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Your search keyword '"MESH : Muscle Relaxation"' showing total 2 results
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2 results on '"MESH : Muscle Relaxation"'

1. Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?

Author

Emmanuel Naline, Esteban J. Morcillo, C Loustalot, John J. Morrison, Marie-Josèphe Leroy, René Frydman, Céline Rouget, Paul Sagot, Marc Bardou, Charles Advenier, Michèle Breuiller-Fouche, Laboratoire de Pharmacologie et Toxicologie, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Pharmacologie, Université Paris Descartes - Paris 5 (UPD5)-UPRES EA220, La grossesse normale et pathologique: développement et fonctions du placenta et de l'utérus (UMR_S 767), Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Gynécologie Obstétrique, Médecine Foetale et Stérilité Conjugale - Chirurgie Gynécologie et Oncologique [CHU de Dijon], Service de gynécologie-obstétrique, médecine de la reproduction [Béclère], Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of Pharmacology, Universitat de València (UV), Department of Gynaecology and Obstetrics, National University of Ireland [Galway] (NUI Galway), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Université Paris Descartes - Paris 5 ( UPD5 ) -UPRES EA220, La grossesse normale et pathologique: développement et fonctions du placenta et de l'utérus ( UMR_S 767 ), Institut des sciences du Médicament -Toxicologie - Chimie - Environnement ( IFR71 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL ( ENSCP ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL ( ENSCP ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Antoine Béclère, Universitat de València ( UV ), National University of Ireland [Galway] ( NUI Galway ), Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale (LPPCE), Université de Bourgogne (UB), UPRES EA220, Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Leroy, Marie Josèphe

Subjects
Muscle Relaxation, MESH : Receptors, Adrenergic, beta-3, MESH : Adrenergic beta-Agonists, Uterus, Adrenergic beta-3 Receptor Agonists, MESH: Adrenergic beta-Agonists, Pharmacology, Uterine contraction, Uterine Contraction, 0302 clinical medicine, MESH: Pregnancy, MESH : Uterus, Pregnancy, Obstetrics and Gynaecology, Medicine, MESH : Female, MESH: Obstetric Labor, Premature, [ SDV.MHEP.GEO ] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, reproductive and urinary physiology, 0303 health sciences, MESH : Myometrium, Myometrium, MESH : Obstetric Labor, Premature, Obstetrics and Gynecology, Adrenergic beta-Agonists, 3. Good health, medicine.anatomical_structure, Muscle relaxation, 030220 oncology & carcinogenesis, Tocolytic, MESH: Uterine Contraction, MESH: Myometrium, MESH: Uterus, Female, medicine.symptom, Tocolytic agent, medicine.medical_specialty, Adrenergic receptor, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, MESH : Muscle Relaxation, 03 medical and health sciences, Obstetric Labor, Premature, Internal medicine, Humans, 030304 developmental biology, MESH: Humans, business.industry, MESH : Humans, [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, MESH : Pregnancy, Endocrinology, Proceedings, Receptors, Adrenergic, beta-3, MESH: Muscle Relaxation, business, MESH: Receptors, Adrenergic, beta-3, MESH: Female, MESH : Uterine Contraction
Abstract

International audience; The management of premature birth still remains unsatisfactory. Since the relative lack of efficiency and/or safety of current tocolytic agents have been highlighted, it is necessary to develop new uterorelaxant drugs deprived of important maternal and foetal side effects. Our work reported in this review focuses on a potential new target for tocolytic drugs, the beta3-adrenoceptor (ADRB3). This third type of ADRB is shown to be present and functional in human myometrium. We demonstrated that ADRB3 agonists are able to inhibit in-vitro spontaneous contractions of myometrial strips, via a cyclic AMP-mediated pathway. Furthermore, we established that ADRB3 is the predominant subtype over the ADRB2 in human myometrium and that its expression is increased in near-term myometrium, compared to non-pregnant myometrium. Finally, we reported that contrary to ADRB2, the human myometrial ADRB3 is resistant to long-term agonist-induced desensitisation. These compelling data confirm the clinical potential interest of ADRB3 agonists in the pharmacological management of preterm labour.

Published
2007

2. Stability of pedalling mechanics during a prolonged cycling exercise performed at different cadences

Author

G. Sarre, J. Van Hoecke, Romuald Lepers, Motricité - Plasticité, Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), and Van Hoecke, Jacques

Subjects
Male, Hamstring muscles, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], MESH: Muscle Contraction, Muscle Relaxation, MESH : Analysis of Variance, Electromyography, Cohort Studies, 0302 clinical medicine, Voluntary contraction, MESH: Risk Factors, Risk Factors, Orthopedics and Sports Medicine, MESH: Oxygen Consumption, MESH : Oxygen Consumption, MESH: Cohort Studies, Knee extensors, medicine.diagnostic_test, [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Biomechanics, MESH: Comparative Study, MESH : Adult, MESH : Risk Factors, MESH: Muscle Fatigue, Muscle Fatigue, MESH : Electromyography, Cycling, Cadence, MESH: Physical Endurance, MESH : Physical Endurance, Muscle Contraction, Adult, medicine.medical_specialty, MESH: Probability, MESH : Probability, MESH : Male, Physical Exertion, MESH : Exertion, MESH : Cohort Studies, Physical Therapy, Sports Therapy and Rehabilitation, Sensitivity and Specificity, MESH : Muscle Relaxation, MESH: Bicycling, MESH: Electromyography, 03 medical and health sciences, Physical medicine and rehabilitation, Oxygen Consumption, MESH: Analysis of Variance, medicine, MESH: Exertion, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Probability, Analysis of Variance, MESH : S, MESH: Humans, business.industry, MESH : Humans, MESH : Comparative Study, MESH: Adult, 030229 sport sciences, Negative work, MESH : Muscle Fatigue, MESH: Male, Bicycling, body regions, MESH : Exercise Test, Torque, MESH : Bicycling, MESH: S, MESH: Muscle Relaxation, Physical therapy, Exercise Test, Physical Endurance, MESH : Muscle Contraction, business, MESH: Exercise Test, human activities, 030217 neurology & neurosurgery
Abstract

The aim of this study was to analyse the effect of pedalling rate on the pattern of mechanical torque application and on neuromuscular fatigue during prolonged cycling exercise. Eleven well-trained individuals performed three 1-h pedalling sessions, at 50 rev.min-1, 110 rev.min-1 and a freely chosen cadence, at an intensity corresponding to 65% of their maximal aerobic power. The mechanical torque applied on the right pedal was recorded for 30 s every 5 min while pedalling. Contractile and neural properties of the quadriceps and hamstring muscles were analysed before and immediately after each of the three pedalling sessions. The post-exercise reduction in knee extensors maximal voluntary contraction was significant (P

Published
2005

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