Search

Abstract A case of a true dual-genotype IDH-mutant oligoastrocytoma with two different cell types within a single mass in a young woman is presented. Imaging findings of the left frontal infiltrating glioma predicted the two neoplastic components that were identified upon resection. Tissue examination demonstrated areas of tumor with contrasting histologic and molecular features, including specific IDH1, ATRX, TP53, TERT and CIC mutational profiles, consistent with oligodendroglioma and astrocytoma, respectively. The clinical and radiological course over 17 months from first diagnosis included three surgical resections with slow progression of the astrocytic component, and ultimately chemotherapy and radiation treatments were commenced. Reports of the clinical courses for these rare cases of dual-genotype oligoastrocytomas will inform therapy choices, to optimize benefit while minimizing side effects. The steadily increasing number of cases suggests that the neoplasm might be reconsidered as an official entity by the WHO.

The present study aimed to compare the efficiency of different pens and animal flow configuration layouts in freestall pens using a robotic milking system (RMS) with guided flow based on the behavioral patterns of multiparous lactating Holstein dairy cows in a commercial farm. The behavior of 24 cows in freestall pens was evaluated, divided into 4 different stall configurations: original (OR), conversion (CVS), toll-booth I (TBI), and toll-booth II (TBII), each featuring distinct circulation layouts with different configurations of location, position, and number of guided-flow RMS equipment, feed bunk, water trough, commitment pen, sand beds, sorting gates, and one-way gate. Six multiparous cows, parity 2 or 3, with an average (± SD) of 180 ± 20 DIM, were randomly selected from each freestall pen for focal assessment of behavioral patterns. The location, position, and behavior of each animal were recorded in a field ethogram, with individual sequences recorded at 15-min intervals using the focal method during 6 nonconsecutive 10-h periods in each pen, and the proportion of observed time for each behavior was assessed. The pens differed in the number of available milking robots (1, 2, or 3), the number of animals per robot, the quantity and orientation of smart doors, and the placement of feed bunks, water troughs, and sand beds. A completely randomized experimental design was used to compare the 4 stalls, with a nonparametric Kruskal-Wallis test, in which the medians of the treatments were then compared with the Dunn test at a significance level of 5%, using the Minitab software. The behavioral pattern of cows exhibited differences based on the stall configuration with RMS as a proportion of the observed time (60 h). The TBI stall configuration, where the animal needs to be milked to exit the milking robot, showed a higher percentage of observed time spent in the sand bed (68%) and lying position (64%) compared with other stalls, as a proportion of the observed time (60 h). Notably, the TBII stall exhibited a significant amount as a proportion of observed time (60 h) in the holding area (16%), possibly attributed to a layout with a higher number of animals per robot, emphasizing the importance of respecting the number of animals per robot when housing in a stall with RMS. Thus, spatial configuration and the density of robotic systems are factors that influence the behavioral pattern of dairy cows.

This research paper aims to use lean six sigma tools to handle milk in small Brazilian dairy estates. The search for efficiency in this process preponderates in all productive sectors. However, it is still not exploited in the dairy chain, specifically by small-scale producers, although milking is the main income for many of them. In Brazil, small producers are the main suppliers of the chain, and maintaining their competitiveness requires specific actions. Therefore, through the action-research method, four small producers in the center-west of the state of São Paulo, Brazil, were involved in identifying problems in their milking management process, investigating and implementing practical solutions. To this effect, lean tools such as flowcharts, Ishikawa diagrams, value stream mapping, and PDCA cycles were employed, and six feasible improvements were defined. The successful implementation of said improvements led to the acquisition of knowledge by small producers, who received financial returns, i.e., an increase in the amount paid per liter of milk. This research shows that, through interdisciplinarity, positive solutions to problems of different and complex natures, such as those in the dairy chain, can be obtained.

Purpose: The purpose of this paper is to provide a panoramic and systematic view of 10 Sustainable Campus Network (SCN) universities' internal entities in charge of the sustainability effort -- such as offices, committees, units, programs, or other, showing how some institutions have gained increasing deployment and momentum. However, their appearance and growth pathways have had significant disparities. Design/methodology/approach: Global and local agendas have had a strong influence on Chilean higher education institutions. A relevant signal has been the creation of the SCN, formed by 21 Chilean universities, whose vision is to help shape a fair and environmentally healthy civilization contributing from the higher education realm. This work adopts a survey design methodological approach. It describes the following resulting components obtained from the aggregated data: (a) emergence processes and environments, (b) governance models and operational mechanisms, (c) networks and collaboration, and (d) final products generated, for sustainability governing entities within universities in Chile. Findings: The main findings indicate that at the institutional level, the Cleaner Production Agreement for higher education institutions and the creation of the SCN have been key drivers in the formalization of several entities leading the sustainability efforts within Chilean universities. Also, regarding the degree of commitment to sustainability, the most active internal stakeholder corresponds to students. Originality/value: The present work represents a pioneering effort in the Chilean context to identify and systematize the challenges, organizational structures, and key accomplishments of sustainability governing entities in higher education nationwide.

Purpose: In the past few decades, sustainability in higher education has become ever more prevalent, although the diversity in pace of adoption and the wide range of interpretations and practices is huge. The purpose of this study is to present recent research on organizational change processes in universities. Design/methodology/approach: The methodological approach applied corresponds to the social issue maturation framework, to identify, describe and assess patterns of change across higher education institutions. The maturation of sustainability in universities can be divided into four stages: emergence, popularization, formalization and maturity. Findings: The findings indicate that sustainability processes often begin as ad hoc processes which grow and mature over time as a range of different actors join in. However, sustainability in universities is increasingly connected with sustainability in the private sector and with other public actors. Moreover, there is a growing acknowledgement of the interactions between society, industry and academia. Originality/value: The value of the paper is to provide a critical assessment of the potential of living lab projects initiated in Belgium (Brussels) and Chile (Santiago de Chile) to anchor sustainability firmly both in the functioning of the university and in the interactions with the neighborhood. The authors reflect on the requirements and the implementation of these initiatives as a strong indication of mature sustainability integration in, and by way of, universities.

BackgroundImmune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The most effective time to incorporate ICIs remains unknown. Our study profiles systemic anti-tumor immunity perioperatively to help inform the optimal timing of ICIs into current standards of care for EAC patients.MethodsSystemic immunity in 11 EAC patients was phenotyped immediately prior to esophagectomy (POD-0) and post-operatively (POD)-1, 3, 7 and week 6. Longitudinal serological profiling was conducted by ELISA. The frequency of circulating lymphocytes, activation status, immune checkpoint expression and damage-associated molecular patterns was assessed by flow cytometry.ResultsThe frequency of naïve T-cells significantly increased in circulation post-esophagectomy from POD-0 to POD-7 (p

Here we present, for the first time, a glossary of biometeorological terms. The glossary aims to address the need for a reliable source of biometeorological definitions, thereby facilitating communication and mutual understanding in this rapidly expanding field. A total of 171 terms are defined, with reference to 234 citations. It is anticipated that the glossary will be revisited in coming years, updating terms and adding new terms, as appropriate. The glossary is intended to provide a useful resource to the biometeorology community, and to this end, readers are encouraged to contact the lead author to suggest additional terms for inclusion in later versions of the glossary as a result of new and emerging developments in the field.

ABSTRACT The conventional production of eggs in cage systems is intense and compromises the laying hens welfare. More demanding consumer markets have been pushing to abolish the use of cages and thus provide better welfare in poultry laying. This research evaluated the mortality, production, and egg quality of two alternative production systems (free-range and organic free range free-range) and compared them with the conventional system. The research was carried out in two commercial poultry farms and the variables egg weight, shell egg resistance, Haugh unit, mortality and production were recorded during eight months. The results showed that the conventional system presented better production, lower mortality and better shell egg quality. The alternative systems had better internal egg quality. Alternative systems had greater variability in outcomes and problems with disease control, which indicate greater difficulty for proper management.

Software engineering is the application of principles used in engineering design, development, testing, deployment, and management of software systems. One of the software engineering’s approaches, highly used in new industries, is agile development. User stories are a commonly used notation to capture user requirements in agile development. Nevertheless, for the elaboration of user stories, a high level of collaboration with the client is necessary. This professional skill is rarely measured or evaluated in educational contexts. The present work approaches collaboration in software engineering students through multimodal learning analytics, modeling, and evaluating students’ collaboration while they are writing user stories. For that, we used multidirectional microphones in order to derive social network analysis metrics related to collaboration (permanence and prompting) together with human-annotated information (quality of the stories and productivity). Results show that groups with a lower productivity in writing user stories and less professional experience in managing software requirements present a non-collaborative behavior more frequently, and that teams with a fewer number of interventions are more likely to produce a greater number of user stories. Moreover, although low experience subjects produced more user stories, a greater productivity of the most experienced subjects was not statistically verified. We believe that these types of initiatives will allow the measurement and early development of such skills in university students.

ABSTRACT: Lighting, either in its intensity or in its luminous spectrum, affects the eggs quality. This study evaluated the effect of four lamps (sodium vapor lamp, mercury vapor lamp, fluorescent lamp and incandescent lamp) that have different luminous spectra in the form of commercial poultry eggs. For this, 60 laying hens of the same age were separated for 63 days in four aviaries with reduced and distorted scale. In each treatment, different lamps were installed which provided similar luminous intensities. At the end of the period, these eggs were taken as samples for the fluorescent, incandescent, mercury vapor and sodium vapor lamps. In this way, images were made of these eggs, using a camera installed on a fixed tripod on a flat table with black background. In a room with controlled lighting, ensuring the same distance and angle for all eggs. The Matlab® program was used to perform the image analysis, recording measurements of area, perimeter and minimum and maximum distances of the mass center of each egg. The measurements were grouped by treatment and the Tukey's test of averages was applied. The results showed that the eggs removed from the sodium vapor treatment presented a more elongated shape. It is concluded that the light spectrum of the lamps affects the shape of the eggs and this should be considered in the planning of lighting programs in aviaries.

The constant use of synthetic antibiotics as growth promoters can cause bacterial resistance in chicks. Consequently, the use of these drugs has been restricted in different countries. In recent years, antimicrobial peptides have gained relevance due to their minimal capacity for bacterial resistance and does not generate toxic residues that harm the environment and human health. In this study, a Ctx(Ile21)-Ha antimicrobial peptide was employed, due to its previously reported great antimicrobial potential, to evaluate its application effects in laying chicks challenged with Salmonella Enteritidis, resistant to nalidixic acid and spectinomycin. For this, Ctx(Ile21)-Ha was synthesized, microencapsulated and coated with hypromellose phthalate (HPMCP) to be released in the intestine. Two different doses (20 and 40 mg of Ctx(Ile21)-Ha per kg of isoproteic and isoenergetic poultry feed) were included in the chick’s food and administered for 28 days. Antimicrobial activity, effect and response as treatment were evaluated. Statistical results were analyzed in detail and indicate that the formulated Ctx(Ile21)-Ha peptide had a positive and significant effect in relation to the reduction of chick mortality in the first days of life. However, there was moderate evidence (p = 0.07), not considered statistically significant, in the differences in laying chick weight between the control and microencapsulation treatment groups as a function of time. Therefore, the microencapsulated Ctx(Ile21)-Ha antimicrobial peptide can be an interesting and promising option in the substitution of conventional antibiotics.

El derecho es un fenómeno social. Creación propia de la, sociedad, que lo forja y lo impone para su garantía y salvaguarda, varía con ella en función de tres factores: a) tiempo, b) espacio, y c) psicología del grupo.