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4 results on '"MESH: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis"'

1. Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis

Author

Lucy Smyth, Andrea Mazzetti, Charles D. Pusey, Lorraine Harper, Donna Reidlinger, Gina Gregorini, William F. Clark, Pexivas Investigators Pexivas Investigators, Adeera Levin, Toshiko Ito-Ihara, Chen-Au Peh, Xavier Puéchal, Ulrich Specks, Carmel M. Hawley, Oliver Floßmann, Simon Carette, Alina Casian, Wojciech Szczeklik, Peter A. Merkel, Janak de Zoysa, Nader Khalidi, David Jayne, Samir Mehta, Biljana Brezina, Ron Wald, Michael Walsh, Luis Felipe Flores-Suárez, Carol A. McAlear, L. Guillevin, Louis Girard, Natalie Ives, Wladimir Szpirt, Vladimir Tesar, Elizabeth Broadhurst, Christian Pagnoux, Shouichi Fujimoto, McMaster University [Hamilton, Ontario], Royal Adelaide Hospital [Adelaide Australia], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Miyazaki, McMaster University, St. Joseph’s Healthcare, Royal Berkshire Hospital, St. Michael's Hospital, University of British Columbia (UBC), Università degli Studi di Brescia [Brescia], Mount Sinai Hospital [Toronto, Canada] (MSH), Mayo Clinic [Rochester], Charles University [Prague] (CU), Instituto Nacional de Enfermedades Respiratorias [México, Mexico], University of Cambridge [UK] (CAM), Addenbrooke's Hospital, and Cambridge University NHS Trust

Subjects
MESH: Combined Modality Therapy, medicine.medical_specialty, Cyclophosphamide, medicine.medical_treatment, Azathioprine, 030204 cardiovascular system & hematology, urologic and male genital diseases, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Gastroenterology, MESH: Dose-Response Relationship, Drug, MESH: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, 03 medical and health sciences, 0302 clinical medicine, Maintenance therapy, immune system diseases, Internal medicine, Medicine, MESH: Incidence, cardiovascular diseases, 030212 general & internal medicine, skin and connective tissue diseases, Anti-neutrophil cytoplasmic antibody, MESH: Aged, MESH: Kidney Diseases, MESH: Middle Aged, MESH: Humans, business.industry, MESH: Cyclophosphamide, MESH: Adult, Glomerulonephritis, General Medicine, MESH: Plasma Exchange, medicine.disease, MESH: Induction Chemotherapy, MESH: Male, respiratory tract diseases, 3. Good health, MESH: Kidney Failure, Chronic, MESH: Administration, Oral, Rituximab, Plasmapheresis, MESH: Immunosuppressive Agents, MESH: Rituximab, MESH: Glucocorticoids, business, Vasculitis, MESH: Female, medicine.drug
Abstract

BACKGROUND More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis. METHODS We conducted a randomized trial with a 2-by-2 factorial design to evaluate the use of plasma exchange and two regimens of oral glucocorticoids in patients with severe ANCA-associated vasculitis (defined by an estimated glomerular filtration rate of

Published
2020

2. Blockade of the Kinin B1 Receptor Ameloriates Glomerulonephritis

Author

Joao-Bosco Pesquero, David J. Salant, Stéphane Decramer, Eric Neau, J.P. Schanstra, Julie Klein, Peter Heeringa, Flavio Bandin, Jean-Loup Bascands, Julien Gonzalez, Groningen Kidney Center (GKC), Translational Immunology Groningen (TRIGR), Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pédiatrie - Néphrologie, Médecine interne, Hypertension, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Department of Medicine, Boston University [Boston] (BU)-Evans Biomedical Research Center, Boston University [Boston] (BU), Department of Pathology and Medical Biology, University Medical Center Groningen [Groningen] (UMCG), Department of Biophysics, UNIFESP-Escola Paulista de Medicina, and Simon, Marie Francoise

Subjects
Male, Nephrology, Biopsy, MESH: Sulfonamides, MESH: Purpura, Schoenlein-Henoch, UP-REGULATION, Kidney, Receptor, Bradykinin B1, urologic and male genital diseases, ACTIVATION, MESH: Biopsy, Mice, Glomerulonephritis, MESH: Animals, MESH: Dioxoles, IN-VIVO, Sulfonamides, MOUSE MODEL, General Medicine, Kinin, MESH: Chemokines, MESH: Glomerulonephritis, HUMAN LUNG FIBROBLASTS, medicine.anatomical_structure, BRADYKININ B-1 RECEPTOR, Creatinine, REDUCES RENAL FIBROSIS, Chemokines, medicine.symptom, CRESCENTIC GLOMERULONEPHRITIS, medicine.medical_specialty, IgA Vasculitis, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Mice, Inbred Strains, Inflammation, MESH: Creatinine, Dioxoles, ENDOTOXIN-INDUCED INFLAMMATION, MESH: Mice, Inbred Strains, Nephropathy, MESH: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Internal medicine, medicine, Animals, Humans, RNA, Messenger, MESH: Mice, MESH: RNA, Messenger, Retrospective Studies, MESH: Receptor, Bradykinin B1, MESH: Humans, business.industry, Macrophages, MESH: Macrophages, MESH: Retrospective Studies, MESH: Kidney, medicine.disease, MESH: Male, Blockade, Bradykinin B1 Receptor Antagonists, Disease Models, Animal, Basic Research, Immunology, GLOMERULAR INJURY, MESH: Disease Models, Animal, business, Kidney disease
Abstract

International audience; Severe inflammation characterizes rapidly progressive glomerulonephritides, and expression of the kinin B1 receptor (B1R) associates with inflammation. Delayed B1R blockade reduces renal inflammation in a model of unilateral ureteral obstruction, but whether B1R modulates the pathophysiology of glomerulonephritides is unknown. Here, we observed an association of B1R protein expression and inflammation, in both glomeruli and the renal interstitium, in biopsies of patients with glomerulonephritides, Henoch-Schönlein purpura nephropathy, and ANCA-associated vasculitis. In the nephrotoxic serum-induced glomerulonephritis model, we observed upregulation of the B1R receptor; treatment with a B1R antagonist beginning 2 weeks after the onset of disease reduced both glomerular and tubular lesions and improved renal function. B1R blockade reduced renal chemokine expression and macrophage accumulation. Collectively, our data demonstrate that blockade of the kinin B1R has significant potential for the treatment of glomerulonephritis.

Published
2010

3. L19. Lymphoid neogenesis in vascular chronic inflammation

Author

Charles-Antoine Dutertre, Jean-Baptiste Michel, Kevin Guedj, Antonino Nicoletti, Giuseppina Caligiuri, Olivier Thaunat, Marion Morvan, Anh-Thu Gaston, Jamila Khallou-Laschet, Marc Clement, Nicoletti, Antonino, Immunopathologie et immunomodulation des maladies cardiovasculaires, Hémostase, bio-ingénierie et remodelage cardiovasculaires (LBPC), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Transplantation Rénale et d'Immunologie Clinique, Hospices Civils de Lyon (HCL)-Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Université de Lyon, Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Galilée-Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Galilée, and Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Galilée

Subjects
CD4-Positive T-Lymphocytes, Graft Rejection, MESH: Signal Transduction, Isoantigens, Pathology, MESH: Isoantigens, Lymphocyte Activation, MESH: Mice, Knockout, Muscle, Smooth, Vascular, Receptors, Tumor Necrosis Factor, MESH: Lymphangiogenesis, MESH: Atherosclerosis, Mice, 0302 clinical medicine, MESH: Animals, MESH: Immune Evasion, Lymphangiogenesis, Receptor, Aorta, ComputingMilieux_MISCELLANEOUS, Mice, Knockout, B-Lymphocytes, 0303 health sciences, MESH: CD4-Positive T-Lymphocytes, MESH: Aorta, T-Lymphocytes, Helper-Inducer, MESH: Muscle, Smooth, Vascular, MESH: Choristoma, General Medicine, MESH: Chemokines, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Chemokines, Inflammation Mediators, medicine.symptom, Signal Transduction, Adventitia, medicine.medical_specialty, MESH: Inflammation Mediators, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, MESH: Graft Rejection, Inflammation, Choristoma, MESH: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, MESH: B-Lymphocytes, medicine, Animals, Humans, MESH: Thrombosis, MESH: T-Lymphocytes, Helper-Inducer, MESH: Lymphocyte Activation, MESH: Mice, Immune Evasion, 030304 developmental biology, MESH: Humans, Lymphoid neogenesis, business.industry, Macrophages, MESH: Macrophages, Thrombosis, Atherosclerosis, MESH: Adventitia, MESH: Receptors, Tumor Necrosis Factor, Vascular pathology, business, 030215 immunology
Abstract

International audience; no abstract

Published
2013

4. L14. Immunomodulatory properties of apoptotic cells

Author

Philippe Saas, Sylvain Perruche, Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC ( HOTE GREFFON ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Etablissement français du sang [Bourgogne-France-Comté] ( EFS [Bourgogne-France-Comté] ) -Université de Franche-Comté ( UFC ), Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer ( LabEx LipSTIC ), Institut National de la Recherche Agronomique ( INRA ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Université Paris-Sud - Paris 11 ( UP11 ) -École pratique des hautes études ( EPHE ) -Institut Gustave Roussy ( IGR ) -Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ) -Université de Bourgogne ( UB ) -Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ) -Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Fédération Francophone de la Cancérologie Digestive, FFCD-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Etablissement français du sang [Bourgogne-France-Comté] ( EFS [Bourgogne-France-Comté] ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université de Franche-Comté ( UFC ), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (HOTE GREFFON), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-France-Comté] (EFS [Bourgogne-France-Comté])-Université de Franche-Comté (UFC), Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer (LabEx LipSTIC), Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-École pratique des hautes études (EPHE)-Institut Gustave Roussy (IGR)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (CRLCC - CGFL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Fédération Francophone de la Cancérologie Digestive, FFCD-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Etablissement français du sang [Bourgogne-France-Comté] (EFS [Bourgogne-France-Comté])-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Université de Franche-Comté (UFC)-Université de Montpellier (UM), Saas, Philippe, Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Gustave Roussy (IGR)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Fédération Francophone de la Cancérologie Digestive, FFCD-Université de Montpellier (UM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Gustave Roussy (IGR)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Fédération Francophone de la Cancérologie Digestive, FFCD-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Montpellier (UM), and Université de Franche-Comté (UFC)-Etablissement français du sang [Bourgogne-France-Comté] (EFS [Bourgogne-France-Comté])-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
MESH: Inflammation, MESH: Signal Transduction, Cell Transplantation, Neutrophils, medicine.medical_treatment, Apoptosis, MESH: T-Lymphocyte Subsets, Pharmacology, MESH: Neutrophils, T-Lymphocytes, Regulatory, MESH : Neutrophils, MESH : T-Lymphocytes, Regulatory, 0302 clinical medicine, T-Lymphocyte Subsets, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, MESH: Animals, MESH : Antigen-Presenting Cells, MESH: Desensitization, Immunologic, MESH: Phagocytosis, ComputingMilieux_MISCELLANEOUS, Desensitization (medicine), MESH : Macrophages, 0303 health sciences, Phagocytes, tolerance, MESH: Dendritic Cells, MESH: Antigen-Presenting Cells, MESH : Immune Tolerance, General Medicine, MESH: Chemokines, MESH: Cell Transplantation, [SDV.IMM]Life Sciences [q-bio]/Immunology, Chemokines, Inflammation Mediators, medicine.symptom, Signal Transduction, TGF-β, MESH: Immune Tolerance, [SDV.IMM] Life Sciences [q-bio]/Immunology, MESH: Inflammation Mediators, MESH: Immunomodulation, Antigen-Presenting Cells, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Inflammation, Immunomodulation, MESH : Inflammation Mediators, 03 medical and health sciences, MESH: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Cell transplantation, Text mining, Phagocytosis, MESH : Phagocytosis, Immune Tolerance, medicine, Animals, Humans, MESH : Chemokines, 030304 developmental biology, MESH : Immunomodulation, MESH : Signal Transduction, MESH: Humans, MESH : Inflammation, business.industry, Macrophages, MESH: T-Lymphocytes, Regulatory, MESH: Apoptosis, MESH : Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, MESH : Humans, MESH: Macrophages, Dendritic Cells, MESH : T-Lymphocyte Subsets, MESH : Cell Transplantation, Desensitization, Immunologic, inflammation, MESH : Dendritic Cells, MESH : Desensitization, Immunologic, MESH : Animals, business, MESH : Apoptosis, 030215 immunology
Abstract

International audience

Published
2013

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