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1. Immunogenicity of a third dose with mRNA-vaccines in the ChAdOx1-S/BNT162b2 vaccination regimen against SARS-CoV-2 variants

Author

Javier García-Pérez, Alberto M. Borobia, Mayte Pérez-Olmeda, Antonio Portolés, Luis Castaño, Magdalena Campins-Artí, María Jesús Bertrán, Mercedes Bermejo, José Ramón Arribas, Andrea López, Ana Ascaso-del-Rio, Eunate Arana-Arri, Inmaculada Fuentes Camps, Anna Vilella, Almudena Cascajero, María Teresa García-Morales, María Castillo de la Osa, Carla Pérez Ingidua, David Lora, Paloma Jiménez-Santana, Silvia Pino-Rosa, Agustín Gómez de la Cámara, Erick De La Torre-Tarazona, Esther Calonge, Raquel Cruces, Cristóbal Belda-Iniesta, José Alcamí, Jesús Frías, Antonio J. Carcas, Francisco Díez-Fuertes, Lucía Díaz García, Elena Ramírez García, Enrique Seco Meseguer, Stefan Mark Stewart Balbàs, Alicia Marín Candón, Irene García García, Mikel Urroz Elizalde, Paula de la Rosa, Marta Sanz García, Cristina López Crespo, Vega Mauleón Martínez, Raquel de Madariaga Castell, Laura Vitón Vara, Rocío Prieto-Pérez, Emilio Vargas-Castrillón, Leonor Laredo, Ouhao Zhu-Huang, Teresa Iglesias, Natale Imaz-Ayo, Susana Meijide, Aitor García de Vicuña, Ana Santorcuato, Iraide Exposito, Sara de Benito, Alazne Bustinza, Mikel Gallego, Dolores García-Vázquez, Ana Belén de la Hoz, Gustavo Pérez-Nanclares, Josu Aurrekoetxea, Ines Urrutia, Rosa Martínez-Salazar, Janire Orcajo, Begoña Calvo, June Corcuera, Olaia Velasco, Anibal Aguayo, Xavier Martínez-Gómez, Susana Otero-Romero, Lluis Armadans, Blanca Borras-Bermejo, Oleguer Parés, Sonia Uriona, José Ángel Rodrigo Pendás, Cesar Llorente, José Santos, Laia Pinós, Lina Camacho, Judith Riera, Carla Sans, Antonia Agustí, Carmen Altadill, Carla Aguilar Blancafort, Gisela Gili Serrat, Aitana Plaza, Anna Feliu Prius, Maria Margarita Torrens, Esther Palacio, Gloria Torres, Julia Calonge, Elena Ballarin Alins, Eulàlia Pérez-Esquirol, Lourdes Vendrell Bosch, Marta Aldea, Eugènia Mellado, Ma Ángeles Marcos, Marta Tortajada, Lourdes E. Barón-Mira, Laura Granés, Sulayman Lazaar, Sara Herranz, Montserrat Malet, Sebastiana Quesada, Anna Llupià, Victoria Olivé, Antoni Trilla, Begoña Gómez, Elisenda González, Sheila Romero, Francisco Javier Gámez, Cristina Casals, Laura Burunat, Juan José Castelló, Patricia Fernández, Josep Lluís Bedini, Jordi Vila, Juan Carlos Hurtado, Isabel Jado, Giovanni Fedele, Concepción Perea, Mónica González, Isabel Grajera, María Ángeles Murillo, Pilar Balfagón, Irene Díaz-Marín, and Gema González-Pardo

Subjects
Immunology, Immune response, Science
Abstract

Summary: CombiVacS study has demonstrated a strong immune response of the heterologous ChAdOx1-S/BNT162b2 vaccine combination. The primary outcomes of the study were to assess the humoral immune response against SARS-CoV-2, 28 days after a third dose of a mRNA vaccine, in subjects that received a previous prime-boost scheme with ChAdOx1-S/BNT162b2. Secondary outcomes extended the study to 3 and 6 months. The third vaccine dose of mRNA-1273 in naive participants previously vaccinated with ChAdOx1-S/BNT162b2 regimen reached higher neutralizing antibodies titers against the variants of concern Delta and BA.1 lineage of Omicron compared with those receiving a third dose of BNT162b2 at day 28. These differences between BNT162b2 and mRNA-1273 arms were observed against the ancestral variant G614 at day 90. Suboptimal neutralizing response was observed against BQ.1.1, XBB.1.5/XBB.1.9, and JN.1 in a relevant proportion of individuals 180 days after the third dose, even after asymptomatic Omicron breakthrough infections. EudraCT (2021-001978-37); ClinicalTrials.gov (NCT04860739).

Published
2024
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2. Evaluation of the LIAISON XL Zika Capture IgM II for the Diagnosis of Zika Virus Infections

Author

Mayte Pérez-Olmeda, María Paz Sánchez-Seco, Ana Vázquez, Pilar Balfagón, Jesús de la Fuente, María Ángeles Murillo, Teodora Minguito, and Fernando de Ory

Subjects
zika virus, chemiluminescent immunoassay, enzyme immunoassay, dengue viruses, chikungunya virus, Microbiology, QR1-502
Abstract

The aim of this study is to evaluate the performance characteristics of the LIAISON XL Zika Capture IgM II. For this purpose we tested 128 samples obtained from recent infections caused by the Zika (ZIKV; 74 samples), dengue (DENV; 10 samples), chikungunya (CHIK V; 11 samples), rubella (RUBV; 10 samples) and measles (MeV; 10 samples) viruses, as well as human parvovirus B19 (HPVB19; 13 samples). The results of the assay under evaluation are compared with those obtained from an indirect immunofluorescence (IIF) assay, and the discrepancies are resolved by considering other laboratory results (PCR and a plaque-reduction neutralization test). The LIAISON showed excellent sensitivity (100%). The specificity (91.25%) was hampered by some false-positive results in recent dengue virus, chikungunya virus, measles virus and human parvovirus B19 infections. The method evaluated is adequate, but the low specificity makes it necessary to consider the clinical and epidemiological contexts of patients, as well as other laboratory results.

Published
2020
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3. Mechanical ventilation during cardiopulmonary bypass in neonates improves postoperative outcome

Author

Marta Macarena Rodríguez-Lima, Antonio González-Calle, Alejandro Adsuar-Gómez, María José Sánchez-Martín, Álvaro Sepúlveda Iturzaeta, Elia Sánchez-Valderrábanos, Juan Antonio García-Hernández, María Ángeles Murillo-Pozo, Antonio Ordóñez-Fernández, and Amir-Reza Hosseinpour

Subjects
Adult, Heart Septal Defects, Ventricular, Pulmonary and Respiratory Medicine, Cardiopulmonary Bypass, Transposition of Great Vessels, Infant, Newborn, General Medicine, Respiration, Artificial, Treatment Outcome, Humans, Surgery, Prospective Studies, Child, Cardiology and Cardiovascular Medicine
Abstract

OBJECTIVES Cardiopulmonary bypass generates a systemic inflammatory response. This inflammatory response is reduced if patients are ventilated during bypass, as evidenced by lower levels of postoperative circulating inflammatory mediators. However, this does not appear to make much clinical difference in adults, at least not consistently, but, to our knowledge, has never been assessed in paediatric cardiac surgery, which is the objective of this study. METHODS This is a prospective clinical study of 12 consecutive neonates operated for the correction of either transposition of the great arteries ± ventricular septal defect or aortic arch hypoplasia ± ventricular septal defect, who were ventilated during cardiopulmonary bypass. These were compared to 11 neonates with the same malformations, who had undergone the same operations but without being ventilated during bypass (historical control group). RESULTS One patient from the control group died on the 15th postoperative day due to sepsis and multi-organ failure. Bypass times and cross-clamp times were similar in the 2 groups. Ventilation on bypass was associated with significantly lower postoperative serum concentrations of C-reactive protein, shorter mechanical ventilation and lower vasoactive-inotropic score. Duration of stay on intensive care unit (ICU) showed a tendency to be shorter in patients who were ventilated on bypass, but this did not reach statistical significance. There were no differences between the 2 groups with respect to postoperative mixed venous oxygen saturations and serum concentrations of lactate and troponin I. CONCLUSIONS Mechanical ventilation during cardiopulmonary bypass in neonates improves postoperative outcome.

Published
2022

4. Comparative evaluation of assays for IgM detection of rubella and measles infections

Author

Desirée Dafouz, Fernando de Ory, José Luis Muñoz, Pilar Balfagón, Mayte Pérez Olmeda, A. García, Juan Carlos Sanz, Jesús de la Fuente, María Ángeles Murillo, and Juan Camacho

Subjects
0301 basic medicine, Microbiology (medical), 030106 microbiology, Antibodies, Viral, medicine.disease_cause, Measles, Rubella, Comparative evaluation, Serology, law.invention, Measles virus, 03 medical and health sciences, 0302 clinical medicine, law, medicine, Humans, Electrochemiluminescence, 030212 general & internal medicine, Chemiluminescence, biology, business.industry, Rubella virus, biology.organism_classification, medicine.disease, Virology, Immunoglobulin M, business
Abstract

Background Serological diagnosis of infections due to measles and rubella viruses is done by IgM detection. The aim of this study was to comparatively evaluate commercial systems for detecting IgM against both viruses, including those of ELISA, in indirect and capture formats, chemiluminescence and electrochemiluminescence. Methods Seven (for rubella) and six (for measles) assays were studied. One hundred and sixty two samples were included in the study (from 90 rubella and 72 measles cases), and all were analyzed in all the assays. Results The ranges of sensitivity, specificity and agreement for rubella were 94.8–100%, 52.4–100% and 75.5–98.1%, respectively. The corresponding ranges for measles assays were 87.0–100%, 53.3–100%, and 73.0–99.4%. Conclusion The best-performing assays were chemiluminescence (for measles and rubella IgM), and electrochemiluminescence (for rubella IgM).

Published
2022

6. Evaluation of the LIAISON XL Zika Capture IgM II for the Diagnosis of Zika Virus Infections

Author

María Paz Sánchez-Seco, Fernando de Ory, Ana Vázquez, Jesús de la Fuente, Pilar Balfagón, Teodora Minguito, Mayte Pérez-Olmeda, María Ángeles Murillo, and Instituto de Salud Carlos III

Subjects
0301 basic medicine, viruses, 030106 microbiology, lcsh:QR1-502, Enzyme-Linked Immunosorbent Assay, Dengue virus, medicine.disease_cause, Antibodies, Viral, Rubella, Measles, Sensitivity and Specificity, Virus, lcsh:Microbiology, Article, Enzyme immunoassay, Dengue fever, Zika virus, Measles virus, 03 medical and health sciences, Virology, medicine, Humans, False Positive Reactions, Serologic Tests, Chemiluminescent immunoassay, Chikungunya, chemiluminescent immunoassay, dengue viruses, chikungunya virus, biology, business.industry, Zika Virus Infection, virus diseases, Zika Virus, medicine.disease, biology.organism_classification, enzyme immunoassay, 030104 developmental biology, Infectious Diseases, Immunoglobulin M, Virus Diseases, Dengue viruses, business, Chikungunya virus
Abstract

The aim of this study is to evaluate the performance characteristics of the LIAISON XL Zika Capture IgM II. For this purpose we tested 128 samples obtained from recent infections caused by the Zika (ZIKV, 74 samples), dengue (DENV, 10 samples), chikungunya (CHIK V, 11 samples), rubella (RUBV, 10 samples) and measles (MeV, 10 samples) viruses, as well as human parvovirus B19 (HPVB19, 13 samples). The results of the assay under evaluation are compared with those obtained from an indirect immunofluorescence (IIF) assay, and the discrepancies are resolved by considering other laboratory results (PCR and a plaque-reduction neutralization test). The LIAISON showed excellent sensitivity (100%). The specificity (91.25%) was hampered by some false-positive results in recent dengue virus, chikungunya virus, measles virus and human parvovirus B19 infections. The method evaluated is adequate, but the low specificity makes it necessary to consider the clinical and epidemiological contexts of patients, as well as other laboratory results.

Published
2020

7. Colaboradores

Author

Molina, Ana Abril, Valencia, Daniel Acevedo, Díaz, Fernando Acosta, Rotaeche, Alexander Agrifoglio, Alonso, Eduardo Aguilar, García, María del Carmen Aguilar, Arboledas, Francisco Javier Alados, Tomillero, Francisco Álamo, Romero, Pedro Alcázar, Pallás, María Teresa Aldabó, Marín, Amelia Alonso, Muñoz, Gema Alonso, Salas, María Teresa Alonso, Bueno, Miguel Álvarez, Sáiz, Alejandra Álvarez, Serna, Tania Amat, Villar, Rosario Amaya, González, César Aragón, Sánchez, José Andrés Arboleda, Garrido, José Julián Arias, Verdú, María Dolores Arias, Sánchez, Álvaro Arjona, Marín, María José Arroyo, Gallardo, Marc Ayala, Bravo, Esther Banderas, Pichardo, Rafael Barba, Ansorregui, Sandra Barbadillo, Mendoza, Jesús Abelardo Barea, Chacón, Juana María Barrera, Barrueco-Francioni, Jesús Emilio, Rodríguez, María Dolores Bautista, Alba, Rafael Bellido, Lozano, José Antonio Benítez, Moreno, María Palma Benítez, Gómez, Alberto Bermejo, Sáez, Isidro Blanco, Saera, María Bodí, Austria, Rafael Ángel Bohollo de, Saris, Alfonso Bonet, Marqués, Rafael Bravo, Cabeza, Francisca, Calandreia, Ana Cabrera, Fuciños, Lucía Cachafeiro, Rodríguez, Ana Calderón, Bonachera, María Dolores Calvo, León, Cristina Calvo, Macías, Custodio Calvo, Pulido, Jorge Calvo, Alonso, José Miguel Camacho, Sola, Estefanía Cámara, Redondo, Nuria Camino, Guerrero, Jesús Carbajal, Cruz, Antonio Cárdenas, Cruz, Dolores Purificación Cárdenas, Pérez, María Luz Carmona, Pinel, Antonio Carranza, Carmona, Francisco José Carrizosa, Hernández, Alejandra Carvajal, Adam, Ángela Casado, Laparra, Eloina Casanoves, Ribas, Patricia Castán, Pérez, José Castaño, Ortega, Álvaro Castellanos, Lorente, Encarnación Castillo, Barranquero, Francisca Gema Cazorla, Sánchez, María José Chaparro, Sáez, Violeta Chica, Fernández, Mario Chico, Ríos, Miguel Ángel Chirosa, Cabrera, Laura Claverias, Torres, Elisabeth Coll, Ruiz, Manuel Colmenero, Pino, Tamara Contreras del, Palomo, Yael Corcia, Lorenzana, María Lourdes Cordero, Delgado, Francisco Cota, Balsera, Emilio Curiel, Ruiz, Domingo Daga, Gestido, Azucena de la Campa, Ruano, Rafael de la Chica Ruiz, Moreno, Jesús de la Cruz, Martos, Carmen de la Fuente, García, Celia de la Hoz, Valverde, Carmen María de la Linde, Prados, María Victoria de la Torre, Blanc, Marina de Miguel, Casado, Nieves Delgado, Castellanos, Miguel Ángel Díaz, Contreras, Remedios Díaz, Monrové, Juan Carlos Díaz, Pernalete, Rosa María Díaz, Torres, Isabel Díaz, García, Pedro Jesús Domínguez, Domínguez-Gil, Beatriz, Roldán, José María Domínguez, Jurado, José María Dueñas, García, Ignacio Durbán, Brutus, Reginald Dusseck, León, Melisa Echeverría, Egea-Guerrero, Juan José, Mendoza, Ana Estalella, Montiel, Belén Estébanez, Foncea, María Antonia Estecha, García, Ángel Estella, Torrús, Andrés Estivill, López-Cuervo, Juan Fajardo, Fernández-Castanys, Esteban Feriche, Carmona, Alberto Fernández, Díez, Inés Fernández, Hinojosa, Esteban Fernández, Mondéjar, Enrique Fernández, Ortega, Juan Francisco Fernández, Porcel, Alba Fernández, Zamora, María Dolores Fernández, Higueras, María José Ferrer, López, Rafael Ferrer, Mata, Álvaro Ferrezuelo, Costa, Eva María Fieira, Rosón, Luis Javier Fierro, Lasierra, José Luis Flordelís, Cordero, Juan Manuel Flores, González, José Carlos Flores, Fregosi, Andrea, Freire-Aragón, María Dolores, Pérez, Manuel Ángel Frías, López, Juan Luis Galeas, Carbajo, Virginia Gallardo, Lara, Sonia Gallego, Martín, José Manuel Galván, Alfaro, Claudio García, Bautista, Ernesto García, Bautista, Jesús Alejo García, Cobo, José García, Lorenzo Mateos, Abelardo García de, Delgado, Manuel García, Rosado, Horacio García-Delgado, Acilu, Marina García García de, Morales, Juan José García, Sánchez, Manuela García, Soler, Patricia García, Garnacho-Montero, José, Castillo, María Luisa Gascón, Gómez, Raquel Gil, Pérez, Juan José Gilbert, Beltrán, Bárbara Giménez, González, Carmen Gómez, Jiménez, Francisco Javier Gómez, Luque, José María Gómez, Muñoz, Cristina Gómez, Ortiz, Francisco Javier González de Molina, Fenoy, Daniel González, Galilea, Ángel González, Gómez, José Manuel González, Hervás, Catalina González, López, Samuel González, Garzón, Manuel González-Ripoll, Brenes, Antonio Gordillo, Romero, Manuel Ángel Gracia, Mier, Manuel Guerrero de, López, Francisco Guerrero, Calle, Gabriel Heras La, Alonso, Benjamín Hernández, Cerdá, Laura Hernández, González, Arturo Hernández, Tejedor, Alberto Hernández, Vidaña, Adoración María Hernández, Gutiérrez, Manuel Enrique Herrera, Avilés, Ángel Herruzo, Muñoz, Fidel Alberto Hijano, Pérez, Rafael Hinojosa, Suazo, José Antonio Hurtado, Rosa, Ignacio Ibarra de la, Morales, Miriam Ibars, Santiago, Alberto Iglesias, Hernández, José Manuel Infantes, Sarrías, José Luis Iribarren, Rocamora, José Antonio Irles, Franco, Mercedes Jaén, Caballero, Susana Jaraba, Gómez-Coronado, Vicente Jerez, Guadarrama, Luis Roberto Jiménez, Moragas, José Manuel Jiménez, Rivera, Juan José Jiménez, Moreno, Belén Jordano, Montosa, Carolina Joya, Díaz, Mar Juan, Pujol, Jordi Klamburg, Aguayo, Pedro Lara, Rosales, Ramón Lara, Noval, Santiago Ramón Leal, Gallardo, Miguel Lebrón, Gil, Cristóbal León, López, Rafael León, Galera, Sagrario Lombardo, Sánchez, José María López, Vázquez, Ana Loza, Calderón, Francisco Lucena, Casas, Juan Francisco Machado, Guarasa, Inés Macías, Municio, Alejandro Manrique, Caño, Javier Manso del, Marín-Caballos, Antonio Jesús, Monserrat, Fernando Luis Maroto, Gamarra, Pilar Márquez, Bermúdez, Rafael Martín, Delgado, María Cruz Martín, García, José Antonio Martín, López, Javier Ignacio Martín, Santaella, Ana Martín, Carmona, Juan Francisco Martínez, Martínez-Caro, Leticia, Escobar, Sergio Martínez, García, Pilar Martínez, López, Pilar Martínez, Padilla, María del Carmen Martínez, Enviz, Joan Ramon Masclans, Arizmendi, Alfonso Mesejo, Febrer, Jaume Mesquida, Manso, Guillermo Milano, Collado, Zaira Molina, Hurtado, José Ramón Molina, García, Manuel Ignacio Monge, González, Juan Carlos Montejo, Candau, Miguel Montero de Espinosa, Pintado, Rocío Monterroso, Ordóñez, Juan Miguel Mora, Quintero, María Luisa Mora, Martínez, Antonio Morales, Fernández, Eduardo Morán, Cecilia, Gonzalo Moratalla, López, Josefina Moreno, Romero, Olga Moreno, Gómez, Ana Mula, Bono, Javier Muñoz, Caballero, María Ángeles Muñoz, Casares, Cristóbal Muñoz, Cabo, Carlos Muñoz de, Garach, Manuel Muñoz, Guillén, Noelia María Muñoz, López, Alfonso Muñoz, Marina, Vanessa Muñoz, Sánchez, Sergio Muñoz, Sánchez, María de los Ángeles Muñoz, Cabezas, Francisco Murillo, Pozo, María Ángeles Murillo, Izurieta, José Ricardo Naranjo, Galdó, Susana Narbona, Navarro, Pedro Navarrete, Guillamón, Laura Navarro, González, María Nieto, Guindo, Pablo Nieto, Vaeza, Nicolás Nin, Ortega, Pilar Nuevo, Hita, Esther Ocete, Jiménez, Victoria Olea, Granados, Gonzalo Olivares, Peña, Lorena Olivencia, Ordiales, Ane Ortega, Vinuesa, Francisco Jesús Ortega, Zarza, Pedro Ortega, Álvarez, Ana Ortiz, Pérez, María Ortiz, Moreno, Pedro Pardo, Parrilla, Julio Parrilla, Ruiz, Francisco Manuel Parrilla, Bailón, Ana Pérez, Civantos, Demetrio Pérez, González, Álvaro Pérez, Madueño, Virginia Pérez, Navero, Juan Luis Pérez, Vacas, Jonathan Pérez, Villares, José Miguel Pérez, Moya, Enrique Pino, Sánchez, Francisca Inmaculada Pino, Guzmán, María Dolores Pola Gallego, Ponce, María del Pilar, López, Francisco Manuel Porras, Pantojo, Manuel Francisco Porras, Aguilera, María Eugenia Poyatos, Laderas, Juan Carlos Pozo, Paula, Juan Francisco Prieto de, Morlán, Araceli Puerto, Valverde, Pablo Pujol, Moreno, Antonio Puppo, García, Juan Guillermo Quesada, Galleymore, Paula Ramírez, Puerta, Rosario Ramírez, Núñez, María Recuerda, Orts, María Redondo, Artacho, María del Carmen Reina, Parras, María del Pilar Reyes, Ferrari, María Dolores Rincón, Espinar, Francisco Rivera, Arista, Juan Carlos Robles, Marcos, Manuel Robles, Castillo, Emilio Martín Robles-Musso, Alonso, Rosa María Rodríguez, Campoy, Patricia Rodríguez, Castaño, Rocío Rodríguez, Delgado, Marina Rodríguez, Espejo, Rosa Rodríguez, Gómez, Jorge Rodríguez, Higueras, Isabel María Rodríguez, Medina, Juan Antonio Rodríguez, Mejías, Candela Rodríguez, Oviedo, Alejandro Rodríguez, Yáñez, Juan Carlos Rodríguez, Amezcua, María Rojas, Cutillas, Ana María Román, Faro, Xan Romaní, Barroso, Isidro Romero, Camacho, Vanessa Rosa, Molina, Carolina Rueda, Bailén, Manuel Ruiz, Azúa-López, Zaida Ruiz de, Fresno, Luis Ruiz del, Ferrón, Francisco Ruiz, Jiménez, Jesús Ruiz, Ruiz-Santana, Sergio, Casco, Luis Vicente Sáenz, Fuente, Ignacio Sáez de la, Coronas, Joaquín Salas, Ramírez, Cristina Salazar, González, Francisco José Saldaña, Díaz, Lourdes Salido, Fernández, María José Salmerón, Cejas, José María San Pedro, Fernández, Norma Sánchez, Ganfornina, Inmaculada Sánchez, González, Yolanda Sánchez, Ramírez, Catalina Sánchez, Rodríguez, Ángel Custodio Sánchez, Román, José Antonio Sánchez, Segovia, José Sánchez, Silos, Francisco Sánchez, Valderrábanos, Elia Sánchez, Gutiérrez, Carmen Santiago, González, Fernando Segura, Pérez, Gemma Seller, Vic, Joaquim Serra, Lázaro, Ainhoa Serrano, Martínez, José Luis Serrano, Simón, José Manuel Serrano, Martínez, María Sevilla, Camerino, Rafael Sierra, Pérez, Manuel Jesús Soriano, Corriente, Macarena Taguas-Casaño, Aranguren, Julia Tejero, Reynoso, Pablo Torrabadella de, Alcalá, José Tomás Torres, Delgado, Eva Torres, Torres, Antonio Torres, Fernández, Carmen Trujillano, Spasova, Tsvetelina Tsvetanova, Iglesias, Alejandro Úbeda, Santamaría, Esther Ulloa, Quintero, Juan Pablo Valencia, Sánchez, Francisco Valenzuela, Báez, Antonio Vallejo, Barrios, José Manuel Vaquero, Vargas, Francisco Javier Vasserot, Florido, Antonio Vázquez, Colmenero, Rosa María Vela, Bueno, José Manuel Velasco, Gimena, Francisco Velasco, Jabalquinto, María José Velasco, Gallardo, Juan Villar, Muñoz, Emilia Villegas, Mateos, Luis Yaguez, Castilla, Cristina Yun, Ossorio, María Eugenia Yuste, Periñán, María José Zarco, and Ganfornina, José Benito Zaya

Published
2022
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8. Midazolam/fentanyl vs. propofol/remifentanil in immediate postoperative with short-term mechanical ventilation

Author

José Domingo López Castilla, Norma Sánchez Fernández, María Teresa Charlo Molina, Antonio Vázquez Florido, Maria Angeles Murillo Pozo, Inmaculada Sánchez Ganfornina, Manuel Fernández Elías, and Elía Sánchez Valderrábanos

Subjects
Sedoanalgesia, Midazolam, Fentanilo, Remifentanilo, Propofol, Pediatrics, RJ1-570
Abstract

Objectives: To compare between 2 sedoanalgesia regimes, the time from withdrawal of the medication until the patient wakes up and until extubation. Methodology: Observational study on pediatric patients after elective surgery that needed mechanical ventilation for a period maximum to 72 h. We compared two independent groups of patients: group A: patients collected prospectively who received sedoanalgesia with propofof-remifentanil and group B: patients who received midazolam-fentanyl collected retrospectively by reviewing medical records and database of the unit. The main variables studied were: Age, weight, sex, interventions type, sedoanalgesia scales, drugs dosages, time from withdrawal of medication to awakening and extubation, and adverse effects. Results: We collected 82 patients, 43 in group A and 39 in group B. Age (arithmetical mean ± standard deviation of patients were 49 ± 65 months, weight 17 ± 16 kg. Mechanical ventilation medium time was 22 h (3–72), wake-up time from withdrawal after removing sedoanalgesia was of 11,8 ± 10,6 min group A and 137,3 ± 45 min group B (P

Published
2022
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9. Role of the pediatric emergency department during SARS-CoV-2 pandemic

Author

Cristina Parra Cotanda, Ana Muñoz Lozón, Eva Botifoll García, David Andina Martinez, Nuria Clerigué Arrieta, Agustín de la Peña Garrido, Marta Bueno Barriocanal, Nuria Gilabert Iriondo, Gloria Guerrero Márquez, Maribel Lázaro Carreño, Abel Martínez Mejías, Conchita Miguez Navarro, Ana Muñoz Lozon, María Angeles Murillo Pozo, Adrián Ranera Malga, Mónica Rebordosa Martínez, Rocío Rodrigo García, Agustin Rodriguez Ortiz, Eva Ruperez García, and Carmen Solano Navarro

Subjects
Pediatrics, RJ1-570
Published
2022
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