1. Growth differentiation factor 11 (GDF11) - a promising anti-ageing factor - is highly concentrated in platelets
- Author
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Rosa Gonzalo-Daganzo, A. Richart, M. Ynigo, E. Flores-Ballester, C. de Miguel, J R Cabrera, Carmen Regidor, José Luis Bueno, José A. García-Marco, and Carlos Vilches
- Subjects
Adult ,Blood Platelets ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Plateletpheresis ,Biology ,Bone morphogenetic protein ,Young Adult ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Platelet ,Aged ,Aged, 80 and over ,Growth differentiation factor ,Hematology ,General Medicine ,Middle Aged ,Growth Differentiation Factors ,030104 developmental biology ,Cytokine ,Apheresis ,Endocrinology ,Bone Morphogenetic Proteins ,GDF11 ,Platelet lysate - Abstract
Recent research suggests that growth differentiation factor 11 (GDF11) could reverse age-related diseases and that its blood concentration decreases with age. This poses plasma from young donors as a therapeutic GDF11 source to treat age-related diseases. In addition, the tissue source of circulating GDF11 remains unknown. We analysed GDF11 levels in paired samples of serum, plasma and platelet lysate (PL) from 23 volunteers. Plasma and PL were collected by plateletpheresis. Here, we show that GDF11 is highly concentrated in platelets and that the circulating levels reported in previous studies could be biased as a result of serum sample manipulation.
- Published
- 2016