5 results on '"Marie-Pierre Maether"'
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2. Reductive dimerization mechanisms of some streptocyanine dyes
- Author
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Marie-Pierre Maether, Fadia Najjar, Theo Tzedakis, Christiane André-Barrès, Corinne Payrastre, Peter Winterton, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Lebanese University - LU (LEBANON), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Laboratoire de Génie Chimique - LGC (Toulouse, France), Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Lebanese University [Beirut] (LU), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Laboratoire de génie chimique [ancien site de Basso-Cambo] (LGC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT), Laboratoire de Génie Chimique (LGC), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Institut National Polytechnique de Toulouse - INPT (FRANCE)
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Cyclic voltammetry ,Dye ,Chemistry ,General Chemical Engineering ,Glassy carbon electrode ,Inorganic chemistry ,Kinetic energy ,Streptocyanine ,Electron transfer ,[CHIM.GENI]Chemical Sciences/Chemical engineering ,Electrochemistry ,Génie chimique ,Convoluted current ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,Current (fluid) ,Génie des procédés ,Dimerization - Abstract
International audience; Cyclic voltammetric studies of streptocyanine dyes were carried out on a glassy carbon electrode. For dye electroreduction, logarithmic analysis of the convoluted current indicates an EC2 mechanism with dimerization following electron transfer. Relevant kinetic and thermodynamic values are reported.
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- 2014
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3. Comparison of diffusivities data of streptocyanine dyes by electrochemical and NMR-DOSY methods
- Author
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Pierre Lavedan, Fadia Najjar, Theodore Tzedakis, Marie-Pierre Maether, Christiane André-Barrès, Corinne Payrastre, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - INPT (FRANCE), Lebanese University - LU (LEBANON), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Service commun de Résonance Magnétique Nucléaire - RMN (Toulouse, France), Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Lebanese University [Beirut] (LU), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT), Laboratoire de Génie Chimique (LGC), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Laboratoire de génie chimique [ancien site de Basso-Cambo] (LGC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, and Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
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Self-diffusion ,NMR-DOSY ,General Chemical Engineering ,Diffusion ,Biochimie, Biologie Moléculaire ,Analytical chemistry ,010402 general chemistry ,Thermal diffusivity ,Electrochemistry ,01 natural sciences ,Analytical Chemistry ,chemistry.chemical_compound ,[CHIM.GENI]Chemical Sciences/Chemical engineering ,TRACER ,Génie chimique ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,Acetonitrile ,Génie des procédés ,Diffusion coefficient ,010405 organic chemistry ,Limiting current ,0104 chemical sciences ,Convolution potential sweep voltammetry ,Solvent ,chemistry ,Deuterium ,Mutual diffusion - Abstract
International audience; Diffusivity data of streptocyanine dyes in acetonitrile were investigated using both transient voltammetric techniques and NMR-DOSY. Results of voltammetric measurements allow determination of the diffusion coefficient D values in the range of 1.2-1.6 x 10-9 m² s-1 for the target dyes. Deuterated acetonitrile solvent was used for NMR-DOSY experiments and diffusivities of streptocyanines are given after calibration of acetonitrile on its tracer diffusion value of D∗ACN of 4.37 x 10-⁹. The results for the two methods appear to be in good agreement allowing use of the convenient NMR-DOSY method to measure diffusivity of streptocyanine dyes at low concentrations and so giving a direct access to the number of exchanged electrons using limiting current electrochemical techniques. This last method affords a great advantage of obtaining diffusion coefficients by non-electrochemical method.
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- 2012
- Full Text
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4. Synthesis and antiplasmodial activity of streptocyanine/peroxide and streptocyanine/4-aminoquinoline hybrid dyes
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Marie-Pierre Maether, Christiane André-Barrès, Virginie Bernat, Sonia Ladeira, Marie Maturano, Corinne Payrastre, Alexis Valentin, and Henri Vial
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Models, Molecular ,Molecular Structure ,Organic Chemistry ,Plasmodium falciparum ,Stereoisomerism ,Carbocyanines ,Crystallography, X-Ray ,Biochemistry ,Peroxide ,Peroxides ,chemistry.chemical_compound ,Antimalarials ,chemistry ,Parasitic Sensitivity Tests ,4-Aminoquinoline ,Cell Line, Tumor ,Aminoquinolines ,Organic chemistry ,Animals ,Humans ,Physical and Theoretical Chemistry ,Vero Cells - Abstract
Two series of streptocyanine dyes incorporating cyclic peroxide or 4-aminoquinoline moieties are prepared and X-ray diffraction structures for three compounds are determined. All hybrid dyes show good antiplasmodial activity (0.06 to 0.66 μM) and are not or are slightly cytotoxic, except 10a.
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- 2011
5. Synthesis and antimalarial properties of streptocyanine dyes
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Marjorie Maynadier, Corinne Payrastre, Marie-Pierre Maether, Valérie Jullian, Albert Izquierdo, Valérie Guieu, Denis Desoubzdanne, Christiane André-Barrès, Séverine Chevalley, Alexis Valentin, Marie Maturano, and Henri Vial
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Plasmodium ,Stereochemistry ,Plasmodium falciparum ,malaria ,Biology ,Biochemistry ,chemistry.chemical_compound ,Antimalarials ,Mice ,Structure-Activity Relationship ,falciparum ,Cell Line, Tumor ,Drug Discovery ,Structure–activity relationship ,Animals ,Humans ,General Pharmacology, Toxicology and Pharmaceutics ,Cyanine ,Cytotoxicity ,Pharmacology ,Organic Chemistry ,cyanine ,Carbocyanines ,biology.organism_classification ,In vitro ,Chain length ,chemistry ,Cell culture ,cytotoxicity ,Molecular Medicine ,antiprotozoal agents - Abstract
Several streptocyanine dyes were synthesized that contain polymethine chains of varying length. Their in vitro antimalarial activities were evaluated against the virulent P. falciparum parasite. In addition to the influence of polymethine chain length, the effects of structural modifications at nitrogen end groups, para substitution of the phenyl groups, and counter-anions were studied. The most potent antimalarial activities were found for heptacarbon chain streptocyanines, with an IC(50) value of 60 nM. Interestingly, most of the compounds were less cytotoxic toward the mammalian cells tested. The best selective toxicity profiles were found for pentacarbon chain streptocyanines, which have a good in vitro specificity index.
- Published
- 2009
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