1. Do respiratory virus infections modify associations of asthma exacerbation with aeroallergens or fine particulate matter? A time series study in Philadelphia PA.
- Author
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Huang, Wanyu, Schinasi, Leah H., Kenyon, Chén C., Auchincloss, Amy H., Moore, Kari, Melly, Steven, Robinson, Lucy F., Forrest, Christopher B., and De Roos, Anneclaire J.
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DISEASE exacerbation , *AIR pollution , *ALLERGENS , *RISK assessment , *POLLEN , *MATHEMATICAL variables , *RESPIRATORY infections , *OUTPATIENT services in hospitals , *RESPIRATORY syncytial virus , *RESEARCH funding , *TIME series analysis , *HOSPITAL emergency services , *RELATIVE medical risk , *MEDICAL appointments , *ELECTRONIC health records , *MEDICAL records , *ACQUISITION of data , *BACTERIAL growth , *RESEARCH , *VIRUS diseases , *PARTICULATE matter , *ASTHMA , *MICROBIOLOGICAL techniques , *DISEASE complications , *CHILDREN - Abstract
Respiratory virus infections are related to over 80% of childhood asthma exacerbations. They enhance pro-inflammatory mediator release, especially for sensitized individuals exposed to pollens/molds. Using a time-series study design, we investigated possible effect modification by respiratory virus infections of the associations between aeroallergens/PM2.5 and asthma exacerbation rates. Outpatient, emergency department (ED), and inpatient visits for asthma exacerbation among children with asthma (28,540/24,444 [warm/cold season]), as well as viral infection counts were obtained from electronic health records of the Children's Hospital of Philadelphia from 2011 to 2016. Rate ratios (RRs, 90th percentile vs. 0) for late-season grass pollen were 1.00 (0.85–1.17), 1.04 (0.95–1.15), and 1.12 (0.96–1.32), respectively, for respiratory syncytial virus (RSV) counts within each tertile. However, similar trends were not observed for weed pollens/molds or PM2.5. Overall, our study provides little evidence supporting effect modification by respiratory viral infections. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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