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Does low concentration mycotoxin exposure induce toxicity in HepG2 cells through oxidative stress?

Authors :
Mercedes Taroncher
Ana Juan-García
María-José Ruiz
Maria-Chiari Pigni
Maria-Natalia Diana
Source :
Toxicology Mechanisms and Methods. 30:417-426
Publication Year :
2020
Publisher :
Informa UK Limited, 2020.

Abstract

The purpose of this study was to determine whether exposure to low concentrations of deoxynivalenol (DON), T-2 toxin (T-2) and patulin (PAT) in a human hepatocellular carcinoma cell line (HepG2) exerts toxic effects through mechanisms related to oxidative stress, and how cells deal with such exposure. Cell viability was determined by the MTT and protein content (PC) assays over 24, 48 and 72 h. The IC

Details

ISSN :
15376524 and 15376516
Volume :
30
Database :
OpenAIRE
Journal :
Toxicology Mechanisms and Methods
Accession number :
edsair.doi.dedup.....3cdcf45abd0763211f4132b3141dc630
Full Text :
https://doi.org/10.1080/15376516.2020.1757000