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Since more and more production tasks are enabled by Industry 4.0 techniques, the number of knowledge-intensive production tasks increases as trivial tasks can be automated and only non-trivial tasks demand human-machine interactions. With this, challenges regarding the competence of production workers, the complexity of tasks and stickiness of required knowledge occur [1]. Furthermore, workers experience time pressure which can lead to a decrease in output quality. Cyber-Physical Systems (CPS) have the potential to assist workers in knowledge-intensive work grounded on quantitative insights about knowledge transfer activities [2]. By providing contextual and situational awareness as well as complex classification and selection algorithms, CPS are able to ease knowledge transfer in a way that production time and quality is improved significantly. CPS have only been used for direct production and process optimization, knowledge transfers have only been regarded in assistance systems with little contextual awareness. Embedding production and knowledge transfer optimization thus show potential for further improvements. This contribution outlines the requirements and a framework to design these systems. It accounts for the relevant factors.

Already successfully used products or designs, past projects or our own experiences can be the basis for the development of new products. As reference products or existing knowledge, it is reused in the development process and across generations of products. Since further, products are developed in cooperation, the development of new product generations is characterized by knowledge-intensive processes in which information and knowledge are exchanged between different kinds of knowledge carriers. The particular knowledge transfer here describes the identification of knowledge, its transmission from the knowledge carrier to the knowledge receiver, and its application by the knowledge receiver, which includes embodied knowledge of physical products. Initial empirical findings of the quantitative effects regarding the speed of knowledge transfers already have been examined. However, the factors influencing the quality of knowledge transfer to increase the efficiency and effectiveness of knowledge transfer in product development have not yet been examined empirically. Therefore, this paper prepares an experimental setting for the empirical investigation of the quality of knowledge transfers.

Künstliche Intelligenz ist in aller Munde. Immer mehr Anwendungsbereiche werden durch die Auswertung von vorliegenden Daten mit Algorithmen und Frameworks z.B. des Maschinellen Lernens erschlossen. Dieses Buch hat das Ziel, einen Überblick über gegenwärtig vorhandene Lösungen zu geben und darüber hinaus konkrete Hilfestellung bei der Auswahl von Algorithmen oder Tools bei spezifischen Problemstellungen zu bieten. Um diesem Anspruch gerecht zu werden, wurden 90 Lösungen mittels einer systematischen Literaturrecherche und Praxissuche identifiziert sowie anschließend klassifiziert. Mit Hilfe dieses Buches gelingt es, schnell die notwendigen Grundlagen zu verstehen, gängige Anwendungsgebiete zu identifizieren und den Prozess zur Auswahl eines passenden ML-Tools für das eigene Projekt systematisch zu meistern.

Objective We propose a data-driven method to detect temporal patterns of disease progression in high-dimensional claims data based on gradient boosting with stability selection. Materials and methods We identified patients with chronic obstructive pulmonary disease in a German health insurance claims database with 6.5 million individuals and divided them into a group of patients with the highest disease severity and a group of control patients with lower severity. We then used gradient boosting with stability selection to determine variables correlating with a chronic obstructive pulmonary disease diagnosis of highest severity and subsequently model the temporal progression of the disease using the selected variables. Results We identified a network of 20 diagnoses (e.g. respiratory failure), medications (e.g. anticholinergic drugs) and procedures associated with a subsequent chronic obstructive pulmonary disease diagnosis of highest severity. Furthermore, the network successfully captured temporal patterns, such as disease progressions from lower to higher severity grades. Discussion The temporal trajectories identified by our data-driven approach are compatible with existing knowledge about chronic obstructive pulmonary disease showing that the method can reliably select relevant variables in a high-dimensional context. Conclusion We provide a generalizable approach for the automatic detection of disease trajectories in claims data. This could help to diagnose diseases early, identify unknown risk factors and optimize treatment plans.

This article presents an exploratory study investigating the influence of an enterprise’s size on its perception and assessment of the benefits and risks expected from participating in open innovation projects. For this purpose an online survey was conducted in Germany, Austria and Switzerland. The result of this paper is empirical evidence showing how the size of an enterprise affects its perception of potential benefits and risks expected within the context of open innovation project participation. Furthermore, the identified effects are discussed against the theory. Existing theory regarding the benefits and risks of open innovation is expanded by 1) finding that they are perceived mostly independently of enterprise size, 2) confirming their practical relevance, and 3) enabling a finer distinction between their degrees of relevance for small, medium, and large enterprises.

Modern production infrastructures of globally operating companies usually consist of multiple distributed production sites. While the organization of individual sites consisting of Industry 4.0 components itself is demanding, new questions regarding the organization and allocation of resources emerge considering the total production network. In an attempt to face the challenge of efficient distribution and processing both within and across sites, we aim to provide a hybrid simulation approach as a first step towards optimization. Using hybrid simulation allows us to include real and simulated concepts and thereby benchmark different approaches with reasonable effort. A simulation concept is conceptualized and demonstrated qualitatively using a global multi-site example.

The paper deals with the increasing growth of embedded systems and their role within structures similar to the Internet (Internet of Things) as those that provide calculating power and are more or less appropriate for analytical tasks. Faced with the example of a cyber-physical manufacturing system, a common objective function is developed with the intention to measure efficient task processing within analytical infrastructures. A first validation is realized on base of an expert panel.

Traditional production systems are enhanced by cyber-physical systems (CPSs) and Internet of Things. As kind of next generation systems, those cyber-physical production systems (CPPSs) are able to raise the level of autonomy of its production components. To find the optimal degree of autonomy in a given context, a research approach is formulated using a simulation concept. Based on requirements and assumptions, a cyber-physical market is modeled and qualitative hypotheses are formulated, which will be verified with the help of the CPPS of a hybrid simulation environment. Big Data Analytics can be used to extract influence factors which explain the optimal degree of autonomy.