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Growth differentiation factor 11 (GDF11) - a promising anti-ageing factor - is highly concentrated in platelets
- Source :
- Vox Sanguinis. 111:434-436
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Recent research suggests that growth differentiation factor 11 (GDF11) could reverse age-related diseases and that its blood concentration decreases with age. This poses plasma from young donors as a therapeutic GDF11 source to treat age-related diseases. In addition, the tissue source of circulating GDF11 remains unknown. We analysed GDF11 levels in paired samples of serum, plasma and platelet lysate (PL) from 23 volunteers. Plasma and PL were collected by plateletpheresis. Here, we show that GDF11 is highly concentrated in platelets and that the circulating levels reported in previous studies could be biased as a result of serum sample manipulation.
- Subjects :
- Adult
Blood Platelets
0301 basic medicine
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Plateletpheresis
Biology
Bone morphogenetic protein
Young Adult
03 medical and health sciences
Internal medicine
medicine
Humans
Platelet
Aged
Aged, 80 and over
Growth differentiation factor
Hematology
General Medicine
Middle Aged
Growth Differentiation Factors
030104 developmental biology
Cytokine
Apheresis
Endocrinology
Bone Morphogenetic Proteins
GDF11
Platelet lysate
Subjects
Details
- ISSN :
- 00429007
- Volume :
- 111
- Database :
- OpenAIRE
- Journal :
- Vox Sanguinis
- Accession number :
- edsair.doi.dedup.....0575f036021a3291dfe77cb57f63c20e