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Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis
- Source :
- Walsh, M, Merkel, P A, Peh, C, Szpirt, W M, Puéchal, X, Fujimoto, S, Hawley, C M, Khalidi, N, Floßmann, O, Wald, R, Girard, L P, Levin, A, Gregorini, G, Harper, L, Clark, W F, Pagnoux, C, Specks, U, Smyth, L, Tesar, V, Ito-ihara, T, De Zoysa, J R, Szczeklik, W, Flores-suárez, L F, Carette, S, Guillevin, L, Pusey, C D, Casian, A L, Brezina, B, Mazzetti, A, Mcalear, C A, Broadhurst, E, Reidlinger, D, Mehta, S, Ives, N & Jayne, D R W 2020, ' Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis ', New England Journal of Medicine, vol. 382, no. 7, pp. 622-631 . https://doi.org/10.1056/NEJMoa1803537, New England Journal of Medicine, New England Journal of Medicine, Massachusetts Medical Society, 2020, 382 (7), pp.622-631. ⟨10.1056/NEJMoa1803537⟩
- Publication Year :
- 2020
- Publisher :
- Massachusetts Medical Society, 2020.
-
Abstract
- BACKGROUND More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis. METHODS We conducted a randomized trial with a 2-by-2 factorial design to evaluate the use of plasma exchange and two regimens of oral glucocorticoids in patients with severe ANCA-associated vasculitis (defined by an estimated glomerular filtration rate of
- Subjects :
- MESH: Combined Modality Therapy
medicine.medical_specialty
Cyclophosphamide
medicine.medical_treatment
Azathioprine
030204 cardiovascular system & hematology
urologic and male genital diseases
[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology
Gastroenterology
MESH: Dose-Response Relationship, Drug
MESH: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
03 medical and health sciences
0302 clinical medicine
Maintenance therapy
immune system diseases
Internal medicine
Medicine
MESH: Incidence
cardiovascular diseases
030212 general & internal medicine
skin and connective tissue diseases
Anti-neutrophil cytoplasmic antibody
MESH: Aged
MESH: Kidney Diseases
MESH: Middle Aged
MESH: Humans
business.industry
MESH: Cyclophosphamide
MESH: Adult
Glomerulonephritis
General Medicine
MESH: Plasma Exchange
medicine.disease
MESH: Induction Chemotherapy
MESH: Male
respiratory tract diseases
3. Good health
MESH: Kidney Failure, Chronic
MESH: Administration, Oral
Rituximab
Plasmapheresis
MESH: Immunosuppressive Agents
MESH: Rituximab
MESH: Glucocorticoids
business
Vasculitis
MESH: Female
medicine.drug
Subjects
Details
- ISSN :
- 15334406 and 00284793
- Volume :
- 382
- Database :
- OpenAIRE
- Journal :
- New England Journal of Medicine
- Accession number :
- edsair.doi.dedup.....9ff53a8321bbaae6bb5cf637d8d822ce