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Genome‐wide association and polygenic risk score estimation of type 2 diabetes mellitus in Kinh Vietnamese—A pilot study.

Authors :
Mai, Thao Phuong
Luong, Bac An
Ma, Phat Tung
Tran, Thang Viet
Dinh Ngo, Tat Thang
Hoang, Chi Khanh
Van Tran, Luong
Le, Bao Hoang
Vu, Hoang Anh
Le, Linh Hoang Gia
Le, Khuong Thai
Truong, Steven
Tran, Nam Quang
Do, Minh Duc
Source :
Journal of Cellular & Molecular Medicine; Jul2024, Vol. 28 Issue 13, p1-8, 8p
Publication Year :
2024

Abstract

A genome‐wide association study (GWAS) is a powerful tool in investigating genetic contribution, which is a crucial factor in the development of complex multifactorial diseases, such as type 2 diabetes mellitus. Type 2 diabetes mellitus is a major healthcare burden in the Western Pacific region; however, there is limited availability of genetic‐associated data for type 2 diabetes in Southeast Asia, especially among the Kinh Vietnamese population. This lack of information exacerbates global healthcare disparities. In this study, 997 Kinh Vietnamese individuals (503 with type 2 diabetes and 494 controls) were prospectively recruited and their clinical and paraclinical information was recorded. DNA samples were collected and whole genome genotyping was performed. Standard quality control and genetic imputation using the 1000 Genomes database were executed. A polygenic risk score for type 2 diabetes was generated in different models using East Asian, European, and mix ancestry GWAS summary statistics as training datasets. After quality control and genetic imputation, 107 polymorphisms reached suggestive statistical significance for GWAS (≤5 × 10−6) and rs11079784 was one of the potential markers strongly associated with type 2 diabetes in the studied population. The best polygenic risk score model predicting type 2 diabetes mellitus had AUC = 0.70 (95% confidence interval = 0.62–0.77) based on a mix of ancestral GWAS summary statistics. These data show promising results for genetic association with a polygenic risk score estimation in the Kinh Vietnamese population; the results also highlight the essential role of population diversity in a GWAS of type 2 diabetes mellitus. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15821838
Volume :
28
Issue :
13
Database :
Complementary Index
Journal :
Journal of Cellular & Molecular Medicine
Publication Type :
Academic Journal
Accession number :
178468481
Full Text :
https://doi.org/10.1111/jcmm.18526