4 results on '"Marie Stévant"'
Search Results
2. A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial.
- Author
-
Yuejun Liu, Aurélie Cotillard, Camille Vatier, Jean-Philippe Bastard, Soraya Fellahi, Marie Stévant, Omran Allatif, Clotilde Langlois, Séverine Bieuvelet, Amandine Brochot, Angèle Guilbot, Karine Clément, and Salwa W Rizkalla
- Subjects
Medicine ,Science - Abstract
Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.Our aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome being change in fasting plasma glucose (FPG) level. Other parameters of plasma glucose homeostasis, lipid profile, adiposity and inflammatory markers were also assessed.In a randomized, double-blind, placebo-controlled study, 62 subjects with a FPG level ranging from 5.55 to 7 mmol/L and a body mass index ≥ 25 kg/m(2), unwilling to change their dietary and physical activity habits, were allocated to receive a 4-month treatment with either 1.2 g/day of the dietary supplement or placebo. Patients were followed up until 6 months post-randomization.Four-month treatment with the dietary supplement decreased FPG compared to placebo (-0.24 ± 0.50 vs +0.12 ± 0.59 mmol/L, respectively, p = 0.02), without detectable significant changes in HbA1c. Insulin sensitivity markers, plasma insulin, plasma lipids and inflammatory markers did not differ between the treatment groups. Although there were no significant differences in changes in body weight and energy or macronutrient intakes between the two groups, fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02). Subjects with a higher FPG level and a milder inflammatory state at baseline benefited most from the dietary supplement.Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes.ClinicalTrials.gov NCT01530685.
- Published
- 2015
- Full Text
- View/download PDF
3. Curative diet supplementation with a melon superoxide dismutase reduces adipose tissue in obese hamsters by improving insulin sensitivity
- Author
-
Marie Stévant, Lucie Knabe, Dominique Lacan, Julie Carillon, Jean-Paul Cristol, Anne Montalban, Jean-Max Rouanet, and Mayoura Keophiphath
- Subjects
Male ,medicine.medical_specialty ,Lipolysis ,Adipose tissue ,medicine.disease_cause ,Antioxidants ,Superoxide dismutase ,chemistry.chemical_compound ,Insulin resistance ,Fibrosis ,Superoxides ,Adipocyte ,Internal medicine ,medicine ,Adipocytes ,Animals ,Obesity ,Glutathione Peroxidase ,biology ,Mesocricetus ,Superoxide Dismutase ,Body Weight ,medicine.disease ,Catalase ,Cucurbitaceae ,Oxidative Stress ,Endocrinology ,chemistry ,Adipose Tissue ,Dietary Supplements ,biology.protein ,Metabolic syndrome ,Insulin Resistance ,Oxidative stress ,Food Science ,Biotechnology - Abstract
Scope Obesity-related metabolic syndrome is often associated with a decrease of insulin sensitivity, inducing several modifications. However, dietary antioxidants could prevent insulin resistance. We have previously shown the preventive effects of a melon superoxide dismutase (SOD) in obese hamsters. However, its antioxidant effects have never been studied on adipose tissue. Methods and results We evaluated the effects of a 1-month curative supplementation with SODB on the adipose tissue of obese hamsters. Animals received either a standard diet or a cafeteria diet for 15 wk. Cafeteria diet induced obesity and related disorders, including insulin resistance and oxidative stress, in the abdominal adipose tissue. After SODB supplementation, the adipose tissue weight was decreased, probably by activating adipocytes lipolysis and thus reducing their size. SODB treatment also resulted in abdominal adipose tissue fibrosis reduction. Finally, SODB administration increased the expression of endogenous antioxidant enzymes and thus reduced oxidative stress and insulin resistance. The improvement of insulin sensitivity observed after SODB treatment could explain adipocyte lipolysis activation and fibrosis reduction. Conclusion These findings demonstrate that a dietary SOD supplementation could be a useful strategy against obesity-related modifications in adipose tissue.
- Published
- 2013
4. A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial
- Author
-
Séverine Bieuvelet, Salwa W. Rizkalla, Camille Vatier, Aurélie Cotillard, Marie Stévant, Jean-Philippe Bastard, Karine Clément, Amandine Brochot, Angèle Guilbot, Yuejun Liu, Omran Allatif, Clotilde Langlois, Soraya Fellahi, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AdipoPhYt, Groupe PiLeJe, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and HAL-UPMC, Gestionnaire
- Subjects
Adult ,Blood Glucose ,Chromium ,Male ,medicine.medical_specialty ,Cinnamomum zeylanicum ,Placebo-controlled study ,lcsh:Medicine ,Overweight ,Placebo ,Placebos ,Prediabetic State ,Double-Blind Method ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Obesity ,Prediabetes ,lcsh:Science ,Aged ,2. Zero hunger ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Multidisciplinary ,medicine.diagnostic_test ,Plant Extracts ,business.industry ,Carnosine ,Muscles ,lcsh:R ,Correction ,Fasting ,Middle Aged ,medicine.disease ,3. Good health ,Endocrinology ,Diabetes Mellitus, Type 2 ,Dietary Supplements ,Body Composition ,Lean body mass ,lcsh:Q ,Female ,medicine.symptom ,business ,Lipid profile ,Body mass index ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Research Article - Abstract
Background Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue. Objectives Our aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome being change in fasting plasma glucose (FPG) level. Other parameters of plasma glucose homeostasis, lipid profile, adiposity and inflammatory markers were also assessed. Methods In a randomized, double-blind, placebo-controlled study, 62 subjects with a FPG level ranging from 5.55 to 7 mmol/L and a body mass index ≥25 kg/m2, unwilling to change their dietary and physical activity habits, were allocated to receive a 4-month treatment with either 1.2 g/day of the dietary supplement or placebo. Patients were followed up until 6 months post-randomization. Results Four-month treatment with the dietary supplement decreased FPG compared to placebo (-0.24±0.50 vs +0.12±0.59 mmol/L, respectively, p = 0.02), without detectable significant changes in HbA1c. Insulin sensitivity markers, plasma insulin, plasma lipids and inflammatory markers did not differ between the treatment groups. Although there were no significant differences in changes in body weight and energy or macronutrient intakes between the two groups, fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02). Subjects with a higher FPG level and a milder inflammatory state at baseline benefited most from the dietary supplement. Conclusions Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes. Trial Registration ClinicalTrials.gov NCT01530685
- Published
- 2015
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.