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Data of in vivo screening of antiulcer activity for methanolic extract of Vernonia elaeagnifolia DC
- Source :
- Data in Brief, Data in Brief, Vol 23, Iss, Pp-(2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- The data present in this article is related to evaluation of standardized methanolic extract of Vernonia elaeagnifolia aerial parts [MEVE], a species of Asteraceae family for antiulcer potential. Antiulcer activity of MEVE (200 and 400 mg/kg, b.w., p.o.) was evaluated with ethanol and aspirin induced ulcer models and pylorus ligation induced gastric ulcer model. The antioxidant potential of MEVE was evaluated with nitric oxide radicals, hydroxyl radical and H2O2 radical scavenging assay against standard ascorbic acid to correlate antioxidant and antiulcerogenic action. MEVE significantly protects the gastric mucosa against the ethanol and aspirin induced ulcer and pylorus ligation induced ulcer challenge. MEVE had shown significant [normal control: p
- Subjects :
- p.o, per oral
Antioxidant
medicine.medical_treatment
CPCSEA, Committee for the purpose of control and supervision of experimentation on animals
LD50, Median lethal dose
H2O2, Hydrogen peroxide
mEq, Milliequivalents
chemistry.chemical_compound
%, percentage
0302 clinical medicine
mg, Milligram
Medicinal plants
Omeprazole
bd.wt, body weight
0303 health sciences
Multidisciplinary
Traditional medicine
Chemistry
IAEC, Institutional Animal Ethical Committee
Pharmacology, Toxicology and Pharmaceutical Science
SEM, standard error of mean
medicine.anatomical_structure
lcsh:R858-859.7
Antiulcer activity
medicine.symptom
ANOVA, Analysis of variance
medicine.drug
OECD, Economic Cooperation and Development
lcsh:Computer applications to medicine. Medical informatics
Nitric oxide
03 medical and health sciences
Vernonia elaeagnifolia
mg/kg, Milligram per Kilogram
MEVE, Methanolic extract of Vernonia elaeagnifolia
medicine
Gastric mucosa
lcsh:Science (General)
Mode of action
Pylorus ligation
030304 developmental biology
NO, nitric oxide
Ethanol
Aspirin
mL, Millilitre
Ascorbic acid
digestive system diseases
Mechanism of action
030217 neurology & neurosurgery
lcsh:Q1-390
Subjects
Details
- Language :
- English
- ISSN :
- 23523409
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Data in Brief
- Accession number :
- edsair.doi.dedup.....5371a246af0695b966f82bfa1022200e