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15 results on '"Mackay, D.S."'

3. Contributors

Author

Akhlaghi, M., primary, Angeloni, C., additional, Arora, R., additional, Azizi, F., additional, Baliga, M.S., additional, Bandy, B., additional, Batchu, S.N., additional, Benadé, A.J.S., additional, Beulens, J.W.J., additional, Bhatia, A., additional, Bolling, S.F., additional, Cai, W., additional, Cãmara, N.O.S., additional, Celik, M., additional, Celik, T., additional, Chaudhary, K.R., additional, Chedraui, P., additional, Chen, H., additional, Chen, J., additional, Correa-Matos, N.J., additional, Dalmeijer, G.W., additional, Dsouza, J.J., additional, Fernández-Alonso, A.M., additional, Fuchs, D., additional, Gormley, J.J., additional, Gostner, J.M., additional, Goswami, B., additional, Goudevenos, J.A., additional, Gylling, H., additional, Haniadka, R., additional, Hosseini-Esfahani, F., additional, Hrelia, S., additional, Hsieh, T.-C., additional, Hummel, S.L., additional, Hwang, H., additional, Jackson, K.G., additional, Jaffe, R., additional, Jaxa-Chamiec, T., additional, Jenny, M., additional, Jones, P.J.H., additional, Juturu, V., additional, Kastorini, C.-M., additional, Katz, J., additional, Kaufmanz, P.B., additional, Kirakosyan, A., additional, Kondoleon, M.G., additional, Konhilas, J.P., additional, Kumar, S., additional, Kumar, Y., additional, MacKay, D.S., additional, Maggini, S., additional, Mathai, B., additional, Mathew, N., additional, Maulik, S.K., additional, McCune, L.M., additional, Miettinen, T.A., additional, Milionis, H.J., additional, Minihane, A.M., additional, Mirmiran, P., additional, Moffatt, R.J., additional, Movahed, M.R., additional, Palatty, P.L., additional, Panagiotakos, D.B., additional, Periera, D.M., additional, Prabhu, A.N., additional, Prabhu, D., additional, Pérez-López, F.R., additional, Rios, F.J.O., additional, Roysommuti, S., additional, Schroecksnadel, S., additional, Seubert, J.M., additional, Seymour, E.M., additional, Sharma, R., additional, Shivashankara, A.R., additional, Simoncini, T., additional, Singh, R.B., additional, Slemmer, J.E., additional, Spitzer, V., additional, Sweeney, M.I., additional, Tummuri, G.R., additional, Ueberall, F., additional, Vaghefi, S.B., additional, van der Schouw, Y.T., additional, van Rooyen, J., additional, Wiebe, G.J., additional, Wu, J.M., additional, and Wyss, J.M., additional

Published
2013
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6. First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid- chromatography–Urgent need for harmonisation of analytical methods

Author

Lütjohann, D. (Dieter), Björkhem, I. (Ingemar), Friedrichs, S. (Silvia), Kerksiek, A. (Anja), Lövgren-Sandblom, A. (Anita), Geilenkeuser, W.J. (Wolf Jochen), Ahrends, R. (Robert), Andrade, I. (Isabel), Ansorena-Artieda, D. (Diana), Astiasarán, I. (Iciar), Baila-Rueda, L. (Lucía), Barriuso, B. (Blanca), Becker, S. (Susen), Bretillon, L. (Lionel), Browne, R.W. (Richard W.), Caccia, C. (Claudio), Ceglarek, U. (Uta), Cenarro, A. (Ana), Crick, P.J. (Peter J.), Fauler, G. (Günter), Garcia-Llatas, G. (Guadalupe), Gray, R. (Robert), Griffiths, W.J. (William J.), Gylling, H. (Helena), Harding, S. (Scott), Helmschrodt, C. (Christin), Iuliano, L. (Luigi), Janssen, H.G. (Hans Gerd), Jones, P. (Peter), Kaipiainen, L. (Leena), Kannenberg, F. (Frank), Lagarda, M.J. (María Jesús), Leoni, V. (Valerio), Lottenberg, A.M. (Ana María), Myrie, S.B. (Semone B.), MacKay, D.S. (Dylan S.), Matysik, S. (Silke), McDonald, J. (Jeff), Menendez-Carreño, M. (María), Nunes, V.S. (Valeria Sutti), Ostlund, R.E. (Richard E.), Polisecki, E. (Eliana), Ramos, F. (Fernando), Rideout, T.C. (Todd C.), Schaefer, E.J. (Ernst J.), Schmitz, G. (Gerd), Wang, Y. (Yuqin), Zerbinati, C. (Chiara), Diczfalusy, U. (Ulf), and Schött, H.F. (Hans Frieder)

Subjects
Cholesterol balance, Cholesterol synthesis, Phytosterols, lipids (amino acids, peptides, and proteins), Cholesterol absorption, Surrogate marker, Atherosclerosis
Abstract

Serum concentrations of lathosterol, the plant sterols campesterol and sitosterol and the cholesterol metabolite 5α-cholestanol are widely used as surrogate markers of cholesterol synthesis and absorption, respectively. Increasing numbers of laboratories utilize a broad spectrum of well-established and recently developed methods for the determination of cholesterol and non-cholesterol sterols (NCS). In order to evaluate the quality of these measurements and to identify possible sources of analytical errors our group initiated the first international survey for cholesterol and NCS. The cholesterol and NCS survey was structured as a two-part survey which took place in the years 2013 and 2014. The first survey part was designed as descriptive, providing information about the variation of reported results from different laboratories. A set of two lyophilized pooled sera (A and B) was sent to twenty laboratories specialized in chromatographic lipid analysis. The different sterols were quantified either by gas chromatography-flame ionization detection, gas chromatography- or liquid chromatography-mass selective detection. The participants were requested to determine cholesterol and NCS concentrations in the provided samples as part of their normal laboratory routine. The second part was designed as interventional survey. Twenty-two laboratories agreed to participate and received again two different lyophilized pooled sera (C and D). In contrast to the first international survey, each participant received standard stock solutions with defined concentrations of cholesterol and NCS. The participants were requested to use diluted calibration solutions from the provided standard stock solutions for quantification of cholesterol and NCS. In both surveys, each laboratory used its own internal standard (5α-cholestane, epicoprostanol or deuterium labelled sterols). Main outcome of the survey was, that unacceptably high interlaboratory variations for cholesterol and NCS concentrations are reported, even when the individual laboratories used the same calibration material. We discuss different sources of errors and recommend all laboratories analysing cholesterol and NCS to participate in regular quality control programs.

Published
2019

10. Impact of subwatershed partitioning on modeled source- and transport-limited sediment yields in an agricultural nonpoint source pollution model

Author

FitzHugh, T.W. and Mackay, D.S.

Subjects
Agricultural research -- Research -- Analysis -- Models, Agriculture -- Research -- Analysis -- Models, Agricultural industry -- Research -- Analysis -- Models, Sedimentation and deposition -- Models -- Analysis -- Research, Sediment transport -- Analysis -- Models -- Research, Valley ecology -- Research -- Models -- Analysis, Environmental issues, Analysis, Models, Research
Abstract

ABSTRACT: Distributed parameter hydrologic models have a potential use as tools for supporting watershed management policy. However, proper model implementation will require an understanding of how to integrate data collection [...]

Published
2001

11. Screening of a large cohort of leber congenital amaurosis and retinitis pigmentosa patients identifies novel LCA5 mutations and new genotype-phenotype correlations

Author

Mackay, D.S., Borman, A.D., Sui, R., Born, L.I. van den, Berson, E.L., Ocaka, L.A., Davidson, A.E., Heckenlively, J.R., Branham, K., Ren, H., Lopez, I., Maria, M., Azam, M., Henkes, A., Blokland, E., Group, L.C.A.S., Andreasson, S., Baere, E. de, Bennett, J., Chader, G.J., Berger, W., Golovleva, I., Greenberg, J., Hollander, A.I. den, Klaver, C.C., Klevering, B.J., Lorenz, B., Preising, M.N., Ramsear, R., Roberts, L., Roepman, R., Rohrschneider, K., Wissinger, B., Qamar, R., Webster, A.R., Cremers, F.P.M., Moore, A.T., Koenekoop, R.K., Mackay, D.S., Borman, A.D., Sui, R., Born, L.I. van den, Berson, E.L., Ocaka, L.A., Davidson, A.E., Heckenlively, J.R., Branham, K., Ren, H., Lopez, I., Maria, M., Azam, M., Henkes, A., Blokland, E., Group, L.C.A.S., Andreasson, S., Baere, E. de, Bennett, J., Chader, G.J., Berger, W., Golovleva, I., Greenberg, J., Hollander, A.I. den, Klaver, C.C., Klevering, B.J., Lorenz, B., Preising, M.N., Ramsear, R., Roberts, L., Roepman, R., Rohrschneider, K., Wissinger, B., Qamar, R., Webster, A.R., Cremers, F.P.M., Moore, A.T., and Koenekoop, R.K.

Abstract

Item does not contain fulltext, This study was undertaken to investigate the prevalence of sequence variants in LCA5 in patients with Leber congenital amaurosis (LCA), early-onset retinal dystrophy (EORD), and autosomal recessive retinitis pigmentosa (arRP); to delineate the ocular phenotypes; and to provide an overview of all published LCA5 variants in an online database. Patients underwent standard ophthalmic evaluations after providing informed consent. In selected patients, optical coherence tomography (OCT) and fundus autofluorescence imaging were possible. DNA samples from 797 unrelated patients with LCA and 211 with the various types of retinitis pigmentosa (RP) were screened by Sanger sequence analysis of all LCA5 exons and intron/exon junctions. Some LCA patients were prescreened by APEX technology or selected based on homozygosity mapping. In silico analyses were performed to assess the pathogenicity of the variants. Segregation analysis was performed where possible. Published and novel LCA5 variants were collected, amended for their correct nomenclature, and listed in a Leiden Open Variation Database (LOVD). Sequence analysis identified 18 new probands with 19 different LCA5 variants. Seventeen of the 19 LCA5 variants were novel. Except for two missense variants and one splice site variant, all variants were protein-truncating mutations. Most patients expressed a severe phenotype, typical of LCA. However, some LCA subjects had better vision and intact inner segment/outer segment (IS/OS) junctions on OCT imaging. In two families with LCA5 variants, the phenotype was more compatible with EORD with affected individuals displaying preserved islands of retinal pigment epithelium. One of the families with a milder phenotype harbored a homozygous splice site mutation; a second family was found to have a combination of a stop mutation and a missense mutation. This is the largest LCA5 study to date. We sequenced 1,008 patients (797 with LCA, 211 with arRP) and identified 18 probands with LCA5 mu

Published
2013

14. Automated Parameterization of Land Surface Process Models Using Fuzzy Logic.

Author

Mackay, D.S., Samanta, S., Ahl, D.E., Ewers, B.E., Gower, S.T., and Burrows, S.N.

Subjects
*GEOGRAPHIC information systems, *LAND use, *FUZZY logic, *PARAMETER estimation
Abstract

All land surface process models require parameters that are proxies for spatial processes that are impractical or impossible to measure. Recent developments in model parameter estimation theory suggest that information obtained from calibrating such models is inherently uncertain in nature. As a consequence, identification of optimum parameter values is often highly non–specific. A calibration framework using fuzzy logic is presented to deal with such uncertain information. An application of this technique to calibrate the sub–canopy controls on transpiration in a land surface process model demonstrates that objective estimates of parameter values and expected ranges of predictions can be obtained with suitable choices for objective functions. An iterative refinement in parameter estimates was possible with conditional sampling techniques. The automated approach was able to correctly identify parameter tradeoffs such that two strongly different sets of parameters could. [ABSTRACT FROM AUTHOR]

Published
2003
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