1. Daidzein stimulation of bone resorption in pit formation assay.
- Author
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Tobe H, Komiyama O, Komiyama Y, and Maruyama HB
- Subjects
- Animals, Cell Count drug effects, Cells, Cultured, Estrogens, Non-Steroidal chemistry, Genistein, In Vitro Techniques, Isoflavones chemistry, Mice, Mice, Inbred ICR, Molecular Structure, Osteoclasts cytology, Osteoclasts drug effects, Bone Resorption, Bone and Bones drug effects, Estrogens, Non-Steroidal pharmacology, Isoflavones pharmacology
- Abstract
We found that daidzein stimulated bone resorption in the pit formation assay at the concentration of 10(-8)-10(-10) M. On the other hand, genistein and ipriflavone at these concentrations did not have any effect on pit formation. We speculated that daidzein had the ability to induce osteoclasts directly or indirectly from their progenitors and might be a tool by study osteoclast differentiation.
- Published
- 1997
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