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3. A prospective multi-center randomized comparative trial evaluating outcomes of transrectal ultrasound (TRUS)-guided 12-core systematic biopsy, mpMRI-targeted 12-core biopsy, and artificial intelligence ultrasound of prostate (AIUSP) 6-core targeted biopsy for prostate cancer diagnosis

Author

Wang, Xiao, Xie, Yanqi, Zheng, Xiangyi, Liu, Ben, Chen, Hong, Li, Jiangfeng, Ma, Xueyou, Xiang, Jianjian, Weng, Guobin, Zhu, Weizhi, Wang, Gang, Fang, Ye, Cheng, Hongtao, and Xie, Liping

Published
2023
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12. A prospective multi-center randomized comparative trial evaluating outcomes of transrectal ultrasound (TRUS)-guided 12-core systematic biopsy, mpMRI-targeted 12-core biopsy, and artificial intelligence ultrasound of prostate (AIUSP) 6-core targeted biopsy for prostate cancer diagnosis

Author

Wang, Xiao, primary, Xie, Yanqi, additional, Zheng, Xiangyi, additional, Liu, Ben, additional, Chen, Hong, additional, Li, Jiangfeng, additional, Ma, Xueyou, additional, Xiang, Jianjian, additional, Weng, Guobin, additional, Zhu, Weizhi, additional, Wang, Gang, additional, Fang, Ye, additional, Cheng, Hongtao, additional, and Xie, Liping, additional

Published
2022
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13. Additional file 1 of VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells

Author

Ma, Xueyou, Tan, Zenglai, Zhang, Qin, Ma, Kaifang, Xiao, Jun, Wang, Xiong, Wang, Yanan, Zhong, Mengjie, Wang, Yu, Li, Jing, Zeng, Xing, Guan, Wei, Wang, Shaogang, Gong, Kan, Wei, Gong-Hong, and Wang, Zhihua

Subjects
macromolecular substances
Abstract

Additional file 1: Figure S1. (A) Quantitative of HIF-2α expression levels in 786-O cells stably expressing VHL WT and mutants, with or without treatment of MG132. The western blot images were scanning densitometric values were obtained using ImageJ software. HIF-2α Protein levels were normalized to the loading control β-ACTIN. (B) Interaction of HIF-2α with VHL-WT and mutants after MG132 treatment. (C) Western blot for HIF-2α expression in 786-O cells treated with or without hypoxia mimetic CoCl2 and DMOG. CoCl2 was used at 100 uM final concentration for 6 h, DMOG was used at 1 mM final concentration for 8 h. (D) Immunostaining of FLAG-VHL in 786-O cells with and without MG132 treatment, Scale bars, 50 μm.

Published
2022
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14. Additional file 5 of VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells

Author

Ma, Xueyou, Tan, Zenglai, Zhang, Qin, Ma, Kaifang, Xiao, Jun, Wang, Xiong, Wang, Yanan, Zhong, Mengjie, Wang, Yu, Li, Jing, Zeng, Xing, Guan, Wei, Wang, Shaogang, Gong, Kan, Wei, Gong-Hong, and Wang, Zhihua

Subjects
urologic and male genital diseases, female genital diseases and pregnancy complications
Abstract

Additional file 5: Figure S5. Gene set enrichment analysis (GSEA) analysis identifies significant common (A and B) and distinct Hallmark signatures between VHL-deficiency and VHL-S65P/W (C and D). Gene signatures with FDR

Published
2022
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16. Additional file 2 of VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells

Author

Ma, Xueyou, Tan, Zenglai, Zhang, Qin, Ma, Kaifang, Xiao, Jun, Wang, Xiong, Wang, Yanan, Zhong, Mengjie, Wang, Yu, Li, Jing, Zeng, Xing, Guan, Wei, Wang, Shaogang, Gong, Kan, Wei, Gong-Hong, and Wang, Zhihua

Abstract

Additional file 2: Figure S2. (A-B) GSEA-determined hypoxia (A) or glycolysis (B) pathways with S65P-affected gene signature. Genes are ranked by their expression levels in 786-O cells expressing VHL mutation S65P. Plots in the right of A or B show HIF2α ChIP-seq signals of 5 kb around the transcriptional start sites (TSS) of altered genes in hypoxia (A) or glycolysis (B) pathways. (C) VIM or CDH1 is upregulated or downregulated in KIRC patient samples, respectively.

Published
2022
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17. Additional file 4 of VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells

Author

Ma, Xueyou, Tan, Zenglai, Zhang, Qin, Ma, Kaifang, Xiao, Jun, Wang, Xiong, Wang, Yanan, Zhong, Mengjie, Wang, Yu, Li, Jing, Zeng, Xing, Guan, Wei, Wang, Shaogang, Gong, Kan, Wei, Gong-Hong, and Wang, Zhihua

Subjects
urologic and male genital diseases
Abstract

Additional file 4: Figure S4. (A-C) The sum expression levels of VHL-S65W signature gene set are significantly upregulated in human renal cancers compared to normal kidney samples. (D,E) The sum expression levels of VHL-S65W genetic signature positively correlate with EMT scores in the two independent clinical cohorts of ccRCC patient group.

Published
2022
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18. Additional file 3 of VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells

Author

Ma, Xueyou, Tan, Zenglai, Zhang, Qin, Ma, Kaifang, Xiao, Jun, Wang, Xiong, Wang, Yanan, Zhong, Mengjie, Wang, Yu, Li, Jing, Zeng, Xing, Guan, Wei, Wang, Shaogang, Gong, Kan, Wei, Gong-Hong, and Wang, Zhihua

Subjects
urologic and male genital diseases
Abstract

Additional file 3: Figure S3. (A-D) The sum expression levels of VHL-S65P signature gene set are significantly upregulated in human renal cancers compared to normal kidney samples.

Published
2022
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31. CCND1, NOP14 and DNMT3B are involved in miR‐502‐5p–mediated inhibition of cell migration and proliferation in bladder cancer

Author

Ying, Yufan, primary, Li, Jiangfeng, additional, Xie, Haiyun, additional, Yan, Huaqing, additional, Jin, Ke, additional, He, Liujia, additional, Ma, Xueyou, additional, Wu, Jian, additional, Xu, Xin, additional, Fang, Jiajie, additional, Wang, Xiao, additional, Zheng, Xiangyi, additional, Liu, Ben, additional, and Xie, Liping, additional

Published
2020
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34. METTL3/YTHDF2 m6A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer.

Author

Xie, Haiyun, Li, Jiangfeng, Ying, Yufan, Yan, Huaqing, Jin, Ke, Ma, Xueyou, He, Liujia, Xu, Xin, Liu, Ben, Wang, Xiao, Zheng, Xiangyi, and Xie, Liping

Subjects
BLADDER cancer, MESSENGER RNA, METASTASIS, RNA modification & restriction, RNA
Abstract

N6‐Methyladenosine (m6A) modification, the most prevalent modification of eukaryotic messenger RNA (mRNA), is involved in the progression of various tumours. However, the specific role of m6A in bladder cancer (BCa) is still poorly understood. In this study, we demonstrated the tumour‐promoting function and specific regulatory mechanism of m6A axis, consisting of the core 'writer' protein METTL3 and the major reader protein YTHDF2. Depletion of METTL3 impaired cancer proliferation and cancer metastasis in vitro and in vivo. Through transcriptome sequencing, m6A methylated RNA immunoprecipitation (MeRIP) and RIP, we determined that the METTL3/YTHDF2 m6A axis directly degraded the mRNAs of the tumour suppressors SETD7 and KLF4, contributing to the progression of BCa. In addition, overexpression of SETD7 and KLF4 revealed a phenotype consistent with that induced by depletion of the m6A axis. Thus, our findings on the METTL3/YTHDF2/SETD7/KLF4 m6A axis provide the insight into the underlying mechanism of carcinogenesis and highlight potential therapeutic targets for BCa. [ABSTRACT FROM AUTHOR]

Published
2020
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35. Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation

Author

Yang,Chunguang, Ma,Xueyou, Wang,Zhihua, Zeng,Xing, Hu,Zhiquan, Ye,Zhangqun, Shen,Guanxin, Yang,Chunguang, Ma,Xueyou, Wang,Zhihua, Zeng,Xing, Hu,Zhiquan, Ye,Zhangqun, and Shen,Guanxin

Abstract

Chunguang Yang,1,* Xueyou Ma,1,* Zhihua Wang,1 Xing Zeng,1 Zhiquan Hu,1 Zhangqun Ye,1 Guanxin Shen2 1Department of Urology, Tongji Hospital, 2Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China *These authors contributed equally to this work Background: Curcumin induces apoptosis and autophagy in different cancer cells. Moreover, chemical and biological experiments have evidenced that curcumin is a biologically active iron chelator and induces cytotoxicity through iron chelation. We thus hypothesized that curcumin may induce apoptosis and autophagy in castration-resistant prostate cancer (CRPC) cells through its iron-chelating properties.Materials and methods: CRPC cells were loaded with curcumin alone or in combination with ferric ammonium citrate (FAC). Cytotoxicity was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis was assessed by flow cytometry, terminal deoxynucleotidyl transferase nick end labeling (TUNEL) assay and caspase activity. Autophagy status was analyzed by the detection of autophagosomes and light chain 3-II (LC3-II) using transmission electron microscopy and Western blot. Iron-binding activity of curcumin was assessed by spectrophotometry and MTT assay. The expression levels of transferrin receptor 1 (TfR1) and iron regulatory protein 1 (IRP1) were examined by Western blot.Results: Curcumin induced apoptosis and autophagy in CRPC cells. Combining curcumin with autophagy inhibitors (3-methyladenine [3-MA]) synergized the apoptotic effect of curcumin. Moreover, curcumin bound to FAC at a ratio of ~1:1, as assessed by spectrophotometry and MTT assay. Apoptosis and autophagy induced by curcumin were counteracted by equal amounts of FAC. At apoptosis- and autophagy-inducing concentrations, curcumin enhanced the expression levels of TfR1 and IRP1, indicative of iron deprivation induced by curcum

Published
2017

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