1. No influence of PTGS2 polymorphisms on response and remission to antidepressants in major depression
- Author
-
Alessandro Serretti, Carlos Forray, Julien Mendlewicz, Raffaella Calati, Lenore Snyder, Diana De Ronchi, M. Fink, Isabelle Massat, Daniel Souery, Siegfried Kasper, Alberto Chiesa, Yves Lecrubier, Joseph Bollen, Sylvie Linotte, Joseph Zohar, Irina Antonijevic, Serretti, A, Chiesa, A, Calati, R, Massat, I, Linotte, S, Kasper, S, Lecrubier, Y, Fink, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Mendlewicz, J, Serretti A., Chiesa A., Calati R., Massat I., Linotte S., Kasper S., Lecrubier Y., Fink M., Antonijevic I., Forray C., Snyder L., Bollen J., Zohar J., De Ronchi D., Souery D., and Mendlewicz J.
- Subjects
Major depressive disorder, Response, PTGS2 ,Adult ,Male ,Oncology ,medicine.medical_specialty ,Single-nucleotide polymorphism ,Polymorphism, Single Nucleotide ,Internal medicine ,Humans ,Medicine ,Treatment resistance ,Psychiatry ,Biological Psychiatry ,Depression (differential diagnoses) ,Aged ,MAJOR DEPRESSIVE DISORDER ,Depressive Disorder, Major ,response ,Chi-Square Distribution ,business.industry ,PTGS2 ,Middle Aged ,medicine.disease ,Antidepressive Agents ,PTGS2 Gene ,Psychiatry and Mental health ,Cyclooxygenase 2 ,Pharmacogenetics ,Antidepressant ,Major depressive disorder ,Female ,business ,Chi-squared distribution - Abstract
In the present study, aimed at investigating whether a set of single nucleotide polymorphisms (SNPs) within PTGS2 gene (rs4648276, rs2066826 and rs689466) could be associated with antidepressant response, remission and treatment resistance in a sample of major depression patients, we did not find evidence supporting any of such associations. © 2010 Elsevier Ltd.
- Published
- 2011
- Full Text
- View/download PDF