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4 results on '"MOLENEURO"'

1. Specification of Motor Axon Trajectory by Ephrin-B:EphB Signaling: Symmetrical Control of Axonal Patterning in the Developing Limb

Author

Luria, Victor, Krawchuk, Dayana, Jessell, Thomas M., Laufer, Ed, and Kania, Artur

Subjects
*AXONS, *CELLULAR signal transduction, *MOTOR neurons, *SYMMETRY (Biology), *LIGANDS (Biochemistry), *DEVELOPMENTAL neurobiology, *INNERVATION, *EXTREMITIES (Anatomy)
Abstract

Summary: Studies of the innervation of limb muscles by spinal motor neurons have helped to define mechanisms by which axons establish trajectories to their targets. Related motor axons select dorsal or ventral pathways at the base of the limb, raising the question of how these alternate trajectories are specified. EphA signaling has been proposed to control the dorsal trajectory of motor axons in conjunction with other signaling systems, although the respective contributions of each system to motor axon guidance are unclear. We show that the expression of EphB receptors by motor axons, and ephrin-B ligands by limb mesenchymal cells, directs the ventral trajectory of motor axons. Our findings reveal symmetry in the molecular strategies that establish this aspect of nerve-muscle connectivity. The involvement of ephrin:Eph signaling in guiding both sets of motor axons raises the possibility that other signaling systems function primarily to refine or modulate a core Eph signaling program. [Copyright &y& Elsevier]

Published
2008
Full Text
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2. A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing

Author

Landgraf, Pablo, Rusu, Mirabela, Sheridan, Robert, Sewer, Alain, Iovino, Nicola, Aravin, Alexei, Pfeffer, Sébastien, Rice, Amanda, Kamphorst, Alice O., Landthaler, Markus, Lin, Carolina, Socci, Nicholas D., Hermida, Leandro, Fulci, Valerio, Chiaretti, Sabina, Foà, Robin, Schliwka, Julia, Fuchs, Uta, Novosel, Astrid, and Müller, Roman-Ulrich

Subjects
*NUCLEIC acids, *PRESERVATION of organs, tissues, etc., *ORGANS (Anatomy), *CRYOBIOLOGY
Abstract

Summary: MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mRNAs. In order to identify miRNAs and to assess their expression patterns, we sequenced over 250 small RNA libraries from 26 different organ systems and cell types of human and rodents that were enriched in neuronal as well as normal and malignant hematopoietic cells and tissues. We present expression profiles derived from clone count data and provide computational tools for their analysis. Unexpectedly, a relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues. This broad survey also provides detailed and accurate information about mature sequences, precursors, genome locations, maturation processes, inferred transcriptional units, and conservation patterns. We also propose a subclassification scheme for miRNAs for assisting future experimental and computational functional analyses. [Copyright &y& Elsevier]

Published
2007
Full Text
View/download PDF

3. Specification of Motor Axon Trajectory by Ephrin-B:EphB Signaling: Symmetrical Control of Axonal Patterning in the Developing Limb

Author

Victor Luria, Thomas M. Jessell, Ed Laufer, Artur Kania, and Dayana Krawchuk

Subjects
Dorsum, Neuroscience(all), Green Fluorescent Proteins, LIM-Homeodomain Proteins, DEVBIO, Chick Embryo, Biology, Models, Biological, Mice, Neurofilament Proteins, medicine, Animals, Ephrin, RNA, Messenger, Axon, MOLENEURO, Horseradish Peroxidase, Body Patterning, Receptors, Eph Family, Homeodomain Proteins, Mice, Knockout, Motor Neurons, Extramural, General Neuroscience, Erythropoietin-producing hepatocellular (Eph) receptor, Gene Expression Regulation, Developmental, Extremities, Embryo, Mammalian, Axons, Electroporation, medicine.anatomical_structure, Spinal Cord, nervous system, Mutation, CELLBIO, Axon guidance, Developmental physiology, Ephrins, Neuroscience, Signal Transduction, Transcription Factors
Abstract

SummaryStudies of the innervation of limb muscles by spinal motor neurons have helped to define mechanisms by which axons establish trajectories to their targets. Related motor axons select dorsal or ventral pathways at the base of the limb, raising the question of how these alternate trajectories are specified. EphA signaling has been proposed to control the dorsal trajectory of motor axons in conjunction with other signaling systems, although the respective contributions of each system to motor axon guidance are unclear. We show that the expression of EphB receptors by motor axons, and ephrin-B ligands by limb mesenchymal cells, directs the ventral trajectory of motor axons. Our findings reveal symmetry in the molecular strategies that establish this aspect of nerve-muscle connectivity. The involvement of ephrin:Eph signaling in guiding both sets of motor axons raises the possibility that other signaling systems function primarily to refine or modulate a core Eph signaling program.

Published
2008

4. A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing

Author

Astrid Novosel, Markus Landthaler, Julia Schliwka, Sabina Chiaretti, Miklós Palkovits, Roberto Di Lauro, Nicola Iovino, Mirabela Rusu, Roman-Ulrich Müller, Giuseppe Macino, James W. Nagle, Andreas Bosio, Mihaela Zavolan, Peter Wernet, Alice O. Kamphorst, Charles E. Rogler, Chris Sander, Veit Hornung, James J. Russo, Wayne Tam, Thomas Benzing, Alexei A. Aravin, Uta Fuchs, Thomas Tuschl, Pablo Landgraf, Sébastien Pfeffer, Alain Sewer, Hans Ingo Trompeter, Jason M. Inman, Ruchi Choksi, Amanda J. Rice, Arndt Borkhardt, Robert L. Sheridan, Valerio Fulci, Carolina Lin, Leandro C. Hermida, Michael J. Brownstein, Ute Bissels, Bernhard Schermer, Daniela Frezzetti, Minchen Chien, Grace Teng, Jingyue Ju, Quang Phan, Gunther Hartmann, F. Nina Papavasiliou, Robin Foà, Nicholas D. Socci, David B. Weir, Gabriella De Vita, Peter Lichter, Landgraf, P, Rusu, M, Sheridan, R, Sewer, A, Iovino, N, Aravin, A, Pfeffer, S, Rice, A, Kamphorst, Ao, Landthaler, M, Lin, C, Socci, Nd, Hermida, L, Fulci, V, Chiaretti, S, Foa, R, Schliwka, J, Fuchs, U, Novosel, A, Muller, Ru, Schermer, B, Bissels, U, Inman, J, Phan, Q, Chien, M, Weir, Db, Choksi, R, DE VITA, Gabriella, Frezzetti, D, Trompeter, Hi, Hornung, V, Teng, G, Hartmann, G, Palkovits, M, DI LAURO, Roberto, Wernet, P, Macino, G, Rogler, Ce, Nagle, Jw, Ju, J, Papavasiliou, Fn, Benzing, T, Lichter, P, Tam, W, Brownstein, Mj, Bosio, A, Borkhardt, A, Russo, Jj, Sander, C, Zavolan, M, Tuschl, T., Institut de biologie moléculaire des plantes (IBMP), and Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)

Subjects
Small RNA, moleneuro, molimmuno, rna, Molecular Sequence Data, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Genome, General Biochemistry, Genetics and Molecular Biology, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, IsomiR, Mirtron, Sequence Homology, Nucleic Acid, microRNA, Animals, Humans, Cell Lineage, RNA, Messenger, MOLIMMUNO, Conserved Sequence, Phylogeny, MOLENEURO, Gene Library, 030304 developmental biology, Genetics, Regulation of gene expression, 0303 health sciences, Base Sequence, Biochemistry, Genetics and Molecular Biology(all), Gene Expression Profiling, RNA, Hematopoietic Stem Cells, Rats, Gene expression profiling, MicroRNAs, Gene Expression Regulation, Hematologic Neoplasms, 030220 oncology & carcinogenesis
Abstract

SummaryMicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mRNAs. In order to identify miRNAs and to assess their expression patterns, we sequenced over 250 small RNA libraries from 26 different organ systems and cell types of human and rodents that were enriched in neuronal as well as normal and malignant hematopoietic cells and tissues. We present expression profiles derived from clone count data and provide computational tools for their analysis. Unexpectedly, a relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues. This broad survey also provides detailed and accurate information about mature sequences, precursors, genome locations, maturation processes, inferred transcriptional units, and conservation patterns. We also propose a subclassification scheme for miRNAs for assisting future experimental and computational functional analyses.

Published
2007

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