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Background: Recently, menstrual blood-derived stem cells as a unique source of stem cells with some features such as ease of access, high ability to proliferate and regenerate, lack of immune system stimulation and no tumorigenesis have raised great hopes for heart disease cell therapy. However, the regulatory mechanisms and role of miRNAs in controlling the differentiation of stem cells into cardiomyocytes are not fully understood. In this study, the level of human miR-26b-5p microRNA were investigated before and after differentiation of endometrial stem cells into heart cardiomyocytes. Materials and Methods: Endometrial mesenchymal stem cells were differentiated into cardiomyocyte-like cells for 30 days in the presence of 5-azacitidine and fibroblast growth factor. Then, using bioinformatics studies, human miR-26b-5p microRNA was selected and its expression pattern was performed during days 0, 6, 12, 18, 24 and 30 of differentiation by Real Time qRT PCR Results: Expression Level of human miR-26b-5p showed an uptrend differentiation between days 0 and 6 and then showed a significant decreasing trend differentiation from day 6 to day 18 and an uptrend again after day 18. Conclusion: The non-uniformity in the expression of hsa-miR-26b-5p microRNA during the 24-day differentiation induction period indicates the existence of different messaging pathways involved in the differentiation process as well as different phases in the evolution and differentiation of cardiomyocytes. The miRNAs involved in the differentiation process and their possible role in turning off and on these messaging pathways at the beginning or end of a phase seems necessary.

Lane Algorithm is used to determine optimum cut off grade for a mining operation. There may be three parts in each operation: mining, concentration and refining. In Sarcheshmeh Copper Mine the concentrate coming from the stock has the average grade in addition to the production rate and cost. Therefore, the grade distribution is affected by production rate and cost parameters. The calculation of the cut off grade is done using a modified Lane Algorithm. Therefore, a mix of blending stock received from outside and the concentrate from the mine was considered in the Lane Algorithm. Initially, the profit objective function was taken into account with the addition of the stock limitations; then, the Lane Quartet Model was used and the cut off grade determined. The model uses the technical and economical data of different parts to determine the cut off grade. The result of the model was a cut off grade of (0.1408%), which brings about an increase of848051645 US dollars as profit, in comparison to the cut off grade (0.1617%) that was obtained by the Lane tripartite model.

A wide variety of 2-amino-4 H-chromene derivatives with diverse substituents on the 4 H-chromene ring were efficiently prepared via one-pot three-component reaction of an aromatic aldehyde and malononitrile with 2-hydroxynaphthalene-1,4-dione, ethyl acetoacetate, or naphthols in the presence of triethanolamine as a new organocatalyst under solvent-free conditions. The procedure is transition metal-free and environmentally friendly approach to various 2-amino-4 H-chromene derivatives. Its advantages include short reaction time, high yields, low cost, and straightforward work-up. Triethanolamine is an efficient reusable catalyst. 2-Amino-4 H-benzo[ g]chromenes (ABgC) were applied as novel components of electro synthesis of silver nanoparticles. [ABSTRACT FROM AUTHOR]

The importance of efficiency and improvement of health service for resolving people's health requirement and meeting their expectation is increasing. In addition, it considers as a priority for making decision and manager's activity in health officials. Manager's control on the management principle and the proper use of their management skill and creating a sense of trust and commitment are the tools that were providing a good condition for working and catching the organization's goals. In this quasiexperimentalstudy, before beginning the research, the non-teaching hospitals that are affiliated to the Kurdistan's medical science university were randomly divided into 2 groups. Three hospitals from 3 cities considered as a control group, and three hospitals from 3 cities considered as an intervention group.80 person of hospital's obstetrician staff classified in these 2 group by quota method and the hospital's nurses and obstetrician's manager of case-control involved by census method. The research's tool was Hersi and Gold Smith's standard efficiency questionnaire, which was filled out at the beginning of the study by the obstetricians of both groups and then it gave to the hospital's nurses and obstetrician's managers of the case group's instructing management skills for 16 hours. The efficiency's questionnaire was filled out, compared, and evaluated again by the obstetricians of both groups, 12 weeks after intervention. The data analyzed by the independent T-test, variance analysis, paired T-test, and SPSS 22. The findings showed that the average of the obstetrician's efficiency mainly developed in the intervention team after the instruction of management skills to the managers (P < 0.001). Conclusion: The instruction of the management skill to the nurses and obstetrician's managers caused the efficiency's promotion. Therefore, the instruction of the management skills has suggested as a method of increasing efficiency in hospitals. [ABSTRACT FROM AUTHOR]

Iran's economy dependence on oil revenues has caused some impacts in the form of commodity price fluctuations on current revenues. Accordingly, in the past few years especially in the Second Development Plan, the government included encouragements and reduced the country's dependence on oil revenues in its agenda. Agricultural export, especially livestock and poultry export has a proper status due to its relative advantage. Therefore, this study aims to identify the factors affecting the supply of export animal products. For this purpose, factors affecting the export of livestock products were identified using Co-integration Analysis. Empirical results showed that livestock products export is significantly affected by livestock added-value, changes in price index of export goods, subjective price index of livestock products and climate changes. [ABSTRACT FROM AUTHOR]

An efficient and practical synthesis of 1,3,5-trisubstituted 2-pyrazoline structures was achieved through cyclization of phenylhydrazine with α,β -unsaturated ketones (chalcones) using methanoic acid (formic acid) as catalyst under thermal condition.

Graphite carbon nitride (g-C 3 N 4 ) is a two-dimensional nano-sheet with electronic properties, which shows unique characteristics with high chemical and thermal stability in its structure. The functionalization of these compounds through covalent bonding is an important step towards significantly improving their properties and capabilities. To achieve this goal, a novel strategy for the covalent functionalization of Fe 3 O 4 @g-C 3 N 4 with thiamine hydrochloride (vitamin B1) via cyanuric chloride (TCT), which is a divalent covalent linker, was presented. The efficiency of Fe 3 O 4 @gC 3 N 4 @Thiamine as a heterogeneous organic catalyst in the synthesis of spirooxindole-pyran derivatives and 2-amino-4H-pyran under solvent-free conditions was evaluated and the yields of high-purity products were presented. In addition, easy recycling and reuse for seven consecutive cycles without significant reduction in catalytic activity are other features of this catalyst. Moreover, the performance of the prepared sorbent in the microextraction technique (herein, magnetic solid phase extraction) was studied. The tebuconazole was selected as the target analyte. The target analyte was extracted and determined by HPLC-UV. Under the optimum condition, the linear range of the method (LDR) was estimated in the range of 0.2-100 μg L -1 (the coefficient of determination of 0.9962 for tebuconazole). The detection limit (LOD) of the method for tebuconazole was calculated to be 0.05 µg L -1 . The limit of quantification (LOQ) of the method was also estimated to be 0.16 µg L -1 . In order to check the precision of the proposed method, the intra-day and inter-day relative standard deviations (RSD%) were calculated, which were in the range of 1.5- 2.8%. The method was used for the successful extraction and determination of tebuconazole in tomato, cucumber, and carrot samples., (© 2024. The Author(s).)

In this research, Fe 3 O 4 @SiO 2 @NTMPThio-Cu was introduced as a novel and green heterogeneous nanocatalyst with a dendrimer template that is environmentally friendly and reusable based on Fe 3 O 4 @SiO 2 . In this way, magnetic silica nanoparticles were first modified with cyanuric chloride, followed by melamine and thiosemicarbazide, and ultimately, it's decorated with the cost-effective metal copper. The synthesized nanocatalyst was characterized by various analyses such as FT-IR, XRD, SEM, TGA, and EDX. The efficiency of Fe 3 O 4 @SiO 2 @NTMPThio-Cu was measured in one-pot synthesis of xanthene and spirooxindole-pyran derivatives under mild solvent-free conditions. High efficiency, excellent yield of products, mild reaction conditions, simple operation, no use of toxic organic solvents, and reusability of this catalyst increase the attractiveness of this technique for large-scale environmentally friendly operations., (© 2024. The Author(s).)

This review addresses the current understanding of In Vitro Maturation (IVM) treatment, including indications and effective treatment protocols influencing oocyte developmental competence. A comprehensive literature search was performed to gather relevant studies, clinical trials, and reviews related to IVM. Databases such as PubMed, MEDLINE, and pertinent medical journals were searched. The selected literature was analyzed and synthesized to offer a comprehensive overview. IVM has emerged as a promising technique for inducing maturation in immature oocytes across various developmental stages. Its applications extend to areas utilizing In Vitro Fertilization (IVF), gaining traction as a treatment option for Polycystic Ovary Syndrome (PCOS) and fertility preservation in cancer patients. Recent advancements have led to improved global pregnancy rates, resulting in successful births. IVM also holds potential in reducing risks associated with conventional IVF, including ovarian hyperstimulation syndrome and multiple pregnancies. Despite these advantages, IVM adoption in clinical practice remains limited. Ongoing research aims to refine therapeutic protocols and expand clinical indications. IVM holds promise in assisted reproductive technology, spanning applications from cancer patient fertility preservation to addressing PCOS. Enhanced pregnancy rates highlight efficacy, while risk reduction compared to IVF underscores its importance. Further research is needed for optimal use across patient groups, emphasizing protocol refinement and expanded applications., (Copyright© 2024 Avicenna Research Institute.)

Background: The most common Assisted Reproductive Technology is In-Vitro Fertilization (IVF). During IVF, embryologists commonly perform a morphological assessment to evaluate embryo quality and choose the best embryo for transferring to the uterus. However, embryo selection through morphological assessment is subjective, so various embryologists obtain different conclusions. Furthermore, humans can consider only a limited number of visual parameters resulting in a poor IVF success rate. Artificial intelligence (AI) for embryo selection is objective and can include many parameters, leading to better IVF outcomes., Objectives: This study sought to use AI to (1) predict pregnancy results based on embryo images, (2) assess using more than one image of the embryo in the prediction of pregnancy but based on the current process in IVF labs, and (3) compare results of AI-Based methods and embryologist experts in predicting pregnancy., Methods: A data set including 252 Time-lapse Videos of embryos related to IVF performed between 2017 and 2020 was collected. Frames related to 19 ± 1, 43 ± 1, and 67 ± 1 h post-insemination were extracted. Well-Known CNN architectures with transfer learning have been applied to these images. The results have been compared with an algorithm that only uses the final image of embryos. Furthermore, the results have been compared with five experienced embryologists., Results: To predict the pregnancy outcome, we applied five well-known CNN architectures (AlexNet, ResNet18, ResNet34, Inception V3, and DenseNet121). DeepEmbryo, using three images, predicts pregnancy better than the algorithm that only uses one final image. It also can predict pregnancy better than all embryologists. Different well-known architectures can successfully predict pregnancy chances with up to 75.0% accuracy using Transfer Learning., Conclusion: We have developed DeepEmbryo, an AI-based tool that uses three static images to predict pregnancy. Additionally, DeepEmbryo uses images that can be obtained in the current IVF process in almost all IVF labs. AI-based tools have great potential for predicting pregnancy and can be used as a proper tool in the future., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Borna, Sepehri and Maleki.)

In this research, the extract of Ephedra intermedia Schrenk & C.A.Mey. was encapsulated using the mini-emulsion polymerization method based on methyl methacrylate polymers with a nanometer size. The encapsulated extract was characterized using different analytical techniques. Furthermore, the loading efficiency and release of the plant extract were examined. FT-IR spectroscopy confirmed the formation of an expectational product. The TEM and SEM imaging showed a spherical morphology for the prepared encapsulated extract. The average size of poly-methyl-methacrylate nanoparticles containing Ephedra extract was found to be approximately 47 nm. The extract loading efficiency and encapsulation efficiency test demonstrated a dose-depending behavior on E. intermedia extract for both analyses, which is highly advantageous for traversing biological barriers. The release assay shows a controlled release for the extract at phosphate buffer solution (PBS). A 38 % release was calculated after 36 hours. The results obtained from the present study reveal that encapsulating the plant extract is a suitable alternative to control and increase their medicinal properties., (© 2024 Wiley-VHCA AG, Zurich, Switzerland.)