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Daidzein stimulation of bone resorption in pit formation assay.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 1997 Feb; Vol. 61 (2), pp. 370-1. - Publication Year :
- 1997
-
Abstract
- We found that daidzein stimulated bone resorption in the pit formation assay at the concentration of 10(-8)-10(-10) M. On the other hand, genistein and ipriflavone at these concentrations did not have any effect on pit formation. We speculated that daidzein had the ability to induce osteoclasts directly or indirectly from their progenitors and might be a tool by study osteoclast differentiation.
- Subjects :
- Animals
Cell Count drug effects
Cells, Cultured
Estrogens, Non-Steroidal chemistry
Genistein
In Vitro Techniques
Isoflavones chemistry
Mice
Mice, Inbred ICR
Molecular Structure
Osteoclasts cytology
Osteoclasts drug effects
Bone Resorption
Bone and Bones drug effects
Estrogens, Non-Steroidal pharmacology
Isoflavones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0916-8451
- Volume :
- 61
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 9058980
- Full Text :
- https://doi.org/10.1271/bbb.61.370