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1. MuCol Milestone Report No. 5: Preliminary Parameters

Author

Accettura, Carlotta, Adrian, Simon, Agarwal, Rohit, Ahdida, Claudia, Aimé, Chiara, Aksoy, Avni, Alberghi, Gian Luigi, Alden, Siobhan, Alfonso, Luca, Amapane, Nicola, Amorim, David, Andreetto, Paolo, Anulli, Fabio, Appleby, Rob, Apresyan, Artur, Asadi, Pouya, Mahmoud, Mohammed Attia, Auchmann, Bernhard, Back, John, Badea, Anthony, Bae, Kyu Jung, Bahng, E. J., Balconi, Lorenzo, Balli, Fabrice, Bandiera, Laura, Barbagallo, Carmelo, Barlow, Roger, Bartoli, Camilla, Bartosik, Nazar, Barzi, Emanuela, Batsch, Fabian, Bauce, Matteo, Begel, Michael, Berg, J. Scott, Bersani, Andrea, Bertarelli, Alessandro, Bertinelli, Francesco, Bertolin, Alessandro, Bhat, Pushpalatha, Bianchi, Clarissa, Bianco, Michele, Bishop, William, Black, Kevin, Boattini, Fulvio, Bogacz, Alex, Bonesini, Maurizio, Bordini, Bernardo, de Sousa, Patricia Borges, Bottaro, Salvatore, Bottura, Luca, Boyd, Steven, Breschi, Marco, Broggi, Francesco, Brunoldi, Matteo, Buffat, Xavier, Buonincontri, Laura, Burrows, Philip Nicholas, Burt, Graeme Campbell, Buttazzo, Dario, Caiffi, Barbara, Calatroni, Sergio, Calviani, Marco, Calzaferri, Simone, Calzolari, Daniele, Cantone, Claudio, Capdevilla, Rodolfo, Carli, Christian, Carrelli, Carlo, Casaburo, Fausto, Casarsa, Massimo, Castelli, Luca, Catanesi, Maria Gabriella, Cavallucci, Lorenzo, Cavoto, Gianluca, Celiberto, Francesco Giovanni, Celona, Luigi, Cemmi, Alessia, Ceravolo, Sergio, Cerri, Alessandro, Cerutti, Francesco, Cesarini, Gianmario, Cesarotti, Cari, Chancé, Antoine, Charitonidis, Nikolaos, Chiesa, Mauro, Chiggiato, Paolo, Ciccarella, Vittoria Ludovica, Puviani, Pietro Cioli, Colaleo, Anna, Colao, Francesco, Collamati, Francesco, Costa, Marco, Craig, Nathaniel, Curtin, David, Damerau, Heiko, Da Molin, Giacomo, D'Angelo, Laura, Dasu, Sridhara, de Blas, Jorge, De Curtis, Stefania, De Gersem, Herbert, Delahaye, Jean-Pierre, Del Moro, Tommaso, Denisov, Dmitri, Denizli, Haluk, Dermisek, Radovan, Valdor, Paula Desiré, Desponds, Charlotte, Di Luzio, Luca, Di Meco, Elisa, Diociaiuti, Eleonora, Di Petrillo, Karri Folan, Di Sarcina, Ilaria, Dorigo, Tommaso, Dreimanis, Karlis, Pree, Tristan du, Yildiz, Hatice Duran, Edgecock, Thomas, Fabbri, Siara, Fabbrichesi, Marco, Farinon, Stefania, Ferrand, Guillaume, Somoza, Jose Antonio Ferreira, Fieg, Max, Filthaut, Frank, Fox, Patrick, Franceschini, Roberto, Ximenes, Rui Franqueira, Gallinaro, Michele, Garcia-Sciveres, Maurice, Garcia-Tabares, Luis, Gargiulo, Ruben, Garion, Cedric, Garzelli, Maria Vittoria, Gast, Marco, Generoso, Lisa, Gerber, Cecilia E., Giambastiani, Luca, Gianelle, Alessio, Gianfelice-Wendt, Eliana, Gibson, Stephen, Gilardoni, Simone, Giove, Dario Augusto, Giovinco, Valentina, Giraldin, Carlo, Glioti, Alfredo, Gorzawski, Arkadiusz, Greco, Mario, Grojean, Christophe, Grudiev, Alexej, Gschwendtner, Edda, Gueli, Emanuele, Guilhaudin, Nicolas, Han, Chengcheng, Han, Tao, Hauptman, John Michael, Herndon, Matthew, Hillier, Adrian D, Hillman, Micah, Holmes, Tova Ray, Homiller, Samuel, Jana, Sudip, Jindariani, Sergo, Johannesson, Sofia, Johnson, Benjamin, Jones, Owain Rhodri, Jurj, Paul-Bogdan, Kahn, Yonatan, Kamath, Rohan, Kario, Anna, Karpov, Ivan, Kelliher, David, Kilian, Wolfgang, Kitano, Ryuichiro, Kling, Felix, Kolehmainen, Antti, Kong, K. C., Kosse, Jaap, Krintiras, Georgios, Krizka, Karol, Kumar, Nilanjana, Kvikne, Erik, Kyle, Robert, Laface, Emanuele, Lane, Kenneth, Latina, Andrea, Lechner, Anton, Lee, Junghyun, Lee, Lawrence, Lee, Seh Wook, Lefevre, Thibaut, Leonardi, Emanuele, Lerner, Giuseppe, Li, Peiran, Li, Qiang, Li, Tong, Li, Wei, Lindroos, Mats, Lipton, Ronald, Liu, Da, Liu, Miaoyuan, Liu, Zhen, Voti, Roberto Li, Lombardi, Alessandra, Lomte, Shivani, Long, Kenneth, Longo, Luigi, Lorenzo, José, Losito, Roberto, Low, Ian, Lu, Xianguo, Lucchesi, Donatella, Luo, Tianhuan, Lupato, Anna, Ma, Yang, Machida, Shinji, Madlener, Thomas, Magaletti, Lorenzo, Maggi, Marcello, Durand, Helene Mainaud, Maltoni, Fabio, Manczak, Jerzy Mikolaj, Mandurrino, Marco, Marchand, Claude, Mariani, Francesco, Marin, Stefano, Mariotto, Samuele, Martin-Haugh, Stewart, Masullo, Maria Rosaria, Mauro, Giorgio Sebastiano, Mazzolari, Andrea, Mękała, Krzysztof, Mele, Barbara, Meloni, Federico, Meng, Xiangwei, Mentink, Matthias, Métral, Elias, Miceli, Rebecca, Milas, Natalia, Mohammadi, Abdollah, Moll, Dominik, Montella, Alessandro, Morandin, Mauro, Morrone, Marco, Mulder, Tim, Musenich, Riccardo, Nardecchia, Marco, Nardi, Federico, Nenna, Felice, Neuffer, David, Newbold, David, Novelli, Daniel, Olvegård, Maja, Onel, Yasar, Orestano, Domizia, Osborne, John, Otten, Simon, Torres, Yohan Mauricio Oviedo, Paesani, Daniele, Griso, Simone Pagan, Pagani, Davide, Pal, Kincso, Palmer, Mark, Pampaloni, Alessandra, Panci, Paolo, Pani, Priscilla, Papaphilippou, Yannis, Paparella, Rocco, Paradisi, Paride, Passeri, Antonio, Pasternak, Jaroslaw, Pastrone, Nadia, Pellecchia, Antonello, Piccinini, Fulvio, Piekarz, Henryk, Pieloni, Tatiana, Plouin, Juliette, Portone, Alfredo, Potamianos, Karolos, Potdevin, Joséphine, Prestemon, Soren, Puig, Teresa, Qiang, Ji, Quettier, Lionel, Rabemananjara, Tanjona Radonirina, Radicioni, Emilio, Radogna, Raffaella, Rago, Ilaria Carmela, Ratkus, Andris, Resseguie, Elodie, Reuter, Juergen, Ribani, Pier Luigi, Riccardi, Cristina, Ricciardi, Stefania, Robens, Tania, Robert, Youri, Rogers, Chris, Rojo, Juan, Romagnoni, Marco, Ronald, Kevin, Rosser, Benjamin, Rossi, Carlo, Rossi, Lucio, Rozanov, Leo, Ruhdorfer, Maximilian, Ruiz, Richard, Saini, Saurabh, Sala, Filippo, Salierno, Claudia, Salmi, Tiina, Salvini, Paola, Salvioni, Ennio, Sammut, Nicholas, Santini, Carlo, Saputi, Alessandro, Sarra, Ivano, Scarantino, Giuseppe, Schneider-Muntau, Hans, Schulte, Daniel, Scifo, Jessica, Sen, Tanaji, Senatore, Carmine, Senol, Abdulkadir, Sertore, Daniele, Sestini, Lorenzo, Rêgo, Ricardo César Silva, Simone, Federica Maria, Skoufaris, Kyriacos, Sorbello, Gino, Sorbi, Massimo, Sorti, Stefano, Soubirou, Lisa, Spataro, David, Queiroz, Farinaldo S., Stamerra, Anna, Stapnes, Steinar, Stark, Giordon, Statera, Marco, Stechauner, Bernd Michael, Su, Shufang, Su, Wei, Sun, Xiaohu, Sytov, Alexei, Tang, Jian, Tang, Jingyu, Taylor, Rebecca, Kate, Herman Ten, Testoni, Pietro, Thiele, Leonard Sebastian, Garcia, Rogelio Tomas, Topp-Mugglestone, Max, Torims, Toms, Torre, Riccardo, Tortora, Luca, Tortora, Ludovico, Trifinopoulos, Sokratis, Udongwo, Sosoho-Abasi, Vai, Ilaria, Valente, Riccardo Umberto, van Rienen, Ursula, Van Weelderen, Rob, Vanwelde, Marion, Velev, Gueorgui, Venditti, Rosamaria, Vendrasco, Adam, Verna, Adriano, Vernassa, Gianluca, Verweij, Arjan, Verwilligen, Piet, Villamizar, Yoxara, Vittorio, Ludovico, Vitulo, Paolo, Vojskovic, Isabella, Wang, Dayong, Wang, Lian-Tao, Wang, Xing, Wendt, Manfred, Widorski, Markus, Wozniak, Mariusz, Wu, Yongcheng, Wulzer, Andrea, Xie, Keping, Yang, Yifeng, Yap, Yee Chinn, Yonehara, Katsuya, Yoo, Hwi Dong, You, Zhengyun, Zanetti, Marco, Zaza, Angela, Zhang, Liang, Zhu, Ruihu, Zlobin, Alexander, Zuliani, Davide, and Zurita, José Francisco

Subjects
Physics - Accelerator Physics
Abstract

This document is comprised of a collection of updated preliminary parameters for the key parts of the muon collider. The updated preliminary parameters follow on from the October 2023 Tentative Parameters Report. Particular attention has been given to regions of the facility that are believed to hold greater technical uncertainty in their design and that have a strong impact on the cost and power consumption of the facility. The data is collected from a collaborative spreadsheet and transferred to overleaf.

Published
2024
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2. Interim report for the International Muon Collider Collaboration (IMCC)

Author

Accettura, C., Adrian, S., Agarwal, R., Ahdida, C., Aimé, C., Aksoy, A., Alberghi, G. L., Alden, S., Amapane, N., Amorim, D., Andreetto, P., Anulli, F., Appleby, R., Apresyan, A., Asadi, P., Mahmoud, M. Attia, Auchmann, B., Back, J., Badea, A., Bae, K. J., Bahng, E. J., Balconi, L., Balli, F., Bandiera, L., Barbagallo, C., Barlow, R., Bartoli, C., Bartosik, N., Barzi, E., Batsch, F., Bauce, M., Begel, M., Berg, J. S., Bersani, A., Bertarelli, A., Bertinelli, F., Bertolin, A., Bhat, P., Bianchi, C., Bianco, M., Bishop, W., Black, K., Boattini, F., Bogacz, A., Bonesini, M., Bordini, B., de Sousa, P. Borges, Bottaro, S., Bottura, L., Boyd, S., Breschi, M., Broggi, F., Brunoldi, M., Buffat, X., Buonincontri, L., Burrows, P. N., Burt, G. C., Buttazzo, D., Caiffi, B., Calatroni, S., Calviani, M., Calzaferri, S., Calzolari, D., Cantone, C., Capdevilla, R., Carli, C., Carrelli, C., Casaburo, F., Casarsa, M., Castelli, L., Catanesi, M. G., Cavallucci, L., Cavoto, G., Celiberto, F. G., Celona, L., Cemmi, A., Ceravolo, S., Cerri, A., Cerutti, F., Cesarini, G., Cesarotti, C., Chancé, A., Charitonidis, N., Chiesa, M., Chiggiato, P., Ciccarella, V. L., Puviani, P. Cioli, Colaleo, A., Colao, F., Collamati, F., Costa, M., Craig, N., Curtin, D., D'Angelo, L., Da Molin, G., Damerau, H., Dasu, S., de Blas, J., De Curtis, S., De Gersem, H., Del Moro, T., Delahaye, J. -P., Denisov, D., Denizli, H., Dermisek, R., Valdor, P. Desiré, Desponds, C., Di Luzio, L., Di Meco, E., Di Petrillo, K. F., Di Sarcina, I., Diociaiuti, E., Dorigo, T., Dreimanis, K., Pree, T. du, Edgecock, T., Fabbri, S., Fabbrichesi, M., Farinon, S., Ferrand, G., Somoza, J. A. Ferreira, Fieg, M., Filthaut, F., Fox, P., Franceschini, R., Ximenes, R. Franqueira, Gallinaro, M., Garcia-Sciveres, M., Garcia-Tabares, L., Gargiulo, R., Garion, C., Garzelli, M. V., Gast, M., Gerber, C. E., Giambastiani, L., Gianelle, A., Gianfelice-Wendt, E., Gibson, S., Gilardoni, S., Giove, D. A., Giovinco, V., Giraldin, C., Glioti, A., Gorzawski, A., Greco, M., Grojean, C., Grudiev, A., Gschwendtner, E., Gueli, E., Guilhaudin, N., Han, C., Han, T., Hauptman, J. M., Herndon, M., Hillier, A. D., Hillman, M., Holmes, T. R., Homiller, S., Jana, S., Jindariani, S., Johannesson, S., Johnson, B., Jones, O. R., Jurj, P. -B., Kahn, Y., Kamath, R., Kario, A., Karpov, I., Kelliher, D., Kilian, W., Kitano, R., Kling, F., Kolehmainen, A., Kong, K. C., Kosse, J., Krintiras, G., Krizka, K., Kumar, N., Kvikne, E., Kyle, R., Laface, E., Lane, K., Latina, A., Lechner, A., Lee, J., Lee, L., Lee, S. W., Lefevre, T., Leonardi, E., Lerner, G., Li, P., Li, Q., Li, T., Li, W., Voti, R. Li, Lindroos, M., Lipton, R., Liu, D., Liu, M., Liu, Z., Lombardi, A., Lomte, S., Long, K., Longo, L., Lorenzo, J., Losito, R., Low, I., Lu, X., Lucchesi, D., Luo, T., Lupato, A., Métral, E., Mękała, K., Ma, Y., Mańczak, J. M., Machida, S., Madlener, T., Magaletti, L., Maggi, M., Durand, H. Mainaud, Maltoni, F., Mandurrino, M., Marchand, C., Mariani, F., Marin, S., Mariotto, S., Martin-Haugh, S., Masullo, M. R., Mauro, G. S., Mazzolari, A., Mele, B., Meloni, F., Meng, X., Mentink, M., Miceli, R., Milas, N., Mohammadi, A., Moll, D., Montella, A., Morandin, M., Morrone, M., Mulder, T., Musenich, R., Nardecchia, M., Nardi, F., Neuffer, D., Newbold, D., Novelli, D., Olvegård, M., Onel, Y., Orestano, D., Osborne, J., Otten, S., Torres, Y. M. Oviedo, Paesani, D., Griso, S. Pagan, Pagani, D., Pal, K., Palmer, M., Pampaloni, A., Panci, P., Pani, P., Papaphilippou, Y., Paparella, R., Paradisi, P., Passeri, A., Pastrone, N., Pellecchia, A., Piccinini, F., Piekarz, H., Pieloni, T., Plouin, J., Portone, A., Potamianos, K., Potdevin, J., Prestemon, S., Puig, T., Qiang, J., Quettier, L., Rabemananjara, T. R., Radicioni, E., Radogna, R., Rago, I. C., Ratkus, A., Resseguie, E., Reuter, J., Ribani, P. L., Riccardi, C., Ricciardi, S., Robens, T., Robert, Y., Roger, C., Rojo, J., Romagnoni, M., Ronald, K., Rosser, B., Rossi, C., Rossi, L., Rozanov, L., Ruhdorfer, M., Ruiz, R., Queiroz, F. S., Saini, S., Sala, F., Salierno, C., Salmi, T., Salvini, P., Salvioni, E., Sammut, N., Santini, C., Saputi, A., Sarra, I., Scarantino, G., Schneider-Muntau, H., Schulte, D., Scifo, J., Sen, T., Senatore, C., Senol, A., Sertore, D., Sestini, L., Rêgo, R. C. Silva, Simone, F. M., Skoufaris, K., Sorbello, G., Sorbi, M., Sorti, S., Soubirou, L., Spataro, D., Stamerra, A., Stapnes, S., Stark, G., Statera, M., Stechauner, B. M., Su, S., Su, W., Sun, X., Sytov, A., Tang, J., Taylor, R., Kate, H. Ten, Testoni, P., Thiele, L. S., Garcia, R. Tomas, Mugglestone, M. Topp, Torims, T., Torre, R., Tortora, L. T., Trifinopoulos, S., Udongwo, S. -A., Vai, I., Valente, R. U., van Rienen, U., van Weelderen, R., Vanwelde, M., Velev, G., Venditti, R., Vendrasco, A., Verna, A., Verweij, A., Verwilligen, P., Villamzar, Y., Vittorio, L., Vitulo, P., Vojskovic, I., Wang, D., Wang, L. -T., Wang, X., Wendt, M., Widorski, M., Wozniak, M., Wu, Y., Wulzer, A., Xie, K., Yang, Y., Yap, Y. C., Yonehara, K., Yoo, H. D., You, Z., Zanetti, M., Zaza, A., Zhang, L., Zhu, R., Zlobin, A., Zuliani, D., and Zurita, J. F.

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment
Abstract

The International Muon Collider Collaboration (IMCC) [1] was established in 2020 following the recommendations of the European Strategy for Particle Physics (ESPP) and the implementation of the European Strategy for Particle Physics-Accelerator R&D Roadmap by the Laboratory Directors Group [2], hereinafter referred to as the the European LDG roadmap. The Muon Collider Study (MuC) covers the accelerator complex, detectors and physics for a future muon collider. In 2023, European Commission support was obtained for a design study of a muon collider (MuCol) [3]. This project started on 1st March 2023, with work-packages aligned with the overall muon collider studies. In preparation of and during the 2021-22 U.S. Snowmass process, the muon collider project parameters, technical studies and physics performance studies were performed and presented in great detail. Recently, the P5 panel [4] in the U.S. recommended a muon collider R&D, proposed to join the IMCC and envisages that the U.S. should prepare to host a muon collider, calling this their "muon shot". In the past, the U.S. Muon Accelerator Programme (MAP) [5] has been instrumental in studies of concepts and technologies for a muon collider., Comment: This document summarises the International Muon Collider Collaboration (IMCC) progress and status of the Muon Collider R&D programme

Published
2024

4. Gantries for carbon ions

Author

Pullia, M. G., Felcini, E., Benedetto, E., Dassa, L., De Matteis, E., Donetti, M., Frisella, G., Karppinen, M., Kurfurst, C., Mariotto, S., Mereghetti, A., Mirandola, A., Pella, A., Perini, D., Piacentini, L., Pivi, M. T. F., Prioli, M., Ratkus, A., Rossi, L., Sabbatini, L., Savazzi, S., Stock, M., Torims, T., Uberti, S., Valente, R., Vannozzi, A., and Vretenar, M.

Published
2024
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5. Biomarkers for cognitive impairment in alpha-synucleinopathies: an overview of systematic reviews and meta-analyses

Author

Elisa Mantovani, Alice Martini, Alessandro Dinoto, Chiara Zucchella, Sergio Ferrari, Sara Mariotto, Michele Tinazzi, and Stefano Tamburin

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Cognitive impairment (CI) is common in α-synucleinopathies, i.e., Parkinson’s disease, Lewy bodies dementia, and multiple system atrophy. We summarize data from systematic reviews/meta-analyses on neuroimaging, neurophysiology, biofluid and genetic diagnostic/prognostic biomarkers of CI in α-synucleinopathies. Diagnostic biomarkers include atrophy/functional neuroimaging brain changes, abnormal cortical amyloid and tau deposition, and cerebrospinal fluid (CSF) Alzheimer’s disease (AD) biomarkers, cortical rhythm slowing, reduced cortical cholinergic and glutamatergic and increased cortical GABAergic activity, delayed P300 latency, increased plasma homocysteine and cystatin C and decreased vitamin B12 and folate, increased CSF/serum albumin quotient, and serum neurofilament light chain. Prognostic biomarkers include brain regional atrophy, cortical rhythm slowing, CSF amyloid biomarkers, Val66Met polymorphism, and apolipoprotein-E ε2 and ε4 alleles. Some AD/amyloid/tau biomarkers may diagnose/predict CI in α-synucleinopathies, but single, validated diagnostic/prognostic biomarkers lack. Future studies should include large consortia, biobanks, multi-omics approach, artificial intelligence, and machine learning to better reflect the complexity of CI in α-synucleinopathies.

Published
2024
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6. Application of the international criteria for optic neuritis in the Acute Optic Neuritis Network

Author

Philipp Klyscz, Susanna Asseyer, Ricardo Alonso, Charlotte Bereuter, Omer Bialer, Atira Bick, Sara Carta, John J. Chen, Leila Cohen, Yamit Cohen‐Tayar, Edgar Carnero Contentti, Russell C. Dale, Eoin P. Flanagan, Jonathan A. Gernert, Julian Haas, Joachim Havla, Christoph Heesen, Mark Hellmann, Netta Levin, Pablo Lopez, Itay Lotan, Maria Belen Luis, Sara Mariotto, Christina Mayer, Alvaro Jose Mejia Vergara, Cassandra Ocampo, Susana Ochoa, Frederike C. Oertel, Maja Olszewska, José Luis Peralta Uribe, Jaume Sastre‐Garriga, Dario Scocco, Sudarshini Ramanathan, Natthapon Rattanathamsakul, Fu‐Dong Shi, Jemal Shifa, Ilya Simantov, Sasitorn Siritho, Alon Tiosano, Nanthaya Tisavipat, Isabel Torres, Adi Vaknin Dembinsky, Angela Vidal‐Jordana, Adi Wilf‐Yarkoni, Ti Wu, Sol Zamir, Luis Alfonso Zarco, Hanna G. Zimmermann, Axel Petzold, Friedemann Paul, and Hadas Stiebel‐Kalish

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Objective The first international consensus criteria for optic neuritis (ICON) were published in 2022. We applied these criteria to a prospective, global observational study of acute optic neuritis (ON). Methods We included 160 patients with a first‐ever acute ON suggestive of a demyelinating CNS disease from the Acute Optic Neuritis Network (ACON). We applied the 2022 ICON to all participants and subsequently adjusted the ICON by replacing a missing relative afferent pupillary defect (RAPD) or dyschromatopsia if magnetic resonance imaging pathology of the optical nerve plus optical coherence tomography abnormalities or certain biomarkers are present. Results According to the 2022 ICON, 80 (50%) patients were classified as definite ON, 12 (7%) patients were classified as possible ON, and 68 (43%) as not ON (NON). The main reasons for classification as NON were absent RAPD (52 patients, 76%) or dyschromatopsia (49 patients, 72%). Distribution of underlying ON etiologies was as follows: 78 (49%) patients had a single isolated ON, 41 (26%) patients were diagnosed with multiple sclerosis, 25 (16%) patients with myelin oligodendrocyte glycoprotein antibody‐associated disease, and 15 (9%) with neuromyelitis optica spectrum disorder. The application of the adjusted ON criteria yielded a higher proportion of patients classified as ON (126 patients, 79%). Interpretation According to the 2022 ICON, almost half of the included patients in ACON did not fulfill the requirements for classification of definite or possible ON, particularly due to missing RAPD and dyschromatopsia. Thorough RAPD examination and formal color vision testing are critical to the application of the 2022 ICON.

Published
2024
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8. Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy

Author

Gelpi, Ellen, Reinecke, Raphael, Gaig, Carles, Iranzo, Alex, Sabater, Lidia, Molina-Porcel, Laura, Aldecoa, Iban, Endmayr, Verena, Högl, Birgit, Schmutzhard, Erich, Poewe, Werner, Pfausler, Bettina, Popovic, Mara, Pretnar-Oblak, Janja, Leypoldt, Frank, Matschke, Jakob, Glatzel, Markus, Erro, Elena Maria, Jerico, Ivonne, Caballero, Maria Cristina, Zelaya, Maria Victoria, Mariotto, Sara, Heidbreder, Anna, Kalev, Ognian, Weis, Serge, Macher, Stefan, Berger-Sieczkowski, Evelyn, Ferrari, Julia, Reisinger, Christoph, Klupp, Nikolaus, Tienari, Pentti, Rautila, Osma, Niemelä, Marja, Yilmazer-Hanke, Deniz, Guasp, Mar, Bloem, Bas, Van Gaalen, Judith, Kusters, Benno, Titulaer, Maarten, Fransen, Nina L., Santamaria, Joan, Dawson, Thimoty, Holton, Janice L., Ling, Helen, Revesz, Tamas, Myllykangas, Liisa, Budka, Herbert, Kovacs, Gabor G., Lewerenz, Jan, Dalmau, Josep, Graus, Francesc, Koneczny, Inga, and Höftberger, Romana

Published
2024
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9. Towards a Muon Collider

Author

Accettura, Carlotta, Adams, Dean, Agarwal, Rohit, Ahdida, Claudia, Aimè, Chiara, Amapane, Nicola, Amorim, David, Andreetto, Paolo, Anulli, Fabio, Appleby, Robert, Apresyan, Artur, Apyan, Aram, Arsenyev, Sergey, Asadi, Pouya, Mahmoud, Mohammed Attia, Azatov, Aleksandr, Back, John, Balconi, Lorenzo, Bandiera, Laura, Barlow, Roger, Bartosik, Nazar, Barzi, Emanuela, Batsch, Fabian, Bauce, Matteo, Berg, J. Scott, Bersani, Andrea, Bertarelli, Alessandro, Bertolin, Alessandro, Boattini, Fulvio, Bogacz, Alex, Bonesini, Maurizio, Bordini, Bernardo, Bottaro, Salvatore, Bottura, Luca, Braghieri, Alessandro, Breschi, Marco, Bruhwiler, Natalie, Buffat, Xavier, Buonincontri, Laura, Burrows, Philip, Burt, Graeme, Buttazzo, Dario, Caiffi, Barbara, Calviani, Marco, Calzaferri, Simone, Calzolari, Daniele, Capdevilla, Rodolfo, Carli, Christian, Casaburo, Fausto, Casarsa, Massimo, Castelli, Luca, Catanesi, Maria Gabriella, Cavoto, Gianluca, Celiberto, Francesco Giovanni, Celona, Luigi, Cerri, Alessandro, Cesarini, Gianmario, Cesarotti, Cari, Chachamis, Grigorios, Chance, Antoine, Chen, Siyu, Chien, Yang-Ting, Chiesa, Mauro, Colaleo, Anna, Collamati, Francesco, Collazuol, Gianmaria, Costa, Marco, Craig, Nathaniel, Curatolo, Camilla, Curtin, David, Da Molin, Giacomo, Dam, Magnus, Damerau, Heiko, Dasu, Sridhara, de Blas, Jorge, De Curtis, Stefania, De Matteis, Ernesto, De Rosa, Stefania, Delahaye, Jean-Pierre, Denisov, Dmitri, Denizli, Haluk, Densham, Christopher, Dermisek, Radovan, Di Luzio, Luca, Di Meco, Elisa, Di Micco, Biagio, Dienes, Keith, Diociaiuti, Eleonora, Dorigo, Tommaso, Dudarev, Alexey, Edgecock, Robert, Errico, Filippo, Fabbrichesi, Marco, Farinon, Stefania, Ferrari, Anna, Somoza, Jose Antonio Ferreira, Filthaut, Frank, Fiorina, Davide, Fol, Elena, Forslund, Matthew, Franceschini, Roberto, Ximenes, Rui Franqueira, Gabrielli, Emidio, Gallinaro, Michele, Garosi, Francesco, Giambastiani, Luca, Gianelle, Alessio, Gilardoni, Simone, Giove, Dario Augusto, Giraldin, Carlo, Glioti, Alfredo, Greco, Mario, Greljo, Admir, Groeber, Ramona, Grojean, Christophe, Grudiev, Alexej, Gu, Jiayin, Han, Chengcheng, Han, Tao, Hauptman, John, Henning, Brian, Hermanek, Keith, Herndon, Matthew, Holmes, Tova Ray, Homiller, Samuel, Huang, Guoyuan, Jana, Sudip, Jindariani, Sergo, Kahn, Yonatan, Karpov, Ivan, Kelliher, David, Kilian, Wolfgang, Kolehmainen, Antti, Kong, Kyoungchul, Koppenburg, Patrick, Kreher, Nils, Krintiras, Georgios, Krizka, Karol, Krnjaic, Gordan, Kumar, Nilanjana, Lechner, Anton, Lee, Lawrence, Li, Qiang, Voti, Roberto Li, Lipton, Ronald, Liu, Zhen, Lomte, Shivani, Long, Kenneth, Gomez, Jose Lorenzo, Losito, Roberto, Low, Ian, Lu, Qianshu, Lucchesi, Donatella, Ma, Lianliang, Ma, Yang, Machida, Shinji, Maltoni, Fabio, Mandurrino, Marco, Mansoulie, Bruno, Mantani, Luca, Marchand, Claude, Mariotto, Samuele, Martin-Haugh, Stewart, Marzocca, David, Mastrapasqua, Paola, Mauro, Giorgio, Mazzolari, Andrea, McGinnis, Navin, Meade, Patrick, Mele, Barbara, Meloni, Federico, Mentink, Matthias, Merlassino, Claudia, Metral, Elias, Miceli, Rebecca, Milas, Natalia, Mokhov, Nikolai, Montella, Alessandro, Mulder, Tim, Musenich, Riccardo, Nardecchia, Marco, Nardi, Federico, Neufeld, Niko, Neuffer, David, Onel, Yasar, Orestano, Domizia, Paesani, Daniele, Griso, Simone Pagan, Palmer, Mark, Panci, Paolo, Panico, Giuliano, Paparella, Rocco, Paradisi, Paride, Passeri, Antonio, Pastrone, Nadia, Pellecchia, Antonello, Piccinini, Fulvio, Portone, Alfredo, Potamianos, Karolos, Prioli, Marco, Quettier, Lionel, Radicioni, Emilio, Radogna, Raffaella, Rattazzi, Riccardo, Redigolo, Diego, Reina, Laura, Resseguie, Elodie, Reuter, Jürgen, Ribani, Pier Luigi, Riccardi, Cristina, Ricci, Lorenzo, Ricciardi, Stefania, Ristori, Luciano, Robens, Tania Natalie, Rodejohann, Werner, Rogers, Chris, Romagnoni, Marco, Ronald, Kevin, Rossi, Lucio, Ruiz, Richard, Queiroz, Farinaldo S., Sala, Filippo, Sala, Paola, Salko, Jakub, Salvini, Paola, Salvioni, Ennio, Santiago, Jose, Sarra, Ivano, Esteban, Francisco Javier Saura, Schieck, Jochen, Schulte, Daniel, Selvaggi, Michele, Senatore, Carmine, Senol, Abdulkadir, Sertore, Daniele, Sestini, Lorenzo, Sharma, Varun, Shiltsev, Vladimir, Shu, Jing, Simone, Federica Maria, Simoniello, Rosa, Skoufaris, Kyriacos, Sorbi, Massimo, Sorti, Stefano, Stamerra, Anna, Stapnes, Steinar, Stark, Giordon Holtsberg, Statera, Marco, Stechauner, Bernd, Stolarski, Daniel, Stratakis, Diktys, Su, Shufang, Su, Wei, Sumensari, Olcyr, Sun, Xiaohu, Sundrum, Raman, Swiatlowski, Maximilian J, Sytov, Alexei, Kuchma, Benjamin T., Tait, Tim M. P., Tang, Jian, Tang, Jingyu, Tesi, Andrea, Testoni, Pietro, Thomas, Brooks, Thompson, Emily Anne, Torre, Riccardo, Tortora, Ludovico, Tortora, Luca, Trifinopoulos, Sokratis, Vai, Ilaria, Valente, Riccardo, Valente, Riccardo Umberto, Valente, Marco, Valenti, Alessandro, Valle, Nicolò, van Rienen, Ursula, Venditti, Rosamaria, Verweij, Arjan, Verwilligen, Piet, Vittorio, Ludovico, Vitulo, Paolo, Wang, Liantao, Weber, Hannsjorg, Wozniak, Mariusz, Wu, Richard, Wu, Yongcheng, Wulzer, Andrea, Xie, Keping, Yamamoto, Akira, Yang, Yifeng, Yonehara, Katsuya, Zaza, Angela, Zhao, Xiaoran, Zlobin, Alexander, Zuliani, Davide, and Zurita, Jose

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

A muon collider would enable the big jump ahead in energy reach that is needed for a fruitful exploration of fundamental interactions. The challenges of producing muon collisions at high luminosity and 10~TeV centre of mass energy are being investigated by the recently-formed International Muon Collider Collaboration. This Review summarises the status and the recent advances on muon colliders design, physics and detector studies. The aim is to provide a global perspective of the field and to outline directions for future work., Comment: 118 pages, 103 figures

Published
2023

10. Data Analysis Applied to Driver Profile Data Obtained Through Vehicle Telemetry and Classification Algorithms

Author

de Lima, Raphael Romildo Mariotto, da Rocha Mendes Albano, Giancarlo Pellegrino, da Silva, Jederson Fernando Ribeiro, Reynoso-Meza, Gilberto, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Salgado-Guerrero, Juan Pablo, editor, Vega-Carrillo, Hector Rene, editor, García-Fernández, Gonzalo, editor, and Robles-Bykbaev, Vladimir, editor

Published
2024
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11. Element- and enantiomer-selective visualization of molecular motion in real-time

Author

Mincigrucci, R, Rouxel, JR, Rossi, B, Principi, E, Bottari, C, Catalini, S, Pelli-Cresi, JS, Fainozzi, D, Foglia, L, Simoncig, A, Matruglio, A, Kurdi, G, Capotondi, F, Pedersoli, E, Perucchi, A, Piccirilli, F, Gessini, A, Giarola, M, Mariotto, G, Oppermann, M, Mukamel, S, Bencivenga, F, Chergui, M, and Masciovecchio, C

Abstract

Ultrafast optical-domain spectroscopies allow to monitor in real time the motion of nuclei in molecules. Achieving element-selectivity had to await the advent of time resolved X-ray spectroscopy, which is now commonly carried at X-ray free electron lasers. However, detecting light element that are commonly encountered in organic molecules, remained elusive due to the need to work under vacuum. Here, we present an impulsive stimulated Raman scattering (ISRS) pump/carbon K-edge absorption probe investigation, which allowed observation of the low-frequency vibrational modes involving specific selected carbon atoms in the Ibuprofen RS dimer. Remarkably, by controlling the probe light polarization we can preferentially access the enantiomer of the dimer to which the carbon atoms belong.

Published
2023

15. Evolving patterns in systemic treatment utilization and survival among older patients with advanced cutaneous melanoma

Author

Yoon Duk Hong, Lindsey Enewold, Elad Sharon, Jeremy L. Warner, Amy J. Davidoff, Chris Zeruto, and Angela B. Mariotto

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Introduction In the last decade, melanoma treatment has improved significantly. However, data on population‐level treatment utilization and survival trends among older patients is limited. This study aimed to analyze trends in systemic anticancer therapy (Rx), including the uptake of immune checkpoint inhibitors (ICIs), in conjunction with trends in cause‐specific survival among older patients (66+) diagnosed with advanced melanoma (2008–2019). Methods We used the Surveillance, Epidemiology, and End Results (SEER)‐Medicare Condensed Resource to assess any Rx utilization among patients first diagnosed with advanced melanoma in 2008–2010, 2011–2014, and 2015–2019, stratified by stage, and type of first‐line Rx among patients receiving Rx. The SEER dataset was used to evaluate trends in cause‐specific survival by year of diagnosis. Results Rx utilization (any type) almost doubled, from 28.6% (2008–2010) to 55.4% (2015–2019) for stage 3 melanoma, and from 35.5% to 68.0% for stage 4 melanoma. In 2008–2010, the standard first‐line treatment was cytokines/cytotoxic chemotherapy/other. By 2015–2019, only 5.1% (stage 3) and

Published
2024
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16. Pulsed‐Laser‐Driven CO2 Reduction Reaction for the Control of the Photoluminescence Quantum Yield of Organometallic Gold Nanocomposites

Author

Tahir, Guilherme C. Concas, Mariana Gisbert, Marco Cremona, Fernando Lazaro, Marcelo Eduardo H. Maia da Costa, Suellen D. T. De Barros, Ricardo Q. Aucélio, Tatiana Saint Pierre, José Marcus Godoy, Diogo Mendes, Gino Mariotto, Nicola Daldosso, Francesco Enrichi, Alexandre Cuin, Aldebarã F. Ferreira, Walter M. de Azevedo, Geronimo Perez, Celso SantAnna, Braulio Soares Archanjo, Yordy E. Licea Fonseca, Andre L. Rossi, Francis L. Deepak, Rajwali Khan, Quaid Zaman, Sven Reichenberger, Theo Fromme, Giancarlo Margheri, José R. Sabino, Gabriella Fibbi, Mario Del Rosso, Anastasia Chillà, Francesca Margheri, Anna Laurenzana, and Tommaso Del Rosso

Subjects
CO2 reduction reaction, laser synthesis and processing of colloids in water, organometallic colloidal nanocomposites, photoluminescence quantum yield, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Over the last decade, the CO2 reduction reaction (CO2RR) has been increasingly exploited for the synthesis of high‐value raw materials in gaseous or liquid form, although no examples of CO2 fixation in nanoparticle systems have been demonstrated. Herein, CO2 fixation into solid nanomaterials by laser synthesis and processing of gold colloids in water, traditionally considered a green approach leading to ligand‐free nanoparticles without the formation of by‐products, is reported. If carbon monoxide‐rich gold nanoparticles are observable even after synthesis in deionized water, the presence of CO2 derivatives in alkaline water environment leads to C2 and C3 coupling with the production of carboxylic acids as a typical CO2RR fingerprint. While laser processing of preformed gold colloids is selective for C2 coupling, both C2 and C3 coupling to lactic acid are observed during pulsed laser ablation of a gold target. In the latter case, it is demonstrated that it is possible to synthesize photoluminescent organometallic nanocomposites in the blue spectral region with a quantum yield of about 20% under adequate experimental conditions. In this research, new pathways are offered to be explored in energetics, photonics, catalysis, and synthesis at the nanoscale.

Published
2024
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17. Protocol of a prospective multicenter study on comorbidity impact on multiple sclerosis and antibody-mediated diseases of the central nervous system (COMMIT)

Author

Sara Samadzadeh, Rafl Adnan, Paulina Berglova, Mahdi Barzegar, Birgit Debrabant, Stine Gundtoft Roikjaer, Michael Levy, Axel Petzold, Jacqueline Palace, Eoin P. Flanagan, Sara Mariotto, Soeren T. Skou, Anne Froelich, Itay Lotan, Silvia Messina, Ruth Geraldes, Susanna Asseyer, Hadas Stiebel-Kalish, Frederike Cosima Oertel, Vahid Shaygannejad, Mohammad Ali Sahraian, Ho Jin Kim, Jeffrey L. Bennett, Chotima Böttcher, Hanna G. Zimmermann, Brian G. Weinshenker, Friedemann Paul, and Nasrin Asgari

Subjects
multiple sclerosis, neuromyelitis optica spectrum disorder, myelin oligodendrocyte glycoprotein antibody-associated disease, antibody-mediated diseases of the central nervous system, comorbidity, Immunologic diseases. Allergy, RC581-607
Abstract

Comorbidities in patients with multiple sclerosis (MS) and antibody-mediated diseases of the central nervous system (CNS) including neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein (MOG)-antibody-associated disease (MOGAD) are common and may influence the course of their neurological disease. Comorbidity may contribute to neuronal injury and therefore limit recovery from attacks, accelerate disease progression, and increase disability. This study aims to explore the impact of comorbidity, particularly vascular comorbidity, and related risk factors on clinical and paraclinical parameters of MS, NMOSD and MOGAD. We propose COMMIT, a prospective multicenter study with longitudinal follow-up of patients with MS, NMOSD, and MOGAD, with or without comorbidities, as well as healthy subjects as controls. Subjects will be stratified by age, sex and ethnicity. In consecutive samples we will analyze levels of inflammation and neurodegeneration markers in both fluid and cellular compartments of the peripheral blood and cerebrospinal fluid (CSF) using multiple state-of-the-art technologies, including untargeted proteomics and targeted ultrasensitive ELISA assays and quantitative reverse transcription polymerase chain reaction (RT-qPCR) as well as high-dimensional single-cell technologies i.e., mass cytometry and single-cell RNA sequencing. Algorithm-based data analyses will be used to unravel the relationship between these markers, optical coherence tomography (OCT) and magnetic resonance imaging (MRI), and clinical outcomes including frequency and severity of relapses, long-term disability, and quality of life. The goal is to evaluate the impact of comorbidities on MS, NMOSD, and MOGAD which may lead to development of treatment approaches to improve outcomes of inflammatory demyelinating diseases of the CNS.

Published
2024
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18. A Work Proposal for a Collaborative Study of Magnet Technology for a Future Muon Collider

Author

Bottura, L., Aguglia, D., Auchmann, B., Arndt, T., Beard, J., Bersani, A., Boattini, F., Breschi, M., Caiffi, B., Chaud, X., Dam, M., Debray, F., De Gersem, H., De Matteis, E., Dudarev, A., Farinon, S., Kario, A., Losito, R., Mariotto, S., Mentink, M., Musenich, R., Ogitsu, T., Prioli, M., Quettier, L., Rossi, L., Schulte, D., Senatore, C., Sorbi, M., Statera, M., Kate, H. Ten, Valente, R. U., Yamamoto, A., and Yang, Y.

Subjects
Physics - Accelerator Physics
Abstract

In this paper we elaborate on the nature and challenges for the magnet systems of a muon collider as presently considered within the scope of the International Muon Collider Collaboration (IMCC). We outline the structure of the work proposed over the coming period of five years to study and demonstrate relevant magnet technology. The proposal, which is part of the overall work planned to establish feasibility of a muon collider, is in direct response to the recent recommendations received from the Laboratories Directors Group (LDG). The plan is to profit from joint activities, within the scope of the IMCC and beyond, implemented through direct and EU-funded contributions., Comment: contribution to Snowmass 2021

Published
2022

19. A Muon Collider Facility for Physics Discovery

Author

Stratakis, D., Mokhov, N., Palmer, M., Pastrone, N., Raubenheimer, T., Rogers, C., Schulte, D., Shiltsev, V., Tang, J., Yamamoto, A., Aimè, C., Mahmoud, M. A., Bartosik, N., Barzi, E., Bersani, A., Bertolin, A., Bonesini, M., Caiffi, B., Casarsa, M., Catanesi, M. G., Cerri, A., Curatolo, C., Dam, M., Damerau, H., De Matteis, E., Denizli, H., Di Micco, B., Dorigo, T., Farinon, S., Filthaut, F., Fiorina, D., Giove, D., Greco, M., Grojean, C., Han, T., Jindariani, S., Koppenburg, P., Krizka, K., Li, Q., Liu, Z., Long, K. R., Lucchesi, D., Mariotto, S., Meloni, F., Merlassino, C., Métral, E., Montella, A., Musenich, R., Nardecchia, M., Nardi, F., Neuffer, D., Griso, S. Pagan, Potamianos, K., Prioli, M., Radicioni, E., Reina, L., Riccardi, C., Ristori, L., Rossi, L., Salvini, P., Santiago, J., Senol, A., Sestini, L., Sorbi, M., Stark, G., Statera, M., Sun, X., Vai, I., and Valente, R. U.

Subjects
Physics - Accelerator Physics
Abstract

Muon colliders provide a unique route to deliver high energy collisions that enable discovery searches and precision measurements to extend our understanding of the fundamental laws of physics. The muon collider design aims to deliver physics reach at the highest energies with costs, power consumption and on a time scale that may prove favorable relative to other proposed facilities. In this context, a new international collaboration has formed to further extend the design concepts and performance studies of such a machine. This effort is focused on delivering the elements of a $\sim$10 TeV center of mass (CM) energy design to explore the physics energy frontier. The path to such a machine may pass through lower energy options. Currently a 3 TeV CM stage is considered. Other energy stages could also be explored, e.g. an s-channel Higgs Factory operating at 125 GeV CM. We describe the status of the R&D and design effort towards such a machine and lay out a plan to bring these concepts to maturity as a tool for the high energy physics community., Comment: 23 pages, 3 figures. arXiv admin note: text overlap with arXiv:2201.07895

Published
2022

23. Erratum: Towards a muon collider

Author

Carlotta Accettura, Dean Adams, Rohit Agarwal, Claudia Ahdida, Chiara Aimè, Nicola Amapane, David Amorim, Paolo Andreetto, Fabio Anulli, Robert Appleby, Artur Apresyan, Aram Apyan, Sergey Arsenyev, Pouya Asadi, Mohammed Attia Mahmoud, Aleksandr Azatov, John Back, Lorenzo Balconi, Laura Bandiera, Roger Barlow, Nazar Bartosik, Emanuela Barzi, Fabian Batsch, Matteo Bauce, J. Scott Berg, Andrea Bersani, Alessandro Bertarelli, Alessandro Bertolin, Kevin Black, Fulvio Boattini, Alex Bogacz, Maurizio Bonesini, Bernardo Bordini, Salvatore Bottaro, Luca Bottura, Alessandro Braghieri, Marco Breschi, Natalie Bruhwiler, Xavier Buffat, Laura Buonincontri, Philip N. Burrows, Graeme Burt, Dario Buttazzo, Barbara Caiffi, Marco Calviani, Simone Calzaferri, Daniele Calzolari, Rodolfo Capdevilla, Christian Carli, Fausto Casaburo, Massimo Casarsa, Luca Castelli, Maria Gabriella Catanesi, Lorenzo Cavallucci, Gianluca Cavoto, Francesco Giovanni Celiberto, Luigi Celona, Alessandro Cerri, Gianmario Cesarini, Cari Cesarotti, Grigorios Chachamis, Antoine Chance, Siyu Chen, Yang-Ting Chien, Mauro Chiesa, Anna Colaleo, Francesco Collamati, Gianmaria Collazuol, Marco Costa, Nathaniel Craig, Camilla Curatolo, David Curtin, Giacomo Da Molin, Magnus Dam, Heiko Damerau, Sridhara Dasu, Jorge de Blas, Stefania De Curtis, Ernesto De Matteis, Stefania De Rosa, Jean-Pierre Delahaye, Dmitri Denisov, Haluk Denizli, Christopher Densham, Radovan Dermisek, Luca Di Luzio, Elisa Di Meco, Biagio Di Micco, Keith Dienes, Eleonora Diociaiuti, Tommaso Dorigo, Alexey Dudarev, Robert Edgecock, Filippo Errico, Marco Fabbrichesi, Stefania Farinon, Anna Ferrari, Jose Antonio Ferreira Somoza, Frank Filthaut, Davide Fiorina, Elena Fol, Matthew Forslund, Roberto Franceschini, Rui Franqueira Ximenes, Emidio Gabrielli, Michele Gallinaro, Francesco Garosi, Luca Giambastiani, Alessio Gianelle, Simone Gilardoni, Dario Augusto Giove, Carlo Giraldin, Alfredo Glioti, Mario Greco, Admir Greljo, Ramona Groeber, Christophe Grojean, Alexej Grudiev, Jiayin Gu, Chengcheng Han, Tao Han, John Hauptman, Brian Henning, Keith Hermanek, Matthew Herndon, Tova Ray Holmes, Samuel Homiller, Guoyuan Huang, Sudip Jana, Sergo Jindariani, Paul Bogdan Jurj, Yonatan Kahn, Ivan Karpov, David Kelliher, Wolfgang Kilian, Antti Kolehmainen, Kyoungchul Kong, Patrick Koppenburg, Nils Kreher, Georgios Krintiras, Karol Krizka, Gordan Krnjaic, Benjamin T. Kuchma, Nilanjana Kumar, Anton Lechner, Lawrence Lee, Qiang Li, Roberto Li Voti, Ronald Lipton, Zhen Liu, Shivani Lomte, Kenneth Long, Jose Lorenzo Gomez, Roberto Losito, Ian Low, Qianshu Lu, Donatella Lucchesi, Lianliang Ma, Yang Ma, Shinji Machida, Fabio Maltoni, Marco Mandurrino, Bruno Mansoulie, Luca Mantani, Claude Marchand, Samuele Mariotto, Stewart Martin-Haugh, David Marzocca, Paola Mastrapasqua, Giorgio Mauro, Andrea Mazzolari, Navin McGinnis, Patrick Meade, Barbara Mele, Federico Meloni, Matthias Mentink, Claudia Merlassino, Elias Metral, Rebecca Miceli, Natalia Milas, Nikolai Mokhov, Alessandro Montella, Tim Mulder, Riccardo Musenich, Marco Nardecchia, Federico Nardi, Niko Neufeld, David Neuffer, Daniel Novelli, Yasar Onel, Domizia Orestano, Daniele Paesani, Simone Pagan Griso, Mark Palmer, Paolo Panci, Giuliano Panico, Rocco Paparella, Paride Paradisi, Antonio Passeri, Nadia Pastrone, Antonello Pellecchia, Fulvio Piccinini, Alfredo Portone, Karolos Potamianos, Marco Prioli, Lionel Quettier, Emilio Radicioni, Raffaella Radogna, Riccardo Rattazzi, Diego Redigolo, Laura Reina, Elodie Resseguie, Jürgen Reuter, Pier Luigi Ribani, Cristina Riccardi, Lorenzo Ricci, Stefania Ricciardi, Luciano Ristori, Tania Natalie Robens, Werner Rodejohann, Chris Rogers, Marco Romagnoni, Kevin Ronald, Lucio Rossi, Richard Ruiz, Farinaldo S. Queiroz, Filippo Sala, Jakub Salko, Paola Salvini, Ennio Salvioni, Jose Santiago, Ivano Sarra, Francisco Javier Saura Esteban, Jochen Schieck, Daniel Schulte, Michele Selvaggi, Carmine Senatore, Abdulkadir Senol, Daniele Sertore, Lorenzo Sestini, Varun Sharma, Vladimir Shiltsev, Jing Shu, Federica Maria Simone, Rosa Simoniello, Kyriacos Skoufaris, Massimo Sorbi, Stefano Sorti, Anna Stamerra, Steinar Stapnes, Giordon Holtsberg Stark, Marco Statera, Bernd Stechauner, Daniel Stolarski, Diktys Stratakis, Shufang Su, Wei Su, Olcyr Sumensari, Xiaohu Sun, Raman Sundrum, Maximilian J. Swiatlowski, Alexei Sytov, Tim M. P. Tait, Jingyu Tang, Jian Tang, Andrea Tesi, Pietro Testoni, Brooks Thomas, Emily Anne Thompson, Riccardo Torre, Ludovico Tortora, Luca Tortora, Sokratis Trifinopoulos, Ilaria Vai, Marco Valente, Riccardo Umberto Valente, Alessandro Valenti, Nicolò Valle, Ursula van Rienen, Rosamaria Venditti, Arjan Verweij, Piet Verwilligen, Ludovico Vittorio, Paolo Vitulo, Liantao Wang, Hannsjorg Weber, Mariusz Wozniak, Richard Wu, Yongcheng Wu, Andrea Wulzer, Keping Xie, Akira Yamamoto, Yifeng Yang, Katsuya Yonehara, Sangsik Yoon, Angela Zaza, Xiaoran Zhao, Alexander Zlobin, Davide Zuliani, and Jose Zurita

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published
2024
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25. Analysis of inflammatory markers and tau deposits in an autopsy series of nine patients with anti-IgLON5 disease

Author

Berger-Sieczkowski, Evelyn, Endmayr, Verena, Haider, Carmen, Ricken, Gerda, Jauk, Philipp, Macher, Stefan, Pirker, Walter, Högl, Birgit, Heidbreder, Anna, Schnider, Peter, Bradley-Zechmeister, Eszter, Mariotto, Sara, Koneczny, Inga, Reinecke, Raphael, Kasprian, Gregor, Weber, Corinna, Bergmann, Melanie, Milenkovic, Ivan, Berger, Thomas, Gaig, Carles, Sabater, Lidia, Graus, Francesc, Gelpi, Ellen, and Höftberger, Romana

Published
2023
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26. SARS-CoV-2 antibodies in inflammatory neurological conditions: a multicentre retrospective comparative study

Author

Zivelonghi, Cecilia, Dinoto, Alessandro, Irani, Sarosh R., McKeon, Andrew, Pilotto, Andrea, Padovani, Alessandro, Masciocchi, Stefano, Magni, Eugenio, Mancinelli, Chiara R., Capra, Ruggero, Maniscalco, Giorgia T., Volonghi, Irene, Easton, Ava, Alberti, Daniela, Zanusso, Gianluigi, Monaco, Salvatore, Salvagno, Gian Luca, Lippi, Giuseppe, Ferrari, Sergio, and Mariotto, Sara

Published
2023
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28. Prevalence of cognitive impairment and associated factors in older people

Author

Campos, Ana Carolina Brunatto Falchetti, Teixeira, Iara Gonçalves, Moraes, Nayara de Souza, Cadorin, Isabela de Jesus, Morelli, Patrícia Mariotto, Lidio, Adrielly Vargas, Medeiros, Eduarda Behenck, Garcez, Michelle Lima, Keller, Gabriela Serafim, Kucharska, Ewa, da Rosa, Maria Inês, Ceretta, Luciane Bisognin, Quevedo, João, and Budni, Josiane

Published
2024
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30. Erratum: Towards a muon collider

Author

Accettura, Carlotta, Adams, Dean, Agarwal, Rohit, Ahdida, Claudia, Aimè, Chiara, Amapane, Nicola, Amorim, David, Andreetto, Paolo, Anulli, Fabio, Appleby, Robert, Apresyan, Artur, Apyan, Aram, Arsenyev, Sergey, Asadi, Pouya, Mahmoud, Mohammed Attia, Azatov, Aleksandr, Back, John, Balconi, Lorenzo, Bandiera, Laura, Barlow, Roger, Bartosik, Nazar, Barzi, Emanuela, Batsch, Fabian, Bauce, Matteo, Berg, J. Scott, Bersani, Andrea, Bertarelli, Alessandro, Bertolin, Alessandro, Black, Kevin, Boattini, Fulvio, Bogacz, Alex, Bonesini, Maurizio, Bordini, Bernardo, Bottaro, Salvatore, Bottura, Luca, Braghieri, Alessandro, Breschi, Marco, Bruhwiler, Natalie, Buffat, Xavier, Buonincontri, Laura, Burrows, Philip N., Burt, Graeme, Buttazzo, Dario, Caiffi, Barbara, Calviani, Marco, Calzaferri, Simone, Calzolari, Daniele, Capdevilla, Rodolfo, Carli, Christian, Casaburo, Fausto, Casarsa, Massimo, Castelli, Luca, Catanesi, Maria Gabriella, Cavallucci, Lorenzo, Cavoto, Gianluca, Celiberto, Francesco Giovanni, Celona, Luigi, Cerri, Alessandro, Cesarini, Gianmario, Cesarotti, Cari, Chachamis, Grigorios, Chance, Antoine, Chen, Siyu, Chien, Yang-Ting, Chiesa, Mauro, Colaleo, Anna, Collamati, Francesco, Collazuol, Gianmaria, Costa, Marco, Craig, Nathaniel, Curatolo, Camilla, Curtin, David, Da Molin, Giacomo, Dam, Magnus, Damerau, Heiko, Dasu, Sridhara, de Blas, Jorge, De Curtis, Stefania, De Matteis, Ernesto, De Rosa, Stefania, Delahaye, Jean-Pierre, Denisov, Dmitri, Denizli, Haluk, Densham, Christopher, Dermisek, Radovan, Di Luzio, Luca, Di Meco, Elisa, Di Micco, Biagio, Dienes, Keith, Diociaiuti, Eleonora, Dorigo, Tommaso, Dudarev, Alexey, Edgecock, Robert, Errico, Filippo, Fabbrichesi, Marco, Farinon, Stefania, Ferrari, Anna, Somoza, Jose Antonio Ferreira, Filthaut, Frank, Fiorina, Davide, Fol, Elena, Forslund, Matthew, Franceschini, Roberto, Ximenes, Rui Franqueira, Gabrielli, Emidio, Gallinaro, Michele, Garosi, Francesco, Giambastiani, Luca, Gianelle, Alessio, Gilardoni, Simone, Giove, Dario Augusto, Giraldin, Carlo, Glioti, Alfredo, Greco, Mario, Greljo, Admir, Groeber, Ramona, Grojean, Christophe, Grudiev, Alexej, Gu, Jiayin, Han, Chengcheng, Han, Tao, Hauptman, John, Henning, Brian, Hermanek, Keith, Herndon, Matthew, Holmes, Tova Ray, Homiller, Samuel, Huang, Guoyuan, Jana, Sudip, Jindariani, Sergo, Jurj, Paul Bogdan, Kahn, Yonatan, Karpov, Ivan, Kelliher, David, Kilian, Wolfgang, Kolehmainen, Antti, Kong, Kyoungchul, Koppenburg, Patrick, Kreher, Nils, Krintiras, Georgios, Krizka, Karol, Krnjaic, Gordan, Kuchma, Benjamin T., Kumar, Nilanjana, Lechner, Anton, Lee, Lawrence, Li, Qiang, Voti, Roberto Li, Lipton, Ronald, Liu, Zhen, Lomte, Shivani, Long, Kenneth, Gomez, Jose Lorenzo, Losito, Roberto, Low, Ian, Lu, Qianshu, Lucchesi, Donatella, Ma, Lianliang, Ma, Yang, Machida, Shinji, Maltoni, Fabio, Mandurrino, Marco, Mansoulie, Bruno, Mantani, Luca, Marchand, Claude, Mariotto, Samuele, Martin-Haugh, Stewart, Marzocca, David, Mastrapasqua, Paola, Mauro, Giorgio, Mazzolari, Andrea, McGinnis, Navin, Meade, Patrick, Mele, Barbara, Meloni, Federico, Mentink, Matthias, Merlassino, Claudia, Metral, Elias, Miceli, Rebecca, Milas, Natalia, Mokhov, Nikolai, Montella, Alessandro, Mulder, Tim, Musenich, Riccardo, Nardecchia, Marco, Nardi, Federico, Neufeld, Niko, Neuffer, David, Novelli, Daniel, Onel, Yasar, Orestano, Domizia, Paesani, Daniele, Griso, Simone Pagan, Palmer, Mark, Panci, Paolo, Panico, Giuliano, Paparella, Rocco, Paradisi, Paride, Passeri, Antonio, Pastrone, Nadia, Pellecchia, Antonello, Piccinini, Fulvio, Portone, Alfredo, Potamianos, Karolos, Prioli, Marco, Quettier, Lionel, Radicioni, Emilio, Radogna, Raffaella, Rattazzi, Riccardo, Redigolo, Diego, Reina, Laura, Resseguie, Elodie, Reuter, Jürgen, Ribani, Pier Luigi, Riccardi, Cristina, Ricci, Lorenzo, Ricciardi, Stefania, Ristori, Luciano, Robens, Tania Natalie, Rodejohann, Werner, Rogers, Chris, Romagnoni, Marco, Ronald, Kevin, Rossi, Lucio, Ruiz, Richard, Queiroz, Farinaldo S., Sala, Filippo, Salko, Jakub, Salvini, Paola, Salvioni, Ennio, Santiago, Jose, Sarra, Ivano, Esteban, Francisco Javier Saura, Schieck, Jochen, Schulte, Daniel, Selvaggi, Michele, Senatore, Carmine, Senol, Abdulkadir, Sertore, Daniele, Sestini, Lorenzo, Sharma, Varun, Shiltsev, Vladimir, Shu, Jing, Simone, Federica Maria, Simoniello, Rosa, Skoufaris, Kyriacos, Sorbi, Massimo, Sorti, Stefano, Stamerra, Anna, Stapnes, Steinar, Stark, Giordon Holtsberg, Statera, Marco, Stechauner, Bernd, Stolarski, Daniel, Stratakis, Diktys, Su, Shufang, Su, Wei, Sumensari, Olcyr, Sun, Xiaohu, Sundrum, Raman, Swiatlowski, Maximilian J., Sytov, Alexei, Tait, Tim M. P., Tang, Jingyu, Tang, Jian, Tesi, Andrea, Testoni, Pietro, Thomas, Brooks, Thompson, Emily Anne, Torre, Riccardo, Tortora, Ludovico, Tortora, Luca, Trifinopoulos, Sokratis, Vai, Ilaria, Valente, Marco, Valente, Riccardo Umberto, Valenti, Alessandro, Valle, Nicolò, Rienen, Ursula van, Venditti, Rosamaria, Verweij, Arjan, Verwilligen, Piet, Vittorio, Ludovico, Vitulo, Paolo, Wang, Liantao, Weber, Hannsjorg, Wozniak, Mariusz, Wu, Richard, Wu, Yongcheng, Wulzer, Andrea, Xie, Keping, Yamamoto, Akira, Yang, Yifeng, Yonehara, Katsuya, Yoon, Sangsik, Zaza, Angela, Zhao, Xiaoran, Zlobin, Alexander, Zuliani, Davide, and Zurita, Jose

Published
2024
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33. Diário da queda de Michel Laub: o fragmento como condição de possibilidade para o narrador contemporâneo

Author

Alexandre Mariotto Botton

Subjects
Narrador, Romance Contemporâneo, Michel Laub, Language and Literature, Literature (General), PN1-6790
Abstract

Este artigo, com notas um tanto quanto ensaísticas, talvez, parte de um paradoxo formulado por Theodor Adorno no ensaio “A posição do narrador no romance contemporâneo”. Segundo ele, há um impasse entre a impossibilidade de narrar, que caracteriza o contemporâneo, e exigência de narração, necessária ao romance. No intento de responder a tal paradoxo, traçou-se um contraponto entre o narrador rememorativo de Em Busca do tempo perdido de Marcel Proust e o narrar fragmentado de O Diário da queda de Michel Laub. O artigo sustenta o tecido fragmentário do romance de Laub como uma condição de possibilidade para o narrador contemporâneo. Compõe base teórica deste artigo, principalmente, Adorno (2003 e 1988), Walter Benjamin (1985) e Jeanne-Marie Gagnebin (1999).

Published
2024
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34. Dynamics and Mechanisms of Reproduction of the Ideology of Consumerism by Transnational Data Firms

Author

Stéfano Mariotto de Moura

Subjects
data firms, ideology, consumerism, International Political Economy, Critical Theory, International relations, JZ2-6530
Abstract

Abstract Through the literature review method, this research identifies a non-exhaustive series of dynamics and mechanisms used by data companies such as Google, Facebook, Amazon, and also by the group of companies known as ‘data brokers’, for the reproduction of the ideology of consumerism. A definition for such ideology is also presented. Five dynamics and 17 mechanisms are described within these two categories. The combination of subsets of elements in the second categorization gives rise to the first. The research question addressed here is: how do transnational data companies act in the international reproduction of the ideology of consumerism? It is argued that they take advantage of a deliberate lack of interest, mainly state interest, in regulating how they operate in the International Political Economy, to capture data through general dynamics that result from the articulation of specific data capture mechanisms. Thus, these companies manage to naturalise, ideologically, the act of consuming. The general dynamics identified by the paper were five: personalisation, web concentration, architecture of choice, infrastructural imperialism, and lock-in. The phenomenon is discussed in the light of the Critical Theory of International Relations.

Published
2024
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35. Molecular and functional profiling of chemotolerant cells unveils nucleoside metabolism-dependent vulnerabilities in medulloblastoma

Author

Elena Mariotto, Elena Rampazzo, Roberta Bortolozzi, Fatlum Rruga, Ilaria Zeni, Lorenzo Manfreda, Chiara Marchioro, Martina Canton, Alice Cani, Ruben Magni, Alessandra Luchini, Silvia Bresolin, Giampietro Viola, and Luca Persano

Subjects
Chemotherapy resistance, Medulloblastoma, High throughput drug screening, Antimetabolites, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Chemotherapy resistance is considered one of the main causes of tumor relapse, still challenging researchers for the identification of the molecular mechanisms sustaining its emergence. Here, we setup and characterized chemotherapy-resistant models of Medulloblastoma (MB), one of the most lethal pediatric brain tumors, to uncover targetable vulnerabilities associated to their resistant phenotype. Integration of proteomic, transcriptomic and kinomic data revealed a significant deregulation of several pathways in resistant MB cells, converging to cell metabolism, RNA/protein homeostasis, and immune response, eventually impacting on patient outcome. Moreover, resistant MB cell response to a large library of compounds through a high-throughput screening (HTS), highlighted nucleoside metabolism as a relevant vulnerability of chemotolerant cells, with peculiar antimetabolites demonstrating increased efficacy against them and even synergism with conventional chemotherapeutics. Our results suggest that drug-resistant cells significantly rewire multiple cellular processes, allowing their adaptation to a chemotoxic environment, nevertheless exposing alternative actionable susceptibilities for their specific targeting.

Published
2023
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36. Towards a muon collider

Author

Carlotta Accettura, Dean Adams, Rohit Agarwal, Claudia Ahdida, Chiara Aimè, Nicola Amapane, David Amorim, Paolo Andreetto, Fabio Anulli, Robert Appleby, Artur Apresyan, Aram Apyan, Sergey Arsenyev, Pouya Asadi, Mohammed Attia Mahmoud, Aleksandr Azatov, John Back, Lorenzo Balconi, Laura Bandiera, Roger Barlow, Nazar Bartosik, Emanuela Barzi, Fabian Batsch, Matteo Bauce, J. Scott Berg, Andrea Bersani, Alessandro Bertarelli, Alessandro Bertolin, Kevin Black, Fulvio Boattini, Alex Bogacz, Maurizio Bonesini, Bernardo Bordini, Salvatore Bottaro, Luca Bottura, Alessandro Braghieri, Marco Breschi, Natalie Bruhwiler, Xavier Buffat, Laura Buonincontri, Philip N. Burrows, Graeme Burt, Dario Buttazzo, Barbara Caiffi, Marco Calviani, Simone Calzaferri, Daniele Calzolari, Rodolfo Capdevilla, Christian Carli, Fausto Casaburo, Massimo Casarsa, Luca Castelli, Maria Gabriella Catanesi, Lorenzo Cavallucci, Gianluca Cavoto, Francesco Giovanni Celiberto, Luigi Celona, Alessandro Cerri, Gianmario Cesarini, Cari Cesarotti, Grigorios Chachamis, Antoine Chance, Siyu Chen, Yang-Ting Chien, Mauro Chiesa, Anna Colaleo, Francesco Collamati, Gianmaria Collazuol, Marco Costa, Nathaniel Craig, Camilla Curatolo, David Curtin, Giacomo Da Molin, Magnus Dam, Heiko Damerau, Sridhara Dasu, Jorge de Blas, Stefania De Curtis, Ernesto De Matteis, Stefania De Rosa, Jean-Pierre Delahaye, Dmitri Denisov, Haluk Denizli, Christopher Densham, Radovan Dermisek, Luca Di Luzio, Elisa Di Meco, Biagio Di Micco, Keith Dienes, Eleonora Diociaiuti, Tommaso Dorigo, Alexey Dudarev, Robert Edgecock, Filippo Errico, Marco Fabbrichesi, Stefania Farinon, Anna Ferrari, Jose Antonio Ferreira Somoza, Frank Filthaut, Davide Fiorina, Elena Fol, Matthew Forslund, Roberto Franceschini, Rui Franqueira Ximenes, Emidio Gabrielli, Michele Gallinaro, Francesco Garosi, Luca Giambastiani, Alessio Gianelle, Simone Gilardoni, Dario Augusto Giove, Carlo Giraldin, Alfredo Glioti, Mario Greco, Admir Greljo, Ramona Groeber, Christophe Grojean, Alexej Grudiev, Jiayin Gu, Chengcheng Han, Tao Han, John Hauptman, Brian Henning, Keith Hermanek, Matthew Herndon, Tova Ray Holmes, Samuel Homiller, Guoyuan Huang, Sudip Jana, Sergo Jindariani, Paul Bogdan Jurj, Yonatan Kahn, Ivan Karpov, David Kelliher, Wolfgang Kilian, Antti Kolehmainen, Kyoungchul Kong, Patrick Koppenburg, Nils Kreher, Georgios Krintiras, Karol Krizka, Gordan Krnjaic, Benjamin T. Kuchma, Nilanjana Kumar, Anton Lechner, Lawrence Lee, Qiang Li, Roberto Li Voti, Ronald Lipton, Zhen Liu, Shivani Lomte, Kenneth Long, Jose Lorenzo Gomez, Roberto Losito, Ian Low, Qianshu Lu, Donatella Lucchesi, Lianliang Ma, Yang Ma, Shinji Machida, Fabio Maltoni, Marco Mandurrino, Bruno Mansoulie, Luca Mantani, Claude Marchand, Samuele Mariotto, Stewart Martin-Haugh, David Marzocca, Paola Mastrapasqua, Giorgio Mauro, Andrea Mazzolari, Navin McGinnis, Patrick Meade, Barbara Mele, Federico Meloni, Matthias Mentink, Claudia Merlassino, Elias Metral, Rebecca Miceli, Natalia Milas, Nikolai Mokhov, Alessandro Montella, Tim Mulder, Riccardo Musenich, Marco Nardecchia, Federico Nardi, Niko Neufeld, David Neuffer, Daniel Novelli, Yasar Onel, Domizia Orestano, Daniele Paesani, Simone Pagan Griso, Mark Palmer, Paolo Panci, Giuliano Panico, Rocco Paparella, Paride Paradisi, Antonio Passeri, Nadia Pastrone, Antonello Pellecchia, Fulvio Piccinini, Alfredo Portone, Karolos Potamianos, Marco Prioli, Lionel Quettier, Emilio Radicioni, Raffaella Radogna, Riccardo Rattazzi, Diego Redigolo, Laura Reina, Elodie Resseguie, Jürgen Reuter, Pier Luigi Ribani, Cristina Riccardi, Lorenzo Ricci, Stefania Ricciardi, Luciano Ristori, Tania Natalie Robens, Werner Rodejohann, Chris Rogers, Marco Romagnoni, Kevin Ronald, Lucio Rossi, Richard Ruiz, Farinaldo S. Queiroz, Filippo Sala, Jakub Salko, Paola Salvini, Ennio Salvioni, Jose Santiago, Ivano Sarra, Francisco Javier Saura Esteban, Jochen Schieck, Daniel Schulte, Michele Selvaggi, Carmine Senatore, Abdulkadir Senol, Daniele Sertore, Lorenzo Sestini, Varun Sharma, Vladimir Shiltsev, Jing Shu, Federica Maria Simone, Rosa Simoniello, Kyriacos Skoufaris, Massimo Sorbi, Stefano Sorti, Anna Stamerra, Steinar Stapnes, Giordon Holtsberg Stark, Marco Statera, Bernd Stechauner, Daniel Stolarski, Diktys Stratakis, Shufang Su, Wei Su, Olcyr Sumensari, Xiaohu Sun, Raman Sundrum, Maximilian J. Swiatlowski, Alexei Sytov, Tim M. P. Tait, Jingyu Tang, Jian Tang, Andrea Tesi, Pietro Testoni, Brooks Thomas, Emily Anne Thompson, Riccardo Torre, Ludovico Tortora, Luca Tortora, Sokratis Trifinopoulos, Ilaria Vai, Marco Valente, Riccardo Umberto Valente, Alessandro Valenti, Nicolò Valle, Ursula van Rienen, Rosamaria Venditti, Arjan Verweij, Piet Verwilligen, Ludovico Vittorio, Paolo Vitulo, Liantao Wang, Hannsjorg Weber, Mariusz Wozniak, Richard Wu, Yongcheng Wu, Andrea Wulzer, Keping Xie, Akira Yamamoto, Yifeng Yang, Katsuya Yonehara, Sangsik Yoon, Angela Zaza, Xiaoran Zhao, Alexander Zlobin, Davide Zuliani, and Jose Zurita

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract A muon collider would enable the big jump ahead in energy reach that is needed for a fruitful exploration of fundamental interactions. The challenges of producing muon collisions at high luminosity and 10 TeV centre of mass energy are being investigated by the recently-formed International Muon Collider Collaboration. This Review summarises the status and the recent advances on muon colliders design, physics and detector studies. The aim is to provide a global perspective of the field and to outline directions for future work.

Published
2023
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39. Synthesis and Biological Evaluation of Novel 2-Aroyl Benzofuran-Based Hydroxamic Acids as Antimicrotubule Agents

Author

Elena Mariotto, Martina Canton, Chiara Marchioro, Andrea Brancale, Ernest Hamel, Katia Varani, Fabrizio Vincenzi, Tiziano De Ventura, Chiara Padroni, Giampietro Viola, and Romeo Romagnoli

Subjects
dual-target inhibitors, anticancer agents, benzo[b]furan, tubulin, histone deacetylase (HDAC), Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Because of synergism between tubulin and HDAC inhibitors, we used the pharmacophore fusion strategy to generate potential tubulin–HDAC dual inhibitors. Drug design was based on the introduction of a N-hydroxyacrylamide or a N-hydroxypropiolamide at the 5-position of the 2-aroylbenzo[b]furan skeleton, to produce compounds 6a–i and 11a–h, respectively. Among the synthesized compounds, derivatives 6a, 6c, 6e, 6g, 11a, and 11c showed excellent antiproliferative activity, with IC50 values at single- or double-digit nanomolar levels, against the A549, HT-29, and MCF-7 cells resistant towards the control compound combretastatin A-4 (CA-4). Compounds 11a and 6g were also 10-fold more active than CA-4 against the Hela cell line. When comparing the inhibition of tubulin polymerization versus the HDAC6 inhibitory activity, we found that 6a–g, 6i, 11a, 11c, and 11e, although very potent as inhibitors of tubulin assembly, did not have significant inhibitory activity against HDAC6.

Published
2024
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43. DO OUTRO ENQUANTO ABSOLUTA ALTERIDADE QUE FUNDAMENTA O ENCONTRO

Author

Péricles Mariotto

Subjects
Philosophy. Psychology. Religion
Abstract

Peregrinos de caminhos desejados por uma liberdade que insiste na possibilidade de vencermos as facticidades que nos rodeiam, inquietes diante de uma realidade que pode ser isto ou aquilo sem, no entanto, esgotar-se nisto ou naquilo mas velando-se no pudor do mistério que a envolve e sustenta, suspensos entre uma sístole e uma diástole, espaço ínfimo de tempo no qual já somos passado e o futuro ainda não se fez, por tudo isto, perambulamos nas orlas do manto da vida, véu de Maia em cuja presença apenas o silêncio é possível e coerente.

Published
2024

44. Element- and enantiomer-selective visualization of ibuprofen dimer vibrations

Author

Mincigrucci, R., Rouxel, Jeremy, Rossi, Barbara, Principi, Emiliano, Bottari, Cettina, Catalini, Sara, Fainozzi, Danny, Foglia, Laura, Simoncig, Alberto, Matruglio, Alessia, Kurdi, Gabor, Capotondi, Flavio, Pedersoli, Emanuele, Perucchi, Andrea, Piccirilli, Federica, Gessini, Alessandro, Giarola, Marco, Mariotto, Gino, Mukamel, Shaul, Bencivenga, Filippo, Chergui, Majed, and Masciovecchio, Claudio

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

In chemistry, biology and materials science, the ability to access interatomic interactions and their dynamical evolution has become possible with the advent of femtosecond lasers. In particular, the observation of vibrational wave packets via optical (UV-visible-IR) spectroscopies has been a major achievement as it can track the motion of nuclei within the system. However, optical spectroscopies only detect the effect of the interatomic vibrations on the global electronic surfaces. New tuneable, pulsed and polarized sources of short-wavelength radiation, such as X-Ray Free electron lasers, can overcome this limitation, allowing for chemical and, of primary importance in biochemistry, enantiomeric selectivity. This selectivity may be complemented by taking into account the chemical shifts of atoms belonging to different molecular moieties

Published
2020

45. Cartéis em licitações públicas

Author

Ivan Mariotto

Subjects
direito da concorrência, cartel em licitação, proibição de participar em licitações, Cade, lei de defesa da concorrência., International relations, JZ2-6530, Commercial law, K1000-1395, Competition, HD41
Abstract

Contexto: Os cartéis em licitações públicas estão entre as infrações mais graves à ordem econômica previstas na Lei de Defesa da Concorrência (LDC) e têm ganhado maior relevância nos últimos anos. Dentre as penas previstas na LDC para infrações à ordem econômica está a proibição de participar em licitações públicas por período não inferior a 5 anos, prevista em seu art. 38, II. Objetivo: O artigo analisou a jurisprudência do Conselho Administrativo de Defesa Econômica (Cade), com o objetivo de identificar quais foram os critérios utilizados para justificar a aplicação dessa sanção nas decisões proferidas, bem como a forma pela qual esses critérios foram empregados. A partir disso, buscou-se constatar se há coerência e segurança jurídica na jurisprudência do Tribunal do Cade quanto aos critérios discutidos na aplicação dessa pena. Método: O artigo foi estruturado a partir de uma análise de jurisprudência, com enfoque nos elementos das decisões analisadas. O recorte jurisprudencial foi temático e temporal, considerando as condenações pela proibição de licitar determinadas pelo Cade entre os anos 2007 e 2022. A pesquisa de casos foi feita por meio de busca textual na página de pesquisa pública do Cade, no Sistema Eletrônico de Informações (SEI), e de pedidos de acesso à informação feitos por meio do Serviço de Informação ao Cidadão (SIC). Conclusão: Como resultado, foi possível identificar que apenas 55% das decisões pela aplicação dessa pena foram acompanhadas de algum critério, não havendo uniformidade nos critérios empregados nas decisões. Foram identificados 7 critérios diferentes, que podem ser classificados como positivos ou negativos. Alguns deles trazem ainda problemas e questões relevantes na maneira em que foram aplicados.

Published
2023
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46. A novel cell-based immunofluorescence assay for the detection of autoantibodies to myelin-associated glycoprotein

Author

Sara Mariotto, Piera de Gaspari, Dominik Jäger, Stefanie Hahn, Cindy Forni, Sandra Saschenbrecker, Erik Lattwein, Alessandro Dinoto, and Sergio Ferrari

Subjects
cell-based assay, HNK-1, human natural killer-1, IgM autoantibodies, MAG, myelin-associated glycoprotein, Neurology. Diseases of the nervous system, RC346-429
Abstract

Peripheral neuropathy with antibodies to myelin-associated glycoprotein (MAG) is an autoimmune demyelinating disorder of the peripheral nervous system caused by pathogenic IgM recognizing the human natural killer-1 glycoepitope expressed on MAG. This study aimed to analyze the performance of a new indirect immunofluorescence cell-based assay (CBA, EUROIMMUN) for the detection of anti-MAG IgM. Antibody reactivity was determined in sera from 95 patients with clinical and neurophysiological evidence of anti-MAG-associated neuropathy and in control samples from 55 patients with other forms of peripheral neuropathy. Compared to the results of the gold standard method (ELISA, Bühlmann) and using samples at a dilution of 1:100, the CBA had a sensitivity of 98.9% and a specificity of 100% (PPV 100%, NPV 98.2%). In conclusion, the CBA allows the detection of antibodies to MAG using an easy and standardized technique, and it presents a sensitive and specific alternative to the more time-consuming ELISA. Larger studies are needed to address anti-MAG titer monitoring in parallel with clinical activity.

Published
2023
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