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Does low concentration mycotoxin exposure induce toxicity in HepG2 cells through oxidative stress?
- Source :
- Toxicology Mechanisms and Methods. 30:417-426
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- The purpose of this study was to determine whether exposure to low concentrations of deoxynivalenol (DON), T-2 toxin (T-2) and patulin (PAT) in a human hepatocellular carcinoma cell line (HepG2) exerts toxic effects through mechanisms related to oxidative stress, and how cells deal with such exposure. Cell viability was determined by the MTT and protein content (PC) assays over 24, 48 and 72 h. The IC
- Subjects :
- Time Factors
Cell Survival
Health, Toxicology and Mutagenesis
Mitochondria, Liver
Hepatic carcinoma
010501 environmental sciences
Toxicology
medicine.disease_cause
01 natural sciences
Patulin
Inhibitory Concentration 50
03 medical and health sciences
chemistry.chemical_compound
medicine
Humans
Mycotoxin
Volume concentration
0105 earth and related environmental sciences
Membrane Potential, Mitochondrial
0303 health sciences
Dose-Response Relationship, Drug
Toxin
Chemistry
030302 biochemistry & molecular biology
food and beverages
Hep G2 Cells
Mycotoxins
Molecular biology
digestive system diseases
Oxidative Stress
T-2 Toxin
Hepg2 cells
Toxicity
Hepatocytes
Lipid Peroxidation
Reactive Oxygen Species
Trichothecenes
Oxidative stress
Subjects
Details
- ISSN :
- 15376524 and 15376516
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Toxicology Mechanisms and Methods
- Accession number :
- edsair.doi.dedup.....3cdcf45abd0763211f4132b3141dc630
- Full Text :
- https://doi.org/10.1080/15376516.2020.1757000