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A genome‐wide association study (GWAS) is a powerful tool in investigating genetic contribution, which is a crucial factor in the development of complex multifactorial diseases, such as type 2 diabetes mellitus. Type 2 diabetes mellitus is a major healthcare burden in the Western Pacific region; however, there is limited availability of genetic‐associated data for type 2 diabetes in Southeast Asia, especially among the Kinh Vietnamese population. This lack of information exacerbates global healthcare disparities. In this study, 997 Kinh Vietnamese individuals (503 with type 2 diabetes and 494 controls) were prospectively recruited and their clinical and paraclinical information was recorded. DNA samples were collected and whole genome genotyping was performed. Standard quality control and genetic imputation using the 1000 Genomes database were executed. A polygenic risk score for type 2 diabetes was generated in different models using East Asian, European, and mix ancestry GWAS summary statistics as training datasets. After quality control and genetic imputation, 107 polymorphisms reached suggestive statistical significance for GWAS (≤5 × 10−6) and rs11079784 was one of the potential markers strongly associated with type 2 diabetes in the studied population. The best polygenic risk score model predicting type 2 diabetes mellitus had AUC = 0.70 (95% confidence interval = 0.62–0.77) based on a mix of ancestral GWAS summary statistics. These data show promising results for genetic association with a polygenic risk score estimation in the Kinh Vietnamese population; the results also highlight the essential role of population diversity in a GWAS of type 2 diabetes mellitus. [ABSTRACT FROM AUTHOR]

Introduction: Genetic mutations of PROC and PROS1 are well‐known risk factors for deep venous thrombosis (DVT) in the Asian population. However, the genetic profile of Vietnamese patients with DVT remains elusive. This study aimed to investigate the spectrum of genetic mutations of these two genes in Vietnamese patients diagnosed with idiopathic DVT. Materials and methods: A total of 50 Vietnamese patients diagnosed with idiopathic DVT were recruited in this study. The entire coding regions of the protein C and protein S genes were amplified and directly sequenced to determine genetic alterations. Results: Four and six genetic mutations were detected in protein C and protein S genes, respectively, in 24 Vietnamese DVT patients. PROC c.565C > T (p.R189W) was the most common mutation found in 13 out of 50 patients, while the mutations of PROS1 comprised three missense and three nonsense variants which diffuse along the gene. Conclusions: This study shows that mutations of protein C and protein S genes are prevalent in Vietnamese patients diagnosed with idiopathic DVT, and PROC c.565C > T (p.R189W) was the most common genetic alteration. [ABSTRACT FROM AUTHOR]

Purpose: The interest in the possibility of CRM application in the public sector has begun to emerge again recently with the development of e-government. In this paper, we show the optimistic support to the application of the CRM implementation in the public sector. Design/methodology/approach: In this study, we attempted to explore the potentials of CRM application in public sectors by reviewing the existing literature on the traditional CRM concepts as well as in the context of government over the last decades. Findings: CRM has not been utilised commonly by governments due to the number of complexities that needed to be more investigated and fixed by resolutions. A number of researchers have figured out the big gaps between private and public sectors which lead to difficulties in apply CRM in public services. Social implications: This paper would be the initial foundation for our coming empirical research to get more insights into this area as we do believe that the implementation of CRM in the public sector is an emerging research potential that is valuable and significantly beneficial to the scientific innovation relating to government operation. Originality/value: The paper reviewed existing findings to provide a better understanding of the field and figured out the main potentials of CRM in promoting government reputation, engaging citizens to the operating system, and improving the quality of service delivery in the public services system. [ABSTRACT FROM AUTHOR]