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Introduction: Lesions in the gastroinestinal (GI) tract that are distal to the Treitz ligament are what cause the lower gastrointestinal bleeding (LGB) system. The purpose of this study was to investigate and compare the Charlson Comorbidity Index (CCI), mortality rates, length of hospital stays, need for intensive care, need for blood products, and surgical rates in patients with acute LGB. Material and Method: Retrospective research was done on patients who had lower GI bleeding and had been seen in our gastroenterology clinic between 2015 and 2021. We looked into the impact of CCI on patients' follow-up after LGB. Results: The mean age of the 210 patients who had lower GI bleeding was 67.70±13.67 years. For all of the patients, the median CCI value was 4.00. (2.00-5.00). While 16 study participants (group 1) passed away, 194 participants (group 2) were released from the hospital. The variance in the median CCI values between the two groups was statistically significant (p>0.001). The results of a multivariate logistic regression analysis revealed that CCI was a reliable predictor of mortality (p>0.001). Conclusion: It was found that CCI was an accurate predictor of mortality. CCI ought to be regarded as a crucial factor in the treatment of patients who are bleeding from their lower gastrointestinal tract.

Decreased mismatch negativity (MMN) is a proposed biomarker for psychotic disorders. However, the magnitude of the effect appears to be attenuated in first-episode populations. Furthermore, how mismatch negativity amplitudes are related to brain connectivity in this population is unclear. In this study, we used high-density EEG to record duration-deviant MMN from 22 patients with first-episode psychosis (FEP) and 23 age-matched controls (HC). Consistent with past work, we found decreased MMN amplitude in FEP over a large area of the frontal scalp. We also found decreased latency over the occipital scalp. MMN amplitude was negatively correlated with antipsychotic dose. We used Granger causality to investigate directional connectivity between frontal, midline, left, and right scalp during MMN and found reduced connectivity in FEP compared to HC and following deviant stimuli compared to standard stimuli. FEP participants with smaller decreases in connectivity from standard to deviant stimuli had worse disorganization symptoms. On the other hand, connectivity from the front of the scalp following deviant stimuli was relatively preserved in FEP compared to controls. Our results suggest that a relative imbalance of bottom-up and top-down perceptual processing is present in the early stages of psychotic disorders.

Purpose:This study aimed to investigate whether breastfeeding in early childhood affect the risk of devoloping IBD. Methods:In order to investigate the effect of breast milk on the development of IBD and in order to reduce the effects of genetic and environmental factors, the patient data obtained from the survey were compared to the data of their non-IBD siblings as a control group. Results: The data of 122 Crohn's disease patients were compared with the sibling group of 332 individuals, and the data of 182 ulcerative colitis patients with the sibling group of 508 individuals. Compared to the control group, it was determined that the proportion of those who never breastfed was statistically significantly higher in both the CD and UC groups (7.4% vs. 2.1% for CD, p=0.017 and 3.9% vs. 0.8% for UC, p=0.01), and the risk of disease increased significantly in those who wasn’t breastfed (OR= 3.70 [1.35-10.16] for CD, p=0.017 and OR= 5.07 for UC [1.47-17.53], p=0.010). It was determined that the protective effect increased against CD as the duration of breastfeeding increased, but that the protection increased with breastfeeding for up to 12 months for UC, and breastfeeding for more than 12 months did not provide additional protection. There was no relationship between breastfeeding and demographic and behavioral chracteristics of patients. Conclusions: Not having been breastfed in infancy increases the risk of developing both UC and CD, and as the duration of breastfeeding increases, the protection against disease risk increases.

BACKGROUND: The extent to which health care systems have adapted to the COVID-19 pandemic to provide necessary cardiac diagnostic services is unknown.OBJECTIVES: The aim of this study was to determine the impact of the pandemic on cardiac testing practices, volumes and types of diagnostic services, and perceived psychological stress to health care providers worldwide.METHODS: The International Atomic Energy Agency conducted a worldwide survey assessing alterations from baseline in cardiovascular diagnostic care at the pandemic's onset and 1 year later. Multivariable regression was used to determine factors associated with procedure volume recovery.RESULTS: Surveys were submitted from 669 centers in 107 countries. Worldwide reduction in cardiac procedure volumes of 64% from March 2019 to April 2020 recovered by April 2021 in high- and upper middle-income countries (recovery rates of 108% and 99%) but remained depressed in lower middle- and low-income countries (46% and 30% recovery). Although stress testing was used 12% less frequently in 2021 than in 2019, coronary computed tomographic angiography was used 14% more, a trend also seen for other advanced cardiac imaging modalities (positron emission tomography and magnetic resonance; 22%-25% increases). Pandemic-related psychological stress was estimated to have affected nearly 40% of staff, impacting patient care at 78% of sites. In multivariable regression, only lower-income status and physicians' psychological stress were significant in predicting recovery of cardiac testing.CONCLUSIONS: Cardiac diagnostic testing has yet to recover to prepandemic levels in lower-income countries. Worldwide, the decrease in standard stress testing is offset by greater use of advanced cardiac imaging modalities. Pandemic-related psychological stress among providers is widespread and associated with poor recovery of cardiac testing.

Endoscopic retrograde cholangiopancreatography (ERCP) is an important therapeutic tool for many biliary diseases. Selective biliary cannulation is the first step of the treatment process. Needle knife fistulotomy (NKF) and conventional precut sphincterotomy (CPS) are widely used in difficult biliary cannulation. However, there are different results in their effectiveness and safety. This study aimed to compare both methods regarding cannulation success and adverse event profile.All eligible consecutive patients with naive papillae who underwent biliary ERCP by a single experienced endoscopist over a 3-year period were included retrospectively. The standard cannulation method with a guidewire-loaded sphincterotome was initially used for biliary cannulation in all patients. Cannulation was accepted as difficult in the case of failure of standard cannulation within 5 minutes or despite 5 attempts or insertion of the guidewire to the pancreatic duct 5 times. Three modalities in patients with difficult biliary cannulation were employed according to the structure and configuration of the papillae in addition to unintentional pancreatic cannulation: (1) NKF, (2) CPS, (3) Double guidewire technique or guidewire orientation/precut following pancreatic stenting. Latter was excluded to enable direct comparison between NKF and CPS groups.A total of 644 patients were recruited. Analyses were performed with 541 patients after the exclusion of 103 patients. Mean (SD) age was 60.4 (18.2) years, and 257 (47.5%) patients were male. While standard cannulation was successful in 366 (67.6%), difficult biliary cannulation was observed in 175 (32.4%) patients. NKF was performed in 101 (57.7%) patients, and cannulation success was 100% in the first ERCP session. In contrast, CPS was performed in 74 (42.3%) patients with a lower cannulation success rate (79.7%) than NKF ( P0.001). Post-ERCP pancreatitis rate was higher in CPS (9.5%) than NKF group (3.0%, P =0.063). Bleeding and cholangitis were similar in both groups.In patients with difficult biliary cannulation with appropriate papillary structure and configuration, NKF should be used as the first choice in experienced hands because of high biliary cannulation success and low Post-ERCP pancreatitis risk.

BACKGROUND: There is limited data in the literature analyzing the efficacy of methotrexate in Crohn’s disease used after thiopurine analogs. We aimed in our study to show the efficacy of methotrexate in Crohn’s disease patients who failed to respond to thiopurine treatment. METHODS: The study included 29 azathioprine refractory patients with Crohn’s disease. Intramuscular methotrexate (25 mg/week) in the induction of remission and intramuscular methotrexate (15 mg/week) in 29 CD patients with a median follow-up time of 13 months was performed. In 15 (51.7%) patients, methotrexate was used in combination with anti-Tumour necrosis factor (TNF) (combination group), while it was used in 14 (48.3%) patients in monotherapy (monotherapy group). RESULTS: The mean Harvey–Bradshaw index score significantly decreased in the follow-up period (Wk0 = 7.6, last visit = 4.5, P < .001). Remission and response rates at week 12 were 75.9% and 79.3%, respectively. Maintenance of remission (77.8% vs 37.5%, respectively, P = .1) and response rates (77.8% vs 50%, respectively, P = .3) due to last visit examination were numerically higher in combination group but they were not statistically significant. The cumulative probability of remission maintenance in patients with methotrexate therapy was 72.7%, 33.1%, and 22.0% at 1, 2 ,and 4 years after starting methotrexate, respectively. CONCLUSION: Our results show that parenteral use of methotrexate is efficacious in inducing and maintaining remission as a step-up agent in azathioprine refractory Crohn’s disease patients.

Background The initial treatment for fecal incontinence (FI) includes supportive treatment and medical treatment. If the initial treatment fails, biofeedback therapy (BFT) is recommended. However, there are limited and conflicting results in the literature supporting the beneficial effect of BFT for FI. The aim of the study is to analyze the efficacy of BFT in 126 patients who have FI due to several causes. Methods The data of 126 patients (88 females (69.8%) and 38 males (30.2%)) were collected retrospectively. Colonoscopy, anorectal manometry (ARM), and 3D-Endoanal ultrasonography (EAUS) were performed for all patients before applying BFT. In addition, all patients received toilet training instruction and training in Kegel and other pelvic floor strengthening exercises from an experienced nurse, before BFT. Results The median age of participants was 54 years (range 18-75 years). While 80 patients (63.5%) had clinical and manometric benefit from BFT, 46 patients (36.5%) did not respond to BFT. According to the EAUS and ARM findings, BFT was beneficial in patients who had partial external sphincter failure, and was unsuccessful in patients who had both internal and external sphincter failure, both internal and external sphincter tears, and external sphincter tear rates of more than 25%. After BFT, significant increases in squeeze pressures were observed, with this increase being higher in the positive-response group. Conclusion The results suggest that BFT is effective in the treatment of FI for specific patient populations.

Objective: In this study we aimed to determine the coexistence of overactive bladder in patients with gastroenterological disorders including hepatitis, cirrhosis and IBD. Materials and Methods: we prospectively collected the data of patients who admitted to the outpatient clinic of department of gastroenterology at xxx hospital between May 2017 and February 2019. All patients with chronic gastroenterological disorders such as hepatitis and irritable bowel syndrome willing to participate the study after the verbal consent were included the study Results: A total of 289 female patients were included the study. The mean age of the patients was 49.9 ±13 years. The mean BMI value was 27.9± 4.5 kg/m2. Among 289 patients, 135 (46.7%) had Hepatitis B, 53 (18.3%) had ulcerative colitis, 35 (12.1%) had Crohn’s disease, 22 (7.6%) had autoimmune hepatitis, 19 (6.6%) had primer biliary cirrhosis, 13 (4.5%) had Hepatitis C and 12(4.2%) had celiac disease. The mean age of patients was similar between patients having OAB-v8 higher and lower than 8 (p=0.46). However, patients having OAB score>8 had higher BMI compared to patients who had OAB score

The aim of this study is to develop a land quality index (LQI) based on expert opinion and multi criteria decision support approaches specific to the region and to apply it on agricultural lands. The study was carried out in 7 soil series and 43 land units of Mugla-Dalaman General Directorate of Agriculture Management with an area of 3338.61 ha, representing Mediterranean climate ecology. In this study, 13 indicators; I) Land: soil depth, slope, stoniness and drainage, ii) Physical: available water capacity, bulk density, texture, iii) Chemical: pH, electrical conductivity (EC), organic matter content, phosphors, potassium, and total nitrogen which are representative of one or more of the land and soil characteristics were selected in the light of expert and literature knowledge. Analytical Hierarchy Process which is a multi-criteria decision approach was used for pairwise comparisons of the indicators. As a result of the LQI assessment, 61.56% of the farmland was classified as “very high” and “high” quality and the agricultural quality class of the 35.29% of the land was determined as “low” and “very low” quality and mapped in a geographical information system environment. According to obtained results it was determined that the final quality index values of the lands were affected by depth (12.5%), slope (12%), EC (11.1%) and texture (10.7%) indicators with high weight coefficients. In addition, it has been suggested that areas with low agricultural quality values can reach to high-quality classes with some improvement measures (development of drainage channels, the addition of organic material, removal of stones).

Although field surveys represent an essential method for determining soil productivity, the use of remote sensing techniques has become a popular option over recent years due to its economic and practical applications. The fundamental basis of this approach is the estimation of soil productivity by using the vegetation indices as an indicator, with reference to the yield. In this study, it is aimed to estimate the productivity potential of the agriculture areas from biomass density in case of limited pedological and parcel-based data. For this purpose, relationships between the FAO Soil Productivity Rating (SPR) and different vegetation indices were investigated. The indices NDVI, RE-OSAVI, and REMCARI were used with Sentinel-2A images. Wheat was selected as an indicator plant to estimate the yield because it is the most occupied (27.47%) cultigen in the field. The study was conducted at the Karacabey State Farm with an area of 87 km(2) and is located in Bursa province, Turkey. The research showed a positive relationship between SPR and 2018 yield values (r(2) = 0.616). During the tillering period, the r(2) for RE-OSAVI was 0.629. In the heading stage, the r(2) for NDVI was 0.577. The index REMCARI provided yield estimations with low accuracy coefficient (0.216

Objectives: The first case of COVID-19 infection was confirmed in Turkey on March 11, 2020 and the Turkish government ordered a nation-wide school closure and lockdown for people younger than 20 years old by 1st of April. School closure and home confinement might have adverse effects on children's physical and mental health. In this study, we aimed to compare the effect of the COVID-19 pandemic on psychological reactions and coping of CF patients and healthy controls. Methods: 132 CF patients and 135 volunteers, ages 7 years and older, were included in the study. The survey included questions regarding family environment and peer relations, self care during lockdown and psychological reactions to the COVID-19 pandemic. Results: Compared to the patient group, the control group showed more anxiety symptoms, tried to have new hobbies during lockdown and needed more psychological help (Table 1). [Table presented] Conclusion: Surprisingly, symptoms of anxiety were higher in the control group compared to the CF group. CF patients seem to show more resiliance in coping with the outbreak and with school closure than their peers. Also, they reported needing less psychological help (not statistically significant). Since CF patients are already used to wearing face masks and follow infection control measures in their daily lives, these measures may not cause extra anxiety as in their healthy peers. Screening for psychological symptoms should be recommended both for CF patients and healthy children. Children with CF and also healthy children should be screened for anxiety symptoms and appropriate psychological support should be provided to them, if needed.

Celiac disease is a chronic immune-mediated disease of the small intestine. It has been known that dilated cardiomyopathy and ischemic coronary artery disease have become more frequent in patients with celiac disease. The aim of the study was to assess Tp-e interval and Tp-e/QT ratio in patients with celiac disease.This study was conducted at a single center in collaboration with gastroenterology and cardiology clinics. Between January 2014 and June 2015, a total of 76 consecutive patients were enrolled (38 patients with celiac disease and 38 control subjects). Tp-e interval, Tp-e/QT and Tp-e/QTc ratio were measured from the 12-lead electrocardiogram.Tp-e interval (64.2±11.0 vs. 44.5±6.0; p0.001), Tp-e/QT ratio (0.18±0.02 vs. 0.13±0.02; p0.001) and Tp-e/QTc ratio (0.16±0.02 vs. 0.11±0.01; p0.001) were significantly higher in patients with celiac disease than control subjects. There was a significant positive correlation between Tp-e/QTc ratio and disease duration in patients with celiac disease (r=0.480, p=0.003) and also there was a significant positive correlation between Tp-e/QTc ratio and erythrocyte sedimentation rate (r=0.434, p0.001).Our study showed that Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in patients with celiac disease. Whether these changes increase the risk of ventricular arrhythmia deserve further studies.

Giris ve Amac: Inflamatuvar barsak hastaliklari kronik inflamasyon ve aterosklerozda artisla karakterize hastaliklardir. Bircok calismada inflamatuvar barsak hastaliklarinda kardiyovaskuler hastaliklar icin potansiyel neden olabilecek lipid anormallikleri arastirilmistir. Biz bu calismamizda inflamatuvar barsak hastaliklarinda lipid parametreleri uzerinde etkisi olabilecek ilac tedavisi, operasyon ve hastalik suresi gibi degiskenleri inceledik. Gerec ve Yontem: Turkiye Yuksek Ihtisas Egitim ve Arastirma Hastanesi Inflamatuvar Barsak Hastaliklari Poliklinigi’nde Ocak 2016-Mart 2016 arasinda ardisik olarak takip ve tedavi edilen hastalar calismaya alindi. Bulgular: Calismaya toplam 138 hasta (ulseratif kolit: 71 hasta, Crohn: 67 hasta) alindi. Hastalarin yas ortalamasi 45 olup 47 kadin, 71 erkek hasta vardi. Total kolesterol ve dusuk yogunluklu lipoprotein seviyeleri ulseratif kolit hastalarinda Crohn hastaligina gore anlamli olarak fazlaydi (sirasiyla p=0,003 ve p=0,001). Ulseratif kolitte proktit, sol kolon tutulumlu ve ekstensif tutulumlu hastalar arasinda total kolesterol, trigliserid, yuksek yogunluklu lipoprotein ve dusuk yogunluklu lipoprotein seviyeleri arasinda fark yoktu. Crohn hastalarinda inflamatuvar, penetran ve strikturan fenotipler arasinda total kolesterol, trigliserid, yuksek yogunluklu lipoprotein ve dusuk yogunluklu lipoprotein arasinda fark yoktu. Azatiyopurin ve mesalazin alan ve almayan hastalar arasinda bakilan lipid parametreleri icin fark bulunmadi. Anti-tumor nekrozis faktor alan hastalarda ise total kolesterol ve dusuk yogunluklu lipoprotein kolesterol seviyeleri anti-tumor nekrozis faktor almayan hastalara kiyasla anlamli olarak daha dusuk izlendi (sirasiyla p=0,01 ve p=0,02). Hastalarin aldiklari ilac tedavi sureleri ile total kolesterol, trigliserid, dusuk yogunluklu lipoprotein ve yuksek yogunluklu lipoprotein seviyeleri arasinda korelasyon izlenmedi. Sonuc: Inflamatuvar barsak hastaliklarinda lipid anormallikleri uzerine etkili olabilecek ilac, operasyon, hastalik fenotipi ve hastalik tutulum yeri gibi faktorlerin bilinmesi, ateroskleroz gibi potansiyel komplikasyonlarin onlenebilmesine olanak taniyabilir.

The objective here is to examine the role of overall oxidative stress in the etiopathogenesis of gluten-sensitive enteropathy disease and its relationship with gluten free diet and autoantibodies.Eighty gluten-sensitive enteropathy patients and 80 control group participants were included in the study. As oxidative stress parameters, we researched total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase-1 and arylesterase parameters in the serum samples of gluten-sensitive enteropathy patients.In comparison to the control group, gluten-sensitive enteropathy patients had lower TAS, paraoxonase-1 and arylesterase levels and gluten-sensitive enteropathy patients had considerable TOS and OSI levels. In contrast, patients who agreed to the gluten free eating routine had a higher OSI proportion and patients who did not conform to the gluten free eating regimen had a lower paraoxonase-1 level. An affirming reciprocation was de tected amidst TOS and OSI proportion and gluten-sensitive enteropathy autoantibodies and C-reactive protein levels and a negative correlation was found between arylesterase level and gluten-sensitive enteropathy autoantibodies.We observed oxidative stress levels to be higher in gluten-sensitive enteropathy patients contrasted with the control group. Oxidative stress level showed differences in gluten-sensitive enteropathy patients depending on gluten diet content and autoantibody positivity. In point of fact, C-reactive protein and gluten-sensitive enteropathy autoantibodies are identified with oxidative anxiety parameters resulting in the possibility that oxidative stress might be successful in the gluten-sensitive enteropathy pathogenesis.Cilj je ovde bio da se ispita uloga ukupnog oksidativnog stresa u etiopatogenezi glutenske enteropatije i njegov odnos sa bezglutenskom ishranom i autoantitelima.Osamdeset pacijenata sa glutenskom enteropatijom i 80 članova kontrolne grupe je uključeno u studiju. Kao parametri oksidativnog stresa, istraživani su ukupni antioksidantni status (UAS), ukupni oksidantni status (UOS), indeks oksidativnog stresa (IOS), paraoksonaza 1 i arilesteraza u uzorcima seruma pacijenata sa glutenskom enteropatijom.U poređenju s kontrolnom grupom, pacijenti sa glutenskom enteropatijom imali su niže nivoe UAS-a, paraoksonaze-1 i arilesteraze a pacijenti sa glutenskom enteropatijom imali su znatne nivoe UOS-a i IOS-a. Za razliku od toga, pacijenti koji su pristali na bezglutenski režim ishrane imali su višu proporciju IOS-a a pacijenti koji nisu pristali na bezglutenski režim imali su niži nivo paraoksonaze 1. Afirmativan reciprocitet utvrđen je između UOS-a i proporcije IOS-a i autoantitela za glutensku enteropatiju i nivoa C-reaktivnog proteina, a negativna korelacija je pronađena između nivoa arilesteraze i auto antitela za glutensku enteropatiju.Uočili smo da je nivo oksidativnog stresa bio viši kod pacijenata sa glutenskom enteropatijom u poređenju s kontrolnom grupom. Nivo oksidativnog stresa pokazao je razlike među pacijentima s glutenskom enteropatijom zavisno od sadržaja glutena u ishrani i pozitivnih autoanti tela. Zapravo,C-reaktivni protein i autoantitela za glutensku entero patiju identifikuju se sa parametrima oksidativne anksioznosti, {to rezultira mogućnošću da oksidativni stres uspešno učestvuje u patogenezi glutenske enteropatije.

Giris ve Amac: Normal populasyona gore inflamatuvar barsak hastaliginin tromboz riskinde artisla beraber oldugu iyi bilinir. Biz burada ulseratif kolit ve Crohn hastaligi olan hastalarimizda tromboz sikligini, tromboz saptanan hastalarin klinik seyirlerini ve trombozlarin ozelliklerini belirlemeyi amacladik. Gerec ve Yontem: Turkiye Yuksek Ihtisas Egitim ve Arastirma Hastanesi Inflamatuvar Barsak Hastaliklari polikliniginde takip edilen 3128 hasta tromboz yonunden retrospektif olarak incelendi. Bulgular: Calismamiza toplam 20 hasta alindi. Hastalarin yas ortalamasi 40,45 (22-70) olup 16 hasta erkek, 4 hasta kadindi. Hastalarimizin 10 tanesinde tromboz bacak derin venlerinde iken 4 hastada bacak derin venleriyle beraber pulmoner emboli seklinde goruldu. 2 hastada tromboflebit, 1 hastada serebral ven trombozu, 1 hastada mezenterik ven trombozu ve 2 hastada da portal ve hepatik ven trombozu olarak goruldu. Ilk inflamatuvar barsak hastaligi tanisi ile ilk tromboz tanisi arasi gecen sure ortanca 16 ay (2-240)’di. Trombozlar 15 hastada aktif hastalik esnasinda olusmustu. 20 hastanin 13 tanesinde tromboz tanisi sonrasi aldiklari medikal tedavilerde bir ust basamaga gecis goruldu. Sonuc: Inflamatuvar barsak hastaligi tromboza zemin hazirlayan bir hastaliktir. Tromboz gelisen hastalarin erken tani ve tedavisi morbidite ve hatta mortalitede azalmaya neden olacaktir. Tromboz ciddi seyredecek inflamatuvar barsak hastaliginin habercisi olabilir. Aktif hastalik ozellikle pretomboti bir durum olarak degerlendirilmeli ve gerekli antikoagulasyon baslanmalidir.

Objective There is no precise consensus at present on age to define elderly patients with inflammatory bowel disease (IBD), but recently, age of more than 60 years has been widely accepted. Characteristics of IBD in the elderly are somewhat different from what is seen in younger patients. The elderly have milder disease activity, and therapeutic options are fewer because of their age and features such as comorbidities, drug interactions, and loss of organ function. There are few reports on Crohn's disease in the elderly. Herein, first report on this topic with respect to population of this country is presented. Methods Characteristics of 95 patients with Crohn's disease, who were over age 60 from 3125 patients with IBD treated in our clinic between 1996 and 2015 were analyzed. Research was performed using patient files, and outpatient clinic visits, when possible. Results Median age of the group was 66 years, and male:female ratio was 1.6. Of the total, 48.4% of the patients had colonic disease, 37.9% had ileocolonic disease, and 13.7% had small bowel disease. Data indicated that 23.1% of patients had undergone surgical procedures, which were primarily right hemicolectomy and ileotransversostomy. Disease was most often managed with mesalazine or azathioprine. It was also determined that 12.6% patients had 2 or more comorbidities, and findings indicated coronary heart disease and hypertension were most prevalent. Conclusion Analysis revealed similar features in characteristics of disease compared with recent knowledge reported in the literature. This is the first report from our country to describe Crohn's disease in the elderly population, and the number of patients is sufficient to provide general information about this group.

We aimed to determine the levels of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) and paraoxonase1/arylesterase levels in inflammatory bowel disease (IBD), and the relation be - tween these molecules and the activity index of the disease.Eighty IBD patients (ulcerative colitis (UC)/Crohn disease (CD) 40/40) and 80 control group participants were included in the study. Oxidative stress parameters were measured using the colorimetric method. As disease activity indexes, the endoscopic activity index (EAI) was used for UC and the CD activity index (CDAI) was used for CD.In IBD patients, mean TAS (1.3±0.2 vs 1.9±0.2, respectively; p0.001) and arylesterase (963.9±232.2 vs 1252.9±275, respectively; p0.001) levels were found to be lower and TOS level (5.6±1.6 vs 4.0±1.0, respectively; p0.001) and OSI rate (4.5±1.6 vs 2.2±0.8, respectively; p0.001) were found to be higher compared to the control group. A strong positive correlation was found between EAI and TOS levels (r=0.948, p0.001) and OSI rate (r=0.894, p0.001) for UC patients. A very strong positive correlation was found between EAI and TOS levels (r=0.964, p0.001) and OSI rate (r=0.917, p0.001) for CD patients. It was found in a stepwise regression model that C-reactive protein, OSI and arylesterase risk factors were predictors of IBD compared to the control group. Conclusion: Increased oxidative stress level in IBD patients and the detection of OSI rate as an independent predictor for disease activity indexes lead to the idea that oxidative stress might be related to the pathogenesis of IBD.Na{ cilj bio je da odredimo nivoe ukupnog antioksidativnog statusa (TAS), ukupnog oksidativnog statusa (TOS), indeks oksidativnog stresa (OSI) i nivoe paraoksonaze 1/arilesteraze u zapaljenskoj bolesti creva (IBD), kao i odnos između ovih molekula i indeksa aktivnosti bolesti.U studiju je uključeno 80 pacijenata sa IBD (ulcerozni kolitis (UC) / Kronova bolest (CD) 40/40) i 80 subjekata kao kontrolna grupa. Parametri oksidativnog stresa mereni su kolorimetrijskom metodom. Kao indeksi aktivnosti bolesti, indeks endoskopske aktivnosti (EAI) koriščen je za UC, dok je za CD korišćen indeks aktivnosti CD (CDAI).Kod obolelih od IBD, nađeno je da su srednji TAS (1,3±0,2 vs 1,9±0,2; p0,001) i nivoi arilesteraze (963,9±232,2 vs 1252,9±275; p0,001) bili niži, a nivo TOS (5,6±1,6 vs 4,0±1,0; p0,001) i stopa OSI 4,5±1,6 vs 2,2±0,8; p0,001) viši u poređenju s kontrolnom grupom. Otkrivena je snažna pozitivna korelacija između nivoa EAI i TOS (r=0,948, p0,001) i stope OSI (r=0,894, p0,001) za obolele od UC. Veoma jaka pozitivna korelacija nađena je između nivoa EAI i TOS (r=0,964, p0,001) i stope OSI (r=0,917, p0,001) za obolele od CD. U modelu stepwise regresije uočeno je da su C-reaktivni protein, OSI i faktori rizika za arilesterazu bili prediktori za IBD u poređenju s kontrolnom grupom.Povišen nivo oksidativnog stresa kod pacijenata sa IBD i detekcija stope OSI kao nezavisnog prediktora za indekse aktivnosti bolesti navode na ideju da oksidativni stres može biti povezan sa patogenezom IBD.

Giriş:Elektrokardiyografide (EKG) ventriküler repolarizasyon Tp-eintervali ve kalp hızına göre düzeltilmiş QT (QTc) aralığıkullanılarak değerlendirilir. Uzamış Tp-e/QTc oranı aritmiler vekardiyak mortalite riskinde artışla ilişkilidir. NASH(nonalkolik steatohepatit)’in ventriküler repolarizasyon üzerine etkileriyle ilgili az sayıdaçalışma olduğu için, NASHhastalarında Tp-einterval ölçümlerini ve Tp-e/QT oranını değerlendirmeyiamaçladık. Gereçve Yöntemler: Çalışmamıza toplam97 NASHhastası ile 77 kişilik kontrol grubu dahil edildi. Tp-e intervali,Tp-e/QT ve Tp-e/QTc oranları 12-lead elektrokardiyogram ileölçüldü.Bulgular:Kalp hızı her iki grupta da benzerdi (74.8± 10.1 vs.75.7± 11.7;p=0.598). QT interval (396.0± 34.2 vs.384.6± 30.7;p=0.023) ve QTc interval (403.6± 34.8 vs.399.9± 36.3;p=0.027), Tp-e interval (100.4± 13.6 vs.91.4± 13.4;p, Aim: Ventricular repolarization is assessed usingthe Tp-e interval and QT interval corrected by the heart rate (QTc) via anelectrocardiogram (ECG). Prolonged Tp-e/QTc is related with an increased riskof arrhythmias and cardiac mortality. As there have been few reports regardingthe effects of NAFLD on ventricular repolarization, we aimedto appraise the assessment of Tp-einterval and Tp-e/QT ratio in patients with NAFLD. Materialand Methods: Totally 97 patients with NAFLD and 77 control subjects were enrolled in our study. Tp-e interval, Tp-e/QT and Tp-e/QTcratios were measured from the 12-lead electrocardiogram. Results:Heart rate was similar between groups (74.8 ± 10.1 vs. 75.7 ± 11.7; p=0.598). QT interval(396.0 ± 34.2 vs.384.6 ± 30.7;p=0.023) and QTc interval (403.6 ± 34.8 vs. 399.9 ± 36.3; p=0.027), Tp-einterval (100.4 ± 13.6 vs.91.4 ± 13.4;p

Background and Aim: We aimed to identify ischemia-modified albumin (IMA) levels in inflammatory bowel disease (IBD) and IBD subgroups, and to examine its relation with disease activity index. Methods: Sixty-eight patients with IBD (35 ulcerative colitis [UC] and 33 crohn disease [CD]) and 65 healthy volunteers were included in the study. Rachmilewitz scoring system (endoscopic activity index [EAI]) was used to determine UC activity, and as for CD activity, CD activity index (CDAI) scoring was used. IMA measurement was performed with ELISA kit. Results: Ischemia-modified albumin levels in IBD, UC, and CD groups were comparably higher than the control group (37.7 ng/mL vs 42.4 ng/mL vs 36.4 ng/mL vs 21.8 ng/mL, respectively; P

We aimed to identify the levels of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and interleukin 17A (IL-17A) in inflammatory bowel disease (IBD) and to examine their relationship with disease activity.A total of 92 patients with IBD, in which 54 patients were diagnosed with ulcerative colitis and 38 patients with Crohn's disease (CD), and 104 healthy controls were included in the study. The Rachmilewitz endoscopic activity index was calculated in ulcerative colitis, and the CD activity index was calculated in CD.sTWEAK (P0.001) and IL-17A (P = 0.006) levels were higher in the IBD group than in the control group. Both in the IBD group and ulcerative colitis and CD subgroups, in active patients, sTWEAK and IL-17A levels were found to be higher than in inactive and control groups. In the IBD group, a positive correlation was determined between sTWEAK and IL-17A, and C-reactive protein, endoscopic activity index, and CD activity index. In multivariable regression analysis, C-reactive protein and sTWEAK levels were determined to be an independent risk factor for both endoscopic activity index and CD activity index. In receiver operating curve analysis, the sTWEAK level was determined to predict IBD with high sensitivity and specificity with a value of588.34 pg/mL and activity with a value of669.28 pg/mL.Based on these results, we ascertain that sTWEAK has a role in etiopathogenesis of IBD. In addition, we believe that sTWEAK could be used as a marker for both disease activity criteria and treatment monitoring.

Background/aim: We aimed to examine the effect of plastic biliary stenting in the treatment of common bile duct (CBD) stones. Materials and methods: The data of 13,034 patients in our unit who had endoscopic retrograde cholangiopancreatography (ERCP) between 2008 and 2015 were scanned retrospectively. Results: A biliary stent was placed in 61 of 74 patients. While the plastic biliary stent was placed in patients, the mean stone size after the 1st ERCP was 20 mm and the bile duct size was 13 mm. At the time of the 2nd ERCP conducted approximately 73.9 days later, the mean stone size was found to be 15 mm and the bile duct size was 12 mm. With recurrent ERCPs, the CBD stone was successfully removed in 53 patients but could not be removed in 8 patients. Among the 53 successful cases, 29 removals were successful in the 2nd ERCP session, 16 were successful in the 3rd session, 2 were successful in the 4th session, 1 was successful in the 5th session, 4 were successful in the 6th session, and 1 was successful in the 7th session. Conclusion: For CBD stones that cannot be removed by standard methods, temporary plastic stenting is an alternative method.

Elazig Ili Baskil Ilcesi’ ne bagli Seyh Hasan Koyu’nde yaklasik 400 hektar alan uzerinde yurutulen bu calisma, topraklarin farkli arazi kullanimlari altinda, toplam azot (N), yarayisli fosfor (Pav) ve yarayisli potasyum (Kav) iceriklerinin konumsal dagilimlarini belirlemek amaciyla gerceklestirilmistir. Bu amacla, 174 farkli noktadan 0-15 cm derinlikten toprak ornekleri alinarak alansal dagilimi belirlemek icin 5 farkli enterpolasyon yontemi karsilastirilmis ve en iyi dagilimi veren yontem belirlenerek toplam N, Pav ve Kav’ un konumsal dagilim haritalari hazirlanmistir. Elde edilen dagilim haritalarina gore, calisma alani FAO siniflamasi dikkate alindiginda toplam N ve Kav yonunden yeterli duzeyde belirlenmistir. Diger taraftan Pav’in calisma alaninin cok az bir kisminda az duzeyde buna karsin genelde yeterli duzeyde oldugu belirlenmistir.

Objectives: Liver transplantation is increasingly being used in the treatment of end-stage liver disease. Ischemia-reperfusion injury is one of the major problems encountered in transplantation. In this study, we aimed to compare the effects of melatonin, pentoxifylline, and dimethyl sulfoxide (DMSO), in hepatic ischemia-reperfusion injury with different methods such as biochemical/ultrastructural changes and hepatobiliary scintigraphy. Methods: Thirty rabbits were used in the Laboratory of Experimental Animals of Trakya University under appropriate conditions. Sham laparotomy and only ischemia reperfusion group were planned. They were used melatonin, pentoxifylline, and DMSO after ischemia-reperfusion in the other three groups. 6 rabbits were randomly selected for each group. Rabbits in all groups were subjected to liver scintigraphy. Following scintigraphy, 2 cm2 of liver tissue was removed to examining for liver antioxidant enzyme levels (superoxide dismutase [SOD] and glutathione peroxidase [GPx]) and for liver electron microscopy. Results: Pentoxifylline and melatonin protected significantly uptake and excretion functions in liver scintigraphy. When the effects of all three substances were examined by electron microscopy, it was found that the three substances protected the liver from the effects of ischemia-reperfusion damage at varying rates. All three agents were found to protect SOD and GPx from falling in various amounts. Conclusions: Studies to prevent ischemia-reperfusion injury, which may develop as a result of the Pringle maneuver applied to liver transplantations as well as to liver resections or liver injuries, still maintain their popularity. In our study, the effects of agents were identified in three different ways. Ischemia-reperfusion injury-reducing effect of pentoxifylline gave parallel results with three methods.

In this study, we aimed to examine dynamic thiol/disulfide homeostasis in type 1 diabetes mellitus (T1DM) and identify the factors associated with thiol oxidation. Thirty-eight subjects (18 male, 20 female) diagnosed with T1DM and 38 (17 male, 21 female) healthy volunteers without any known diseases were included in the study. Thiol/disulfide homeostasis concentrations were measured by a newly developed method (Erel & Neselioglu) in this study. After native thiol, total thiol and disulfide levels were determined; measures such as disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol were calculated. In T1DM patients, compared to the control group, disulfide (p = 0.024), disulfide/native thiol (p

BACKGROUND/AIMS The development of colonic stenosis is a rare complication of Crohn's disease (CD) without a surgical anastomosis history. So, the management and long-term follow-up results of colonic stricture due to CD have not been clearly defined. In this study, we aimed to characterize de novo colonic stricture due to CD. MATERIALS AND METHODS We evaluated 702 patients with CD to investigate colonic stricture. Colonic stricture was considered to exist when passage of a standard colonoscope was not possible and was diagnosed radiologically and endoscopically in this study. RESULTS Of the 702 patients, 14 had colonic stricture according to the definition above. Of the 14, 8 were male. The interval between diagnosis of disease and recognition of the stricture varied from 0 to 13 years. Localization of the strictures differed from the rectum to cecum. Of the 14, 3 patients had more than 1 stricture. Pathological examination of the stricture(s) did not show dysplasia or malignancy initially or during the follow-up. CONCLUSION De novo colonic stricture due to CD is a rare condition according to the presented study's results. Distribution of the stricture(s) varied from the rectum to cecum without increased colonic cancer risk. We observed the antifibrotic role of thiopurines and biologic agents in this study.

Giriş ve Amaç: Crohn hastalığı için üstgastrointestinal sistem tutulumu sıklığı %0,5-4 arasında değişir. Bu hastalarıntedavi ve takipleri ileokolonik hastalıktan farklılık gösterir. Biz buçalışmada kliniğimizde Crohn hastalığının üst gastrointestinal sistemietkilediği hastalarımızı sunduk.Gereç ve Yöntem: Hastanemiz Gastroenteroloji Kliniğinde takip edilen ve üst gastrointestinalsistem tutulumu olan Crohn hastaları çalışmaya alındı. Bulgular: On hastada üst gastrointestinalsistem tutulumu izlendi. Hastaların yaş ortancası 40,5 (31-53) olup 6 hasta(%60) erkek 4 hasta (%40) ise kadındı. Ortanca takip süresi 29 (1-228) ay oluphastaların 4 tanesinde (%40) izole üst gastrointestinal sistem tutulumu varkengeri kalan 6 hastanın (%60) beraberinde ileal veya ileokolonik hastalığı vardı.Organ tutulumlarına bakıldığında 1 hastada (%10) özofagus, 2 hastada mide (%20)ve 7 hastada (%70) duodenum tutulumu izlendi. Endoskopik görünümler hastadanhastaya değişmekle beraber Crohn hastalığı için tipik sayılan kaldırım taşıgörünümü 2 hastada, ülserler 7 hastada ve nodülarite ise 4 hastada endoskopikolarak tanımlandı. Biyopsilerde granülom 3 hastada izlendi (%30)Sonuç: Crohn hastalığı tanısıolan bir bireyde gelişen epigastrik ağrı, bulantı-kusma ve disfaji gibişikayetler üst gastrointestinal sisteminendoskopik incelenmesini zorunlu hale getirmektedir. Erken tanı ve uygun tedavigelişebilecek komplikasyonların önüne geçebilir., Background and Aim: The frequency of upper gastrointestinal system involvement in Crohn’s disease is 0.5%–4%. Treatment and follow-up strategies of these patients differ from those of ileocolonic disease. Here we present our patients who had Crohn’s disease with upper gastrointestinal system involvement. Materials and Methods: We retrospectively investigated our patients who had Crohn’s disease with upper gastrointestinal system involvement. Results: Upper gastrointestinal system involvement was detected in 10 patients. The median age of patients was 40.5 years (31-53 years); 6 patients were male and 4 patients were female. The median follow-up period after diagnosis was 29 (1-228) months. Four patients had isolated upper gastrointestinal system involvement, while 6 patients had ileocolonic disease. The frequency of organ involvement was 10% (1 patient) for the esophagus, 20% (2 patients) for the stomach, and 70% (7 patient) for the duodenum. Endoscopic appearances varies among patients; cobble stone appearances were detected in 2 patients, ulcers were detected in 7 patients and nodulariy were detected in 4 patients. Granulomas were detected histopathologically in 3 patients (30%). Conclusion: Complaints like epigastric pain, nausea and vomiting, and/or dysphagia must warrant clinicians to investigate the upper gastrointestinal system in Crohn’s disease. Early diagnosis and appropriate treatment are necessary to prevent complications.

We investigated the sensitivity of neutrophil to lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), as well as a combination of NLR and PLR to predict endoscopic disease severity based on mucosal assessment in ulcerative colitis (UC).The study group consisted 104 patients with active UC, 104 patients in remission, and 105 healthy individuals. Disease activity was described with Rachmilewitz endoscopic activity index (EAI). Curve analysis was used to determine the optimal cutoff values of NLR and PLR for obtaining remission. The patients with both PLR and NLR values higher than the cutoff values were coded as »high risk,« those with one parameter higher were coded as »moderate risk«, those with both parameters lower than the cutoff values were coded as »low-risk« patients.The mean NLR and PLR values in the endoscopically active disease group were higher than the others, with higher values in the endoscopic remission group compared with the control group (p0.001). Rachmilewitz EAI in high-risk patients was significantly higher than that in others (p0.001). In Cox regression analyses, moderate and high risk, high erythrocyte sedimentation rate and high EAI were found as independent predictors of endoscopic active disease.This is the first study that investigated the use of NLR and PLR combination to assess endoscopic disease severity in UC. Either high NLR or PLR levels can predict active endoscopic disease. However, the use of these parameters in combination is more accurate in evaluating mucosal disease and inflammation in UC.Izučavana je osetljivost odnosa neutrofili prema limfocitima (NLR) i trombociti prema limfocitima (PLR), kao i kombinacija NLR i PLR za predviđanje težine endoskopskog oboljenja na osnovu procene oštećenja mukoze u ulcerativnom kolitisu (UC).Izučavanje je obuhvatilo 104 pacijenta sa aktivnin UC, 104 pacijenta u remisiji i 105 zdravih osoba. Težina oboljenja opisivana je sa Rachmilewitz-ovim endoskopskim indeksom aktivnosti (EAI). Određene su optimalne »cutoff« vrednosti NLR i PLR za dobijenu remisiju. Pacijenti sa obe vrednosti PLR i NLR više od predviđenih »cuoff« vrednosti označene su kao »visoki rizik«, one sa jednim višim parametrom označene su kao »umereni ritzik«, a one sa oba niža paramatera od »cutoff« vrednosti kao pacijenti sa »niskim rizikom«.Srednje vrednosti NLR i PLR u grupi endoskopski aktivih oboljenja bile su više nego kod drugih sa višim vrednostima u grupi sa endskopskom remisijom u poređenju sa kontrolnom grupom (p0,001). Rachmilewitz EAI u pacijenata sa visokimm rizikom bile su značajno više nego kod drugih pacijenata (p0,001). Primenom Cox regresione analize, umereni i visoki rizik, visoka sedimentacija eritrocita i visoki EAI su nađeni kao nezavisni prediktori endoskopski aktivnog oboljenja.Ovo je prvo izučavanje koje je koristilo NLR i PLR kombinaciju za procenu težine endoskopskog oboljenja u UC, kao i da li visoki nivoi NLR i PLR mogu da predvide aktivno endoskopsko oboljenje. Međutim, primena ovih parametara u kombinaciji mnogo je korisnija za priocenu mukoznog oboljenja i inflamacije u UC.

Objective: Autoimmune hepatitis (AIH) is a liver disorder that affects both children and adults. It is characterized by inflammatory liver histology, elevated transaminase level, circulating nonorgan-specific autoantibodies, and increased level of immunoglobulin G in the absence of known etiology. Ventricular repolarization has been evaluated using T wave and QT interval measurements in patients with hepatic cirrhosis. Ventricular repolarization may be defined using QT interval, QT dispersion, and T wave measurements. Recently, it has been demonstrated that peak and end of the T wave (Tp-e) interval, Tp-e/QT, and Tp-e/corrected QT interval (QTc) ratios can be novel indicators for prediction of ventricular arrhythmias and mortality. In this study, an investigation of ventricular repolarization using Tp-e interval and Tp-e/QT ratio in patients with AIH was performed. Methods: Total of 31 patients with AIH and 31 controls were enrolled in the present study. Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were measured on 12-lead electrocardiogram. Results: QT interval (378.9+-41.4 vs. 350.0+-22.7; p=0.001), QTc interval (396.8+-46.7 vs. 367.3+-34.9; p=0.039), Tp-e interval (68.2+-12.3 vs. 42.5+-6.8; p

Backgrounds and Aim: After the colonoscopic polypectomy, patients were followed-up according to international guidelines. In this study, we aimed to determine whether there was compliance with follow-up intervals as specified by the guidelines. Also, we researched whether there is any beneficial effect of reduced follow-up intervals for detecting AAP and/or colon carcinoma. Material and Methods: Patients who had a colonoscopy between January 2008 and December 2015 in Türkiye Yüksek İhtisas Training and Research Hospital, Gastroenterology Department, Endoscopy Unit were enrolled in the study. Patients who had detected adenoma on their first colonoscopy were divided into two groups: Group A and Group B. In Group A, colonoscopic surveillance was performed earlier according to the current guideline, and in Group B, colonoscopic surveillance was performed properly according to the current guideline. Between the two groups, the detection rate of AAP and/or colon carcinoma were compared. Results: Overall, 270 patients (mean age: 56.8 years) were included in the study. At their first colonoscopies, 759 polyps, 528 adenomas, and 95 AAPs were detected. In our clinical practice, the interval between the first and second colonoscopy was 21 months. Group A had 228 patients (84.1%), and Group B had 42 patients (15.9%). Between the two groups, the detection rates of AAP and cancer could be compared. Between the two groups, the presence of AAP (6.6% vs. 11.9%; p = 0.2) and colon carcinoma (0.4% vs. 0%; p = 1.0) was not different. Conclusion: Compared with current guidelines, reduced follow-up intervals between the first and second colonoscopies are not associated with conferring additional beneficial effects to patients., Giriş ve Amaç: Kolonoskopikpolipektomi yapıldıktan sonra hastalar uluslararası kılavuzlarca önerilen takiparalıklarına göre izlenir. Bu çalışmada klinik pratikte, kılavuzlarcabelirlenmiş olan takip aralıklarına uyulup uyulmadığı ve takip aralığınıkısaltmanın advanced adenomatöz polip (AAP) ve/veya kolon kanseri saptanmasıüzerine önleyici etkisi olup olmadığının araştırılması amaçlanmıştır.Gereç ve Yöntem:Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi Gastroenteroloji KliniğiEndoskopi Ünitesinde Ocak 2008-Aralık 2015 tarihleri arasında kolonoskopiyapılan 2178 hastanın verileri retrospektif olarak incelendi. İlk kolonoskopideadenomsaptanan olgular, kılavuzların belirttiğinden daha erken takip kolonoskopisiyapılan (Grup A) ve kılavuzların önerdiği sürede takip kolonoskopisi yapılanlar(Grup B) şeklinde 2 gruba ayrılarak AAP ve kanser varlığı açısından karşılaştırıldı.Bulgular: Çalışmaya başlangıç kolonoskopi esnasında yaşortalaması 56,8 olan 270 olgu dahil edildi. Bu hastaların ilk kolonoskopisinde759 polip, 582 adenom ve 95 AAP tespit edildi. Klinik uygulamamızda ilkkolonoskopi ile ikinci kolonoskopi arası ortanca süre 21 aydı. Olguların 228(%84,1)’i Grup A, 42 (%15,9)’si ise Grup B’de idi. İki grup arasında takipkolonoskopi esnasında AAP (%6,6 vs. %11,9, p=0,2) veya kanser (%0,4 vs. %0 p=1.0) varlığı açısındananlamlı bir fark bulunmadı.Sonuç:İlkkolonoskopide polip saptanan hastalara kılavuzlara göre belirtilen süreden dahakısa aralıklarda takip kolonoskopi yapmanın anlamlı düzeyde ek bir faydasıgösterilememiştir.

We aimed to investigate the prognostic importance of platelet-lymphocyte ratio (PLR) and neutro - phil-lymphocyte ratio(NLR) combination for patients diagnosed with acute pancreatitis and its relationship with mortality.This retrospective study was included 142 patients diagnosed with acute pancreatitis. Ranson, Atlanta and BISAP 0h, 24h and 48h scores of the patients were calculated by examining their patient files. The patients were divided into three groups as low-risk, medium-risk and high-risk patients according to their PLR and NLR levels.The number of patients with acute pancreatitis complications such as necrotizing pancreatitis, acute renal failure, sepsis and cholangitis was significantly higher in the high-risk group compared to other groups. Mortality rate was found to be 90% in the high-risk group, 16% in the medium-risk group, and 1.9% in the low-risk group. The number of patients with a Ranson score of 5 and 6, a severe Atlanta score, a BISAP 0h score of 3 and 4, a BISAP 24h and 48h score of 4 and 5 was higher in the high-risk group compared to other groups. PLR-NLR combination, Atlanta and Ranson scores, and C-reactive protein level were determined to be independent risk factors predicting mortality in stepwise regression model. PLR-NLR combination had the highest area under curve value in terms of predicting acute claspancreatitis prognosis and had a similar diagnostic discrimination with other scoring systems.In our study it was found that PLR-NLR combination had a similar prognostic importance with other scoring systems used to determine acute pancreatitis prognosis.Svrha ovog istraživanja je da se utvrdi značajnost kombinacije trombocitno-limfocitnog odnosa (PLR) i neutrofilnolimfocitnog odnosa (NLR) za dijagnostikovanje aktunog pankreatitisa kao i u odnosu na mortalitet.Retrospektivno izučavanje obuhvatilo je 142 pacijenta sa dijagnozom akutnog pankreatitisa. Ranson, Atlanta i BISAP 0h, 24h i 48h skorovi kod pacijenata računati su uvidom u istorije bolesti pacijenata. Pacijenti su podeljeni u tri grupe i to niskog, srednjeg i visokog rizika prema nivoima njihovih PLR i NLR.Broj pacijenata sa akutnim pankreasnim komplikacijama kao što su nekrotizirajuči pankreatitis, akutni renalni poremečaj, sepsa i holangitis bili su znaćajno viši u grupi sa visokim rizikom u odnosu na druge grupe. Nađeno je da je kod visoko rizićne grupe mortalitet iznosio 90%, 16% kod grupe sa srednjim rizikom i 1,9% kod grupe niskog rizika. Broj pacijenata sa Ranson skorom 5 i 6, teškim Atlanta skorom, i BISAP 0h skorom 3 i 4, i BISAP 24h i 48h skorom 4 i 5 je bio viši u grupi sa visokim rizikom u odnosu na druge grupe. Utvrđeno je da su PLR-NLR kombinacija, Atlanta i Ranson skorovi, i nivo C-reaktivnog proteina bili nezavisni faktori rizika u predviđanju mortalitea u regresionom modelu. PLR-NLR kombinacija je imala največu površinu ispod vrednosti krive u predviđanju prognoze akutnog pankreatitisa i slićnu dijagnostićku diskriminaciju sa drugim skor sistemima.U našem izučavanju nađeno je da PLR-NLR kombinacija ima sličan prognostički značaj sa drugim skor sistemima koji se koriste za utvrđivanje prognoze akutnog pankreatitisa.