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2 results on '"MEVE, Methanolic extract of Vernonia elaeagnifolia"'

1. Data of in vivo screening of antiulcer activity for methanolic extract of Vernonia elaeagnifolia DC

Author

N. Priyanka, Sneha Nawale, Sujit Das, and M. Ganga Raju

Subjects
p.o, per oral, Antioxidant, medicine.medical_treatment, CPCSEA, Committee for the purpose of control and supervision of experimentation on animals, LD50, Median lethal dose, H2O2, Hydrogen peroxide, mEq, Milliequivalents, chemistry.chemical_compound, %, percentage, 0302 clinical medicine, mg, Milligram, Medicinal plants, Omeprazole, bd.wt, body weight, 0303 health sciences, Multidisciplinary, Traditional medicine, Chemistry, IAEC, Institutional Animal Ethical Committee, Pharmacology, Toxicology and Pharmaceutical Science, SEM, standard error of mean, medicine.anatomical_structure, lcsh:R858-859.7, Antiulcer activity, medicine.symptom, ANOVA, Analysis of variance, medicine.drug, OECD, Economic Cooperation and Development, lcsh:Computer applications to medicine. Medical informatics, Nitric oxide, 03 medical and health sciences, Vernonia elaeagnifolia, mg/kg, Milligram per Kilogram, MEVE, Methanolic extract of Vernonia elaeagnifolia, medicine, Gastric mucosa, lcsh:Science (General), Mode of action, Pylorus ligation, 030304 developmental biology, NO, nitric oxide, Ethanol, Aspirin, mL, Millilitre, Ascorbic acid, digestive system diseases, Mechanism of action, 030217 neurology & neurosurgery, lcsh:Q1-390
Abstract

The data present in this article is related to evaluation of standardized methanolic extract of Vernonia elaeagnifolia aerial parts [MEVE], a species of Asteraceae family for antiulcer potential. Antiulcer activity of MEVE (200 and 400 mg/kg, b.w., p.o.) was evaluated with ethanol and aspirin induced ulcer models and pylorus ligation induced gastric ulcer model. The antioxidant potential of MEVE was evaluated with nitric oxide radicals, hydroxyl radical and H2O2 radical scavenging assay against standard ascorbic acid to correlate antioxidant and antiulcerogenic action. MEVE significantly protects the gastric mucosa against the ethanol and aspirin induced ulcer and pylorus ligation induced ulcer challenge. MEVE had shown significant [normal control: p

Published
2019

2. Data of in vivo screening of antiulcer activity for methanolic extract of Vernonia elaeagnifolia DC.

Author

Nawale S, Priyanka N, Das S, and Ganga Raju M

Abstract

The data present in this article is related to evaluation of standardized methanolic extract of Vernonia elaeagnifolia aerial parts [MEVE] , a species of Asteraceae family for antiulcer potential. Antiulcer activity of MEVE (200 and 400 mg/kg, b.w., p.o. ) was evaluated with ethanol and aspirin induced ulcer models and pylorus ligation induced gastric ulcer model. The antioxidant potential of MEVE was evaluated with nitric oxide radicals, hydroxyl radical and H 2 O 2 radical scavenging assay against standard ascorbic acid to correlate antioxidant and antiulcerogenic action. MEVE significantly protects the gastric mucosa against the ethanol and aspirin induced ulcer and pylorus ligation induced ulcer challenge. MEVE had shown significant [normal control: p < 0.0001, disease control: p < 0.0001, standard: p < 0.0001] decrease in the ulcer index produced by all three models in rats as compared to the standard drug omeprazole [20 mg/kg, b.w., p.o. ]. The present data suggest that aerial parts of Vernonia elaeagnifolia possess significant antiulcer activity, which may attributed to its antioxidant mechanism of action.

Published
2019
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