Back to Search
Start Over
A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial
- Source :
- PLoS ONE, PLoS ONE, Public Library of Science, 2015, 10 (9), pp. e0138646. ⟨10.1371/journal.pone.0138646⟩, PLoS ONE, 2015, 10 (9), pp. e0138646. ⟨10.1371/journal.pone.0138646⟩, PLoS ONE, Vol 10, Iss 9, p e0138646 (2015)
- Publication Year :
- 2015
- Publisher :
- Public Library of Science (PLoS), 2015.
-
Abstract
- Background Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue. Objectives Our aim was to evaluate the effects of 4-month treatment with a dietary supplement containing cinnamon, chromium and carnosine in moderately obese or overweight pre-diabetic subjects, the primary outcome being change in fasting plasma glucose (FPG) level. Other parameters of plasma glucose homeostasis, lipid profile, adiposity and inflammatory markers were also assessed. Methods In a randomized, double-blind, placebo-controlled study, 62 subjects with a FPG level ranging from 5.55 to 7 mmol/L and a body mass index ≥25 kg/m2, unwilling to change their dietary and physical activity habits, were allocated to receive a 4-month treatment with either 1.2 g/day of the dietary supplement or placebo. Patients were followed up until 6 months post-randomization. Results Four-month treatment with the dietary supplement decreased FPG compared to placebo (-0.24±0.50 vs +0.12±0.59 mmol/L, respectively, p = 0.02), without detectable significant changes in HbA1c. Insulin sensitivity markers, plasma insulin, plasma lipids and inflammatory markers did not differ between the treatment groups. Although there were no significant differences in changes in body weight and energy or macronutrient intakes between the two groups, fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02). Subjects with a higher FPG level and a milder inflammatory state at baseline benefited most from the dietary supplement. Conclusions Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes. Trial Registration ClinicalTrials.gov NCT01530685
- Subjects :
- Adult
Blood Glucose
Chromium
Male
medicine.medical_specialty
Cinnamomum zeylanicum
Placebo-controlled study
lcsh:Medicine
Overweight
Placebo
Placebos
Prediabetic State
Double-Blind Method
Internal medicine
Diabetes mellitus
medicine
Humans
Obesity
Prediabetes
lcsh:Science
Aged
2. Zero hunger
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
Multidisciplinary
medicine.diagnostic_test
Plant Extracts
business.industry
Carnosine
Muscles
lcsh:R
Correction
Fasting
Middle Aged
medicine.disease
3. Good health
Endocrinology
Diabetes Mellitus, Type 2
Dietary Supplements
Body Composition
Lean body mass
lcsh:Q
Female
medicine.symptom
business
Lipid profile
Body mass index
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....7a23ec4ea8510e2a554d2146c02389f0