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6 results on '"MALUTAN, ANDREI M."'

1. GRP78 levels, regional fat distribution and endometrial cáncer

Author

Ciortea, Răzvan, Malutan, Andrei M, Angheluta, Lenuta M, Bucuri, Carmen E, Rada, Maria P, and Mihu, Dan

Subjects
Adipose Tissue, Obesity, Endoplasmic Reticulum Stress, Endometrial Neoplasms
Abstract

Background: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance. Aim: To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer. Material and methods: Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured. Results: GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (p

Published
2016

2. GRP78 levels, regional fat distribution and endometrial cáncer

Author

Ciortea,Răzvan, Malutan,Andrei M, Angheluta,Lenuta M, Bucuri,Carmen E, Rada,Maria P, and Mihu,Dan

Subjects
Adipose Tissue, Obesity, Endoplasmic Reticulum Stress, Endometrial Neoplasms
Abstract

Background: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance. Aim: To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer. Material and methods: Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured. Results: GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (p

Published
2016

5. Pro-inflammatory cytokines for evaluation of inflammatory status in endometriosis.

Author

MALUTAN, ANDREI M., DRUGAN, TUDOR, COSTIN, NICOLAE, CIORTEA, RAZVAN, BUCURI, CARMEN, RADA, MARIA P., and MIHU, DAN

Subjects
*CYTOKINES, *ENDOMETRIOSIS, *IMMUNOLOGY of inflammation, *IMMUNOLOGY, *TUMOR necrosis factor regulation
Abstract

The aim of the study was to investigate the serum pro-inflammatory cytokine profile in patients with diagnosed endometriosis. Material and methods: The study included 160 women, who were divided in two study groups (Group I - endometriosis; Group 2 - healthy). We evaluated the serum levels of interleukin (IL)-lß, lL-5, IL-6, IL-7, and IL-12, and of tumour necrosis factor a (TNF-a) with the use of Human Multiplex Cytokine Panels. Conclusions: Women with endometriosis have elevated levels of key pro-inflammatory cytokines, i.e. IL-1β, IL-6, and TNF-a. At the same time, IL-1ß and IL-6 could be used as predictors for endometriosis. [ABSTRACT FROM AUTHOR]

Published
2015
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6. GRP78 levels, regional fat distribution and endometrial cáncer.

Author

Ciortea R, Malutan AM, Angheluta LM, Bucuri CE, Rada MP, and Mihu D

Subjects
Absorptiometry, Photon, Aged, Biomarkers, Tumor blood, Case-Control Studies, Endometrial Neoplasms physiopathology, Endoplasmic Reticulum Chaperone BiP, Female, Humans, Middle Aged, Neoplasm Staging, Body Fat Distribution, Endometrial Neoplasms blood, Endoplasmic Reticulum Stress physiology, Heat-Shock Proteins blood
Abstract

Background: The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance., Aim: To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer., Material and Methods: Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured., Results: GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (p<0.01). Gynoid fat had a negative correlation with plasma GRP78 levels (p<0.01)., Conclusions: GRP78 levels are associated with the distribution of adipose tissue and are higher in patients with endometrial cancer.

Published
2016
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