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18 results on '"Margiotta D.P.E."'

1. Guidelines for biomarkers in autoimmune rheumatic diseases - evidence based analysis

Author

Giacomelli, R. Afeltra, A. Alunno, A. Bartoloni-Bocci, E. Berardicurti, O. Bombardieri, M. Bortoluzzi, A. Caporali, R. Caso, F. Cervera, R. Chimenti, M.S. Cipriani, P. Coloma, E. Conti, F. D'Angelo, S. De Vita, S. Di Bartolomeo, S. Distler, O. Doria, A. Feist, E. Fisher, B.A. Gerosa, M. Gilio, M. Guggino, G. Liakouli, V. Margiotta, D.P.E. Meroni, P. Moroncini, G. Perosa, F. Prete, M. Priori, R. Rebuffi, C. Ruscitti, P. Scarpa, R. Shoenfeld, Y. Todoerti, M. Ursini, F. Valesini, G. Vettori, S. Vitali, C. Tzioufas, A.G.

Abstract

Autoimmune rheumatic diseases are characterised by an abnormal immune system response, complement activation, cytokines dysregulation and inflammation. In last years, despite many progresses in managing these patients, it has been shown that clinical remission is reached in less than 50% of patients and a personalised and tailored therapeutic approach is still lacking resulting in a significant gap between guidelines and real-world practice. In this context, the need for biomarkers facilitating early diagnosis and profiling those individuals at the highest risk for a poor outcome has become of crucial interest. A biomarker generally refers to a measured characteristic which may be used as an indicator of some biological state or condition. Three different types of medical biomarkers has been suggested: i. mechanistic markers; ii. clinical disease markers; iii. therapeutic markers. A combination of biomarkers from these different groups could be used for an ideal more accurate diagnosis and treatment. However, although a growing body of evidence is focused on improving biomarkers, a significant amount of this information is not integrated on standard clinical care. The overarching aim of this work was to clarify the meaning of specific biomarkers during autoimmune diseases; their possible role in confirming diagnosis, predicting outcome and suggesting specific treatments. © 2018

Published
2019

2. International consensus: What else can we do to improve diagnosis and therapeutic strategies in patients affected by autoimmune rheumatic diseases (rheumatoid arthritis, spondyloarthritides, systemic sclerosis, systemic lupus erythematosus, antiphospholipid syndrome and Sjogren's syndrome)?: The unmet needs and the clinical grey zone in autoimmune disease management

Author

Giacomelli, R. Afeltra, A. Alunno, A. Baldini, C. Bartoloni-Bocci, E. Berardicurti, O. Carubbi, F. Cauli, A. Cervera, R. Ciccia, F. Cipriani, P. Conti, F. De Vita, S. Di Benedetto, P. Doria, A. Drosos, A.A. Favalli, E.G. Gandolfo, S. Gatto, M. Grembiale, R.D. Liakouli, V. Lories, R. Lubrano, E. Lunardi, C. Margiotta, D.P.E. Massaro, L. Meroni, P. Minniti, A. Navarini, L. Pendolino, M. Perosa, F. Pers, J.-O. Prete, M. Priori, R. Puppo, F. Quartuccio, L. Ruffatti, A. Ruscitti, P. Russo, B. Sarzi-Puttini, P. Shoenfeld, Y. Somarakis, G.A. Spinelli, F.R. Tinazzi, E. Triolo, G. Ursini, F. Valentini, G. Valesini, G. Vettori, S. Vitali, C. Tzioufas, A.G.

Abstract

Autoimmune diseases are a complex set of diseases characterized by immune system activation and, although many progresses have been done in the last 15 years, several unmet needs in the management of these patients may be still identified. Recently, a panel of international Experts, divided in different working groups according to their clinical and scientific expertise, were asked to identify, debate and formulate a list of key unmet needs within the field of rheumatology, serving as a roadmap for research as well as support for clinicians. After a systematic review of the literature, the results and the discussions from each working group were summarised in different statements. Due to the differences among the diseases and their heterogeneity, a large number of statements was produced and voted by the Experts to reach a consensus in a plenary session. At all the steps of this process, including the initial discussions by the steering committee, the identification of the unmet needs, the expansion of the working group and finally the development of statements, a large agreement was attained. This work confirmed that several unmet needs may be identified and despite the development of new therapeutic strategies as well as a better understanding of the effects of existing therapies, many open questions still remain in this field, suggesting a research agenda for the future and specific clinical suggestions which may allow physicians to better manage those clinical conditions still lacking of scientific clarity. © 2017

Published
2017

5. FRI0014 Low-dose aspirin may have a role as primary prophylaxis of cardiovascular events in rheumatoid arthritis: evidence from an italian multicentric retrospective study

Author

Iacono, D., primary, Fasano, S., additional, Pantano, I., additional, D’Abrosca, V., additional, Ruscitti, P., additional, Margiotta, D.P.E., additional, Navarini, L., additional, Maruotti, N., additional, Cantatore, F.P., additional, Afeltra, A., additional, Giacomelli, R., additional, and Valentini, G., additional

Published
2018
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8. SAT0489 Biologic Therapies and Infections in The Daily Practice: A Study on Historical Cohort from 3 Italian Rheumatologic Units

Author

Cipriani, P., primary, Berardicurti, O., additional, Masedu, F., additional, D'Onofrio, F., additional, Navarini, L., additional, Ruscitti, P., additional, Maruotti, N., additional, Margiotta, D.P.E., additional, Liakouli, V., additional, Di Benedetto, P., additional, Carubbi, F., additional, Valenti, M., additional, Cantatore, F.P., additional, Afeltra, A., additional, and Giacomelli, R., additional

Published
2016
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16. Subclinical and clinical atherosclerosis in rheumatoid arthritis: results from the 3-year, multicentre, prospective, observational GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study

Author

Raffaele Scarpa, Francesco Paolo Cantatore, Licia Picciariello, Federico Perosa, Giulia Maria Destro Castaniti, Piero Ruscitti, Nicola Maruotti, Luca Navarini, Sara Bongiovanni, Domenico Paolo Emanuele Margiotta, Rosa Daniela Grembiale, Roberto Giacomelli, Giacomo Emmi, Antonella Afeltra, Daniela Iacono, Fabiola Atzeni, Paola Cipriani, Giuliana Guggino, Francesco Caso, Francesco Ciccia, Gerardo Di Scala, Vasiliki Liakouli, Ilenia Pantano, Ruscitti, P., Cipriani, P., Liakouli, V., Iacono, D., Pantano, I., Margiotta, D. P. E., Navarini, L., Destro Castaniti, G. M., Maruotti, N., Di Scala, G., Picciariello, L., Caso, F., Bongiovanni, S., Grembiale, R. D., Atzeni, F., Scarpa, R., Perosa, F., Emmi, G., Cantatore, F. P., Guggino, G., Afeltra, A., Ciccia, F., Giacomelli, R., Ruscitti P., Cipriani P., Liakouli V., Iacono D., Pantano I., Margiotta D.P.E., Navarini L., Destro Castaniti G.M., Maruotti N., Di Scala G., Picciariello L., Caso F., Bongiovanni S., Grembiale R.D., Atzeni F., Scarpa R., Perosa F., Emmi G., Cantatore F.P., Guggino G., Afeltra A., Ciccia F., and Giacomelli R.

Subjects
0301 basic medicine, Male, Time Factors, lcsh:Diseases of the musculoskeletal system, Type 2 diabetes, Comorbidity, Arthritis, Rheumatoid, 0302 clinical medicine, Prospective Studies, Subclinical infection, Aged, 80 and over, education.field_of_study, Incidence (epidemiology), Incidence, Age Factors, Middle Aged, Prognosis, Cardiovascular disease, Survival Rate, Cardiovascular diseases, Italy, Rheumatoid arthritis, Atherosclerosi, Cohort, Disease Progression, Female, Research Article, Adult, medicine.medical_specialty, Remission, Population, 03 medical and health sciences, Young Adult, Age Distribution, Sex Factors, Internal medicine, medicine, Humans, Sex Distribution, education, Rheumatoid arthriti, Aged, 030203 arthritis & rheumatology, business.industry, Atherosclerosis, medicine.disease, Rheumatology, Settore MED/16 - Reumatologia, 030104 developmental biology, Blood pressure, lcsh:RC925-935, business, Follow-Up Studies
Abstract

Background Rheumatoid arthritis (RA) is associated with an increased risk of morbidity and mortality, when compared with general population, largely due to enhanced atherosclerotic disease. In this work, we aimed at assessing both occurrence and predictive factors of subclinical and clinical atherosclerosis in RA. Methods From January 1, 2015, to December 31, 2015, consecutive participants with RA, admitted to Italian Rheumatology Units, were assessed in the GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) cohort. After that, those participants were followed up in a 3-year, prospective, observational study, assessing the occurrence of subclinical and clinical atherosclerosis and possible predictive factors. McNemar test was employed to assess the changes in subclinical and clinical atherosclerosis, and regression analyses exploited the ORs for the occurrence of those comorbidities. Results We analysed 841 participants, mostly female (82.2%) and with median age of 60 years (range 21–90). The remission was achieved and maintained by 41.8% of participants during the follow-up. We observed an increased rate of subclinical atherosclerosis at the end of follow-up (139 vs 203 participants, p

Published
2019

17. Guidelines for biomarkers in autoimmune rheumatic diseases - evidence based analysis

Author

Maria Sole Chimenti, Raffaele Scarpa, Serena Vettori, Monica Todoerti, Pier Luigi Meroni, Salvatore De Vita, Gianluca Moroncini, Salvatore Di Bartolomeo, Alessandra Bortoluzzi, Domenico Paolo Emanuele Margiotta, E Bartoloni-Bocci, Benjamin A Fisher, Eugen Feist, Francesco Ursini, Roberto Caporali, Francesco Caso, Guido Valesini, Roberto Giacomelli, Onorina Berardicurti, Marcella Prete, Emmanuel Coloma, Paola Cipriani, Ricard Cervera, Federico Perosa, Roberta Priori, Vasiliki Liakouli, Maria Gerosa, Andrea Doria, Chiara Rebuffi, Athanasios G. Tzioufas, Antonella Afeltra, Alessia Alunno, Claudio Vitali, Giuliana Guggino, Oliver Distler, Salvatore D'Angelo, Michele Gilio, Yehuda Shoenfeld, Michele Bombardieri, Fabrizio Conti, Piero Ruscitti, Giacomelli R., Afeltra A., Alunno A., Bartoloni-Bocci E., Berardicurti O., Bombardieri M., Bortoluzzi A., Caporali R., Caso F., Cervera R., Chimenti M.S., Cipriani P., Coloma E., Conti F., D'Angelo S., De Vita S., Di Bartolomeo S., Distler O., Doria A., Feist E., Fisher B.A., Gerosa M., Gilio M., Guggino G., Liakouli V., Margiotta D.P.E., Meroni P., Moroncini G., Perosa F., Prete M., Priori R., Rebuffi C., Ruscitti P., Scarpa R., Shoenfeld Y., Todoerti M., Ursini F., Valesini G., Vettori S., Vitali C., Tzioufas A.G., Giacomelli, Roberto, Afeltra, Antonella, Alunno, Alessia, Bartoloni-Bocci, Elena, Berardicurti, Onorina, Bombardieri, Michele, Bortoluzzi, Alessandra, Caporali, Roberto, Caso, Francesco, Cervera, Ricard, Chimenti, Maria Sole, Cipriani, Paola, Coloma, Emmanuel, Conti, Fabrizio, D'Angelo, Salvatore, De Vita, Salvatore, Di Bartolomeo, Salvatore, Distler, Oliver, Doria, Andrea, Feist, Eugen, Fisher, Benjamin A., Gerosa, Maria, Gilio, Michele, Guggino, Giuliana, Liakouli, Vasiliki, Margiotta, Domenico Paolo Emanuele, Meroni, Pierluigi, Moroncini, Gianluca, Perosa, Federico, Prete, Marcella, Priori, Roberta, Rebuffi, Chiara, Ruscitti, Piero, Scarpa, Raffaele, Shoenfeld, Yehuda, Todoerti, Monica, Ursini, Francesco, Valesini, Guido, Vettori, Serena, Vitali, Claudio, and Tzioufas, Athanasios G.

Subjects
0301 basic medicine, Evidence-based practice, Immunology, Inflammation, Guidelines as Topic, Systemic lupus erythematosu, Bioinformatics, Antiphospholipid syndrome, Biomarker, Rheumatoid arthritis, Sjögren syndrome, Spondyloarthritides, Systemic lupus erythematosus, Systemic sclerosis, Autoimmune Disease, Autoimmune Diseases, Rheumatic Disease, 03 medical and health sciences, Therapeutic approach, Systemic sclerosi, Economica, 0302 clinical medicine, Immune system, Early Diagnosi, Rheumatic Diseases, medicine, Immunology and Allergy, Humans, Rheumatoid arthriti, 030203 arthritis & rheumatology, Spondyloarthritide, business.industry, medicine.disease, Clinical disease, Biomarkers, Early Diagnosis, Evidence-Based Practice, Settore MED/16 - Reumatologia, 030104 developmental biology, Biomarker (medicine), medicine.symptom, business, Human
Abstract

Autoimmune rheumatic diseases are characterised by an abnormal immune system response, complement activation, cytokines dysregulation and inflammation. In last years, despite many progresses in managing these patients, it has been shown that clinical remission is reached in less than 50% of patients and a personalised and tailored therapeutic approach is still lacking resulting in a significant gap between guidelines and real-world practice. In this context, the need for biomarkers facilitating early diagnosis and profiling those individuals at the highest risk for a poor outcome has become of crucial interest. A biomarker generally refers to a measured characteristic which may be used as an indicator of some biological state or condition. Three different types of medical biomarkers has been suggested: i. mechanistic markers; ii. clinical disease markers; iii. therapeutic markers. A combination of biomarkers from these different groups could be used for an ideal more accurate diagnosis and treatment. However, although a growing body of evidence is focused on improving biomarkers, a significant amount of this information is not integrated on standard clinical care. The overarching aim of this work was to clarify the meaning of specific biomarkers during autoimmune diseases; their possible role in confirming diagnosis, predicting outcome and suggesting specific treatments.

Published
2019

18. International consensus: What else can we do to improve diagnosis and therapeutic strategies in patients affected by autoimmune rheumatic diseases (rheumatoid arthritis, spondyloarthritides, systemic sclerosis, systemic lupus erythematosus, antiphospholipid syndrome and Sjogren's syndrome)?: The unmet needs and the clinical grey zone in autoimmune disease management

Author

Pier Luigi Meroni, Serena Vettori, Vasiliki Liakouli, Paola Cipriani, Piero Ruscitti, Laura Massaro, Elisa Tinazzi, Chiara Baldini, Domenico Paolo Emanuele Margiotta, Yehuda Shoenfeld, Mariele Gatto, Saviana Gandolfo, Alberto Cauli, Gabriele Valentini, Francesco Puppo, Onorina Berardicurti, Alexandros A. Drosos, E Bartoloni-Bocci, Alessia Alunno, Francesco Ursini, George Somarakis, Ennio Lubrano, Federico Perosa, Luca Navarini, Jacques-Olivier Pers, Piercarlo Sarzi-Puttini, Francesco Carubbi, Andrea Doria, Luca Quartuccio, Paola Di Benedetto, Amelia Ruffatti, Antonia Minniti, Marcella Prete, Salvatore De Vita, Fabrizio Conti, Ricard Cervera, Athanasios G. Tzioufas, Claudio Lunardi, M. Pendolino, Rik Lories, Francesca Romana Spinelli, Barbara Russo, Rosa Daniela Grembiale, Antonella Afeltra, Francesco Ciccia, Claudio Vitali, Giovanni Triolo, Roberto Giacomelli, Ennio Giulio Favalli, Guido Valesini, Roberta Priori, Giacomelli, R., Afeltra, A., Alunno, A., Baldini, C., Bartoloni-bocci, E., Berardicurti, O., Carubbi, F., Cauli, A., Cervera, R., Ciccia, F., Cipriani, P., Conti, F., De Vita, S., Di Benedetto, P., Doria, A., Drosos, A., Favalli, E., Gandolfo, S., Gatto, M., Grembiale, R., Liakouli, V., Lories, R., Lubrano, E., Lunardi, C., Margiotta, D., Massaro, L., Meroni, P., Minniti, A., Navarini, L., Pendolino, M., Perosa, F., Pers, J., Prete, M., Priori, R., Puppo, F., Quartuccio, L., Ruffatti, A., Ruscitti, P., Russo, B., Sarzi-puttini, P., Shoenfeld, Y., Somarakis, G., Spinelli, F., Tinazzi, E., Triolo, G., Ursini, F., Valentini, G., Valesini, G., Vettori, S., Vitali, C., Tzioufas, A., Division of Rheumatology, Department of Internal Medicine, Università degli studi di Palermo - University of Palermo, Rheumatology Unit (Rheum Unit - PISA), University of Pisa - Università di Pisa, 2nd Chair of Rheumatolog, Department of Medical Sciences, University of Cagliari, Autoinflammatory Diseases Clinical Unit (Department of Autoimmune Diseases Working Group of Adult Rare Diseases), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Udine and University Hospital of Udine, Department of Clinical and Biological Sciences, Oral Medicine and Oral Oncology Section, University of Turin, Rheumatology Unit, Universita degli Studi di Padova, Laboratory of Tissue Homeostasis and Disease, Laborory of Tissue homeostasis and Disease, Department of Clinical and Experimental Medicine, Università degli Studi di Verona, Allergy, Clinical Immunology and Rheumatology, University of Milan, Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), University of Udine and University Hospital- Udine, Università degli Studi di Udine - University of Udine [Italie], Free University of Bozen-Bolzano, Sackler Faculty of Medicine, Tel Aviv University [Tel Aviv], Cattedra e Unità Operativa di Reumatologia, Policlinico Universitario, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), CNR Istituto di Fotonica e Nanotecnologie [Milano] (IFN), Consiglio Nazionale delle Ricerche [Roma] (CNR), Dipartimento di Fisica, Politecnico di Milano [Milan] (POLIMI), Department of Internal Medicine, Lupus Clinic, Sapienza University [Rome], Sections of Rheumatology (Rheumatol - LECCO), Instituto San Giuseppe, Department of Pathophysiology, Medical School, University of Athens, Giacomelli, Roberto, Afeltra, Antonella, Alunno, Alessia, Baldini, Chiara, Bartoloni Bocci, Elena, Berardicurti, Onorina, Carubbi, Francesco, Cauli, Alberto, Cervera, Ricard, Ciccia, Francesco, Cipriani, Paola, Conti, Fabrizio, De Vita, Salvatore, Di Benedetto, Paola, Doria, Andrea, Drosos, Alexandros A., Favalli, Ennio Giulio, Gandolfo, Saviana, Gatto, Mariele, Grembiale, Rosa Daniela, Liakouli, Vasiliki, Lories, Rik, Lubrano, Ennio, Lunardi, Claudio, Margiotta, Domenico Paolo Emanuele, Massaro, Laura, Meroni, Pierluigi, Minniti, Antonia, Navarini, Luca, Pendolino, Monica, Perosa, Federico, Pers, Jacques Olivier, Prete, Marcella, Priori, Roberta, Puppo, Francesco, Quartuccio, Luca, Ruffatti, Amelia, Ruscitti, Piero, Russo, Barbara, Sarzi Puttini, Piercarlo, Shoenfeld, Yehuda, Somarakis, George A., Spinelli, Francesca Romana, Tinazzi, Elisa, Triolo, Giovanni, Ursini, Francesco, Valentini, Gabriele, Valesini, Guido, Vettori, Serena, Vitali, Claudio, Tzioufas, Athanasios G., University of Verona (UNIVR), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Giacomelli R., Afeltra A., Alunno A., Baldini C., Bartoloni-Bocci E., Berardicurti O., Carubbi F., Cauli A., Cervera R., Ciccia F., Cipriani P., Conti F., De Vita S., Di Benedetto P., Doria A., Drosos A.A., Favalli E.G., Gandolfo S., Gatto M., Grembiale R.D., Liakouli V., Lories R., Lubrano E., Lunardi C., Margiotta D.P.E., Massaro L., Meroni P., Minniti A., Navarini L., Pendolino M., Perosa F., Pers J.-O., Prete M., Priori R., Puppo F., Quartuccio L., Ruffatti A., Ruscitti P., Russo B., Sarzi-Puttini P., Shoenfeld Y., Somarakis G.A., Spinelli F.R., Tinazzi E., Triolo G., Ursini F., Valentini G., Valesini G., Vettori S., Vitali C., and Tzioufas A.G.

Subjects
0301 basic medicine, Quality management, Effectiveness, law.invention, Systemic sclerosi, 0302 clinical medicine, Antiphospholipid syndrome, Biologic drugs treatment, Remission, Rheumatoid arthritis, Sjogren's syndrome, Spondyloarthritides, Systemic lupus erythematosus, Systemic sclerosis, Unmet needs, Immunology and Allergy, Immunology, law, Disease management (health), ComputingMilieux_MISCELLANEOUS, Spondyloarthritide, Clinical Trials as Topic, Effectivene, Disease Management, Quality Improvement, 3. Good health, [SDV.IMM]Life Sciences [q-bio]/Immunology, Unmet need, medicine.medical_specialty, Systemic lupus erythematosu, rheumatoid arthritis, spondyloarthritides, NO, Autoimmune Diseases, 03 medical and health sciences, Internal medicine, Rheumatic Diseases, medicine, Humans, Intensive care medicine, Rheumatoid arthriti, 030203 arthritis & rheumatology, Autoimmune disease, therapy, business.industry, medicine.disease, Rheumatology, 030104 developmental biology, autoimmune rheumatic diseases, Physical therapy, CLARITY, business, Working group
Abstract

Autoimmune diseases are a complex set of diseases characterized by immune system activation and, although many progresses have been done in the last 15 years, several unmet needs in the management of these patients may be still identified. Recently, a panel of international Experts, divided in different working groups according to their clinical and scientific expertise, were asked to identify, debate and formulate a list of key unmet needs within the field of rheumatology, serving as a roadmap for research as well as support for clinicians. After a systematic review of the literature, the results and the discussions from each working group were summarised in different statements. Due to the differences among the diseases and their heterogeneity, a large number of statements was produced and voted by the Experts to reach a consensus in a plenary session. At all the steps of this process, including the initial discussions by the steering committee, the identification of the unmet needs, the expansion of the working group and finally the development of statements, a large agreement was attained. This work confirmed that several unmet needs may be identified and despite the development of new therapeutic strategies as well as a better understanding of the effects of existing therapies, many open questions still remain in this field, suggesting a research agenda for the future and specific clinical suggestions which may allow physicians to better manage those clinical conditions still lacking of scientific clarity.

Published
2017

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