1. Differential Inductive Sensor for Continuous Non-Invasive Cell Growth Monitoring in Disposable Bioreactors
- Author
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Maria Allers, Tobias Reinecke, Tamanna Nagraik, Dörte Solle, Kai Bakes, Marc Berger, Thomas Scheper, and Stefan Zimmermann
- Subjects
cell growth monitoring ,single use bioreactor ,inductive permittivity measurements ,dielectric spectroscopy ,differential transformer ,General Works - Abstract
In this work, we present a low-cost sensor system for continuous non-invasive cell growth monitoring, especially for single use bioreactor (SUB) applications. The sensor system is based on a differential transformer. Using this differential setup, the influence of the primary magnetic flux is eliminated from the measuring signal, enabling highly sensitive non-invasive detection of permittivity changes in the culture medium. To evaluate the sensor, E. coli cultivations are performed and the cell density is measured through the polymer foil of a SUB. We found a linear dependency with low data scattering between measuring signal and cell density.
- Published
- 2017
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