibrium of Cu2+/Cu+in binary alkaline sulfate melts
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Yamamoto, T., Yamano-uchi, N., Masamura, K., Tamura, M., and Iwase, M.
- Abstract
Oxidation-reduction equilibria for a Cu2+/Cu+couple in binary alkaline sulfate melts, Li2SO4+ R2SO4(R = Na, K, Rb, Cs), were determined at temperatures of 973, 1023, and 1073 K by equilibrating these melts with gas mixtures of Ar + O2+ SO2. RedOx equilibria are well interpreted by the average ionic radii of alkaline metals: r(average) = X(Li2SO4) r(Li) + X(R2SO4) r(R), whererandXdenote, respectively, mole fraction and the ionic radii of alkaline metal. The oxygen anion activities would increase with an increase in R2SO4mole fractions of binary sulfates Li2SO4+ R2SO4. more...
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- 1996
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13. Polarization Behavior of High-Alloy OCTG in CO2Environment as Affected by Chlorides and Sulfides
- Author
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Masamura, K., primary, Hashizume, S., additional, Sakai, J., additional, and Matsushima, I., additional
- Published
- 1987
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14. ChemInform Abstract: THE DISSOLUTION OF MAGNETITE IN ACIDIC PERCHLORATE SOLUTIONS
- Author
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HARUYAMA, S., primary and MASAMURA, K., additional
- Published
- 1978
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15. ENVIRONMENTAL EFFECTS ON CORROSION BEHAVIOR OF STAINLESS STEEL IN A SIMULATED REFUSE INCINERATOR CONDITION
- Author
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Masamura, K., Takemura, Masahiro, Shimada, Toru, and Sakai, Jun-ichi
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- 1994
- Full Text
- View/download PDF
16. Assessment of hand-arm vibration exposure among traffic police motorcyclists
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Mirbod, S.M, Yoshida, H, Jamali, M, Masamura, K, Inaba, R, and Iwata, H
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- 1998
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17. Effects of crevice on SCC behavior of CRA; s in sour environment
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Masamura, K [Jun-ichi Sakai (JP)]
- Published
- 1989
18. Impact of Antiplatelet Therapy on 5-Year Outcomes After Fractional Flow Reserve-Guided Deferral of Revascularization in Nonsignificant Obstructive Coronary Artery Disease.
- Author
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Kurita T, Kuramitsu S, Ishii M, Takasaki A, Domei T, Matsuo H, Horie K, Ando H, Terai H, Kikuta Y, Ishihara T, Saigusa T, Sakamoto T, Suematsu N, Shiono Y, Asano T, Tsujita K, Masamura K, Doijiri T, Toyota F, Ogita M, Shiraishi J, Harada K, Isogai H, Anai R, Sonoda S, Yokoi H, Tanaka N, and Dohi K more...
- Abstract
Background: Because the clinical benefit of antiplatelet therapy (APT) for patients with nonsignificant coronary artery disease (CAD) remains poorly understood, we evaluated it in patients after fractional flow reserve (FFR)-guided deferral of revascularization., Methods and Results: From the J-CONFIRM (Long-Term Outcomes of Japanese Patients with Deferral of Coronary Intervention Based on Fractional Flow Reserve in Multicenter Registry), we investigated 265 patients with deferred lesions who did not require APT for secondary prevention of cardiovascular disease. A 2-year landmark analysis assessed the relationship between APT at 2 years and 5-year major cardiac adverse events (MACE: composite of all-cause death, target vessel-related myocardial infarction, clinically driven target vessel revascularization). Of the 265 patients, 163 (61.5%) received APT. The 5-year MACE did not significantly differ between the APT and non-APT groups after adjustment for baseline clinical characteristics (9.2% vs. 6.9%, inverse probability weighted hazard ratio, 1.40 [95% confidence interval, 0.53-3.69]; P=0.49). There was a marginal interaction between the effect of APT on MACE and FFR values (< or ≥0.84) (P for interaction=0.066)., Conclusions: The 5-year outcomes after FFR-guided deferral of revascularization did not significantly differ between the APT and non-APT groups, suggesting that APT might not be a critical requirement for nonsignificant obstructive CAD patients not requiring APT for secondary prevention of cardiovascular disease., Competing Interests: S.K. receives lecture fees from Abbott Vascular Japan and Boston Scientific Japan; H.M. receives lecture fees from Abbott Vascular Japan, Boston Scientific Japan, and Phillips Japan; Y.K. receives lecture fees from Abbott Vascular Japan and Phillips Japan; Y.S. receives lecture fees from Abbott Vascular Japan and Phillips Japan; T.A. receives lecture fees from Abbott Vascular Japan and Phillips Japan; K.T. is a member of Circulation Journal’s and Circulation Reports’ Editorial Team; N.T. receives lecture fees from Abbott Vascular Japan and Boston Scientific Japan; H.Y. receives lecture fees from Boston Scientific Japan. The other authors report no conflicts., (Copyright © 2024, THE JAPANESE CIRCULATION SOCIETY.) more...
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- 2024
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19. Sex Differences in 5-Year Outcomes After Deferral of Revascularization Following Physiological Coronary Assessment.
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Ishihara T, Kuramitsu S, Matsuo H, Horie K, Takashima H, Terai H, Kikuta Y, Saigusa T, Sakamoto T, Suematsu N, Shiono Y, Asano T, Tsujita K, Masamura K, Doijiri T, Toyota F, Ogita M, Kurita T, Matsuo A, Harada K, Yaginuma K, Sonoda S, Yokoi H, Tanaka N, and Mano T more...
- Abstract
Background: The relationship between sex differences and long-term outcomes after fractional flow reserve (FFR)- and instantaneous wave-free ratio (iFR)-guided deferral of revascularization has yet to be elucidated. Methods and Results: From the J-CONFIRM registry (long-term outcomes of Japanese patients with deferral of coronary intervention based on FFR in a multicenter registry), this study included 432 lesions from 385 patients (men, 323 lesions in 286 patients; women, 109 lesions in 99 patients) with paired data of FFR and iFR. The primary endpoint was the cumulative 5-year incidence of target vessel failure (TVF), including cardiac death, target vessel-related myocardial infarction, and clinically driven target vessel revascularization. The median FFR value was lower in men than in women (0.85 [0.81, 0.88] vs. 0.87 [0.83, 0.91], P=0.002), but the iFR value was comparable between men and women (0.94 [0.90, 0.98] vs. 0.93 [0.89, 0.98], P=0.26). The frequency of discordance between FFR and iFR was comparable between men and women (19.5% vs. 23.9%, P=0.34), although with different discordance patterns (P=0.036). The cumulative incidence of 5-year TVF did not differ between men and women after adjustment for baseline characteristics (13.9% vs. 6.9%, adjusted hazard ratio 1.82 [95% confidence interval: 0.44-7.56]; P=0.41). Conclusions: Despite sex differences in the results for physiological indexes, the 5-year TVF in deferred lesions did not differ between men and women after adjustment for baseline characteristics., Competing Interests: S.K. receives lecture fees from Abbott Vascular Japan, Boston Scientific Japan, and Phillips Japan; H.M. serves as advisory board member for Zeon Medical and receives lecture fees from Abbott Vascular Japan, Boston Scientific Japan, and Phillips Japan; Y.K. receives lecture fees from Abbott Vascular Japan and Phillips Japan; Y.S. receives lecture fees from Abbott Vascular Japan and Phillips Japan; T.A. receives lecture fees from Abbott Vascular Japan and Phillips Japan; N.T. serves as advisory board member for Abbott Vascular Japan and Boston Scientific Japan; H.Y. receives lecture fees from Boston Scientific Japan. K.T. is a member of Circulation Reports’ Editorial Team. The other authors report no conflicts., (Copyright © 2024, THE JAPANESE CIRCULATION SOCIETY.) more...
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- 2024
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20. Prognostic Impact of Renal Function on 5-Year Outcomes After Fractional Flow Reserve-Guided Deferral of Revascularization.
- Author
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Itakura R, Kuramitsu S, Kikuchi J, Kawase Y, Mizukami T, Shinozaki T, Horie K, Takashima H, Terai H, Kikuta Y, Ishihara T, Saigusa T, Sakamoto T, Suematsu N, Shiono Y, Asano T, Tsujita K, Masamura K, Doijiri T, Toyota F, Ogita M, Kurita T, Matsuo A, Harada K, Yaginuma K, Sonoda S, Yokoi H, Tanaka N, and Matsuo H more...
- Subjects
- Humans, Prognosis, Coronary Angiography, Kidney physiology, Treatment Outcome, Myocardial Revascularization, Coronary Artery Disease complications, Coronary Artery Disease diagnosis, Coronary Artery Disease surgery, Fractional Flow Reserve, Myocardial, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic diagnosis, Renal Insufficiency, Chronic epidemiology, Kidney Failure, Chronic, Percutaneous Coronary Intervention adverse effects, Coronary Stenosis
- Abstract
Background Chronic kidney disease (CKD) might influence fractional flow reserve (FFR) value, potentially attenuating its prognostic utility. However, few large-scale data are available regarding clinical outcomes after FFR-guided deferral of revascularization in patients with CKD. Methods and Results From the J-CONFIRM registry (Long-Term Outcomes of Japanese Patients With Deferral of Coronary Intervention Based on Fractional Flow Reserve in Multicenter Registry), 1218 patients were divided into 3 groups according to renal function: (1) non-CKD (estimated glomerular filtration rate ≥60 mL/min per 1.73 m
2 ), n=385; (2) CKD (estimated glomerular filtration rate 15-59 mL/min per 1.73 m2 , n=763); and (3) end-stage renal disease (ESRD) (eGFR <15 mL/min per 1.73 m2 , n=70). The primary study end point was the cumulative 5-year incidence of target vessel failure (TVF), defined as a composite of cardiac death, target vessel myocardial infarction, and clinical driven target vessel revascularization. Cumulative 5-year incidence of TVF was significantly higher in the ESRD group than in the CKD and non-CKD group, whereas it did not differ between the CKD and non-CKD groups (26.3% versus 11.9% versus 9.5%, P <0.001). Although the 5-year TVF risk increased as the FFR value decreased regardless of renal function, patients with ESRD had a remarkably higher risk of TVF at every FFR value than those with CKD and non-CKD. Conclusions At 5 years, patients with ESRD showed a higher incidence of TVF than patients with CKD and non-CKD, although with similar outcomes between patients with CKD and non-CKD. Patients with ESRD had an excess risk of 5-year TVF at every FFR value compared with those with CKD and non-CKD. Registration URL: https://www.umin.ac.jp; Unique identifier: UMIN000014473. more...- Published
- 2023
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21. Five-Year Outcomes After Fractional Flow Reserve-Guided Deferral of Revascularization in Infarct-Related Artery Lesions.
- Author
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Ohashi H, Kuramitsu S, Takashima H, Matsuo H, Horie K, Terai H, Kikuta Y, Ishihara T, Saigusa T, Sakamoto T, Suematsu N, Shiono Y, Asano T, Tsujita K, Masamura K, Doijiri T, Sasaki Y, Ogita M, Kurita T, Matsuo A, Harada K, Yaginuma K, Sonoda S, Amano T, Yokoi H, and Tanaka N more...
- Abstract
Background: Little evidence is available about the long-term safety of fractional flow reserve (FFR)-guided deferral of revascularization in infarct-related artery (IRA) lesions, especially when measuring FFR in the late setting after myocardial infarction (MI). This study aimed to assess the long-term outcomes after deferral of revascularization in IRA lesions based on FFR assessed in the late phase of post-MI., Methods: From the J-CONFIRM registry (Long-Term Outcomes of Japanese Patients With Deferral of Coronary Intervention Based on Fractional Flow Reserve in Multicenter Registry), data on 1447 lesions (1263 patients) were divided into 2 groups: the IRA and non-IRA groups. The primary study end point was the cumulative 5-year incidence of target vessel failure (TVF), such as cardiac death, target vessel-related MI, and clinically driven target vessel revascularization., Results: Of the 1447 lesions, 138 (9.5%) were classified into the IRA group. The median duration of FFR measurement was 716 days after MI. The frequency of visual-functional mismatches (ie, FFR >0.80 and percent diameter stenosis ≥50% or FFR ≤0.80 and percent diameter stenosis <50%) was comparable between the IRA and non-IRA groups (31.9% vs 36.3%). The cumulative 5-year incidence of TVF did not differ between the groups (9.2% vs 11.8%; inverse probability-weighted hazard ratio, 1.18, 95% confidence intervals, 0.48-2.91, P = .71). Similar results were observed irrespective of regional wall motion assessed by ultrasonic cardiography and acute MI type., Conclusions: The 5-year TVF rate did not differ between the IRA and non-IRA lesions when deferring revascularization guided by FFR in the late setting of post-MI., (© 2023 The Authors.) more...
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- 2023
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22. Association of guideline-directed medical therapy adherence with outcomes after fractional flow reserve-based deferral of revascularization.
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Ishii M, Kuramitsu S, Yamanaga K, Matsuo H, Horie K, Takashima H, Terai H, Kikuta Y, Ishihara T, Saigusa T, Sakamoto T, Suematsu N, Shiono Y, Asano T, Masamura K, Doijiri T, Toyota F, Ogita M, Kurita T, Matsuo A, Harada K, Yaginuma K, Kanemura N, Sonoda S, Yokoi H, Tanaka N, and Tsujita K more...
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- Guideline Adherence, Humans, Myocardial Revascularization adverse effects, Registries, Fractional Flow Reserve, Myocardial, Myocardial Infarction etiology
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Aims: Guideline-directed medical therapy (GDMT) is essential to prevent future cardiovascular events in chronic coronary syndrome (CCS) patients. However, whether achieving optimal GDMT could improve clinical outcomes in CCS patients with deferred lesions based on fraction flow reserve (FFR) remains thoroughly investigated. We sought to evaluate the association of GDMT adherence with long-term outcomes after FFR-based deferral of revascularization in a real-world registry., Methods and Results: This is a post-hoc analysis of the J-CONFIRM registry (long-term outcomes of Japanese patients with deferral of coronary intervention based on fractional flow reserve in multicentre registry). Optimal GDMT was defined as combining four types of medications: antiplatelet drug, angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker, beta-blocker, and statin. After stratifying patients by the number of individual GDMT agents at 2 years, landmark analysis was conducted to assess the relationship between GDMT adherence at 2 years and 5-year major adverse cardiac events (MACEs), defined as a composite of all-cause death, target vessel-related myocardial infarction, clinically driven target vessel revascularization. Compared with the suboptimal GDMT group (continuing ≤3 types of medications, n = 974), the optimal GDMT group (n = 139) showed a lower 5-year incidence of MACE (5.2% vs. 12.4%, P = 0.02). The optimal GDMT was associated with a lower risk of MACE (hazard ratio: 0.41; 95% confidence interval: 0.18 to 0.92; P = 0.03)., Conclusion: Patients with optimal GDMT were associated with better outcomes, suggesting the importance of achieving optimal GDMT on long-term prognosis in CCS patients after FFR-guided deferral of revascularization., (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.) more...
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- 2022
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23. Long-Term Outcomes in Elderly Patients After Deferral of Coronary Revascularization Guided by Fractional Flow Reserve.
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Ueki Y, Kuramitsu S, Saigusa T, Senda K, Matsuo H, Horie K, Takashima H, Terai H, Kikuta Y, Ishihara T, Sakamoto T, Suematsu N, Shiono Y, Asano T, Tsujita K, Masamura K, Doijiri T, Sasaki Y, Ogita M, Kurita T, Matsuo A, Harada K, Yaginuma K, Kanemura N, Sonoda S, Yokoi H, and Tanaka N more...
- Subjects
- Aged, Constriction, Pathologic complications, Coronary Angiography adverse effects, Death, Humans, Myocardial Revascularization adverse effects, Treatment Outcome, Coronary Artery Disease complications, Coronary Stenosis complications, Fractional Flow Reserve, Myocardial, Myocardial Infarction etiology
- Abstract
Background: Little evidence is available regarding the long-term outcome in elderly patients after deferral of revascularization based on fractional flow reserve (FFR)., Methods and results: From the J-CONFIRM registry (long-term outcomes of Japanese patients with deferral of coronary intervention based on fractional flow reserve in multicenter registry), 1,262 patients were divided into 2 groups according to age: elderly and younger patients (aged ≥75 or <75 years, respectively). The primary endpoint was the cumulative 5-year incidence of target vessel failure (TVF), defined as a composite of cardiac death, target vessel-related myocardial infarction (TVMI), and clinically driven target vessel revascularization (CDTVR). Cumulative 5-year incidence of TVF was not significantly different between elderly and younger patients (14.3% vs. 10.8%, P=0.12). Cardiac death occurred more frequently in elderly patients than younger patients (4.4% vs. 0.8%, P<0.001), whereas TVMI and CDTVR did not differ between groups (1.3% vs. 0.9%, P=0.80; 10.7% vs. 10.1%, P=0.80, respectively). FFR values in lesions with diameter stenosis <50% were significantly higher in elderly patients than in younger patients (0.88±0.07 vs. 0.85±0.07, P=0.01), whereas this relationship was not observed in those with diameter stenosis ≥50%., Conclusions: Elderly patients had no excess risk of ischemic events related to the deferred coronary lesions by FFR, although FFR values in mild coronary artery stenosis were modestly different between elderly and younger patients. more...
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- 2022
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24. Thrombotic Risk and Cardiovascular Events in Patients With Revascularization Deferral After Fractional Flow Reserve Assessment.
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Shiono Y, Kuramitsu S, Matsuo H, Horie K, Takashima H, Terai H, Kikuta Y, Ishihara T, Saigusa T, Sakamoto T, Suematsu N, Asano T, Tsujita K, Masamura K, Doijiri T, Toyota F, Ogita M, Kurita T, Matsuo A, Harada K, Yaginuma K, Sonoda S, Tanaka A, Yokoi H, and Tanaka N more...
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- Coronary Angiography, Humans, Myocardial Revascularization adverse effects, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Coronary Artery Disease complications, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease therapy, Coronary Stenosis diagnostic imaging, Coronary Stenosis therapy, Fractional Flow Reserve, Myocardial
- Abstract
Objectives: The aim of this study was to evaluate the impact of thrombotic risk on the occurrence of cardiovascular events in patients with coronary artery disease with deferred revascularization after fractional flow reserve (FFR) measurements., Background: Deferral of revascularization on the basis of FFR is generally considered to be safe, but after deferral, some patients have cardiovascular events over time., Methods: From J-CONFIRM registry (Long-Term Outcomes of Japanese Patients With Deferral of Coronary Intervention Based on Fractional Flow Reserve in Multicenter Registry), 1,263 patients with deferral of revascularization on the basis of FFR were evaluated. The association between thrombotic risk as assessed by CREDO-Kyoto (Coronary Revascularization Demonstrating Outcome Study in Kyoto) thrombotic score and 5-year target vessel failure (TVF) and major adverse cardiac and cerebrovascular events (MACCE) was investigated., Results: FFR and high thrombotic risk (HTR) were associated with increased risk for 5-year TVF (FFR per 0.01-unit decrease: HR: 1.08; 95% CI: 1.05-1.11; P < 0.001; HTR: HR: 2.16; 95% CI: 1.37-3.39; P < 0.001) and MACCE (FFR per 0.01-unit decrease: HR: 1.05; 95% CI: 1.02-1.06; P < 0.001; HTR: HR: 2.11; 95% CI: 1.56-2.84; P = 0.001). Patients with HTR had higher risk for 5-year TVF (HR: 2.30; 95% CI: 1.45-3.66; P < 0.001) and MACCE (HR: 2.34; 95% CI: 1.75-3.13; P < 0.001) than those without HTR, even when they had negative FFR., Conclusions: Assessment of thrombotic risk provides additional prognostic value to FFR in predicting 5-year TVF and MACCE in patients with deferral of revascularization after FFR measurements. (Long-Term Outcomes of Japanese Patients With Deferral of Coronary Intervention Based on Fractional Flow Reserve in Multicenter Registry; UMIN000014473)., Competing Interests: Funding Support and Author Disclosures This work was supported by Abbott Medical Japan, Phillips Japan, and Boston Scientific Japan. The funders of the study had no role in the study design, data collection, data analysis, interpretation of the data, writing of the report, or decision to submit the paper for publication. Dr Shiono has received lecture fees from Abbott Medical Japan and Phillips Japan. Dr Kuramitsu has received lecture fees from Abbott Medical Japan and Boston Scientific Japan. Dr Matsuo serves as an advisory board member for Zeon Medical; and has received lecture fees from Abbott Medical Japan, Phillips Japan, and Boston Scientific Japan. Dr Kikuta has received lecture fees from Abbott Medical Japan and Phillips Japan. Dr Asano has received lecture fees from Abbott Medical Japan and Phillips Japan. Dr Tanaka serves as advisory board member for Abbott Medical Japan and Boston Scientific Japan. Dr Yokoi has received lecture fees from Boston Scientific Japan. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.) more...
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- 2022
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25. Five-Year Outcomes After Fractional Flow Reserve-Based Deferral of Revascularization in Chronic Coronary Syndrome: Final Results From the J-CONFIRM Registry.
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Kuramitsu S, Matsuo H, Shinozaki T, Horie K, Takashima H, Terai H, Kikuta Y, Ishihara T, Saigusa T, Sakamoto T, Suematsu N, Shiono Y, Asano T, Tsujita K, Masamura K, Doijiri T, Toyota F, Ogita M, Kurita T, Matsuo A, Harada K, Yaginuma K, Sonoda S, Yokoi H, and Tanaka N more...
- Subjects
- Coronary Angiography adverse effects, Death, Female, Humans, Male, Myocardial Revascularization adverse effects, Registries, Risk Factors, Time Factors, Treatment Outcome, Coronary Artery Disease complications, Coronary Stenosis, Fractional Flow Reserve, Myocardial, Myocardial Infarction etiology
- Abstract
Background: Little large-scale data is available about the long-term (beyond 3 years) clinical outcomes after fractional flow reserve (FFR)-based deferral of revascularization in clinical practice. We sought to assess the 5-year outcomes after deferral of revascularization based on FFR., Methods: The J-CONFIRM registry (Long-Term Outcomes of Japanese Patients With Deferral of Coronary Intervention Based on Fractional Flow Reserve in Multicenter Registry) prospectively enrolled 1263 patients with 1447 lesions in whom revascularization was deferred based on FFR from 28 Japanese centers. The primary study end point was the cumulative 5-year incidence of target vessel failure (TVF), including cardiac death, target vessel-related myocardial infarction, and clinically driven target vessel revascularization., Results: Five-year follow-up was completed in 92.2% of patients. The 5-year TVF rate was 11.6% in deferred lesions, mainly driven by clinically driven target vessel revascularization (9.8%). Cardiac death and target vessel-related myocardial infarction were 1.9% and 0.95%, respectively. Cumulative 5-year incidence of TVF was similar between the FFR 0.75 to 0.80 and 0.81 to 0.85 groups even after adjustment for baseline characteristics (12.2% versus 13.0%, inverse probability-weighted hazard ratio, 0.86 [95% CI, 0.46-1.60]; P =0.63). Compared with the almost normal FFR (0.86-1.00) group, the significant (<0.75) and borderline (0.75-0.85) FFR groups showed a higher incidence of TVF at 5 years (29.9% versus 12.8% versus 8.6%, P <0.001). Independent predictors of the 5-year TVF were hemodialysis, FFR value, left main coronary artery lesion, prior percutaneous coronary intervention, and male sex., Conclusions: The 5-year TVF rate was 11.6% in deferred lesions, mainly driven by clinically driven target vessel revascularization. Notably, cardiac death and target vessel-related myocardial infarction rarely occurred during the follow-up. Our findings highlight the long-term safety of FFR-based deferral of revascularization in patients with chronic coronary syndrome. Registration: URL: https://www.umin.ac.jp/ctr; Unique identifier: UMIN000014473. more...
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- 2022
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26. Two-Year Outcomes of Asymptomatic vs. Symptomatic Patients After Deferral of Revascularization Based on Fractional Flow Reserve - Insights From the J-CONFIRM Registry.
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Horie K, Kuramitsu S, Matsuo H, Shinozaki T, Takashima H, Shiono Y, Terai H, Kikuta Y, Ishihara T, Saigusa T, Sakamoto T, Asano T, Tsujita K, Masamura K, Doijiri T, Ogita M, Kurita T, Matsuo A, Sonoda S, Yokoi H, and Tanaka N more...
- Abstract
Background: The effect of symptoms on clinical outcomes after deferral of revascularization based on fractional flow reserve (FFR) remains poorly understood. Methods and Results: From the J-CONFIRM (Long-Term Outcomes of Japanese Patients With Deferral of Coronary Intervention Based on Fractional Flow Reserve in Multicenter) Registry, this study evaluated 1,215 patients with stable coronary artery disease, including symptomatic and asymptomatic patients (n=571 and 644, respectively). The primary endpoint was the cumulative 2-year incidence of target vessel failure (TVF), including cardiac death, target vessel-related myocardial infarction (TVMI), and clinically driven target vessel revascularization (CDTVR). An inverse probability weighted analysis was performed to adjust for the differences in baseline clinical characteristics between the 2 groups. At 2 years, the TVF rate did not differ significantly between symptomatic and asymptomatic patients (6.5% vs. 4.9%, respectively; P=0.15) or between symptomatic and asymptomatic patients with lesions with an FFR ≤0.80 (8.0% vs. 12.3%, respectively; P=0.20). Conversely, symptomatic patients showed significantly higher rates of TVF (6.2% vs. 3.3%; P=0.01) and CDTVR (6.2% vs. 3.1%; P=0.009) than asymptomatic patients, regardless of negative FFR values (>0.80). Conclusions: Despite negative FFR values, symptomatic patients were at higher risk of TVF than asymptomatic patients, driven primarily by a higher rate of CDTVR. Conversely, those with a positive FFR were likely to develop TVF regardless of their symptoms., Competing Interests: S.K. has received lecture fees from Boston Scientific Japan. H.M. has served as an advisory board member for Zeon Medical and has received lecture fees from Abbott Vascular Japan, Phillips Japan, and Boston Scientific Japan. Y.K. has received lecture fees from Abbott Vascular Japan and Phillips Japan. Y.S. has received lecture fees from Abbott Vascular Japan and Phillips Japan. T.A. has received lecture fees from Boston Scientific Japan and Phillips Japan. K.T. is an Associate Editor for Circulation Reports. H.Y. has received lecture fees from Boston Scientific Japan. N.T. has served as an advisory board member for Abbott Vascular Japan and Boston Scientific Japan. The other authors have no conflicts of interest to report., (Copyright © 2020, THE JAPANESE CIRCULATION SOCIETY.) more...
- Published
- 2020
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27. Two-Year Outcomes After Deferral of Revascularization Based on Fractional Flow Reserve: The J-CONFIRM Registry.
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Kuramitsu S, Matsuo H, Shinozaki T, Horie K, Takashima H, Terai H, Kikuta Y, Ishihara T, Saigusa T, Sakamoto T, Suematsu N, Shiono Y, Mizuno A, Tsujita K, Masamura K, Yokoi H, and Tanaka N
- Subjects
- Aged, Cause of Death, Clinical Decision-Making, Coronary Angiography, Coronary Artery Disease mortality, Coronary Artery Disease physiopathology, Female, Humans, Japan, Male, Middle Aged, Myocardial Infarction mortality, Predictive Value of Tests, Prospective Studies, Registries, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Cardiac Catheterization, Coronary Artery Disease diagnosis, Coronary Artery Disease therapy, Fractional Flow Reserve, Myocardial, Myocardial Revascularization adverse effects, Myocardial Revascularization mortality, Time-to-Treatment
- Abstract
Background: The safety of fractional flow reserve (FFR)-based deferral of revascularization remains to be fully established in real-world practice. We sought to assess clinical outcomes after deferral of revascularization based on FFR., Methods: The J-CONFIRM registry (Long-Term Outcomes of Japanese Patients With Deferral of Coronary Intervention Based on Fractional Flow Reserve in Multicenter Registry) prospectively enrolled 1263 patients with 1447 lesions in whom revascularization was deferred based on FFR at 28 Japanese centers. The primary study end point was the cumulative 2-year incidence of target vessel failure, including cardiac death, target-vessel related myocardial infarction, and clinically driven target vessel revascularization., Results: The mean FFR was 0.86±0.06. At 2 years, the target vessel failure rate was 5.5% in deferred lesions, mainly driven by a high rate of clinically driven target vessel revascularization (5.2%), and significantly increased with decreasing FFR, especially in the proximal location. Cardiac death and target-vessel related myocardial infarction rarely occurred during the 2-year follow-up (0.41% and 0.41%, respectively). Independent predictors of 2-year target vessel failure were FFR value (per 0.01 decrease; hazard ratio [HR] 1.07 [95% CI, 1.04-1.11], P <0.001), left main coronary artery lesion (HR, 5.89 [95% CI, 2.72-12.8], P <0.001), moderately to severely calcified lesion (HR, 2.49 [95% CI, 1.36-4.58]; P =0.003), hemodialysis (HR, 2.90 [95% CI, 1.11-7.58]; P =0.03), and right coronary artery lesion (HR, 1.78 [95% CI, 1.02-3.11], P =0.042)., Conclusions: The J-CONFIRM registry demonstrated the 2-year target vessel failure rate was 5.5% in deferred lesions, highlighting the safety of FFR-based deferral of revascularization in daily practice., Clinical Trial Registration: URL: http://www.umin.ac.jp. Unique identifier: UMIN000014473. more...
- Published
- 2020
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28. Mineralocorticoid receptor is overexpressed in cardiomyocytes of patients with congestive heart failure.
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Yoshida M, Ma J, Tomita T, Morikawa N, Tanaka N, Masamura K, Kawai Y, and Miyamori I
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- Aged, Aged, 80 and over, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Diuretics therapeutic use, Female, Heart Failure drug therapy, Humans, Immunoenzyme Techniques, In Situ Hybridization, Male, Middle Aged, Mineralocorticoid Receptor Antagonists therapeutic use, Nitroglycerin therapeutic use, Spironolactone therapeutic use, Heart Failure metabolism, Myocytes, Cardiac metabolism, Receptors, Mineralocorticoid metabolism
- Abstract
Mineralocorticoid receptors (MRs) have been identified in the human cardiovascular tissues. We determined MR expression in the failing heart to clarify the mechanism of action of aldosterone antagonist in the treatment of congestive heart failure. MR protein and MR mRNA content were detected by immunohistochemical staining and in situ hybridization in the cardiac tissues. Immunohistochemical staining of the receptor, as well as in situ hybridization of MR mRNA, was dense in cardiomyocytes of the failing left ventricle as compared with the controls. The staining ratio of the cytoplasm to the interstitium showed that MRs were located mainly in the cytoplasm. The cytoplasm to the interstitium in the failing left ventricle was 1.53+/-0.13, which was significantly higher than that of the controls 1.25+/-0.19 (p<0.05). These findings suggest that the efficacy of aldosterone antagonists in treating congestive heart failure may be in part through blocking the MRs, which are upregulated in the failing heart. more...
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- 2005
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29. Myocardial metabolic regulation through peroxisome proliferator-activated receptor alpha after myocardial infarction.
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Masamura K, Tanaka N, Yoshida M, Kato M, Kawai Y, Oida K, and Miyamori I
- Abstract
Although peroxisome proliferator-activated receptor alpha (PPARalpha) is closely associated with myocardial fatty acid metabolism, the pathophysiological role of PPARalpha in myocardial infarction (MI) is not yet known. The aim of the present study was to clarify the relationship between cardiac energy metabolism and PPARalpha expression in the remodelling of myocardium after MI. We assayed the expression of PPARalpha and several metabolic genes in cultured cardiac cells (myocytes and nonmyocytes) and in MI hearts. PPARalpha was strongly expressed in cardiac myocytes but not in nonmyocytes (mainly fibroblasts). In MI rats, PPARalpha and PPARalpha-regulated genes (lipoprotein lipase, heart-type fatty acid binding protein, long-chain acyl-CoA dehydrogenase and uncoupling protein-3) were decreased concomitantly, whereas uncoupling protein-2 was not decreased in severely ischemic regions. Immunohistochemical staining for PPARalpha was less decreased in borderline myocardium than in sham-operated hearts. Furthermore, in electron microscopic study, there were no lipid droplet accumulations in surviving myocardium after MI. Our results suggest that the reduced expression of PPARalpha is closely related to that of fatty acid metabolism genes in infarcted myocardium, and PPARalpha may play an important role in cardiac energy metabolism during remodelling after MI. more...
- Published
- 2003
30. Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family.
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Masamura K, Oida K, Kanehara H, Suzuki J, Horie S, Ishii H, and Miyamori I
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- Bacterial Toxins pharmacology, Cells, Cultured, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors pharmacology, Leucine pharmacology, Mevalonic Acid pharmacology, Polyisoprenyl Phosphates pharmacology, RNA, Messenger analysis, Umbilical Veins, Up-Regulation, Bacterial Proteins, Endothelium, Vascular metabolism, Leucine analogs & derivatives, Monomeric GTP-Binding Proteins antagonists & inhibitors, Quinolines pharmacology, Thrombomodulin metabolism, Thromboplastin metabolism
- Abstract
Objective: 3-hydroxyl-3-methyl coenzyme A reductase inhibitors (statins) can function to protect the vasculature in a manner that is independent of their lipid-lowering activity. The main feature of the antithrombotic properties of endothelial cells is an increase in the expression of thrombomodulin (TM) without induction of tissue factor (TF) expression. We investigated the effect of statins on the expression of TM and TF by endothelial cells., Methods and Results: The incubation of endothelial cells with pitavastatin led to a concentration- and time-dependent increase in cellular TM antigen and mRNA levels. In contrast, the expression of TF mRNA was not induced under the same conditions. A nuclear run-on study revealed that pitavastatin accelerates TM transcription rate. The stimulation of TM expression by pitavastatin was prevented by either mevalonate or geranylgeranylpyrophosphate. Specific inhibition of geranylgeranyltransferase-I and Rac/Cdc42 by GGTI-286 and Clostridium sordellii lethal toxin, respectively, enhanced TM expression, whereas inactivation of Rho by Clostridium botulinum C3 exoenzyme was ineffective., Conclusions: Statins regulate TM expression via inhibition of small G proteins of the Rho family; Rac/Cdc42. A statin-mediated increase in TM expression by endothelial cells may contribute to the beneficial effects of statins on endothelial function. more...
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- 2003
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31. Amphiregulin is a potent mitogen for the vascular smooth muscle cell line, A7r5.
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Kato M, Inazu T, Kawai Y, Masamura K, Yoshida M, Tanaka N, Miyamoto K, and Miyamori I
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- Amphiregulin, Animals, Base Sequence, Cell Division drug effects, Cell Line, DNA biosynthesis, EGF Family of Proteins, Enzyme Activation drug effects, Epidermal Growth Factor genetics, ErbB Receptors genetics, Glycoproteins genetics, Glycoproteins metabolism, Intercellular Signaling Peptides and Proteins genetics, Intercellular Signaling Peptides and Proteins metabolism, MAP Kinase Signaling System, Mitogen-Activated Protein Kinases metabolism, Muscle, Smooth, Vascular cytology, Muscle, Smooth, Vascular metabolism, Proto-Oncogene Proteins metabolism, Proto-Oncogene Proteins c-akt, RNA, Messenger genetics, RNA, Messenger metabolism, Rats, Thrombin pharmacology, Up-Regulation drug effects, Glycoproteins pharmacology, Intercellular Signaling Peptides and Proteins pharmacology, Mitogens pharmacology, Muscle, Smooth, Vascular drug effects, Protein Serine-Threonine Kinases
- Abstract
The regulation of amphiregulin, an epidermal growth factor (EGF) family member, and its effect on vascular smooth muscle cells (VSMC) were examined. Amphiregulin mRNA was upregulated by amphiregulin itself as well as alpha-thrombin. Amphiregulin caused an approximate 3-fold increase in DNA synthesis. Its effect on growth was compared with those of other mitogens, and was found to be approximately 3.5-, 2.4-, and 1.0-fold greater than those of endothelin-I (ET-I), alpha-thrombin, and platelet-derived growth factor-AB (PDGF-AB), respectively. As evidenced by Western blot analysis, amphiregulin stimulated the phosphorylation of p42/p44-mitogen-activated protein kinase (MAPK), p38-MAPK, c-Jun NH2-terminal protein kinase (JNK), and Akt/protein kinase B (PKB), respectively. By statistical analysis, the amphiregulin-induced growth effect was significantly decreased by the MAP kinase/ extracellular regulated kinase kinase-1 (MEK-1) inhibitor PD98059, p38-MAPK inhibitor SB203580, and phosphatidylinositol 3-kinase (PI-3 kinase) inhibitor wortmannin, respectively, but was not decreased by JNK inhibitor SP600125. These results suggest that amphiregulin is the most potent mitogen of the mitogens tested, and its growth effect is mediated at least in part through the p42/p44-MAPK, p38-MAPK, and PI-3 kinase-Akt/PKB pathways in VSMC. more...
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- 2003
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32. A role of heparin-binding epidermal growth factor-like growth factor in cardiac remodeling after myocardial infarction.
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Tanaka N, Masamura K, Yoshida M, Kato M, Kawai Y, and Miyamori I
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- Animals, Animals, Newborn, Cells, Cultured, Epidermal Growth Factor genetics, ErbB Receptors metabolism, Fibroblasts cytology, Fibroblasts metabolism, Heparin-binding EGF-like Growth Factor, Intercellular Signaling Peptides and Proteins, Myocardium cytology, Myocardium pathology, Rats, Rats, Sprague-Dawley, Epidermal Growth Factor metabolism, Myocardial Infarction pathology, Myocardium metabolism, Ventricular Remodeling physiology
- Abstract
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is known to induce cell growth in various cell types via transactivation of epidermal growth factor receptor (EGFR). To investigate the involvement of HB-EGF and EGFR in cardiac remodeling after myocardial infarction (MI), we examined the expressions of mRNA and protein in rat hearts 6 weeks after MI-induction. Where increased expressions of HB-EGF mRNA and protein were observed, infarcted myocardium was replaced by extracellular matrix and interstitial fibroblasts. EGFR mRNA and protein expression did not show significant changes in sham-operated heart tissues, non-infarcted region, and infarcted region. In vitro study demonstrated that HB-EGF mRNA was expressed mainly in cultured fibroblasts rather than in myocytes. We suggest that the interaction between HB-EGF and EGFR transactivation is closely related to the proliferation of cardiac fibroblasts and cardiac remodeling after MI in an autocrine, paracrine, and juxtacrine manner. more...
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- 2002
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33. Remnant lipoprotein particles are taken up into myocardium through VLDL receptor--a possible mechanism for cardiac fatty acid metabolism.
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Kamataki A, Takahashi S, Masamura K, Iwasaki T, Hattori H, Naiki H, Yamada K, Suzuki J, Miyamori I, Sakai J, Fujino T, and Yamamoto TT
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- Animals, Animals, Newborn, Cells, Cultured, Endocytosis, Fasting, Heart growth & development, Kinetics, Lipids analysis, Male, Mice, Mice, Inbred BALB C, Myocardium ultrastructure, Oleic Acid metabolism, RNA, Messenger biosynthesis, Rats, Rats, Sprague-Dawley, Receptors, LDL genetics, Fatty Acids metabolism, Lipoproteins, VLDL metabolism, Myocardium metabolism, Receptors, LDL metabolism
- Abstract
The VLDL (very low-density lipoprotein) receptor is a peripheral lipoprotein receptor expressing in fatty acid active tissues abundantly. In the Balb/c fasting mice, VLDL receptor as well as LPL (lipoprotein lipase), FAT (fatty acid translocase)/CD36, H-FABP (heart-type fatty acid-binding protein), ACS (acyl-CoA synthetase) and LCAD (long-chain acyl-CoA dehydrogenase) expressions increased. An electron microscopic examination indicated the lipid droplets that accumulated in the hearts of fasting Balb/c mice. During the development of SD (Sprague-Dawley) rats, VLDL receptor, LPL, FAT/CD36, H-FABP, ACS, and LCAD mRNAs concomitantly increased with growth. However, PK (pyruvate kinase) mRNA expression was negligible. In cultured neonatal rat cardiomyocytes, VLDL receptor expression increased with days in culture. Oil red-O staining showed that cardiomyocytes after 7 days in culture (when the VLDL receptor protein is present) accumulated beta-migrating VLDL. Thereby, we showed that the cardiac VLDL receptor pathway for delivery of remnant lipoprotein particles might be part of a cardiac fatty acid metabolism. more...
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- 2002
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34. Effects of brief glucocorticoid exposure on growth of vascular smooth muscle cells in culture.
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Kawai Y, Hayashi T, Eguchi K, Asazuma K, Masamura K, Iwamuro A, Takano Y, Tada H, Matsukawa S, and Miyamori I
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- Animals, Aorta, Cell Division drug effects, Cell Line, DNA Replication drug effects, Dexamethasone pharmacology, Hormone Antagonists pharmacology, Mifepristone pharmacology, Rats, Thymidine metabolism, Glucocorticoids pharmacology, Muscle, Smooth, Vascular drug effects
- Abstract
While prolonged exposure of vascular smooth muscle cells (VSMC) to glucocorticoid has been shown to inhibit cell proliferation, the effect of a brief pulse exposure is not known. We studied the short-term effects of pulse exposure to dexamethasone (DEX) on DNA synthesis in cultured VSMC. VSMC were pulsed with DEx for varying time intervals and [3H]thymidine incorporation into cells after 24 h was measured. Exposure to DEX for 24 h decreased [3H]thymidine incorporation, while pulse treatments with DEX from 2 min to 6 h significantly increased [3H]thymidine incorporation. Maximal proliferative effect was observed with a 20-min exposure. The effect of a 20-min pulse was dose-dependent, with the half-maximal dose of DEX being approximately 10(-7) M. A selective glucocorticoid receptor antagonist, RU486, inhibited the proliferative effect of DEx. Concentrated conditioned medium from cells exposed to 10(-6) M DEX increased [3H]thymidine incorporation by other VSMC in a dose-dependent manner. These results suggest that short-term pulse DEX exposure is capable of producing one or more autocrine growth factors in VSMC via a glucocorticoid receptor action. This effect of glucocorticoid pulses may contribute to the pathogenesis of arteriosclerosis and hypertension. more...
- Published
- 1998
- Full Text
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35. Erratum.
- Author
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Matsuda S, Omoto M, Imai T, Seki K, Nomura R, Otahara Y, Yoshida T, Shima S, Kurita H, Nagaoka K, Taniwaki H, Asada Y, Shai KP, Koike M, Morita K, Watanabe Y, Mizoguchi H, Masamura K, Nagaya T, Inaba R, Sugiura H, Iwata H, Tanaka T, Ohi G, Uemura I, Akabayashi A, Kai I, Miyasaka M, and Naka K more...
- Published
- 1998
- Full Text
- View/download PDF
36. [Relationship between the experience of steroids side effects and noncompliance with oral steroids treatment in collagen disease patients].
- Author
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Hamano K, Ohta A, Masamura K, Hashiguchi N, Takekuma A, Ushiyama O, Suzuki N, Inoue E, Inoue N, and Nagasawa K
- Subjects
- Anti-Inflammatory Agents adverse effects, Clinical Nursing Research methods, Collagen Diseases psychology, Female, Humans, Male, Medication Errors, Middle Aged, Steroids, Surveys and Questionnaires, Treatment Refusal, Anti-Inflammatory Agents therapeutic use, Collagen Diseases drug therapy
- Abstract
Purpose: To analyze the relationship between the experience of side effect and the compliance with oral steroids drug treatment of the patients in Collagen Disease Clinic., Methods: A questionnaire survey through interview was conducted on 165 outpatients with various collagen disease at Saga Medical School Hospital., Results: 94 patients (57%) had a history of noncompliance to the steroids drug. 49 patients (52.1%) adventitiously had forgotten to take the steroids as ordered and 45 patients (47.9%) intentionally had regulated their steroids dose or had discontinued the steroids drug treatment. Over 80% of the patients had experienced side effects of the steroids. The patients who experienced one or more of the following side effects, osteoporosis, bone fractures, menstrual disorders, moon face, central obesity, alopecia, acnelike eruption, manic-depressive state, and insomnia, intentionally regulated, or discontinued the steroids therapy. In addition, the patients who were not made cognizance about side effects of the steroids by their physicians and nurse tended to noncompliance group., Conclusion: To increase the compliance rate with oral steroids drug treatment, we must make conscious efforts to inform the patients on the condition of their medical states, the efficacy of the prescribed drugs, and the side effects and risk concerning discontinuation of the steroids. It is Also necessary to establish "Drug information and counseling day" in outpatient Department. more...
- Published
- 1997
37. No relationship of salivary flow rate or secretory immunoglobulin A to dental caries in children.
- Author
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Watanabe Y, Mizoguchi H, Masamura K, and Nagaya T
- Abstract
To investigate the relationship between dental caries and the salivary flow rate, secretory immunoglobulin A (sIgA) or other components in children, nonstimulated whole saliva was collected and teeth status was examined in 138 boys and 134 girls aged 11-12 years. The subjects were apparently healthy. The mean salivary flow rate was faster in boys than in girls (0.29 vs 0.18 ml/min, p < 0.001). In both sexes, secretion of salivary sIgA and three other components (total protein, calcium and amylase activity) was markedly dependent on salivary flow rates. These results suggest that basal components of resting saliva are secondarily secreted with the flow of saliva fluid. The mean erupted permanent teeth was 21.0 teeth (range: 10-28 teeth) in boys, and 23.0 teeth (13-28 teeth) in girls (sex-difference: p < 0.001). The means of DMFT, the DMFT ratio (% of DMFT to erupted permanent teeth) and DT+dt (sum of decayed permanent and milk teeth, an index for active caries) were 3.4 DMFT (range: 0-11 DMFT), 16.0% (0-40.0%) and 0.5 DT+dt (0-7 DT + dt) in boys, and 3.8 DMFT (0-12 DMFT), 16.2% (0-44.4%) and 0.8 DT+dt (0-5 DT+dt) in girls, respectively (sex-differences: p>0.05 in all). The salivary flow rate or the four salivary components (either concentration or secretion rate) used here had no relationship to the DMFT ratio or to DT+dt in either sex. Variation in the flow rate or in the basal components of resting saliva may not influence caries development in healthy children. more...
- Published
- 1997
- Full Text
- View/download PDF
38. Assessment of hand-arm vibration exposure among traffic police motorcyclists.
- Author
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Mirbod SM, Yoshida H, Jamali M, Masamura K, Inaba R, and Iwata H
- Subjects
- Adult, Humans, Japan, Male, Middle Aged, Police, Arm Injuries etiology, Motorcycles, Occupational Diseases etiology, Vibration adverse effects
- Abstract
The aims of this study were (1) to evaluate subjective symptoms in the hand-arm system of all traffic police motorcyclists of a city located in the central part of Japan and (2) to assess their hand-arm vibration exposure associated with traffic police motorcycle riding. The study population consisted of 119 motorcycling traffic policemen and 49 male controls. By means of a questionnaire, information on the occupational history and the presence of subjective symptoms in the hand-arm system of all subjects was obtained. Vibration was measured on the handlebars of the representative motorcycles and on the hands of the riders. The 4- and 8-h energy-equivalent frequency-weighted acceleration as well as the lifetime vibration dose were calculated for all police motorcyclists. The prevalence of finger blanching in the traffic police motorcyclists was 4.2%, but none of the controls had this symptom. The rates of finger numbness (19.3%), finger stiffness (16.0%), shoulder pain (13.4%), and shoulder stiffness (45.4%) were significantly higher among police motorcyclists as compared with controls. The root-mean-square (rms) frequency-weighted acceleration on the handlebars of police motorcycles was in the range of 2.2-4.9 m/s2 rms. The computed 4- and 8-h energy-equivalent frequency-weighted acceleration values were 2.8-4.5 and 2.0-3.2 m/s2 rms, respectively. A pattern of increasing percentage prevalence with increasing cumulative vibration dose was noticed. The subjects with a lifetime vibration dose of more than 20.1 m2 h3 s-4 (in scale) showed significantly higher prevalence rates for symptoms in the fingers and shoulders as compared with the control group. As occupational vibration exposure of traffic police motorcyclists might be considered a risk factor for the development of symptoms in the hand-arm system of the riders, its evaluation and control is needed for prevention methodology evolution. more...
- Published
- 1997
- Full Text
- View/download PDF
39. [Self-assessed quality of mastication in relation to remaining teeth and self-assessed health status in elderly persons].
- Author
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Masamura K, Ono K, Inaba R, Iwata H, and Yoshida H
- Subjects
- Aged, Aged, 80 and over, Dental Health Surveys, Female, Humans, Male, Tooth physiology, Dental Care for Aged, Health Status, Mastication physiology, Self-Assessment
- Abstract
To explore factors related to quality of mastication, information about teeth status and self-assessed health status were obtained by a self-administered questionnaire from participants in a dental screening program. Invitation letters for participation in the program were distributed by members of the neighborhood association to 1.275 residents of a town in Gifu prefecture aged 65 years or older. Participation rate in the dental screening program was 40.5%. A total of 513 participants (245 males and 268 females) completed the program and the questionnaire. The results were as follows. 1. Overall, 32% had 20 teeth or more and 88.4% had bridge(s) and/or denture(s). 2. The mean number of remaining teeth were 12.9 for males and 12.5 for females. There was no statistical difference in the number of remaining teeth between males and females. The mean numbers of remaining teeth among those aged 65-69 years was 15.7 and two thirds of them had lost the Lower First Molar. 3. Those who reported to be satisfied with their present mastication were 83.3% of men and 86.3% of women. The proportions were not influenced by age or sex. 4. Quality of mastication was related to self-reported "good physical condition' and "not easily tired'. 5. The proportion of those satisfied with their mastication was large in the groups with remaining teeth index 0-8 and > or = 17, and small in the group with remaining teeth index 9-16, showing a U-shaped curve for satisfaction rate against remaining teeth index. These results suggest a relationship of quality of mastication on health status. The importance of primary dental care for the elderly persons is underlined. more...
- Published
- 1996
40. [Salivary calcium and total protein in relation to dental caries].
- Author
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Masamura K, Inaba R, and Iwata H
- Subjects
- Calcium physiology, Child, Female, Humans, Male, Regression Analysis, Salivary Proteins and Peptides physiology, Sex Factors, Calcium metabolism, Dental Caries epidemiology, Saliva metabolism, Salivary Proteins and Peptides metabolism
- Abstract
To evaluate the relationship between salivary components (calcium: Ca, total protein: T-Pro) and dental caries, we collected nonstimulated and expectorated saliva from 131 primary school children aged 11 years old. All salivary samples were taken in the morning (11:00-11:30 A.M.) on Feb. 17, 1994, while the subjects were at rest. The salivary Ca concentration (mg/dliter), total salivary protein concentration (mg/mliter) and salivary flow rate (mliter/min) were measured based on the salivary sample taken for each person for 30 minutes at most. For each subject the Ca secretion rate (micrograms/min), T-Pro secretion rate (micrograms/min) and Ca/T-Pro ratio were determined. The numbers of permanent teeth erupted, and decayed, missing and filled (DMF) teeth for each subject were obtained from dental records. For the entire group we observed that the numbers of DMF teeth were highly correlated with the numbers of permanent teeth erupted, hence for further analysis we restricted the subjects to 18 boys and 29 girls who were classified as dental age IIIC-IVA (according to Hellman's classification). Multiple linear regression analysis was employed using the number of DMF teeth as a dependent variable. When we included the variables for the Ca/T-Pro ratio, numbers of erupted permanent teeth, sex and salivary flow rate into the model as independent variables, there was a statistically significant association (P < 0.05) between the Ca/T-Pro ratio and the numbers of DMF teeth. However, in other models there was no significant association between the numbers of DMF teeth with Ca concentration, Ca flow rate, total protein concentration, or total protein flow rate.(ABSTRACT TRUNCATED AT 250 WORDS) more...
- Published
- 1995
- Full Text
- View/download PDF
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