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Your search keyword '"MOLECULE N-CAM"' showing total 3 results
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3 results on '"MOLECULE N-CAM"'

2. Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets

Author

Clemens van Blitterswijk, J. Hilderink, Siebe Spijker, Marcel Karperien, Marten A. Engelse, Aart A. van Apeldoorn, Eelco J.P. de Koning, Françoise Carlotti, Lydia Lange, Faculty of Science and Technology, Developmental BioEngineering, CTR, RS: MERLN - Complex Tissue Regeneration (CTR), Institute MERLN, and Hubrecht Institute for Developmental Biology and Stem Cell Research

Subjects
Male, endocrine system diseases, type 1 diabetes, Cell, Mice, SCID, CULTURE, Non-U.S. Gov't, Cells, Cultured, Cell Aggregation, islets, geography.geographical_feature_category, Research Support, Non-U.S. Gov't, MIN6 PSEUDOISLETS, Middle Aged, Islet, Cell aggregation, Cell biology, medicine.anatomical_structure, METIS-310109, Molecular Medicine, PDX1, Female, EXPRESSION, medicine.medical_specialty, endocrine system, Cell Survival, Biology, Research Support, INSULIN-SECRETION, Islets of Langerhans, Cell Line, Tumor, Internal medicine, IR-95265, medicine, Journal Article, Animals, Humans, SEGREGATION, Comparative Study, pseudoislets bioengineering beta cells, Insulinoma, Cell Size, RELEASE, Type 1 diabetes, geography, TRANSPLANTATION, Pancreatic islets, islets type 1 diabetes, Reproducibility of Results, Original Articles, Cell Biology, pseudoislets bioengineering, HUMAN BETA-CELLS, medicine.disease, Transplantation, beta cells, Glucose, Endocrinology, MOLECULE N-CAM, CLUSTERS
Abstract

Clinical islet transplantation is a promising treatment for patients with type 1 diabetes. However, pancreatic islets vary in size and shape affecting their survival and function after transplantation because of mass transport limitations. To reduce diffusion restrictions and improve islet cell survival, the generation of islets with optimal dimensions by dispersion followed by reassembly of islet cells, can help limit the length of diffusion pathways. This study describes a microwell platform that supports the controlled and reproducible production of three-dimensional pancreatic cell clusters of human donor islets. We observed that primary human islet cell aggregates with a diameter of 100–150 μm consisting of about 1000 cells best resembled intact pancreatic islets as they showed low apoptotic cell death (

Published
2015

3. Development and diseases of the pancreas

Author

Johansson, K. A. and Grapin-Botton, A.

Subjects
insulin, molecule n-cam, diabetes, islet, gland, organogenesis, endocrine-cells, transgenic mice, in-vitro, mouse pancreas, matrix metalloproteinase mmp-2, exocrine pancreas, beta-cells, cancer, type-2 diabetes-mellitus, endoderm, homeobox gene isl-1
Abstract

The pancreas is a vital gland of exocrine and endocrine function. It is the target of two main affections: diabetes and pancreatic cancer. We describe the tissue interactions, signaling pathways and intracellular targets that are involved in the emergence of the pancreas primordium and its proliferation, morphogenesis and differentiation. It appears that several genes of developmental relevance have an adult function and are involved in pancreas affections. Embryological experimentation in animals contributed to provide candidate genes for human disease and holds promise for future treatments.

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