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4 results on '"Maria Gleiziane Araújo Franca"'

1. In Vitro Evaluation of Photodynamic Activity of Plant Extracts from Senna Species against Microorganisms of Medical and Dental Interest

Author

Analú Barros de Oliveira, Túlio Morandin Ferrisse, Sarah Raquel de Annunzio, Maria Gleiziane Araújo Franca, Maria Goretti de Vasconcelos Silva, Alberto José Cavalheiro, Carla Raquel Fontana, and Fernanda Lourenção Brighenti

Subjects
antimicrobial photodynamic therapy, natural photosensitizer, Senna spp., bioprospecting, Pharmacy and materia medica, RS1-441
Abstract

Background: Bacterial resistance requires new treatments for infections. In this context, antimicrobial photodynamic therapy (aPDT) is an effective and promising option. Objectives: Three plant extracts (Senna splendida, Senna alata, and Senna macranthera) were evaluated as photosensitizers for aPDT. Methods: Cutibacterium acnes (ATCC 6919), Streptococcus mutans (ATCC 35668), Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), and Candida albicans (ATCC 90028) were evaluated. Reactive oxygen species production was also verified. Oral keratinocytes assessed cytotoxicity. LC-DAD-MS analysis identified the chemical components of the evaluated extracts. Results: Most species cultured in the planktonic phase showed total microbial reduction (>6 log10 CFU/mL/p < 0.0001) for all extracts. C. albicans cultured in biofilm showed total microbial reduction (7.68 log10 CFU/mL/p < 0.0001) for aPDT mediated by all extracts. Extracts from S. macranthera and S. alata produced the highest number of reactive oxygen species (p < 0.0001). The S. alata extract had the highest cell viability. The LC-DAD-MS analysis of active extracts showed one naphthopyrone and seven anthraquinones as potential candidates for photoactive compounds. Conclusion: This study showed that aPDT mediated by Senna spp. was efficient in microbial suspension and biofilm of microorganisms of medical and dental interest.

Published
2023
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2. Chemical composition, in vitro cytotoxic and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macranthera

Author

Anderson F. de Sousa, Maria Gleiziane Araújo Franca, Fátima de Cássia Evangelista de Oliveira, Maria Teresa Salles Trevisan, Maria Goretti de Vasconcelos Silva, Daniele Rodrigues de Lima, Cláudia Pessoa, Cristiane Félix de Paiva, Alberto José Cavalheiro, Federal University of Ceará, and Universidade Estadual Paulista (UNESP)

Subjects
Antioxidant, ABTS, antioxidant, biology, Traditional medicine, DPPH, Senna, medicine.medical_treatment, Senna macranthera, Organic Chemistry, Plant Science, acetylcholinesterase, biology.organism_classification, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, Rutin, chemistry, Senna spectabilis, medicine, cytotoxicity, Quercetin
Abstract

Made available in DSpace on 2022-05-01T10:51:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 In this study, we investigated the phenolic and antioxidant content, cytotoxic, and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macranthera. The antioxidant activities performed by the DPPH and ABTS methods showed that the extracts possess good antioxidant activity, with emphasis on the S. macranthera extract, which obtained results very similar to the rutin pattern. In the evaluation of the cytotoxic activity, the species S. spectabilis var. excelsa presented expressive cytotoxicity against the cellular lines PC3 and HL60 with IC50 values 21.08 and 31.37 μg mL−1, respectively. The results of anticholinesterase activity showed that both the plants induced enzyme inhibition, reaching 14 mm of inhibition in the case of S. spectabilis var. excelsa. The good results obtained in this work may be related to the presence of compounds such as apigenin-7-apioglucoside, quercetin 3,4'-diglucoside, cassine and spectaline identified in the extracts in our previous work. Department of Organic and Inorganic Chemistry/Department of Analytical Chemistry and Physical-Chemistry Federal University of Ceará Department of Physiology and Pharmacology Federal University of Ceará Chemistry Institute São Paulo State University - UNESP Chemistry Institute São Paulo State University - UNESP

Published
2021
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3. POTENCIAL ANTIBACTERIANO DO COGUMELO COMESTÍVEL Pleurotus ostreatus FRENTE À Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853 E Escherichia coli ATCC 25922

Author

Daniele Rodrigues de Lima, Francisco Lucas Alves Batista, Luiz Francisco Wemmenson Gonçalves Moura, Fábio Roger Vasconcelos, Silvio Alencar Cândido Sobrinho, Maria Gleiziane Araújo Franca, Francisco Ernani Alves Magalhães, Maria Izabel Florindo Guedes, Eduardo Augusto Torres da Silva Filho, Márcia Rocha Torres, and Messias Vidal de Oliveira

Subjects
biology, Pseudomonas aeruginosa, Staphylococcus aureus, Chemistry, General Engineering, medicine, General Earth and Planetary Sciences, Pleurotus ostreatus, biology.organism_classification, medicine.disease_cause, Escherichia coli, General Environmental Science, Microbiology
Abstract

Este trabalho reporta o potencial antibacteriano do cogumelo comestivel Pleurotus ostreatus . Extratos orgânicos, bem como β-glucânico e quitosânico, ambos nas concentracoes de 100, 300 e 500 ppm, foram submetidos a ensaios de disco-difusao contra quatro bacterias padroes: duas Gram positivas ( Staphylococcus aureus ATCC 25923 e Enterococcus faecalis ATCC 29212) e duas Gram negativas ( Escherichia coli ATCC 25922 e Pseudomonas aeruginosa ATCC 27853). Os extratos que apresentaram halo de inibicao (HI) do crescimento bacteriano iguais a 8 mm foram classificados como ativos. Dos extratos testados, o extrato β-glucânico se mostrou ativo, em ambas concentracoes, contra a bacteria Pseudomonas aeruginosa ATCC 27853 e na concentracao de 500 ppm contra as bacterias Staphylococcus aureus ATCC 25923 e Escherichia coli ATCC 25922. O extrato quitosânico apresentou atividade somente contra Pseudomonas aeruginosa ATCC 27853 na concentracao de 500 ppm. Estes resultados sao considerados promissores, pois apontam o extrato β-glucânico com potencial contra bacterias Gram positivas e Gram negativas. Futuros estudos bioguiados sob a acao antibacteriana desse extrato devem ser realizados para producao, purificacao e caracterizacao fisico-quimica do constituinte bioativo de interesse farmacologico.

Published
2017

4. Potencial antifúngico de quitosanases extracelulares de Fusarium solani FA14 contra os fitopatógenos Aspergillus niger, Colletotrichum gloeosporioides e Lasiodiplodia theobromae

Author

Samuel Alves Bezerra Neto, Daniele Rodrigues de Lima, Francisco das Chagas Oliveira Freire, Maria Izabel Florindo Guedes, Erlândia Alves Magalhães, Luiz Francisco Wemmenson Gonçalves Moura, Cristiane Félix de Paiva, Francisco Ernani Alves Magalhães, Maria Gleiziane Araújo Franca, Francisco Lucas Alves Batista, Messias Vital Oliveira, and Lorena Nogueira Frota da Costa

Subjects
General Earth and Planetary Sciences, General Environmental Science
Abstract

O trabalho reporta o potencial antifungico de quitosanases extracelulares do fungo Fusarium solani FA14 contra os fitopatogenos Aspergillus niger , Colletotrichum gloeosporioides e Lasiodiplodia theobromae . Inicialmente, a cepa foi submetida a ensaio de atividade quitosanase (AQ) e se mostrou ativa, com valor de AQ igual a 1,1 significantemente igual (p

Published
2016

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