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Subclinical and clinical atherosclerosis in rheumatoid arthritis: results from the 3-year, multicentre, prospective, observational GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study
- Source :
- Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-10 (2019), Arthritis Research & Therapy
- Publication Year :
- 2019
-
Abstract
- Background Rheumatoid arthritis (RA) is associated with an increased risk of morbidity and mortality, when compared with general population, largely due to enhanced atherosclerotic disease. In this work, we aimed at assessing both occurrence and predictive factors of subclinical and clinical atherosclerosis in RA. Methods From January 1, 2015, to December 31, 2015, consecutive participants with RA, admitted to Italian Rheumatology Units, were assessed in the GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) cohort. After that, those participants were followed up in a 3-year, prospective, observational study, assessing the occurrence of subclinical and clinical atherosclerosis and possible predictive factors. McNemar test was employed to assess the changes in subclinical and clinical atherosclerosis, and regression analyses exploited the ORs for the occurrence of those comorbidities. Results We analysed 841 participants, mostly female (82.2%) and with median age of 60 years (range 21–90). The remission was achieved and maintained by 41.8% of participants during the follow-up. We observed an increased rate of subclinical atherosclerosis at the end of follow-up (139 vs 203 participants, p
- Subjects :
- 0301 basic medicine
Male
Time Factors
lcsh:Diseases of the musculoskeletal system
Type 2 diabetes
Comorbidity
Arthritis, Rheumatoid
0302 clinical medicine
Prospective Studies
Subclinical infection
Aged, 80 and over
education.field_of_study
Incidence (epidemiology)
Incidence
Age Factors
Middle Aged
Prognosis
Cardiovascular disease
Survival Rate
Cardiovascular diseases
Italy
Rheumatoid arthritis
Atherosclerosi
Cohort
Disease Progression
Female
Research Article
Adult
medicine.medical_specialty
Remission
Population
03 medical and health sciences
Young Adult
Age Distribution
Sex Factors
Internal medicine
medicine
Humans
Sex Distribution
education
Rheumatoid arthriti
Aged
030203 arthritis & rheumatology
business.industry
Atherosclerosis
medicine.disease
Rheumatology
Settore MED/16 - Reumatologia
030104 developmental biology
Blood pressure
lcsh:RC925-935
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-10 (2019), Arthritis Research & Therapy
- Accession number :
- edsair.doi.dedup.....988518b7f505caf90cc0a57913c5b8fa