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11 results on '"MESH : Electromyography"'

1. Hedonic reactivity to visual and olfactory cues: rapid facial electromyographic reactions are altered in anorexia nervosa

Author

Benoist Schaal, Jean-Pierre Royet, Robert Soussignan, Tao Jiang, Daniel Rigaud, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Neurosciences Sensorielles Comportement Cognition, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Université Claude Bernard Lyon 1 ( UCBL ), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS )

Subjects
MESH : Galvanic Skin Response, Pleasure, REWARD, Anorexia Nervosa, [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition, AUTOMATIC PROCESS, MESH : Photic Stimulation, Facial Muscles, MESH : Analysis of Variance, Automatic processing, Electromyography, Audiology, Developmental psychology, 0302 clinical medicine, Heart Rate, MESH: Smell, MESH : Female, MESH: Heart Rate, medicine.diagnostic_test, General Neuroscience, digestive, oral, and skin physiology, Galvanic Skin Response, MESH : Adult, MESH : Odors, Smell, Neuropsychology and Physiological Psychology, MESH: Photic Stimulation, MESH: Pleasure, MESH: Young Adult, MESH : Anorexia Nervosa, MESH: Galvanic Skin Response, MESH : Electromyography, Female, FACIAL EMG, Cues, Psychology, Arousal, Facial electromyography, MESH: Anorexia Nervosa, Adult, medicine.medical_specialty, HEDONIC, MESH : Young Adult, Olfactory cues, MESH : Pleasure, Olfaction, Stimulus (physiology), MESH: Psychophysics, MESH : Facial Muscles, MESH: Electromyography, 03 medical and health sciences, Young Adult, MESH: Analysis of Variance, medicine, Psychophysics, Reaction Time, Humans, Sensory cue, MESH : Arousal, Analysis of Variance, MESH: Humans, MESH: Odors, MESH : Cues, MESH : Heart Rate, MESH: Arousal, MESH: Facial Muscles, MESH : Humans, MESH: Adult, 030227 psychiatry, MESH: Reaction Time, MESH : Psychophysics, Electrophysiology, FOOD-CUE REACTIVITY, MESH : Reaction Time, Odorants, MESH : Smell, MESH: Female, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery, MESH: Cues, Photic Stimulation
Abstract

IDS Number: 745AY; International audience; Though it has been suggested that hedonic processing is altered in anorexia nervosa (AN), few studies have used objective measures to assess affective processes in this eating disorder. Accordingly, we investigated facial electromyographic, autonomic and subjective reactivity to the smell and sight of food and non-food stimuli, and assessed more particularly rapid facial reactions reflecting automatic processing of pleasantness. AN and healthy control (HC) women were exposed, before and after a standardized lunch, to pictures and odorants of foods differing in energy density, as well as to non-food sensory cues. Whereas the temporal profile of zygomatic activity in AN patients was typified by a fast drop to sensory cues within the 1000 ms following stimulus onset, HC showed a larger EMG reactivity to pictures in a 800-1000 ms time window. In contrast, pleasantness ratings discriminated the two groups only for high energy density food cues suggesting a partial dissociation between objective and subjective measures of hedonic processes in AN patients. The findings suggest that the automatic processing of pleasantness might be altered in AN, with the sensitivity to reward being modulated by controlled processes.

Published
2010

2. Subliminal fear priming potentiates negative facial reactions to food pictures in women with anorexia nervosa

Author

Robert Soussignan, Benoist Schaal, Tao Jiang, Jean-Pierre Royet, D. Rigaud, Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Neurosciences Sensorielles Comportement Cognition, Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon

Subjects
Pleasure, MESH : Galvanic Skin Response, Anorexia Nervosa, MESH : Recognition (Psychology), Audiology, Developmental psychology, Adult Affect Analysis of Variance Anorexia Nervosa/ psychology Cues Electromyography/methods/statistics & numerical data Face Facial Expression Fear/ psychology Female Food Galvanic Skin Response Heart Rate Humans Hunger Motivation Muscle, MESH : Fear, Task Performance and Analysis, Emotional expression, MESH : Task Performance and Analysis, MESH : Muscle, Skeletal, media_common, MESH : Reinforcement (Psychology), MESH: Subliminal Stimulation, digestive, oral, and skin physiology, Fear, MESH: Recognition (Psychology), MESH: Reinforcement (Psychology), Facial Expression, Psychiatry and Mental health, MESH: Photic Stimulation, MESH: Pleasure, MESH : Motivation, Visual Perception, MESH : Face, MESH : Food, Facial electromyography, Reinforcement, Psychology, MESH: Anorexia Nervosa, MESH : Visual Perception, medicine.medical_specialty, media_common.quotation_subject, MESH: Motivation, MESH : Facial Expression, MESH: Electromyography, MESH : Hunger, Humans, MESH: Humans, MESH: Satiation, MESH: Visual Perception, MESH : Cues, Electromyography, MESH : Humans, Recognition, Psychology, MESH: Adult, MESH: Task Performance and Analysis, medicine.disease, Disgust, Food, Face, MESH: Female, Photic Stimulation, MESH: Cues, MESH: Facial Expression, Hunger, [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition, MESH: Fear, MESH : Photic Stimulation, MESH : Analysis of Variance, Anorexia nervosa, Heart Rate, MESH: Unconscious (Psychology), MESH : Female, MESH: Heart Rate, Applied Psychology, MESH: Muscle, Skeletal, Unconscious, Psychology, MESH: Affect, Galvanic Skin Response, MESH : Adult, Skeletal Photic Stimulation/ methods Pleasure Recognition (Psychology) Reinforcement (Psychology) Satiation Subliminal Stimulation Task Performance and Analysis Unconscious (Psychology) Visual Perception, MESH : Unconscious (Psychology), MESH: Hunger, MESH: Galvanic Skin Response, MESH : Anorexia Nervosa, MESH : Electromyography, Female, Cues, Psychology, MESH : Subliminal Stimulation, Priming (psychology), MESH: Face, MESH: Food, Adult, MESH : Pleasure, Satiation, Subliminal Stimulation, MESH: Analysis of Variance, medicine, Muscle, Skeletal, Facial expression, Analysis of Variance, Motivation, MESH : Heart Rate, Subliminal stimuli, MESH : Affect, Affect, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, MESH : Satiation
Abstract

BackgroundTo investigate hedonic reactivity and the influence of unconscious emotional processes on the low sensitivity to positive reinforcement of food in anorexia nervosa (AN).MethodAN and healthy women were exposed to palatable food pictures just after a subliminal exposure to facial expressions (happy, disgust, fear and neutral faces), either while fasting or after a standardized meal (hungerversussatiety). Both implicit [facial electromyographic (EMG) activity from zygomatic and corrugator muscles, skin conductance, heart rate, and videotaped facial behavior] and explicit (self-reported pleasure and desire) measures of affective processes were recorded.ResultsIn contrast to healthy women, the AN patients did not display objective and subjective indices of pleasure to food pictures when they were in the hunger states. Pleasure to food cues (liking) was more affected than the desire to eat (wanting) in AN patients. Subliminal ‘fear faces’ increased corrugator muscle reactivity to food stimuli in fasting AN patients, as compared to controls.ConclusionsThe results suggest that unconscious fear cues increase the negative appraisal of alimentary stimuli in AN patients and thus contribute to decreased energy intake.

Published
2010

3. Kinetics of neuromuscular changes during low-frequency electrical stimulation

Author

Maria Papaiordanidou, David Guiraud, Alain Varray, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Artificial movement and gait restoration (DEMAR), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Euromov (EuroMov), Université de Montpellier (UM), Université de Bourgogne (UB) - Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier (UM) - Centre National de la Recherche Scientifique (CNRS) - Université de Montpellier (UM) - Centre National de la Recherche Scientifique (CNRS) - Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria) - Institut National de Recherche en Informatique et en Automatique (Inria), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Artificial movement and gait restoration ( DEMAR ), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier ( LIRMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Euromov ( EuroMov ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Varray, Alain, Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

Subjects
Male, Physiology, MESH : Electric Stimulation, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], MESH: Muscle Contraction, Action Potentials, Stimulation, 0302 clinical medicine, Reference Values, Evoked potential, MESH : Muscle, Skeletal, MESH: Action Potentials, Motor Neurons, MESH: Muscle, Skeletal, Chemistry, [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], MESH: Reference Values, MESH: Electric Stimulation, Anatomy, MESH: Follow-Up Studies, MESH : Adult, medicine.anatomical_structure, MESH: Muscle Fatigue, Muscle Fatigue, [ SCCO.NEUR ] Cognitive science/Neuroscience, MESH : Electromyography, medicine.symptom, Early phase, MESH: Motor Neurons, Muscle contraction, Muscle Contraction, Adult, medicine.medical_specialty, MESH : Motor Neurons, MESH : Male, MESH : Reference Values, MESH: Electromyography, 03 medical and health sciences, Cellular and Molecular Neuroscience, Median frequency, MESH : Action Potentials, Physiology (medical), Internal medicine, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Muscle, Skeletal, MESH: Humans, Electromyography, [SCCO.NEUR]Cognitive science/Neuroscience, MESH : Humans, [SCCO.NEUR] Cognitive science/Neuroscience, MESH : Follow-Up Studies, MESH: Adult, 030229 sport sciences, Motor neuron, Electric Stimulation, MESH : Muscle Fatigue, MESH: Male, Electrophysiology, Endocrinology, MESH : Muscle Contraction, Neurology (clinical), H-reflex, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

International audience; The purpose of the study was to examine the time course of neuromuscular fatigue components during a low-frequency electrostimulation (ES) session. Three bouts of 17 trains of stimulation at 30 HZ (4 s on, 6 s off) were used to electrically induce fatigue in the plantar flexor muscles. Before and after every 17-train bout, torque, electromyographic activity [expressed as root mean square (RMS) and median frequency (MF) values], evoked potentials (M-wave and H-reflex), and the level of voluntary activation (LOA, using twitch interpolation technique) were assessed. Torque during maximal voluntary contraction decreased significantly from the very first stimulation bout (-6.6 +/- 1.11%, P < 0.001) and throughout the session (-10.32 +/- 1.68% and -11.53 +/- 1.27%, for the second and third bouts, respectively). The LOA and RMS/Mmax values were significantly decreased during the ES session (-2.9 +/- 1.07% and -17.5 +/- 6.14%, P < 0.01 and P< 0.001, respectively, at the end of the protocol), while MF showed no changes. The Hmax/Mmax ratio and Mmax were not significantly modified during the session. All twitch parameters were significantly potentiated after the first bout and throughout the session (P < 0.001). The maximal torque decrease was evident from the early phase of a low-frequency ES protocol, with no concomitant inhibition of motoneuron excitability or depression of muscle contractile properties. These results are consistent with an early failure of the central drive to the muscle.

Published
2010

4. Discrete and effortful imagined movements do not specifically activate the autonomic nervous system

Author

Hervé Normand, Laurent Demougeot, Pierre Denise, Charalambos Papaxanthis, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Mobilités : Cognition et Temporalité, Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), This work was supported by the Conseil Général de Bourgogne, Autard, Delphine, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cognition, Mobilités, Temporalité (COMETE), Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, MESH : Movement, Physiology, Blood Pressure, MESH: Movement, Electromyography, MESH : Autonomic Nervous System, MESH: Autonomic Nervous System, Orthostatic vital signs, 0302 clinical medicine, Heart Rate, Nervous System Physiological Phenomena, MESH: Heart Rate, MESH: Nervous System Physiological Phenomena, 0303 health sciences, Neuroscience/Behavioral Neuroscience, Multidisciplinary, medicine.diagnostic_test, Movement (music), MESH: Blood Pressure, Anatomy, MESH : Adult, MESH : Nervous System Physiological Phenomena, MESH : Electromyography, Medicine, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Research Article, Adult, Science, Movement, MESH : Male, Baroreflex, Biology, Autonomic Nervous System, MESH: Electromyography, 03 medical and health sciences, Motor imagery, Motor system, medicine, MESH : Blood Pressure, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 030304 developmental biology, Neuroscience/Cognitive Neuroscience, MESH: Humans, MESH : Heart Rate, MESH : Humans, MESH: Adult, Trunk, MESH: Male, Autonomic nervous system, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neuroscience, 030217 neurology & neurosurgery
Abstract

International audience; BACKGROUND: The autonomic nervous system (ANS) is activated in parallel with the motor system during cyclical and effortful imagined actions. However, it is not clear whether the ANS is activated during motor imagery of discrete movements and whether this activation is specific to the movement being imagined. Here, we explored these topics by studying the baroreflex control of the cardiovascular system. METHODOLOGY/PRINCIPAL FINDINGS: Arterial pressure and heart rate were recorded in ten subjects who executed or imagined trunk or leg movements against gravity. Trunk and leg movements result in different physiological reactions (orthostatic hypotension phenomenon) when they are executed. Interestingly, ANS activation significantly, but similarly, increased during imagined trunk and leg movements. Furthermore, we did not observe any physiological modulation during a control mental-arithmetic task or during motor imagery of effortless movements (horizontal wrist displacements). CONCLUSIONS/SIGNIFICANCE: We concluded that ANS activation during motor imagery is general and not specific and physiologically prepares the organism for the upcoming effortful action.

Published
2009

5. Evidence of a dosage effect and a physiological endplate acetylcholinesterase deficiency in the first mouse models mimicking Schwartz-Jampel syndrome neuromyotonia

Author

Morgane Stum, Arnaud Ferry, Frédédrique Rene, Christophe Marcel, Andoni Echaniz-Laguna, Véronique Bernard, Claire-Sophie Davoine, Bertrand Fontaine, Eric Krejci, Sophie Nicole, Alban Vignaud, Marie Bangratz, Emmanuelle Girard, Jordi Molgó, Marc Herbin, Affections de la Myeline et des Canaux Ioniques Musculaires, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de neurobiologie cellulaire et moléculaire (NBCM), Centre National de la Recherche Scientifique (CNRS), Institut de Neurobiologie Alfred Fessard (INAF), Biologie des Jonctions Neuromusculaires Normales et Pathologiques (U686), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Mécanismes adaptatifs : des organismes aux communautés (MAOAC), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Groupe Myologie, Institut de Myologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de signalisation moléculaire et neurodégénerescence, Université Louis Pasteur - Strasbourg I-IFR37-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Neurologie, Hôpital Civil de Strasbourg, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Fédération des Maladies du Système Nerveux, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Muséum national d'Histoire naturelle (MNHN)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Laboratoire de neurobiologie cellulaire et moléculaire ( NBCM ), Centre National de la Recherche Scientifique ( CNRS ), Institut de Neurobiologie Alfred Fessard ( INAF ), Biologie des Jonctions Neuromusculaires Normales et Pathologiques ( U686 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Mécanismes adaptatifs : des organismes aux communautés ( MAOAC ), Muséum National d'Histoire Naturelle ( MNHN ) -Collège de France ( CdF ) -Centre National de la Recherche Scientifique ( CNRS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Association française contre les myopathies ( AFM-Téléthon ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Association française contre les myopathies ( AFM-Téléthon ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Louis Pasteur - Strasbourg I-IFR37-Institut National de la Santé et de la Recherche Médicale ( INSERM ), and Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP]

Subjects
Male, Neuromyotonia, MESH: Mice, Mutant Strains, MESH: Muscle Contraction, Gene Dosage, medicine.disease_cause, MESH: Gene Dosage, MESH: Motor Endplate, chemistry.chemical_compound, Mice, 0302 clinical medicine, Missense mutation, MESH : Female, MESH : Gene Dosage, MESH: Animals, Genetics (clinical), 0303 health sciences, Mutation, biology, General Medicine, Acetylcholinesterase, MESH : Mice, Transgenic, MESH : Phenotype, medicine.anatomical_structure, Phenotype, MESH : Electromyography, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH : Heparan Sulfate Proteoglycans, Muscle Contraction, medicine.medical_specialty, MESH : Isaacs Syndrome, MESH: Mice, Transgenic, MESH : Male, Schwartz–Jampel syndrome, Mutation, Missense, Mice, Transgenic, MESH : Mice, Inbred C57BL, Perlecan, Osteochondrodysplasias, MESH: Phenotype, Motor Endplate, Neuromuscular junction, MESH : Acetylcholinesterase, MESH: Electromyography, 03 medical and health sciences, In vivo, MESH: Mice, Inbred C57BL, Internal medicine, MESH : Mice, Genetics, medicine, Animals, Humans, MESH: Isaacs Syndrome, Molecular Biology, MESH: Mice, Alleles, 030304 developmental biology, MESH : Osteochondrodysplasias, MESH: Mutation, Missense, MESH: Humans, Electromyography, MESH: Alleles, MESH : Humans, MESH : Motor Endplate, MESH: Acetylcholinesterase, medicine.disease, MESH: Osteochondrodysplasias, MESH : Disease Models, Animal, Mice, Mutant Strains, MESH: Male, MESH : Mice, Mutant Strains, Mice, Inbred C57BL, Disease Models, Animal, stomatognathic diseases, Endocrinology, chemistry, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], biology.protein, MESH: Heparan Sulfate Proteoglycans, MESH : Muscle Contraction, MESH : Animals, Isaacs Syndrome, MESH: Disease Models, Animal, MESH : Alleles, MESH: Female, MESH : Mutation, Missense, 030217 neurology & neurosurgery, Heparan Sulfate Proteoglycans
Abstract

International audience; Schwartz-Jampel syndrome (SJS) is a recessive neuromyotonia with chondrodysplasia. It results from hypomorphic mutations of the gene encoding perlecan, leading to a decrease in the levels of this heparan sulphate proteoglycan in basement membranes (BMs). It has been suggested that SJS neuromyotonia may result from endplate acetylcholinesterase (AChE) deficiency, but this hypothesis has never been investigated in vivo due to the lack of an animal model for neuromyotonia. We used homologous recombination to generate a knock-in mouse strain with one missense substitution, corresponding to a human familial SJS mutation (p.C1532Y), in the perlecan gene. We derived two lines, one with the p.C1532Y substitution alone and one with p.C1532Y and the selectable marker Neo, to down-regulate perlecan gene activity and to test for a dosage effect of perlecan in mammals. These two lines mimicked SJS neuromyotonia with spontaneous activity on electromyogramm (EMG). An inverse correlation between disease severity and perlecan secretion in the BMs was observed at the macroscopic and microscopic levels, consistent with a dosage effect. Endplate AChE levels were low in both lines, due to synaptic perlecan deficiency rather than major myofibre or neuromuscular junction disorganization. Studies of muscle contractile properties showed muscle fatigability at low frequencies of nerve stimulation and suggested that partial endplate AChE deficiency might contribute to SJS muscle stiffness by potentiating muscle force. However, physiological endplate AChE deficiency was not associated with spontaneous activity at rest on EMG in the diaphragm, suggesting that additional changes are required to generate such activity characteristic of SJS.

Published
2008

6. Difficult memory task during postural tasks of various difficulties in young and older people: a pilot study

Author

Simoneau , Emilie M, Billot , Maxime, Martin , Alain, Perennou , Dominic, Van Hoecke , Jacques, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), and Motricité - Plasticité

Subjects
MESH : Ankle Joint, MESH : Pilot Projects, MESH : Male, MESH : Humans, MESH : Memory, MESH : Posture, MESH : Psychomotor Performance, MESH : Adult, MESH : Aging, [ SDV.NEU.SC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, MESH : Postural Balance, MESH : Electromyography, MESH : Muscle Contraction, MESH : Female, MESH : Middle Aged, MESH : Age Factors, MESH : Muscle, Skeletal
Abstract

International audience; OBJECTIVE: This study examined the effects of a difficult and individually tailored additional cognitive task on postural stability and electromyographic (EMG) activities of the ankle dorsi- and plantar-flexors, in young and older individuals performing postural tasks of varying difficulties. METHODS: Eight young (mean age=24 years) and eight older (74 years) men took part in the investigation. Centre of pressure velocity and surface EMG of ankle joint muscles were both examined during various postural conditions. RESULTS: The main findings suggested that high levels of muscle activity were a characteristic of age-related declines in postural stability. Moreover, during the complex posture, the postural instability, as well as the EMG activity of the ankle joint muscles, was decreased in older adults when the difficult memory task was added. Regarding young participants, the performance in the cognitive task was significantly improved during the complex posture compared to the easy one. CONCLUSIONS: These findings showed that the execution of a second task would make it possible to improve the performance in the original task. SIGNIFICANCE: This pilot study seemed to show that, depending on age, the task of highest priority would be the cognitive one for young adults and the postural one for older people.

Published
2008

7. How to extend the elbow with a weak or paralyzed triceps: control of arm kinematics for aiming in C6-C7 quadriplegic patients

Author

Agnès Roby-Brami, Gilles Hoffmann, Sylvain Hanneton, Isabelle Laffont, Neurophysique et physiologie du système moteur (NPSM), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Institut fédératif de recherche sur le handicap / Réseau fédératif de recherche sur le handicap (IFRH / RFRH), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Montpellier 1 (UM1)-Institut national d'études démographiques (INED)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Bordeaux Segalen - Bordeaux 2-Université de Lille, Sciences et Technologies-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bourgogne (UB)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université Jean Monnet - Saint-Étienne (UJM)-Université Paris Diderot - Paris 7 (UPD7)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-INST GARCHES-CTNERHI-Université de Lille, Sciences Humaines et Sociales-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Université de Rennes 2 (UR2)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Service de médecine physique et de réadaptation, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Raymond Poincaré [AP-HP], Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Lille, Droit et Santé-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Sciences Humaines et Sociales-CTNERHI-INST GARCHES-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris Diderot - Paris 7 (UPD7)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Polytechnique Hauts-de-France (UPHF)-Université de Bourgogne (UB)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Lille, Sciences et Technologies-Université Bordeaux Segalen - Bordeaux 2-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national d'études démographiques (INED)-Université Montpellier 1 (UM1)-Université Panthéon-Sorbonne (UP1), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP Hôpital Raymond Poincaré [Garches], Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Lille, Droit et Santé-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Sciences Humaines et Sociales-CTNERHI-INST GARCHES-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris Diderot - Paris 7 (UPD7)-Université Jean Monnet [Saint-Étienne] (UJM)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Bourgogne (UB)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Lille, Sciences et Technologies-Université Bordeaux Segalen - Bordeaux 2-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national d'études démographiques (INED)-Université Montpellier 1 (UM1)-Université Paris 1 Panthéon-Sorbonne (UP1), Université Paris Descartes - Paris 5 (UPD5) - Centre National de la Recherche Scientifique (CNRS), Neurophysique et physiologie du système moteur ( NPSM ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut fédératif de recherche sur le handicap / Réseau fédératif de recherche sur le handicap ( IFRH / RFRH ), Université Panthéon-Sorbonne ( UP1 ) -Université Montpellier 1 ( UM1 ) -Institut national d'études démographiques ( INED ) -Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Bordeaux Segalen - Bordeaux 2-Université de Lille, Sciences et Technologies-Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université de Bourgogne ( UB ) -Université de Valenciennes et du Hainaut-Cambresis ( UVHC ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Conservatoire National des Arts et Métiers [CNAM] ( CNAM ) -INST GARCHES-CTNERHI-Université de Lille, Sciences Humaines et Sociales-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Lille, Droit et Santé-Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), and Assistance publique - Hôpitaux de Paris (AP-HP)-AP-HP Hôpital Raymond Poincaré [Garches]

Subjects
Male, MESH: Range of Motion, Articular, MESH : Movement, Elbow, Kinematics, MESH: Movement, Wrist, MESH : Rotation, MESH : Elbow, 0302 clinical medicine, MESH: Rotation, Scapula, MESH: Elbow, Paralysis, motor control, MESH : Biomechanics, MESH : Female, MESH : Paralysis, Range of Motion, Articular, MESH : Muscle, Skeletal, MESH: Biomechanics, MESH: Muscle, Skeletal, learning, MESH : Torque, General Neuroscience, 05 social sciences, Biomechanics, MESH : Adult, MESH: Torque, Biomechanical Phenomena, medicine.anatomical_structure, MESH : Quadriplegia, MESH : Electromyography, Upper limb, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, Adult, medicine.medical_specialty, Rotation, Movement, MESH : Male, MESH: Paralysis, upper limb, MESH: Psychomotor Performance, Quadriplegia, 050105 experimental psychology, handicap, biomechanics, MESH: Electromyography, 03 medical and health sciences, Physical medicine and rehabilitation, medicine, Humans, 0501 psychology and cognitive sciences, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Muscle, Skeletal, MESH: Humans, Electromyography, business.industry, MESH : Humans, Motor control, MESH: Adult, MESH : Psychomotor Performance, MESH: Male, body regions, Torque, MESH : Range of Motion, Articular, MESH: Quadriplegia, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Physical therapy, business, MESH: Female, Psychomotor Performance, 030217 neurology & neurosurgery
Abstract

This study aims to investigate how quadriplegic patients with a C6-C7 spinal lesion coordinate their upper limb to extend the elbow despite the paralysis or weakness of the triceps brachii, and what is the effect of a surgical musculotendinous transfer. For this purpose, aiming movements in a wide workspace were recorded in seven healthy subjects and in patients with incomplete (five cases) or complete (eight cases) triceps paralysis and after musculotendinous transfer (eight cases). We used four electromagnetic field sensors to quantify hand trajectory and to compute the angles describing the rotations at the scapula, glenohumeral joint, elbow and wrist (10 degrees of freedom). Extent and smoothness of the hand trajectories and hand velocity profiles were surprisingly similar between healthy subjects and quadriplegic patients. The reduction of elbow extension observed in patients was compensated by rotations distributed across several degrees of freedom including the scapula. Principal components analysis showed that the joint rotations could be summarized by an additive combination of two synergies, respectively orientating and stretching out the limb, which explained similar amounts of variance in healthy subjects and in patients. The participations of degrees of freedom in the synergies were roughly similar in the different groups of subjects, the main difference concerning scapular medial-lateral rotation, which seems to be critical in patients with a complete triceps paralysis. This demonstrates that elbow extension in quadriplegic patients is due to anticipated mechanical interaction coupling between upper limb segments. We propose that the persisting (incomplete paralysis) or restored (musculotendinous transfer) elbow extensor strength may act by stabilizing the elbow. This counterintuitive preservation of limb kinematics for horizontal aiming movements in quadriplegic patients despite the drastic changes in muscle action provoked by paralysis and/or by surgery strongly suggests that the motor system does not primarily control forces but the morphological aspects of movement, via joint rotation synergies.

Published
2006

8. Stability of pedalling mechanics during a prolonged cycling exercise performed at different cadences

Author

G. Sarre, J. Van Hoecke, Romuald Lepers, Motricité - Plasticité, Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), and Van Hoecke, Jacques

Subjects
Male, Hamstring muscles, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], MESH: Muscle Contraction, Muscle Relaxation, MESH : Analysis of Variance, Electromyography, Cohort Studies, 0302 clinical medicine, Voluntary contraction, MESH: Risk Factors, Risk Factors, Orthopedics and Sports Medicine, MESH: Oxygen Consumption, MESH : Oxygen Consumption, MESH: Cohort Studies, Knee extensors, medicine.diagnostic_test, [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Biomechanics, MESH: Comparative Study, MESH : Adult, MESH : Risk Factors, MESH: Muscle Fatigue, Muscle Fatigue, MESH : Electromyography, Cycling, Cadence, MESH: Physical Endurance, MESH : Physical Endurance, Muscle Contraction, Adult, medicine.medical_specialty, MESH: Probability, MESH : Probability, MESH : Male, Physical Exertion, MESH : Exertion, MESH : Cohort Studies, Physical Therapy, Sports Therapy and Rehabilitation, Sensitivity and Specificity, MESH : Muscle Relaxation, MESH: Bicycling, MESH: Electromyography, 03 medical and health sciences, Physical medicine and rehabilitation, Oxygen Consumption, MESH: Analysis of Variance, medicine, MESH: Exertion, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Probability, Analysis of Variance, MESH : S, MESH: Humans, business.industry, MESH : Humans, MESH : Comparative Study, MESH: Adult, 030229 sport sciences, Negative work, MESH : Muscle Fatigue, MESH: Male, Bicycling, body regions, MESH : Exercise Test, Torque, MESH : Bicycling, MESH: S, MESH: Muscle Relaxation, Physical therapy, Exercise Test, Physical Endurance, MESH : Muscle Contraction, business, MESH: Exercise Test, human activities, 030217 neurology & neurosurgery
Abstract

The aim of this study was to analyse the effect of pedalling rate on the pattern of mechanical torque application and on neuromuscular fatigue during prolonged cycling exercise. Eleven well-trained individuals performed three 1-h pedalling sessions, at 50 rev.min-1, 110 rev.min-1 and a freely chosen cadence, at an intensity corresponding to 65% of their maximal aerobic power. The mechanical torque applied on the right pedal was recorded for 30 s every 5 min while pedalling. Contractile and neural properties of the quadriceps and hamstring muscles were analysed before and immediately after each of the three pedalling sessions. The post-exercise reduction in knee extensors maximal voluntary contraction was significant (P

Published
2005

9. In vivo and in vitro functional characterization of Andersen's syndrome mutations

Author

Bendahhou, Saïd, Fournier, Emmanuel, Sternberg, Damien, Bassez, Guillaume, Furby, Alain, Sereni, Carole, Donaldson, Matthew R, Larroque, Marie-Madeleine, Fontaine, Bertrand, Barhanin, Jacques, Institut de pharmacologie moléculaire et cellulaire ( IPMC ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Fédération de Neurophysiologie Clinique and Centre de Référence des Canalopathies Musculaires, CHU Pitié-Salpêtrière [APHP], Département de pathologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Institut Mondor de recherche biomédicale ( IMRB ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Hôpital Henri Mondor, Institut de recherche en biothérapie ( IRB ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Université de Montpellier ( UM ), Centre de Recherches de Climatologie ( CRC ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Centre d'étude des environnements terrestre et planétaires ( CETP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Lasers, Plasmas et Procédés photoniques ( LP3 ), Centre National de la Recherche Scientifique ( CNRS ) -Aix Marseille Université ( AMU ), Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut Mondor de recherche biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut de recherche en biothérapie (IRB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Centre de Recherches de Climatologie (CRC), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Centre d'étude des environnements terrestre et planétaires (CETP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Lasers, Plasmas et Procédés photoniques (LP3), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, MESH: Muscle Cells, Patch-Clamp Techniques, MESH : Molecular Sequence Data, Action Potentials, Molecular and Genomic Physiology, MESH: Amino Acid Sequence, Kidney, Mice, Chlorocebus aethiops, MESH: Animals, MESH : Muscle, Skeletal, MESH : Patch-Clamp Techniques, MESH: Action Potentials, MESH: Muscle, Skeletal, MESH : Amino Acid Sequence, MESH: Potassium Channels, Inwardly Rectifying, MESH : Adult, MESH : Kidney, Pedigree, MESH: COS Cells, COS Cells, MESH : Electromyography, MESH : COS Cells, Adult, MESH: Pedigree, MESH : Male, Molecular Sequence Data, Mutation, Missense, Paralyses, Familial Periodic, MESH: Electromyography, MESH: Paralyses, Familial Periodic, MESH : Action Potentials, MESH: Patch-Clamp Techniques, MESH : Mice, Animals, Humans, Amino Acid Sequence, Potassium Channels, Inwardly Rectifying, Muscle, Skeletal, MESH: Mice, Muscle Cells, MESH: Mutation, Missense, MESH: Molecular Sequence Data, MESH: Humans, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, MESH : Muscle Cells, Electromyography, MESH : Humans, MESH: Adult, MESH: Kidney, MESH: Cercopithecus aethiops, MESH: Male, MESH : Paralyses, Familial Periodic, MESH : Pedigree, MESH : Potassium Channels, Inwardly Rectifying, MESH : Animals, MESH : Cercopithecus aethiops, [ SDV.BA.MVSA ] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, MESH : Mutation, Missense
Abstract

The inward rectifier K(+) channel Kir2.1 carries all Andersen's syndrome mutations identified to date. Patients exhibit symptoms of periodic paralysis, cardiac dysrhythmia and multiple dysmorphic features. Here, we report the clinical manifestations found in three families with Andersen's syndrome. Molecular genetics analysis identified two novel missense mutations in the KCNJ2 gene leading to amino acid changes C154F and T309I of the Kir2.1 open reading frame. Patch clamp experiments showed that the two mutations produced a loss of channel function. When co-expressed with Kir2.1 wild-type (WT) channels, both mutations exerted a dominant-negative effect leading to a loss of the inward rectifying K(+) current. Confocal microscopy imaging in HEK293 cells is consistent with a co-assembly of the EGFP-fused mutant proteins with WT channels and proper traffick to the plasma membrane to produce silent channels alone or as hetero-tetramers with WT. Functional expression in C2C12 muscle cell line of newly as well as previously reported Andersen's syndrome mutations confirmed that these mutations act through a dominant-negative effect by altering channel gating or trafficking. Finally, in vivo electromyographic evaluation showed a decrease in muscle excitability in Andersen's syndrome patients. We hypothesize that Andersen's syndrome-associated mutations and hypokalaemic periodic paralysis-associated calcium channel mutations may lead to muscle membrane hypoexcitability via a common mechanism.

Published
2005

10. Muscular performances at the ankle joint in young and elderly men

Author

Jacques Van Hoecke, Alain Martin, Emilie Simoneau, Motricité - Plasticité, Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), and Van Hoecke, Jacques

Subjects
Male, Aging, MESH: Range of Motion, Articular, MESH : Ankle Joint, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], MESH : Electric Stimulation, MESH: Muscle Contraction, MESH : Muscle Weakness, MESH : Aged, MESH: Evoked Potentials, Motor, Isometric exercise, Electromyography, MESH : Evoked Potentials, Motor, 0302 clinical medicine, MESH: Ankle Joint, MESH: Aging, MESH: Isometric Contraction, Range of Motion, Articular, Young adult, MESH : Muscle, Skeletal, 10. No inequality, MESH: Aged, MESH: Muscle, Skeletal, Muscle Weakness, medicine.diagnostic_test, [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], MESH: Muscle Weakness, MESH: Electric Stimulation, MESH : Adult, Coactivation, MESH: Leg, medicine.anatomical_structure, Linear relationship, MESH : Electromyography, Range of motion, Muscle Contraction, Adult, medicine.medical_specialty, MESH : Male, MESH: Research Support, Non-U.S. Gov, MESH: Electromyography, MESH : Isometric Contraction, 03 medical and health sciences, Physical medicine and rehabilitation, Isometric Contraction, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, MESH : Research Support, Non-U.S. Gov, Muscle, Skeletal, Aged, Leg, MESH: Humans, business.industry, MESH : Humans, Mean age, MESH: Adult, 030229 sport sciences, Evoked Potentials, Motor, Electric Stimulation, MESH : Aging, MESH: Male, MESH : Range of Motion, Articular, Physical therapy, MESH : Muscle Contraction, Tibial Nerve, Geriatrics and Gerontology, Ankle, MESH : Leg, business, human activities, Ankle Joint, 030217 neurology & neurosurgery
Abstract

The effect of aging on mechanical and electromyographic characteristics of ankle joint muscles was investigated in 11 young (mean age 24 years) and 12 elderly (mean age 77 years) males. Maximal and submaximal isometric voluntary torques were measured during ankle plantarflexion and dorsiflexion. Electromyographic activities of triceps surae and tibialis anterior muscles were recorded. The elderly group developed equal maximal dorsiflexion torques (42 vs 45 N.m, p >.05), but in plantarflexion, the elderly group was weaker (80 vs 132 N.m, p

Published
2005

11. A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep

Author

Verret , Laure, Goutagny , Romain, Fort , Patrice, Cagnon , Laurène, Salvert , Denise, Léger , Lucienne, Boissard , Romuald, Salin , Paul, Peyron , Christelle, Luppi , Pierre-Hervé, Physio-pathologie des réseaux neuronaux du cycle veille-sommeil, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), Institut des sciences du cerveau de Toulouse. (ISCT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Team Physiopathologie des Réseaux Neuronaux Responsables du Cycle Veille-Sommeil, Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherches sur la Cognition Animale [Toulouse] ( CRCA ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Centre National de la Recherche Scientifique ( CNRS ), Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), and Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS )

Subjects
Central Nervous System, Male, [SDV]Life Sciences [q-bio], MESH: Neurons, MESH : Dose-Response Relationship, Drug, Cell Count, MESH : Neuropeptides, MESH: Rats, Sprague-Dawley, MESH : Cell Count, MESH : Hypothalamic Hormones, MESH: Neuropeptides, MESH: Dose-Response Relationship, Drug, Rats, Sprague-Dawley, MESH: Melanins, MESH: Animals, Neurons, Hypothalamic Hormones, MESH : Rats, MESH: Proto-Oncogene Proteins c-fos, MESH : Central Nervous System, lcsh:QP351-495, Intracellular Signaling Peptides and Proteins, MESH : Melanins, MESH : Injections, Intraventricular, Electroencephalography, respiratory system, Circadian Rhythm, MESH: Pituitary Hormones, MESH : Electromyography, MESH : Pituitary Hormones, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Sleep Stages, MESH : Carrier Proteins, MESH: Injections, Intraventricular, Proto-Oncogene Proteins c-fos, psychological phenomena and processes, hormones, hormone substitutes, and hormone antagonists, Research Article, MESH : Hypothalamus, MESH: Rats, MESH: Sleep, MESH : Male, MESH : Sleep, Hypothalamus, Sleep, REM, MESH: Carrier Proteins, MESH : Sleep Stages, MESH : Neurons, lcsh:RC321-571, MESH: Electromyography, MESH : Intracellular Signaling Peptides and Proteins, MESH: Intracellular Signaling Peptides and Proteins, mental disorders, MESH: Electroencephalography, Animals, MESH: Central Nervous System, MESH: Circadian Rhythm, MESH : Electroencephalography, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Injections, Intraventricular, Melanins, Orexins, Dose-Response Relationship, Drug, Electromyography, MESH: Cell Count, Neuropeptides, MESH : Circadian Rhythm, MESH: Sleep Stages, MESH: Sleep, REM, MESH: Hypothalamus, MESH : Rats, Sprague-Dawley, MESH: Male, Rats, MESH: Hypothalamic Hormones, Pituitary Hormones, MESH : Proto-Oncogene Proteins c-fos, lcsh:Neurophysiology and neuropsychology, nervous system, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH : Sleep, REM, MESH : Animals, Carrier Proteins, Sleep
Abstract

Background Peptidergic neurons containing the melanin-concentrating hormone (MCH) and the hypocretins (or orexins) are intermingled in the zona incerta, perifornical nucleus and lateral hypothalamic area. Both types of neurons have been implicated in the integrated regulation of energy homeostasis and body weight. Hypocretin neurons have also been involved in sleep-wake regulation and narcolepsy. We therefore sought to determine whether hypocretin and MCH neurons express Fos in association with enhanced paradoxical sleep (PS or REM sleep) during the rebound following PS deprivation. Next, we compared the effect of MCH and NaCl intracerebroventricular (ICV) administrations on sleep stage quantities to further determine whether MCH neurons play an active role in PS regulation. Results Here we show that the MCH but not the hypocretin neurons are strongly active during PS, evidenced through combined hypocretin, MCH, and Fos immunostainings in three groups of rats (PS Control, PS Deprived and PS Recovery rats). Further, we show that ICV administration of MCH induces a dose-dependant increase in PS (up to 200%) and slow wave sleep (up to 70%) quantities. Conclusion These results indicate that MCH is a powerful hypnogenic factor. MCH neurons might play a key role in the state of PS via their widespread projections in the central nervous system.

Published
2003

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