1. Does low concentration mycotoxin exposure induce toxicity in HepG2 cells through oxidative stress?
- Author
-
Mercedes Taroncher, Ana Juan-García, María-José Ruiz, Maria-Chiari Pigni, and Maria-Natalia Diana
- Subjects
Time Factors ,Cell Survival ,Health, Toxicology and Mutagenesis ,Mitochondria, Liver ,Hepatic carcinoma ,010501 environmental sciences ,Toxicology ,medicine.disease_cause ,01 natural sciences ,Patulin ,Inhibitory Concentration 50 ,03 medical and health sciences ,chemistry.chemical_compound ,medicine ,Humans ,Mycotoxin ,Volume concentration ,0105 earth and related environmental sciences ,Membrane Potential, Mitochondrial ,0303 health sciences ,Dose-Response Relationship, Drug ,Toxin ,Chemistry ,030302 biochemistry & molecular biology ,food and beverages ,Hep G2 Cells ,Mycotoxins ,Molecular biology ,digestive system diseases ,Oxidative Stress ,T-2 Toxin ,Hepg2 cells ,Toxicity ,Hepatocytes ,Lipid Peroxidation ,Reactive Oxygen Species ,Trichothecenes ,Oxidative stress - Abstract
The purpose of this study was to determine whether exposure to low concentrations of deoxynivalenol (DON), T-2 toxin (T-2) and patulin (PAT) in a human hepatocellular carcinoma cell line (HepG2) exerts toxic effects through mechanisms related to oxidative stress, and how cells deal with such exposure. Cell viability was determined by the MTT and protein content (PC) assays over 24, 48 and 72 h. The IC
- Published
- 2020
- Full Text
- View/download PDF