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A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
- Source :
- Cell, Cell, Elsevier, 2007, 129, pp.1401-1414
- Publication Year :
- 2007
-
Abstract
- SummaryMicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mRNAs. In order to identify miRNAs and to assess their expression patterns, we sequenced over 250 small RNA libraries from 26 different organ systems and cell types of human and rodents that were enriched in neuronal as well as normal and malignant hematopoietic cells and tissues. We present expression profiles derived from clone count data and provide computational tools for their analysis. Unexpectedly, a relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues. This broad survey also provides detailed and accurate information about mature sequences, precursors, genome locations, maturation processes, inferred transcriptional units, and conservation patterns. We also propose a subclassification scheme for miRNAs for assisting future experimental and computational functional analyses.
- Subjects :
- Small RNA
moleneuro
molimmuno
rna
Molecular Sequence Data
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
Genome
General Biochemistry, Genetics and Molecular Biology
Article
Mice
03 medical and health sciences
0302 clinical medicine
IsomiR
Mirtron
Sequence Homology, Nucleic Acid
microRNA
Animals
Humans
Cell Lineage
RNA, Messenger
MOLIMMUNO
Conserved Sequence
Phylogeny
MOLENEURO
Gene Library
030304 developmental biology
Genetics
Regulation of gene expression
0303 health sciences
Base Sequence
Biochemistry, Genetics and Molecular Biology(all)
Gene Expression Profiling
RNA
Hematopoietic Stem Cells
Rats
Gene expression profiling
MicroRNAs
Gene Expression Regulation
Hematologic Neoplasms
030220 oncology & carcinogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 00928674 and 10974172
- Database :
- OpenAIRE
- Journal :
- Cell, Cell, Elsevier, 2007, 129, pp.1401-1414
- Accession number :
- edsair.doi.dedup.....7cb274fd51b59d5bbeca60c58ad3134e