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This paper proposes Hadoop job detection method using the Kalman filter and network configuration procedure for hybrid electro-optical intra-data center networks. The simulation results show improvement of detection accuracy and energy saving effect.

We show a multi-cloud-based network infrastructure for Smart World with demonstrating several types of network control and service including PTP devices for Private LTE, AI-based SFC Platform, WhiteBox-based reliable routing, and disaggregated SDM network.

During transfer experimental autoimmune encephalomyelitis (tEAE), myeline specific autoreactive CD4+ T cells cross the blood brain barrier at the blood vessels of the 5th lumber (L5) cord in a manner dependent on anti-gravity responses via the soleus muscles. This crossing leads to a transient development of neural inflammation. Because the pathology does not last long, negative factors at the region may be present. To investigate the existence of these negative regulators, we performed metabolite analysis of the L5 cord with or without gravity load or electrical stimulation of the soleus muscles and identified flavin-adenine dinucleotide (FAD). The amount of FAD in the L5 cord was decreased in mice suspended by their tails, which reduced the anti-gravity response from the hindlimbs, but recovered in mice with the tail suspension plus electrical stimulation in the soleus muscles. Moreover, FAD administration suppressed the EAE pathology. Thus, FAD was induced by antigravity responses in the spinal cord and suppressed the development of neuroinflammation. Therefore, FAD could be a therapeutic candidate for diseases with neuroinflammation, particularly those involving pathogenic T cells including multiple sclerosis. Funding Statement: This work was supported by KAKENHI (M. M.), the Joint Usage/Research Center Institute for Genetic Medicine, Hokkaido University (M. M.), Takeda Science Foundation (M. M.), Institute for Fermentation Osaka (M. M.), Mitsubishi Foundation (M. M.), Naito Foundation (M. M.) and Uehara Memorial Foundation (M. M.). Declaration of Interests: The authors of this manuscript have no conflicts of interest to disclose. Ethics Approval Statement: The animal experiments used in this study were approved by the Institutional Animal Care and Use Committees of Hokkaido University.

We report a simple process of stabilizing metastable β-Zn2SiO4:Mn nanocrystals in amorphous silica. Zn and Mn ions were incorporated in mesoporous silica by immersing aqueous solution of Mn2+ and Zn2+, and the mesoporous silica was sintered at 1000-1100oC in reducing atmosphere. β-Zn2SiO4:Mn were formed along with α-Zn2SiO4:Mn in sintered mesoporous silica when diameter of pore is as small as 2.4nm. Due to the formation of β-Zn2SiO4:Mn, photoluminescence (PL) spectra exhibited both green and yellow emission originated from α-and β-Zn2SiO4:Mn, respectively. Relative intensity of the two emission was changed by changing heat treatment time and temperature. These results imply that this simple process is promising to stabilize nanocrystal of β-Zn2SiO4:Mn emitting yellow luminescence.

The prototype system of the energy efficient data center network HOLST was introduced and estimated 49% reduction of switching power consumption with application triggered flow classification using operated data center traffic data.

Dynamic resource allocation in virtual packet optical node is deployed and confirmed that required service is placed based on the calculation result of biological attractor selection.

Composites of a long-lasting phosphor, SrAl2O4:Eu,Dy, and glass were prepared by sintering the phosphor and glass powder. To enhance the afterglow luminescence, a borosilicate glass composition was chosen so that the refractive index of the glass matched that of the phosphor. Additional components with a high refractive index, such as La2O3 and Nb2O5, were added to the glass to increase the overall refractive index. As they tend to induce crystallization during sintering, small amounts of at least three types of such components were added to the glass to prevent crystallization. The surface of the composite was observed by a digital microscope with dark-field lighting. The phosphor particles became almost transparent because of the refractive-index matching, although bubbles were observed inside the phosphor particles. The afterglow luminance was, however, almost the same and the transmittance of the composite was not high because of many voids when compared to as that of the sample using the glass with a lower refractive index. The sample prepared under vacuum showed coloration and similar afterglow luminance even though the number of voids inside the composite decreased. To suppress the coloration, the amount of tin in the glass was increased, after which higher transparency and afterglow luminance were obtained. A 4-mm-thick sample showed a luminance of 118 mcd∙m-2 60 min after irradiation by a D65 lamp with 200 lx for 20 min.

The interest in organic–inorganic hybrid molecules as molecular probes for biological systems has been growing rapidly. Such hybrid molecules exhibit unique biological activities. Herein, copper(II) bis(diethyldithiocarbamate) (Cu10) was found to activate the transcription factor NF-E2-related factor 2 (Nrf2), which is responsible for regulating antioxidant and phase II xenobiotic enzymes, in vascular endothelial cells. The copper complex rapidly accumulated within cells and induced nuclear translocation of Nrf2, leading to upregulation of the expression of downstream proteins without cytotoxic effects. However, while copper bis(2-hydroxyethyl)dithiocarbamate activated Nrf2, copper ion, diethyldithiocarbamate ligand with or without zinc or iron failed to exhibit this activity. Intracellular accumulation of Cu10 was higher than that of Cu(II) and Cu(I). While the accumulation of copper(II) bis(dimethyldithiocarbamate) was reduced by small interfering RNA (siRNA)-mediated knockdown of the copper transporter CTR1, the knockdown did not affect Cu10 accumulation, indicating that Cu10 rapidly enters vascular endothelial cells via CTR1-independent mechanisms. In addition, copper and iron complexes with other ligands tested could not activate Nrf2, suggesting that the intramolecular interaction between copper and dithiocarbamate ligand is important for the activation of the transcription factor. Cu10 induced the expression of heme oxygenase-1, NAD(P)H quinone oxidoreductase 1, and γ-glutamylcysteine synthetase, downstream proteins of Nrf2. It was suggested that Cu10-induced activation of Nrf2 was due to proteasome inhibition as well as binding to Kelch-like ECH-associated protein 1. Since the effects of Cu10 on vascular endothelial cells are unique and diverse, the copper complex may be a good molecular probe to analyze the functions of the cells. Electronic supplementary material The online version of this article (doi:10.1007/s00775-016-1337-z) contains supplementary material, which is available to authorized users.

An online parameter-tuning method for the energy-efficient data center network (DCN) named HOLST (high-speed optical layer 1 switch system for time-slot-switching-based optical data center networks) is proposed. HOLST comprises an optical circuit switching network, optical slot switching network, and electrical packet switching network for the spine layer. It requires flows to be assigned to optimal switches to achieve high power savings. In this study, first we experimentally confirm that the change in the DCN characteristics in the short term of actual data center traffic downgrades the accuracy of flow classification. Subsequently, we propose a procedure for reconfiguring a flow classification function and a method for online parameter tuning for this function. Finally, the accuracy of the flow classification method using the proposed tuning and estimated switching energy consumption in the spine layer are evaluated. The proposed online parameter-tuning function increases the accuracy of flow classification and reduces switching energy consumption relative to the conventional flow classification function.

LaPO

For predicting welding distortion and residual stress generated by laser–arc hybrid welding, a series of experiments and analyses were carried out. A bead-on-plate welding was performed on SM490 steel by using a fibre laser and CO2 arc welding by changing their heat input ratio. The experiment was simulated by thermal elastic–plastic analysis with the proposed simulation model considering the penetration shape by laser and arc separately. By using this model, the experimental results could be simulated with high accuracy. Therefore, the validity and generality of the numerical simulation model could be verified. The tendency and magnitude of angular distortion varied with the heat input ratio of laser and arc. The results indicated the possibility of the ideal heat input ratio of laser and arc for controlling angular distortion generated by hybrid welding. On the other hand, it was confirmed that the heat input ratio of laser and arc did not affect residual stress generated by hybrid welding.

Small living insects often attach in a raspberry hole, and Japanese customers hate them. Therefore farmers in Japan are manually checking all harvested raspberries and removing ones with insects before shipping them to fresh markets. It is difficult to find them even with human eyes. Such situation cause high cost and farmer's hard work on the cultivation. In this study, machine vision to detect insects in a hole of raspberry fruit automatically was developed for substitution of human manual work. As the result of the test, insects were identified with high success rate. Although there were several failure cases, it can be considered that they are improved by taking video inside a room with a stable artificial light.

Vascular endothelial cells cover the luminal surface of blood vessels and contribute to the prevention of vascular disorders such as atherosclerosis. Metallothionein (MT) is a low molecular weight, cysteine-rich, metal-binding, inducible protein, which protects cells from the toxicity of heavy metals and active oxygen species. Endothelial MT is not induced by inorganic zinc. Adequate tools are required to investigate the mechanisms underlying endothelial MT induction. In the present study, we found that an organoantimony compound, tris(pentafluorophenyl)stibane, induces gene expression of MT-1A and MT-2A, which are subisoforms of MT in bovine aortic endothelial cells. The data reveal that MT-1A is induced by activation of both the MTF-1-MRE and Nrf2-ARE pathways, whereas MT-2A expression requires only activation of the MTF-1-MRE pathway. The present data suggest that the original role of MT-1 is to protect cells from heavy metal toxicity and oxidative stress in the biological defense system, while that of MT-2 is to regulate intracellular zinc metabolism.

村田誠一先生 退職記念論文集