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Chemical composition, in vitro cytotoxic and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macranthera
- Source :
- Scopus, Repositório Institucional da UNESP, Universidade Estadual Paulista (UNESP), instacron:UNESP
- Publication Year :
- 2021
- Publisher :
- Taylor & Francis, 2021.
-
Abstract
- Made available in DSpace on 2022-05-01T10:51:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 In this study, we investigated the phenolic and antioxidant content, cytotoxic, and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macranthera. The antioxidant activities performed by the DPPH and ABTS methods showed that the extracts possess good antioxidant activity, with emphasis on the S. macranthera extract, which obtained results very similar to the rutin pattern. In the evaluation of the cytotoxic activity, the species S. spectabilis var. excelsa presented expressive cytotoxicity against the cellular lines PC3 and HL60 with IC50 values 21.08 and 31.37 μg mL−1, respectively. The results of anticholinesterase activity showed that both the plants induced enzyme inhibition, reaching 14 mm of inhibition in the case of S. spectabilis var. excelsa. The good results obtained in this work may be related to the presence of compounds such as apigenin-7-apioglucoside, quercetin 3,4'-diglucoside, cassine and spectaline identified in the extracts in our previous work. Department of Organic and Inorganic Chemistry/Department of Analytical Chemistry and Physical-Chemistry Federal University of Ceará Department of Physiology and Pharmacology Federal University of Ceará Chemistry Institute São Paulo State University - UNESP Chemistry Institute São Paulo State University - UNESP
- Subjects :
- Antioxidant
ABTS
antioxidant
biology
Traditional medicine
DPPH
Senna
medicine.medical_treatment
Senna macranthera
Organic Chemistry
Plant Science
acetylcholinesterase
biology.organism_classification
Biochemistry
Analytical Chemistry
chemistry.chemical_compound
Rutin
chemistry
Senna spectabilis
medicine
cytotoxicity
Quercetin
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus, Repositório Institucional da UNESP, Universidade Estadual Paulista (UNESP), instacron:UNESP
- Accession number :
- edsair.doi.dedup.....e22a2f2ef462697f260d2566772293e0
- Full Text :
- https://doi.org/10.6084/m9.figshare.17059742